Details of the Target

General Information of Target

Target ID LDTP06390
Target Name Protein transport protein Sec23A (SEC23A)
Gene Name SEC23A
Gene ID 10484
Synonyms
Protein transport protein Sec23A; hSec23A; SEC23-related protein A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVL
CSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAGISELNQPAELLPQFSSIEYV
VLRGPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGC
EGISKSYVFRGTKDLSAKQLQEMLGLSKVPLTQATRGPQVQQPPPSNRFLQPVQKIDMNL
TDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGM
VVGDELKTPIRSWHDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEM
KCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAI
GPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAIQ
FVTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAIYRAETEEGP
DVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETFSLYPQFMFHLRRSSFLQVFNNSPDES
SYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYH
GETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLS
KVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA
Target Bioclass
Other
Family
SEC23/SEC24 family, SEC23 subfamily
Subcellular location
Cytoplasmic vesicle, COPII-coated vesicle membrane
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane.
Uniprot ID
Q15436
Ensemble ID
ENST00000307712.11
HGNC ID
HGNC:10701
ChEMBL ID
CHEMBL4295827

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.S196C DBIA    Probe Info 
HCT15 SNV: p.W24Ter; p.I130L DBIA    Probe Info 
IM95 SNV: p.A321T DBIA    Probe Info 
JHH7 SNV: p.D745G .
JURKAT SNV: p.V324I .
LS180 SNV: p.C554F DBIA    Probe Info 
MCC26 SNV: p.P225S DBIA    Probe Info 
MDAMB157 SNV: p.F752L DBIA    Probe Info 
NCIH2286 SNV: p.D547Y DBIA    Probe Info 
REH SNV: p.R493H DBIA    Probe Info 
SKNAS SNV: p.P422S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.64  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y705(6.08)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
STPyne
 Probe Info  		K185(6.67); K318(7.23); K329(10.00)  LDD0277  [5]
ONAyne
 Probe Info  		K318(1.20)  LDD0275  [5]
IPM
 Probe Info  		C180(0.00); C61(0.00); C423(0.00); C74(0.00)  LDD0241  [6]
Probe 1
 Probe Info  		Y56(18.80); Y672(26.21); Y678(33.27); Y705(21.84)  LDD3495  [7]
BTD
 Probe Info  		C180(3.31)  LDD1700  [8]
HHS-482
 Probe Info  		Y89(0.87)  LDD0285  [9]
HHS-475
 Probe Info  		Y672(0.48)  LDD0264  [10]
HHS-465
 Probe Info  		Y89(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C432(1.04); C180(0.93)  LDD0078  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K318(0.00); K562(0.00)  LDD0199  [14]
1d-yne
 Probe Info  		N.A.  LDD0358  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C350(0.00); C61(0.00); C449(0.00); C423(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
Lodoacetamide azide
 Probe Info  		C350(0.00); C61(0.00); C449(0.00); C423(0.00)  LDD0037  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
PF-06672131
 Probe Info  		N.A.  LDD0152  [19]
TFBX
 Probe Info  		N.A.  LDD0148  [20]
VSF
 Probe Info  		N.A.  LDD0007  [21]
1c-yne
 Probe Info  		K235(0.00); K198(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		C180(0.00); C423(0.00); C74(0.00); H683(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		C74(0.00); H710(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C180(0.00); C423(0.00); C432(0.00); C74(0.00)  LDD0218  [22]
W1
 Probe Info  		C423(0.00); C74(0.00); C180(0.00)  LDD0236  [6]
NAIA_5
 Probe Info  		C74(0.00); C449(0.00); C423(0.00); C180(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C039
 Probe Info  		5.03  LDD1739  [23]
C165
 Probe Info  		12.47  LDD1845  [23]
C354
 Probe Info  		16.34  LDD2015  [23]
FFF probe13
 Probe Info  		13.38  LDD0475  [24]
FFF probe2
 Probe Info  		5.69  LDD0463  [24]
STS-1
 Probe Info  		N.A.  LDD0136  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [25]
OEA-DA
 Probe Info  		4.20  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C180(0.59)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C180(0.86)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C180(1.30); C423(1.09)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C180(1.29)  LDD2152  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C180(0.57)  LDD2131  [8]
 LDCM0214  AC1 HCT 116 C180(1.13); C432(0.71); C444(0.82); C61(1.45)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C180(0.98); C432(0.88); C444(0.69)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C180(0.93); C432(0.73); C444(0.64); C61(0.77)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C180(0.88); C432(0.55); C444(0.51); C61(0.75)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C180(0.90); C432(0.66); C444(0.57); C61(0.68)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C180(0.78); C432(0.50); C444(0.39); C61(0.87)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C180(0.91); C432(0.59); C444(0.47); C61(0.77)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C180(0.79); C432(0.55); C444(0.44); C61(0.73)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C180(0.83); C432(0.53); C444(0.45); C61(0.94)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C180(0.85); C432(0.65); C444(