Details of the Target

General Information of Target

Target ID LDTP10276
Target Name SAGA-associated factor 29 (SGF29)
Gene Name SGF29
Gene ID 112869
Synonyms
CCDC101; SAGA-associated factor 29; Coiled-coil domain-containing protein 101; SAGA complex-associated factor 29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMGRSPGFAMQHIVGVPHVLVRRGLLGRDLFMTRTLCSPGPSQPGEKRPEEVALGLHHRL
PALGRALGHSIQQRATSTAKTWWDRYEEFVGLNEVREAQGKVTEAEKVFMVARGLVREAR
EDLEVHQAKLKEVRDRLDRVSREDSQYLELATLEHRMLQEEKRLRTAYLRAEDSEREKFS
LFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKG
PVSLQEAIREQASSYSRQQRDLHNLMVDLRGLVHAAGPGQDSGSQAGSPPTRDRDVDVLS
AALKEQLSHSRQVHSCLEGLREQLDGLEKTCSQMAGVVQLVKSAAHPGLVEPADGAMPSF
LLEQGSMILALSDTEQRLEAQVNRNTIYSTLVTCVTFVATLPVLYMLFKAS
Target Bioclass
Other
Family
SGF29 family
Subcellular location
Nucleus
Function
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me. Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival. Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506'.
Uniprot ID
Q96ES7
Ensemble ID
ENST00000317058.8
HGNC ID
HGNC:25156
ChEMBL ID
CHEMBL4523425

