Details of the Target

General Information of Target

Target ID LDTP11924
Target Name Golgi-associated plant pathogenesis-related protein 1 (GLIPR2)
Gene Name GLIPR2
Gene ID 152007
Synonyms
C9orf19; GAPR1; Golgi-associated plant pathogenesis-related protein 1; GAPR-1; Golgi-associated PR-1 protein; Glioma pathogenesis-related protein 2; GliPR 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS
LDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQ
VLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDP
AQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSEL
RFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIML
GVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSA
KRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERS
SSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIK
ELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPS
SPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLA
IERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRD
LNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTR
VSAMDNTQQVDGSASVGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEI
RSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQ
ALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
Target Bioclass
Other
Family
CRISP family
Subcellular location
Golgi apparatus membrane
Uniprot ID
Q9H4G4
Ensemble ID
ENST00000377960.9
HGNC ID
HGNC:18007

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C63(1.73)  LDD0531  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C63(1.73)  LDD0531  [1]
 LDCM0226  AC11 HEK-293T C63(1.06)  LDD1509  [5]
 LDCM0259  AC14 HEK-293T C63(1.06)  LDD1512  [5]
 LDCM0263  AC143 HCT 116 C63(1.08)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C63(1.49)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C63(1.03)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C63(1.24)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C63(0.99)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C63(0.42)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C63(1.01)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C63(1.24)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C63(1.58)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C63(1.09)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C63(0.43)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C63(0.93)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C63(1.32)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C63(0.98)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C63(1.08)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C63(0.98)  LDD1515  [5]
 LDCM0278  AC19 HEK-293T C63(0.96)  LDD1517  [5]
 LDCM0279  AC2 HCT 116 C63(1.62)  LDD0596  [1]
 LDCM0281  AC21 HEK-293T C63(0.91)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C63(0.91)  LDD1521  [5]
 LDCM0284  AC24 HEK-293T C63(0.95)  LDD1523  [5]
 LDCM0285  AC25 HCT 116 C63(1.20)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C63(0.99)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C63(1.03)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C63(1.06)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C63(0.82)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C63(1.41)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C63(0.79)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C63(0.94)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C63(0.76)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C63(1.25)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C63(1.24)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C63(0.58)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C63(0.66)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C63(0.62)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C63(0.75)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C63(0.50)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C63(1.49)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C63(0.47)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C63(0.72)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C63(0.56)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C63(0.59)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C63(0.58)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C63(0.48)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C63(0.99)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C63(0.84)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C63(0.92)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C63(0.59)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C63(1.59)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C63(0.67)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C63(0.81)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C63(0.88)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C63(0.71)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C63(0.77)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C63(0.62)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C63(0.48)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C63(1.09)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C63(1.25)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C63(1.40)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C63(1.03)  LDD1562  [5]
 LDCM0324  AC60 HCT 116 C63(1.38)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C63(1.28)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C63(1.14)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C63(1.04)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C63(1.22)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C63(1.29)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C63(1.20)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C63(1.14)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C63(0.88)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C63(0.92)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C63(0.76)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C63(1.06)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C63(1.11)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C63(0.73)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C63(0.74)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C63(0.75)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C63(0.74)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C63(0.92)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C63(1.06)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C63(0.98)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C63(0.98)  LDD1569  [5]
 LDCM0346  AC80 HCT 116 C63(0.89)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C63(1.10)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C63(0.70)  LDD0665  [1]
 LDCM0248  AKOS034007472 HEK-293T C63(1.02)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C63(1.00)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C63(0.99)  LDD1514  [5]
 LDCM0367  CL1 HCT 116 C63(1.07)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C63(0.75)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C63(1.40)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C63(0.91)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C63(0.74)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C63(1.07)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C63(1.00)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C63(0.88)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C63(0.87)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C63(1.06)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C63(1.12)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C63(0.87)  LDD1582  [5]
 LDCM0379  CL11 HCT 116 C63(0.42)  LDD0696  [1]
 LDCM0380  CL110 HEK-293T C63(0.69)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C63(0.89)  LDD1585  [5]
 LDCM0382  CL112 HCT 116 C63(0.99)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C63(0.92)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C63(0.72)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C63(1.00)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C63(1.20)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C63(0.76)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C63(0.76)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C63(0.67)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C63(0.38)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C63(0.65)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C63(0.91)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C63(0.93)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C63(0.56)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C63(0.56)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C63(1.09)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C63(1.21)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C63(1.32)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C63(1.27)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C63(1.00)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C63(0.98)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C63(0.77)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C63(0.79)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C63(0.71)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C63(0.96)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C63(0.90)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C63(0.94)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C63(0.66)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C63(0.34)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C63(0.23)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C63(1.37)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C63(0.51)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C63(0.39)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C63(0.97)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C63(1.13)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C63(0.87)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C63(0.75)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C63(1.00)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C63(1.05)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C63(1.32)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C63(0.93)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C63(1.25)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C63(0.62)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C63(0.93)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C63(0.88)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C63(0.61)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C63(0.67)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C63(1.11)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C63(0.86)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C63(0.82)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C63(0.32)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C63(0.56)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C63(1.12)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C63(0.78)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C63(1.10)  LDD1640  [5]
 LDCM0438  CL48 HEK-293T C63(0.84)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C63(1.05)  LDD1643  [5]
 LDCM0440  CL5 HCT 116 C63(0.84)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C63(0.73)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C63(1.18)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C63(0.78)  LDD1647  [5]
 LDCM0446  CL55 HEK-293T C63(1.07)  LDD1649  [5]
 LDCM0448  CL57 HEK-293T C63(0.88)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C63(0.97)  LDD1652  [5]
 LDCM0451  CL6 HCT 116 C63(0.74)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C63(1.08)  LDD1655  [5]
 LDCM0453  CL61 HCT 116 C63(1.07)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C63(0.91)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C63(1.01)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C63(0.77)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C63(0.93)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C63(0.63)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C63(1.17)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C63(0.77)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C63(1.05)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C63(0.75)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C63(0.89)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C63(0.92)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C63(0.97)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C63(0.88)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C63(1.16)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C63(0.97)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C63(0.87)  LDD1673  [5]
 LDCM0472  CL79 HEK-293T C63(1.03)  LDD1675  [5]
 LDCM0473  CL8 HCT 116 C63(0.36)  LDD0790  [1]
 LDCM0475  CL81 HEK-293T C63(1.01)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C63(0.99)  LDD1679  [5]
 LDCM0478  CL84 HEK-293T C63(0.84)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C63(0.94)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C63(0.99)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C63(0.96)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C63(1.03)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C63(0.98)  LDD1686  [5]
 LDCM0484  CL9 HCT 116 C63(0.89)  LDD0801  [1]
 LDCM0486  CL91 HCT 116 C63(2.00)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C63(1.37)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C63(1.42)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C63(1.43)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C63(1.20)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C63(1.88)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C63(1.43)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C63(1.22)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C63(1.42)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C63(1.07)  LDD1698  [5]
 LDCM0202  EV-93 T cell C32(4.02)  LDD0514  [6]
 LDCM0468  Fragment33 HCT 116 C63(0.93)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C63(0.37)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C63(1.14)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C63(1.00)  LDD1497  [5]
 LDCM0024  KB05 MOLM-13 C63(1.12)  LDD3333  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-cysteic Acid Small molecular drug DB03661

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840