0.51); C61(0.77)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C180(0.71); C432(0.64); C444(0.62); C61(0.77)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C180(0.98); C432(0.73); C444(0.64); C61(0.78)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C180(0.98); C432(1.09); C444(0.81)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C180(0.80); C432(0.63); C444(0.51); C61(0.82)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C180(0.81); C432(0.53); C444(0.50); C61(0.80)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C180(0.81); C432(0.48); C444(0.37); C61(0.80)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C180(1.08); C432(1.16); C444(1.14); C61(0.98)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C180(1.02); C432(0.79); C444(0.82); C61(1.13)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C180(0.96); C432(0.61); C444(0.67); C61(0.99)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C180(0.99); C432(0.66); C444(0.75); C61(1.12)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C180(0.94); C432(0.85); C444(0.92); C61(1.18)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C180(1.00); C432(0.91); C444(0.98); C61(1.04)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C180(0.96); C432(0.76); C444(0.82); C61(1.10)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C180(1.02); C432(1.16); C444(1.02)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C180(1.01); C432(0.76); C444(0.81); C61(0.89)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C180(0.96); C432(1.15); C444(1.13); C61(0.99)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C180(0.99); C432(0.85); C444(0.81); C61(0.93)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C180(1.03); C432(1.20); C444(1.17); C61(0.75)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C180(1.05); C432(1.13); C444(1.07); C61(1.04)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C180(1.09); C432(0.91); C444(0.97); C61(0.99)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C180(1.02); C432(0.76); C444(0.77); C61(1.08)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C180(1.12); C432(0.80); C444(0.82); C61(1.01)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C180(1.51); C432(1.24); C444(1.13); C85(1.41)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C180(1.64); C432(1.61); C444(1.57); C85(1.17)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C180(1.39); C432(1.14); C444(1.07); C85(1.17)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C180(1.48); C432(1.15); C444(1.19); C85(1.12)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C180(1.21); C432(1.27); C444(1.32); C85(0.79)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C180(1.40); C432(1.03); C444(1.07); C85(1.09)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C180(1.03); C432(0.73); C444(0.79); C85(0.87)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C180(1.29); C432(0.91); C444(0.96); C85(0.96)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C180(1.16); C432(0.90); C444(0.96); C85(0.83)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C180(1.08); C432(1.09); C444(1.09); C85(0.96)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C180(0.96); C432(0.80); C444(0.85); C85(1.03)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C180(1.03); C432(0.77); C444(0.83); C85(0.65)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C180(1.03); C432(1.05); C444(0.80)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C180(1.11); C432(0.72); C444(0.82); C85(0.69)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C180(1.04); C432(0.76); C444(0.86); C85(0.78)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C180(1.20); C432(1.30); C444(1.32); C85(0.75)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C432(1.00); C444(1.00)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C432(0.63); C444(0.69)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C444(0.83); C432(0.91)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C432(0.57); C444(0.64)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C432(0.66); C444(0.69)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C444(0.52); C432(0.55)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C432(0.46); C444(0.50)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C444(0.74); C432(0.94); C180(0.95)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C432(0.82); C444(0.95)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C432(0.78); C444(0.90)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C432(0.55); C444(0.65)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C444(0.50); C432(0.61)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C432(0.78); C444(0.71)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C432(0.74); C444(0.72)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C432(0.99); C444(1.01)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C432(1.02); C444(0.97)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C180(1.00); C61(1.04); C444(1.22); C432(1.26)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C61(0.89); C444(0.97); C432(1.02); C180(1.18)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