Details of the Target

General Information of Target

Target ID LDTP08139
Target Name Centriolin (CNTRL)
Gene Name CNTRL
Gene ID 11064
Synonyms
CEP1; CEP110; Centriolin; Centrosomal protein 1; Centrosomal protein of 110 kDa; Cep110
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIAD
ENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIEN
LEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE
IEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFT
IFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEI
KNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYK
IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE
QLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEA
IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAI
DSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLT
EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQER
DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN
QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD
DNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSL
ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF
DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL
EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ
EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKL
NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR
GYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYW
VYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGM
ALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN
LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL
HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR
LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS
LQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN
EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQA
KADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKE
EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL
ENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWE
KKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQ
EKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQK
EEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEK
ELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE
LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC
IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL
KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKL
NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ
VDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.
Uniprot ID
Q7Z7A1
Ensemble ID
ENST00000373850.6
HGNC ID
HGNC:1858

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.L1943R .
CAL51 Deletion: p.K1802SfsTer9 DBIA    Probe Info 
CCK81 SNV: p.A949D .
HCT116 SNV: p.T1383I .
HCT15 SNV: p.W187Ter; p.Q698H DBIA    Probe Info 
HEC1B Deletion: p.K1802SfsTer9 .
HT SNV: p.K507R DBIA    Probe Info 
HT115 SNV: p.E248Ter .
KASUMI2 SNV: p.Q1073R DBIA    Probe Info 
LNCaP clone FGC Insertion: p.R1722MfsTer4 .
LS180 Deletion: p.K1802SfsTer9
SNV: p.Y393S;p.R584I		 .
MCC13 SNV: p.G138E .
MDAMB453 SNV: p.E707K .
MDAMB468 SNV: p.Q687Ter .
NCIH1944 SNV: p.P1299L .
NCIH446 SNV: p.S19F .
OVISE SNV: p.D492E .
SNU1079 SNV: p.V666G .
SUPT1 SNV: p.H432R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P3
 Probe Info  		9.49  LDD0454  [1]
DBIA
 Probe Info  		C639(1.37)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C639(0.60)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C639(0.79)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C639(1.29)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C639(1.96)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C639(2.11)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C639(1.53)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C639(1.04)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C639(3.19)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C639(3.64)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C639(2.00)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C639(1.42)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C639(1.43)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C639(0.96)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C639(1.60)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C639(1.55)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C639(2.19)  LDD0827  [2]
 LDCM0237  AC12 HEK-293T C639(1.13)  LDD0835  [2]
 LDCM0246  AC128 HEK-293T C639(0.79)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C639(0.40)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C639(0.53)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C639(0.74)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C639(0.69)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C639(0.60)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C639(0.38)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C639(0.55)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C639(0.76)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C639(0.79)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C639(0.57)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C639(0.64)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C639(0.42)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C639(0.71)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C639(0.87)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C639(0.76)  LDD0860  [2]
 LDCM0270  AC15 HEK-293T C639(0.33)  LDD0868  [2]
 LDCM0278  AC19 HEK-293T C1451(1.03)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C639(0.37)  LDD0877  [2]
 LDCM0285  AC25 HEK-293T C639(0.40)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C639(0.22)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C639(0.23)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C639(0.34)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C639(0.25)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C639(1.09)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C639(0.24)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C639(0.39)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C639(0.29)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C639(0.24)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C639(0.41)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C1451(1.06)  LDD1535  [5]
 LDCM0301  AC4 HEK-293T C639(1.10)  LDD0899  [2]
 LDCM0305  AC43 HEK-293T C1451(1.09)  LDD1544  [5]
 LDCM0312  AC5 HEK-293T C639(0.77)  LDD0910  [2]
 LDCM0314  AC51 HEK-293T C1451(1.04)  LDD1553  [5]
 LDCM0320  AC57 HEK-293T C639(0.74)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C639(1.00)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C639(0.81)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C639(1.03)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C639(0.44)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C639(0.33)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C639(0.53)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C639(0.28)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C639(0.52)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C639(0.29)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C639(0.66)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C639(0.39)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C639(0.82)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C639(0.73)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C639(0.66)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C639(0.31)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C639(0.50)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C639(0.46)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C639(0.37)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C639(0.46)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C639(0.72)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C639(0.54)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C639(0.35)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C639(0.30)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C639(0.64)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C639(0.43)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C639(0.55)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C639(0.39)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C639(0.28)  LDD0946  [2]
 LDCM0365  AC98 HEK-293T C639(1.03)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C639(1.96)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C639(0.61)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C639(0.37)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C639(0.34)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C639(1.50)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C639(0.87)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C639(0.57)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C639(0.33)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C639(0.26)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C639(0.34)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C639(0.34)  LDD0971  [2]
 LDCM0379  CL11 HEK-293T C639(0.82)  LDD0977  [2]
 LDCM0382  CL112 HEK-293T C639(0.38)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C639(0.36)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C639(0.13)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C639(0.17)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C639(0.19)  LDD0984  [2]
 LDCM0390  CL12 HEK-293T C639(0.82)  LDD0988  [2]
 LDCM0396  CL125 HEK-293T C639(0.67)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C639(0.55)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C639(0.78)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C639(0.93)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C639(1.03)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C639(1.41)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C639(0.57)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C639(1.06)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C639(0.59)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C639(0.83)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C639(1.19)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C639(1.14)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C639(0.91)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C639(0.65)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C639(0.99)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C639(1.04)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C639(1.11)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C639(0.99)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C639(1.24)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C639(1.04)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C639(1.16)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C639(0.99)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C639(0.83)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C639(1.07)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C1451(1.03)  LDD1624  [5]
 LDCM0429  CL4 HEK-293T C639(0.91)  LDD1027  [2]
 LDCM0433  CL43 HEK-293T C1451(1.15)  LDD1637  [5]
 LDCM0440  CL5 HEK-293T C639(0.76)  LDD1038  [2]
 LDCM0446  CL55 HEK-293T C1451(1.04)  LDD1649  [5]
 LDCM0451  CL6 HEK-293T C639(1.11)  LDD1049  [2]
 LDCM0459  CL67 HEK-293T C1451(1.11)  LDD1662  [5]
 LDCM0462  CL7 HEK-293T C639(0.57)  LDD1060  [2]
 LDCM0472  CL79 HEK-293T C1451(1.18)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C639(0.55)  LDD1071  [2]
 LDCM0484  CL9 HEK-293T C639(0.57)  LDD1082  [2]
 LDCM0486  CL91 HEK-293T C639(1.11)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C639(1.26)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C639(0.84)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C639(0.41)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C639(0.34)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C639(0.74)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C639(0.86)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C639(0.86)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C639(1.30)  LDD1092  [2]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C1535(4.65)  LDD0513  [6]
 LDCM0022  KB02 HCT 116 C639(1.37)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C639(1.31)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C639(1.89)  LDD0082  [2]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.