Details of the Target

General Information of Target

Target ID LDTP19634
Target Name Uncharacterized protein ZSWIM9 (ZSWIM9)
Gene Name ZSWIM9
Gene ID 374920
Synonyms
C19orf68; Uncharacterized protein ZSWIM9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVSADPLSSERAEMNILEINQELRSQLAESNQQFRDLKEKFLITQATAYSLANQLKKYK
CEEYKDIIDSVLRDELQSMEKLAEKLRQAEELRQYKALVHSQAKELTQLREKLREGRDAS
RWLNKHLKTLLTPDDPDKSQGQDLREQLAEGHRLAEHLVHKLSPENDEDEDEDEDDKDEE
VEKVQESPAPREVQKTEEKEVPQDSLEECAVTCSNSHNPSNSNQPHRSTKITFKEHEVDS
ALVVESEHPHDEEEEALNIPPENQNDHEEEEGKAPVPPRHHDKSNSYRHREVSFLALDEQ
KVCSAQDVARDYSNPKWDETSLGFLDTPLARRESVALKGRTRSWQHSSHAN
Target Bioclass
Other
Uniprot ID
Q86XI8
Ensemble ID
ENST00000328759.11
HGNC ID
HGNC:34495

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C403(5.55)  LDD0514  [1]
DBIA
 Probe Info  		C260(0.93); C261(0.93)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
TFBX
 Probe Info  		C171(0.00); C426(0.00)  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C38(1.02)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C38(1.12)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C38(0.97)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C38(1.09)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C38(1.13)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C38(1.04)  LDD0587  [2]
 LDCM0279  AC2 HCT 116 C38(0.99)  LDD0596  [2]
 LDCM0290  AC3 HCT 116 C38(0.98)  LDD0607  [2]
 LDCM0301  AC4 HCT 116 C38(0.97)  LDD0618  [2]
 LDCM0312  AC5 HCT 116 C38(1.07)  LDD0629  [2]
 LDCM0323  AC6 HCT 116 C38(1.01)  LDD0640  [2]
 LDCM0334  AC7 HCT 116 C38(0.99)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C38(0.89)  LDD0662  [2]
 LDCM0248  AKOS034007472 HCT 116 C38(1.21)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C38(1.08)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C38(1.05)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C260(0.93); C261(0.93)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C38(0.95)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C38(1.22)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C38(1.08)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C38(1.06)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C38(1.24)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C38(0.93)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C38(1.04)  LDD0690  [2]
 LDCM0379  CL11 HCT 116 C38(1.06)  LDD0696  [2]
 LDCM0390  CL12 HCT 116 C38(1.04)  LDD0707  [2]
 LDCM0400  CL13 HCT 116 C38(0.99)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C38(1.00)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C38(1.19)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C38(1.00)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C38(1.01)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C38(1.01)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C38(1.02)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C38(0.97)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C38(0.92)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C38(1.25)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C38(1.28)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C38(0.88)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C38(0.88)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C38(0.95)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C38(0.83)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C38(0.89)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C38(0.92)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C38(0.99)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C38(0.98)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C38(0.93)  LDD0736  [2]
 LDCM0429  CL4 HCT 116 C38(0.89)  LDD0746  [2]
 LDCM0440  CL5 HCT 116 C38(0.90)  LDD0757  [2]
 LDCM0451  CL6 HCT 116 C38(1.09)  LDD0768  [2]
 LDCM0453  CL61 HCT 116 C38(0.91)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C38(0.98)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C38(0.77)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C38(0.84)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C38(0.78)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C38(0.74)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C38(0.97)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C38(1.12)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C38(0.85)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C38(0.99)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C38(0.72)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C38(0.69)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C38(1.08)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C38(0.73)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C38(0.62)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C38(0.89)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C38(0.78)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C38(0.91)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C38(0.88)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C38(1.31)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C38(0.91)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C38(0.82)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C38(0.95)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C38(1.02)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C38(1.11)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C38(0.94)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C38(0.96)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C38(0.77)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C38(0.90)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C38(1.16)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C38(0.97)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C38(1.04)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C38(1.04)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C38(0.78)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C38(0.84)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C38(0.82)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C38(0.91)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C38(0.95)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C38(0.92)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C38(0.95)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C38(0.89)  LDD0811  [2]
 LDCM0202  EV-93 T cell C403(5.55)  LDD0514  [1]
 LDCM0468  Fragment33 HCT 116 C38(1.03)  LDD0785  [2]
 LDCM0022  KB02 T cell C403(20.00)  LDD1703  [1]
 LDCM0023  KB03 MDA-MB-231 C171(0.93)  LDD1701  [4]
 LDCM0024  KB05 COLO792 C426(7.77)  LDD3310  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor JunB (JUNB) BZIP family P17275

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840