C180(0.99); C444(1.11); C432(1.15); C61(1.24)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C432(0.74); C444(0.80); C180(1.07); C61(1.38)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C180(0.90); C444(1.11); C61(1.14); C432(1.28)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C180(1.00); C61(1.06); C432(1.13); C444(1.17)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C180(0.87); C432(1.08); C444(1.13); C61(1.16)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C180(1.02); C61(1.06); C432(1.14); C444(1.26)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C180(0.91); C61(1.30); C444(1.32); C432(1.45)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C61(0.79); C432(0.85); C444(0.86); C180(0.88)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C61(0.55); C444(0.57); C432(0.67); C180(0.87)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C444(0.52); C61(0.62); C432(0.66); C180(0.87)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C61(0.49); C444(0.56); C432(0.72); C180(0.88)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C61(0.44); C444(0.49); C432(0.64); C180(0.85)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C432(0.87); C444(0.95); C180(1.19); C61(1.52)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C61(0.42); C444(0.44); C432(0.58); C180(0.91)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C444(0.54); C61(0.62); C432(0.73); C180(0.91)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C444(0.34); C61(0.42); C432(0.48); C180(0.92)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C444(0.42); C432(0.55); C61(0.60); C180(0.86)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C444(0.39); C432(0.50); C61(0.62); C180(0.80)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C180(1.06); C432(1.47); C85(1.50); C88(1.50)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C180(1.05); C432(1.18); C85(1.23); C88(1.23)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C180(0.97); C85(1.05); C88(1.05); C432(1.28)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C180(0.97); C432(1.08); C85(1.08); C88(1.08)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C85(0.65); C88(0.65); C432(0.97); C180(0.99)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C432(0.82); C444(0.92); C180(1.23); C61(1.62)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C85(0.73); C88(0.73); C432(0.86); C444(0.87)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C180(0.95); C85(1.01); C88(1.01); C432(1.10)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C85(0.80); C88(0.80); C444(0.99); C432(1.00)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C444(0.79); C85(0.82); C88(0.82); C432(0.86)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C85(0.97); C88(0.97); C180(1.05); C444(1.13)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C85(0.63); C88(0.63); C444(0.97); C180(1.02)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C61(0.81); C432(0.84); C444(0.89); C180(1.00)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C85(0.43); C88(0.43); C61(0.66); C444(0.88)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C85(0.48); C88(0.48); C61(0.49); C432(0.81)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C85(0.30); C88(0.30); C61(0.34); C444(0.48)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C432(0.81); C444(0.93); C180(1.29); C61(1.54)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C61(0.35); C85(0.52); C88(0.52); C444(0.61)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C85(0.93); C88(0.93); C180(0.94); C432(1.23)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C61(0.88); C432(0.95); C85(0.96); C88(0.96)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C85(0.50); C88(0.50); C61(0.50); C444(0.70)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C61(0.47); C85(0.65); C88(0.65); C444(0.81)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C61(0.34); C85(0.36); C88(0.36); C444(0.57)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C61(0.22); C85(0.25); C88(0.25); C444(0.42)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C432(0.57); C444(0.65); C180(0.89); C61(1.21)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C444(0.48); C432(0.51); C180(0.88); C61(1.20)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C432(0.59); C444(0.66); C180(0.81); C61(1.13)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C444(0.54); C432(0.65); C180(0.87)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C432(0.50); C444(0.59); C180(0.73); C61(1.10)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C444(0.48); C432(0.54); C180(1.03); C61(1.16)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C432(0.69); C444(0.69); C180(0.79); C61(1.38)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C432(0.61); C444(0.66); C180(0.69); C61(1.25)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C432(0.76); C444(0.77); C180(0.81); C61(1.25)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C432(0.44); C444(0.53); C180(0.78); C61(1.12)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C432(0.48); C444(0.56); C180(0.85); C61(1.13)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