Details of the Target
General Information of Target
| Target ID | LDTP07620 | |||||
|---|---|---|---|---|---|---|
| Target Name | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) | |||||
| Gene Name | PAOX | |||||
| Gene ID | 196743 | |||||
| Synonyms |
PAO; Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; EC 1.5.3.13; Polyamine oxidase |
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| 3D Structure | ||||||
| Sequence |
MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGGRIRSERCF
GGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGA SVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEETRKLK LAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFSKGYQGLTNCMMAALPEDT VVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPLGFLREHLDTFF DPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLVWEDTSPLEDAAPELQDAW FRKLIGFVVLPAFASVHVLCGFIAGLESEFMETLSDEEVLLCLTQVLRRVTGNPRLPAPK SVLRSRWHSAPYTRGSYSYVAVGSTGGDLDLLAQPLPADGAGAQLQILFAGEATHRTFYS TTHGALLSGWREADRLLSLWAPQVQQPRPRL |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Flavin monoamine oxidase family
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| Subcellular location |
Peroxisome
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| Function |
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
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| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
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| ChEMBL ID | ||||||
Probe(s) Labeling This Target
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
C049 Probe Info |
 |
5.10 | LDD1747 | [1] | |
|
C059 Probe Info |
 |
7.06 | LDD1756 | [1] | |
|
C060 Probe Info |
 |
6.82 | LDD1757 | [1] | |
|
C063 Probe Info |
 |
17.51 | LDD1760 | [1] | |
|
C064 Probe Info |
 |
27.28 | LDD1761 | [1] | |
|
C130 Probe Info |
 |
12.38 | LDD1812 | [1] | |
|
C141 Probe Info |
 |
12.13 | LDD1823 | [1] | |
|
C143 Probe Info |
 |
19.16 | LDD1825 | [1] | |
|
C145 Probe Info |
 |
9.38 | LDD1827 | [1] | |
|
C147 Probe Info |
 |
8.46 | LDD1829 | [1] | |
|
C193 Probe Info |
 |
6.87 | LDD1869 | [1] | |
|
C211 Probe Info |
 |
17.88 | LDD1885 | [1] | |
|
C225 Probe Info |
 |
5.98 | LDD1898 | [1] | |
|
C226 Probe Info |
 |
6.36 | LDD1899 | [1] | |
|
C228 Probe Info |
 |
22.01 | LDD1901 | [1] | |
|
C362 Probe Info |
 |
30.48 | LDD2023 | [1] | |
|
C366 Probe Info |
 |
6.82 | LDD2027 | [1] | |
|
C367 Probe Info |
 |
6.96 | LDD2028 | [1] | |