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.84  LDD0402  [1]
DBIA
 Probe Info  		C243(1.68)  LDD0080  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
ENE
 Probe Info  		N.A.  LDD0006  [4]
IPM
 Probe Info  		N.A.  LDD0005  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
NAIA_5
 Probe Info  		C74(0.00); C145(0.00); C287(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C059
 Probe Info  		9.38  LDD1756  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C243(1.07); C74(1.11)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C243(0.82); C74(1.13)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C74(1.06)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C74(1.11)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C74(0.82)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C74(0.89)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C74(0.97)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C74(1.05)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C74(1.05)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C74(1.10)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C74(0.87)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C74(0.92)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C243(0.71); C74(1.36)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C74(0.83)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C74(0.91)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C74(1.19)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C74(1.50)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C74(1.06)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C74(1.06)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C74(1.39)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C74(1.12)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C74(1.38)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C74(0.86)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C243(0.74); C74(0.91)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C74(0.77)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C74(1.02)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C74(0.87)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C74(0.98)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C74(1.21)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C74(0.83)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C74(1.30)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C74(1.51)  LDD0843  [2]
 LDCM0259  AC14 HCT 116 C243(0.73); C74(1.10)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C74(0.59)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C74(0.76)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C74(0.65)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C74(0.93)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C74(0.74)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C74(1.11)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C74(0.97)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C243(0.82); C74(1.06)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C74(0.59)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C74(0.59)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C74(1.34)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C74(0.66)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C74(0.74)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C74(0.70)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C74(0.54)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C74(0.41)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C74(0.93)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C74(0.94)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C74(0.87)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C243(0.81); C74(0.96)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C74(0.70)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C74(1.34)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C74(0.85)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C74(0.66)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C74(0.58)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C74(1.22)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C74(1.05)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C74(1.48)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C74(1.47)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C74(1.42)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C243(0.79); C74(1.04)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C74(1.09)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C74(1.13)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C74(1.61)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C74(1.44)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C74(1.30)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C74(2.13)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C74(0.91)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C74(0.86)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C74(1.06)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C74(1.02)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C243(1.00); C74(1.49)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C74(0.96)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C74(1.02)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C74(0.81)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C74(0.79)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C74(1.02)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C74(1.11)  LDD0624  [2]
 LDCM0308  AC46 PaTu 8988t C74(1.01)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C74(0.74)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C74(0.91)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C74(0.72)  LDD1190  [2]
 LDCM0312  AC5 HCT 116 C243(0.80); C74(1.17)  LDD0629  [2]
 LDCM0313  AC50 PaTu 8988t C74(1.29)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C74(0.24)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C74(0.92)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C74(1.17)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C74(0.92)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C74(0.87)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C74(1.58)  LDD1198  [2]
 LDCM0320  AC57 HEK-293T C74(0.81)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C74(0.73)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C74(0.86)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C243(0.93); C74(0.99)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C74(0.60)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C74(0.70)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C74(0.85)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C74(0.78)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C74(0.77)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C74(0.70)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C74(0.72)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C74(0.78)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C243(1.51)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C243(1.05)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C243(0.94); C74(0.98)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C243(1.22)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C243(1.35)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C243(1.36)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C243(1.09)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C243(1.30)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C243(1.15)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C243(1.13)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C243(1.28)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C243(1.03)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C243(1.27)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C74(1.19); C243(1.25)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C243(0.89)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C243(1.20)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C243(1.25)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C74(1.30)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C74(0.93)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C74(0.78)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C74(1.44)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C74(0.71)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C74(0.79)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C74(0.88)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C74(1.67)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C74(0.79)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C74(0.86)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C74(0.63)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C74(1.30)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C74(0.56)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C74(0.75)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C74(0.93)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C74(0.81)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C74(0.79)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C243(0.71); C74(1.41)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C243(0.68); C74(0.96)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C243(0.83); C74(1.61)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C243(1.28)  LDD2171  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C287(0.55)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C74(0.95)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C74(1.54)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C243(0.95); C74(1.18)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C74(1.14); C243(1.42)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C243(0.55); C74(1.36)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C243(0.74); C74(0.92)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C243(0.62); C74(1.07)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C74(1.07)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C74(0.87)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C74(0.79)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C74(1.05)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C74(0.93)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C74(1.36)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C74(0.74)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C74(0.66)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C74(1.09)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C74(1.42)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C74(0.95)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C74(1.18)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C74(1.25)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C74(1.01)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C74(1.23)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C74(0.68)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C74(1.58)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C74(1.31)  LDD0708  [2]
 LDCM0392  CL121 PaTu 8988t C74(1.22)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C74(0.98)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C74(0.70)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C74(0.85)  LDD1274  [2]
 LDCM0396  CL125 HEK-293T C74(0.72)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C74(0.63)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C74(0.84)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C74(0.95)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C74(1.33)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C74(1.32)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C74(1.13)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C74(0.59); C243(1.19)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C74(0.74); C243(1.38)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C74(0.60); C243(2.21)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C74(0.77); C243(1.33)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C74(0.96)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C74(0.84); C243(2.20)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C74(0.87); C243(1.20)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C74(0.91); C243(1.25)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C74(0.91); C243(2.33)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C74(1.00); C243(2.06)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C243(1.21); C74(0.75)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C243(1.66); C74(0.97)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C243(0.88); C74(1.10)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C243(2.19); C74(0.75)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C243(1.40); C74(0.81)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C74(1.04)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C243(1.23); C74(0.64)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C243(1.04); C74(0.71)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C243(1.06); C74(0.77)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C243(0.91); C74(0.82)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C243(0.84); C74(0.80)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C243(1.35); C74(0.93)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C243(1.32); C74(0.86)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C243(1.18); C74(0.91)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C243(1.02); C74(1.31)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C74(0.72)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C243(1.04); C74(0.84)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C243(1.35); C74(1.25)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C243(2.09); C74(0.70)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C243(0.93); C74(0.90)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C243(1.04); C74(0.87)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C243(0.78); C74(0.89)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C243(0.80); C74(0.76)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C243(1.05); C74(0.76)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C243(0.90); C74(0.74)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C243(0.78); C74(0.82)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C74(1.24)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C243(0.87); C74(0.64)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C243(0.87); C74(0.88)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C243(1.02); C74(0.82)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C243(1.75); C74(0.86)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C243(0.98); C74(1.40)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C243(1.00); C74(0.63)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C243(1.27); C74(1.43)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C243(1.21); C74(0.71)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C243(1.01); C74(0.66)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C243(1.19); C74(1.06)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C74(1.15)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C243(0.93); C74(0.84)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C74(0.79)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C74(1.04)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C74(1.31)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C74(1.47)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C74(1.01)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C74(1.05)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C74(1.34)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C74(1.04)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C74(0.93)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C74(1.68)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C74(1.47)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C74(1.31)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C74(0.90)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C74(1.15)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C74(1.23)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C243(0.76); C74(1.02)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C243(1.27); C74(1.01)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C243(1.11); C74(0.97)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C243(1.14); C74(1.17)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C74(0.66)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C243(1.16); C74(0.95)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C243(1.13); C74(0.97)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C243(0.87); C74(1.50)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C243(0.82); C74(1.29)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C243(1.12); C74(1.08)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C243(0.80); C74(1.13)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C243(1.11); C74(1.38)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C243(0.83); C74(1.14)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C243(1.04); C74(2.04)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C243(1.02); C74(0.79)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C74(1.75)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C243(1.14); C74(0.99)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C243(1.61); C74(1.06)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C243(1.49); C74(1.60)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C243(0.78); C74(1.43)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C243(1.20); C74(1.52)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C243(1.08); C74(1.05)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C243(1.53); C74(1.09)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C243(1.27); C74(1.09)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C243(0.93); C74(1.32)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C243(1.03); C74(1.11)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C74(0.99); C243(1.09)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C287(1.18)  LDD1702  [11]
 LDCM0625  F8 Ramos C287(1.48)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C287(0.84)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C287(10.64)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C287(0.98)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C287(1.28)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C287(0.63)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C287(0.79)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C287(0.99)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C287(1.37)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C287(0.80)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C287(1.01)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C287(1.11)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C287(0.95)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C287(1.55)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C74(1.00)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C287(0.60)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C287(0.91)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C243(1.36); C74(0.78)  LDD0744  [2]
 LDCM0569  Fragment7 Ramos C287(0.73)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C287(0.90)  LDD2188  [12]
 LDCM0022  KB02 HCT 116 C243(1.68)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C243(1.50)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C243(1.63)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C243(1.28)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional adapter 3 (TADA3) NGG1 family O75528
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myogenic factor 5 (MYF5) . P13349
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 24 (KRT24) Intermediate filament family Q2M2I5
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Mediator of RNA polymerase II transcription subunit 11 (MED11) Mediator complex subunit 11 family Q9P086
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Synaptopodin (SYNPO) Synaptopodin family Q8N3V7
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Clathrin heavy chain linker domain-containing protein 1 (CLHC1) . Q8NHS4
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Proline and serine-rich protein 3 (PROSER3) . Q2NL68
Small kinetochore-associated protein (KNSTRN) . Q9Y448
Synaptonemal complex central element protein 3 (SYCE3) . A1L190
Testis-expressed protein 12 (TEX12) . Q9BXU0
Uncharacterized protein C20orf202 (C20orf202) . A1L168

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578