C444(0.46); C432(0.56); C180(0.66); C61(1.24)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C61(0.42); C88(0.70); C432(0.87); C444(0.88)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C61(0.35); C88(0.72); C432(0.79); C444(0.87)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C444(0.78); C432(0.85); C180(0.92)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C61(0.26); C88(0.62); C432(0.64); C444(0.71)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C61(0.61); C88(0.87); C444(1.11); C432(1.11)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C61(0.51); C432(0.84); C444(0.89); C88(0.90)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C61(0.19); C444(0.59); C432(0.61); C88(0.69)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C61(0.24); C432(0.73); C444(0.75); C88(0.78)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C61(0.14); C432(0.55); C444(0.60); C88(0.61)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C61(0.39); C88(0.74); C444(0.90); C432(0.91)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C61(0.41); C88(0.73); C444(0.79); C432(0.79)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C61(0.41); C88(0.74); C432(0.80); C444(0.80)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C61(0.69); C432(0.83); C88(0.84); C444(0.89)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C444(0.65); C432(0.75); C180(0.94)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C61(0.58); C88(0.85); C444(0.94); C432(1.04)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C61(0.71); C88(0.73); C432(1.19); C444(1.25)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C61(0.15); C88(0.58); C444(0.70); C432(0.75)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C85(0.44); C88(0.44); C61(0.50); C444(0.54)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C444(0.51); C85(0.51); C88(0.51); C61(0.55)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C85(0.51); C88(0.51); C61(0.67); C444(0.68)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C85(0.48); C88(0.48); C61(0.59); C444(0.69)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C85(0.46); C88(0.46); C180(0.91); C444(0.96)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C85(0.42); C88(0.42); C61(0.69); C444(0.76)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C85(0.42); C88(0.42); C61(0.56); C444(0.56)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C85(0.44); C88(0.44); C180(0.86); C61(1.23)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C61(0.46); C444(0.58); C85(0.64); C88(0.64)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C85(0.52); C88(0.52); C61(0.60); C444(0.61)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C61(0.60); C85(0.62); C88(0.62); C444(0.70)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C61(0.63); C85(0.69); C88(0.69); C432(0.97)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C85(0.43); C88(0.43); C444(0.61); C61(0.76)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C61(0.60); C85(0.77); C88(0.77); C444(0.78)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C85(0.39); C88(0.39); C444(0.48); C61(0.59)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C85(0.14); C88(0.24); C444(0.28); C432(0.33)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C85(0.53); C61(0.68); C88(0.69); C432(0.69)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C180(0.67)  LDD2138  [8]
 LDCM0248  AKOS034007472 HCT 116 C180(1.01); C432(1.05); C444(0.89)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C444(0.72); C432(0.83); C180(1.02)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C444(0.50); C432(0.66); C180(0.92)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C432(1.04); C180(0.93)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C180(0.90)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C180(0.00); C350(0.00); C423(0.00); C74(0.00)  LDD0222  [22]
 LDCM0367  CL1 HCT 116 C180(0.89); C88(0.95); C61(1.03); C432(1.21)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C432(0.63); C444(0.64); C88(0.76); C180(1.00)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C432(0.68); C444(0.81); C180(1.21); C61(1.28)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C444(0.64); C432(0.81); C180(0.91)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C180(0.96); C444(1.01); C432(1.14)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C180(1.04); C444(1.16); C432(1.29)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C444(0.94); C180(0.99); C432(1.14)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C432(1.01); C444(1.03); C180(1.11); C61(1.12)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C61(0.80); C432(0.96); C444(1.01); C180(1.11)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C444(0.90); C432(0.92); C61(0.99); C180(1.12)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C444(0.81); C61(0.92); C432(0.95); C180(1.05)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C444(0.82); C432(0.89); C180(0.94); C61(1.04)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C444(0.73); C432(0.75); C88(0.89); C180(1.05)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C444(0.86); C180(0.91); C432(0.91); C61(0.95)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C444(0.86); C432(0.88); C180(0.98); C61(1.00)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C61(0.68); C444(0.94); C180(0.95); C432(0.98)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C61(0.38); C444(0.40); C432(0.54); C180(0.83)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C61(0.40); C444(0.51); C432(0.57); C180(0.85)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C61(0.47); C444(0.48); C432(0.68); C180(0.88)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C444(0.48); C432(0.57); C61(0.65); C180(0.89)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C85(0.37); C88(0.37); C432(0.66); C444(0.67)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C85(0.70); C88(0.70); C432(0.91); C444(0.91)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C444(0.89); C432(0.90); C85(0.92); C88(0.92)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C432(0.64); C444(0.65); C88(0.73); C180(1.03)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C85(0.93); C88(0.93); C180(1.00); C432(1.13)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C61(0.57); C85(0.66); C88(0.66); C432(1.01)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C61(0.39); C85(0.42); C88(0.42); C444(0.58)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C61(0.54); C444(0.74); C432(0.77); C180(0.79)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C85(0.48); C88(0.48); C61(0.48); C444(0.56)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C432(0.71); C444(0.88); C180(1.00); C61(1.35)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C432(0.55); C444(0.68); C180(0.77); C61(1.05)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C432(0.56); C444(0.60); C180(0.81); C61(0.96)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C432(0.54); C444(0.57); C180(1.01); C61(1.13)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C432(0.72); C444(0.76); C180(1.05); C88(1.14)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C432(0.77); C444(0.80); C88(0.96); C180(1.00)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C432(0.76); C444(0.78); C180(1.02); C88(1.29)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C85(0.63); C432(0.64); C444(0.66); C88(0.71)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C88(0.50); C85(0.59); C444(0.66); C432(0.68)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C444(0.47); C432(0.48); C85(0.78); C61(0.79)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C88(0.43); C85(0.44); C444(0.54); C432(0.55)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C180(0.99); C88(1.01); C432(1.18); C444(1.20)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C88(0.46); C432(0.47); C444(0.48); C85(0.51)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C88(0.39); C85(0.44); C432(0.48); C444(0.49)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C88(0.24); C85(0.28); C432(0.42); C444(0.48)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C432(0.61); C444(0.61); C88(0.66); C85(0.80)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C180(0.97); C432(0.48); C444(0.48); C61(0.96)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C180(0.89); C432(0.53); C444(0.52); C61(0.92)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C180(0.95); C432(0.55); C444(0.58); C61(0.86)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C180(1.03); C432(0.61); C444(0.60); C61(1.03)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C180(0.91); C432(0.42); C444(0.47); C61(1.04)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C180(0.91); C432(0.48); C444(0.51); C61(0.85)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C180(0.93); C432(1.05); C444(1.03); C61(1.44)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C180(0.96); C432(0.72); C444(0.71); C61(0.99)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C180(0.90); C432(0.60); C444(0.67); C61(0.89)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C180(0.89); C432(0.39); C444(0.50); C61(0.53)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C180(0.77); C432(0.48); C444(0.50); C61(0.59)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C180(0.77); C432(0.41); C444(0.46); C61(0.37)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C180(0.82); C432(0.41); C444(0.47); C61(0.45)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C180(0.81); C432(0.43); C444(0.53); C61(0.54)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C180(0.78); C432(0.42); C444(0.46); C61(0.31)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C180(0.82); C432(0.46); C444(0.56); C61(0.47)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C180(1.13); C432(0.96); C444(0.93); C61(1.37)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C180(0.83); C432(0.42); C444(0.50); C61(0.41)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C180(0.82); C432(0.44); C444(0.57); C61(0.66)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C180(0.79); C432(0.43); C444(0.46); C61(0.18)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C180(0.80); C432(0.36); C444(0.44); C61(0.28)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C180(0.77); C432(0.42); C444(0.48); C61(0.34)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C180(0.82); C432(0.40); C444(0.45); C61(0.27)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C180(0.88); C432(2.23); C444(1.56); C61(1.26)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C180(0.93); C432(1.52); C444(1.35); C61(1.06)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C180(0.94); C432(1.95); C444(1.51); C61(1.39)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C180(1.08); C432(1.30); C444(1.26); C61(1.28)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C180(1.11); C432(0.95); C444(0.94); C61(1.48)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C180(0.99); C432(1.56); C444(1.33); C61(1.28)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C180(0.91); C432(1.47); C444(1.28); C61(1.24)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C180(0.85); C432(1.26); C444(1.21); C61(1.40)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C180(0.85); C432(1.59); C444(1.31); C61(0.76)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C180(0.95); C432(1.43); C444(1.17); C61(1.09)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C180(0.95); C432(1.79); C444(1.38); C61(0.84)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C180(0.88); C432(1.23); C444(1.16); C61(0.99)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C180(0.99); C432(1.55); C444(1.34); C61(1.11)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C180(0.95); C432(1.89); C444(1.47); C61(1.24)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C180(0.99); C432(1.25); C444(1.29); C61(1.14)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C180(1.02); C432(0.63); C444(0.64); C61(1.47)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C180(1.01); C432(1.27); C444(1.24); C61(1.36)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C180(0.95); C432(0.94); C444(0.83)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C180(1.05); C432(0.83); C444(0.77)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C180(0.95); C432(0.69); C444(0.68)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C180(0.93); C432(0.69); C444(0.57)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C180(0.99); C432(0.84); C444(0.74)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C180(0.96); C432(0.63); C444(0.50)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C180(0.93); C432(0.67); C444(0.55)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C180(0.81); C432(0.79); C444(0.62)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C180(0.87); C432(0.64); C444(0.55)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C180(1.12); C432(0.78); C444(0.77); C61(1.73)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C180(0.88); C432(0.67); C444(0.57)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C180(0.96); C432(0.75); C444(0.62)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C180(0.99); C432(0.90); C444(0.85)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C180(0.96); C432(0.68); C444(0.60)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C180(0.90); C432(0.68); C444(0.55)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C180(1.18); C432(0.75); C444(0.71); C61(0.60)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C180(1.09); C432(0.87); C444(0.87); C61(0.75)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C180(0.93); C432(0.78); C444(0.77); C61(0.59)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C180(1.07); C432(0.64); C444(0.67); C61(0.55)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C180(0.81); C432(0.66); C444(0.65); C61(0.95)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C180(1.02); C432(0.70); C444(0.67); C61(0.61)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C180(1.07); C432(0.85); C444(0.85); C61(0.60)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C180(1.09); C432(0.82); C444(0.73); C61(0.37)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C180(1.08); C432(0.66); C444(0.61); C61(0.41)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C180(1.04); C432(0.51); C444(0.51); C61(0.24)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C180(0.96); C432(0.71); C444(0.70); C61(0.67)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C180(0.98); C432(1.00); C444(0.98); C61(0.93)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C180(1.06); C432(0.91); C444(0.82); C61(0.98)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C180(1.06); C432(0.84); C444(0.76); C61(0.37)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C180(1.10); C432(0.51); C444(0.51); C61(0.20)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C180(1.00); C432(0.67); C444(0.72); C61(1.01)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C180(0.91); C432(1.29); C444(1.24); C61(0.90)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C180(1.02); C432(0.76); C444(0.74); C61(1.01)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C180(0.98); C432(0.84); C444(0.81); C61(1.02)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C180(1.13); C432(0.88); C444(0.92); C61(1.19)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C180(1.05); C432(0.69); C444(0.86); C61(1.24)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C180(0.98); C432(0.68); C444(0.68); C61(1.16)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C180(1.05); C432(0.71); C444(0.71); C61(1.15)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C180(1.06); C432(0.60); C444(0.64); C61(1.12)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C180(1.09); C432(0.61); C444(0.66); C61(1.18)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C180(1.22); C432(0.70); C444(0.79); C61(1.29)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C180(0.97); C423(0.81); C449(0.99); C277(1.16)  LDD1698  [27]
 LDCM0468  Fragment33 HCT 116 C180(0.93); C432(0.83); C444(0.69)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C180(0.71); C432(0.43); C444(0.43); C61(0.21)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y672(0.48)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y672(0.68)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y672(0.92)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y672(0.88)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y672(1.27)  LDD0268  [10]
 LDCM0107  IAA HeLa C423(0.00); C74(0.00); H710(0.00); H330(0.00)  LDD0221  [22]
 LDCM0123  JWB131 DM93 Y89(0.87)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y705(0.09); Y89(0.61)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y705(0.37); Y89(1.08)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y705(3.13); Y89(2.22)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y705(1.70); Y89(1.45)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y89(0.92)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y705(0.11); Y89(0.38)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y89(0.91)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C432(3.62); C444(3.62); C180(1.03)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C432(3.77); C444(3.77); C180(1.02)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C432(2.77); C444(2.77); C180(1.06)  LDD0082  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C180(0.98)  LDD2121  [8]
 LDCM0109  NEM HeLa H683(0.00); H710(0.00); H697(0.00); H330(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C180(0.90)  LDD2089  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C180(1.09)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C180(1.41)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C180(0.87)  LDD2094  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C423(1.00)  LDD2099  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C180(0.83)  LDD2101  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C180(1.01); C423(0.78)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C180(1.00); C423(0.64)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C180(1.38)  LDD2111  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C180(0.53)  LDD2115  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C423(0.95)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C180(1.15); C423(0.80)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C180(1.52); C423(0.95)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C180(0.80)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C180(0.37)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C180(0.58)  LDD2134  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C180(0.89); C423(0.95)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C180(1.10); C423(0.93); C61(1.10)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C180(3.31)  LDD1700  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C423(1.09)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C180(1.11)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C180(0.48)  LDD2148  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C180(0.71); C74(0.76)  LDD2150  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
SEC23-interacting protein (SEC23IP) PA-PLA1 family Q9Y6Y8
Cyclin-dependent kinase 16 (CDK16) CMGC Ser/Thr protein kinase family Q00536
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) Succinate/malate CoA ligase beta subunit family Q9P2R7
Dynamin-2 (DNM2) Dynamin/Fzo/YdjA family P50570
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Erlin-1 (ERLIN1) Band 7/mec-2 family O75477
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Transport and Golgi organization protein 1 homolog (MIA3) MIA/OTOR family Q5JRA6
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) Tumor necrosis factor family O43557
Tumor necrosis factor ligand superfamily member 6 (FASLG) Tumor necrosis factor family P48023
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Major intrinsically disordered Notch2-binding receptor 1 (MINAR1) MINAR family Q9UPX6
Protein transport protein Sec23B (SEC23B) SEC23/SEC24 family Q15437
Protein transport protein Sec24C (SEC24C) SEC23/SEC24 family P53992
Transmembrane protein 45B (TMEM45B) TMEM45 family Q96B21
C-type lectin domain family 17, member A (CLEC17A) . Q6ZS10
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
WW domain-binding protein 11 (WBP11) . Q9Y2W2

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402