Details of the Target

General Information of Target

Target ID LDTP03230
Target Name Tyrosine-protein kinase JAK1 (JAK1)
Gene Name JAK1
Gene ID 3716
Synonyms
JAK1A; JAK1B; Tyrosine-protein kinase JAK1; EC 2.7.10.2; Janus kinase 1; JAK-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Subcellular location
Endomembrane system
Function
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TTD ID
T62460
Uniprot ID
P23458
DrugMap ID
TTWKB01
Ensemble ID
ENST00000342505.5
HGNC ID
HGNC:6190
ChEMBL ID
CHEMBL2835

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.64  LDD0402  [1]
STPyne
 Probe Info  		K227(0.33); K245(8.07); K541(3.96)  LDD0277  [2]
ONAyne
 Probe Info  		K802(0.74)  LDD0275  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
BTD
 Probe Info  		C988(1.73); C257(0.72)  LDD2109  [4]
Jackson_14
 Probe Info  		2.27  LDD0123  [5]
Johansson_61
 Probe Info  		_(13.02)  LDD1485  [6]
DBIA
 Probe Info  		C1116(1.25); C1120(1.25); C731(1.08); C657(0.90)  LDD0078  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		C257(0.00); C988(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C763(0.00); C257(0.00)  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
NAIA_4
 Probe Info  		C74(0.00); C731(0.00); C944(0.00)  LDD2226  [11]
NAIA_5
 Probe Info  		C1131(0.00); C257(0.00); C988(0.00); C944(0.00)  LDD2224  [11]
WYneN
 Probe Info  		C944(0.00); C257(0.00)  LDD0021  [12]
IPM
 Probe Info  		C543(0.00); C988(0.00); C817(0.00); C544(0.00)  LDD0147  [13]
TFBX
 Probe Info  		C988(0.00); C543(0.00); C810(0.00); C944(0.00)  LDD0148  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		14.80  LDD0443  [15]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		7.36  LDD1850  [16]
STS-2
 Probe Info  		N.A.  LDD0139  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C257(0.79)  LDD2142  [4]
 LDCM0025  4SU-RNA HEK-293T C944(20.00)  LDD0371  [18]
 LDCM0026  4SU-RNA+native RNA HEK-293T C169(3.31)  LDD0372  [18]
 LDCM0214  AC1 HCT 116 C1116(0.97); C1120(0.97); C1131(1.19); C657(1.00)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C810(1.43); C817(1.14); C1116(0.61); C1120(0.61)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C810(1.29); C817(1.29); C1116(0.32); C1120(0.32)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C810(1.13); C817(1.13); C1116(0.37); C1120(0.37)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C810(1.20); C817(1.20); C1116(0.35); C1120(0.35)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C810(1.43); C817(1.43); C1116(0.35); C1120(0.35)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C810(1.13); C817(1.13); C1116(0.38); C1120(0.38)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C810(1.19); C817(1.19); C1116(0.32); C1120(0.32)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C810(1.39); C817(1.39); C1116(0.33); C1120(0.33)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C810(1.28); C817(1.28); C1116(0.42); C1120(0.43)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C810(1.46); C817(1.46); C1116(0.35); C1120(0.37)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C810(1.52); C817(1.52); C1116(0.42); C1120(0.43)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C810(1.29); C817(1.01); C1116(0.73); C1120(0.73)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C810(2.15); C817(2.15); C1116(0.42); C1120(0.36)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C810(1.47); C817(1.47); C1116(0.42); C1120(0.41)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C810(1.61); C817(1.61); C1116(0.38); C1120(0.43)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C810(1.08); C817(1.08); C1131(1.40); C716(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C810(1.17); C817(1.12); C1131(1.64); C716(1.04)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C810(1.22); C817(1.21); C1131(1.18); C716(0.96)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C810(1.38); C817(1.43); C1131(1.47); C716(1.09)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C810(1.10); C817(1.15); C1131(1.46); C716(0.88)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C810(1.07); C817(1.09); C1131(1.98); C716(0.94)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C810(1.17); C817(1.30); C1131(1.24); C716(1.00)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C810(1.40); C817(1.11); C1116(0.71); C1120(0.71)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C810(1.26); C817(1.39); C1131(1.47); C716(1.01)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C810(1.18); C817(1.19); C1131(1.05); C716(0.82)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C810(1.10); C817(1.06); C1131(0.98); C716(0.93)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C810(1.17); C817(1.41); C1131(1.13); C716(0.93)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C810(1.14); C817(1.08); C1131(1.57); C716(0.89)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C810(1.25); C817(1.25); C1131(1.03); C716(0.94)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C810(1.53); C817(1.43); C1131(1.73); C716(0.95)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C810(1.41); C817(1.28); C1131(1.07); C716(0.85)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C810(1.45); C817(1.45); C1116(0.91); C1120(0.91)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C810(1.04); C817(1.04); C1116(0.84); C1120(0.84)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C810(1.36); C817(1.36); C1116(0.90); C1120(0.90)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C810(1.14); C817(1.14); C1116(1.04); C1120(1.04)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C810(1.13); C817(1.13); C1116(0.85); C1120(0.85)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C810(1.19); C817(1.19); C1116(0.96); C1120(0.96)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C810(1.31); C817(1.31); C1116(0.65); C1120(0.65)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C810(1.26); C817(1.26); C1116(0.78); C1120(0.78)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C810(1.08); C817(1.08); C1116(0.74); C1120(0.74)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C810(1.18); C817(1.18); C1116(0.72); C1120(0.72)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C810(1.23); C817(1.23); C1116(0.73); C1120(0.73)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C810(1.11); C817(1.11); C1116(0.69); C1120(0.69)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C810(1.32); C817(0.98); C1116(1.03); C1120(1.03)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C810(1.32); C817(1.32); C1116(0.64); C1120(0.64)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C810(1.17); C817(1.17); C1116(0.85); C1120(0.85)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C810(1.83); C817(1.83); C1116(0.91); C1120(0.91)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C1131(0.88); C1116(0.89); C1120(0.89); C716(1.25)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C1116(0.67); C1120(0.67); C716(1.04); C1131(1.11)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C1116(0.80); C1120(0.80); C716(0.96); C1131(1.01)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C1116(0.69); C1120(0.69); C716(1.05); C1131(1.13)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C1116(0.68); C1120(0.68); C716(1.01); C1131(1.16)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C1116(0.76); C1120(0.76); C1131(0.94); C716(1.58)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C1116(0.58); C1120(0.58); C1131(1.07); C716(1.13)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C1116(0.75); C1120(0.75); C716(1.08); C1131(1.13)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C1116(0.79); C1120(0.79); C1131(0.95); C716(1.06)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C1116(0.76); C1120(0.76); C716(0.91); C1131(1.24)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C1116(0.65); C1120(0.65); C716(1.02); C1131(1.03)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C1116(0.86); C1120(0.86); C1131(0.88); C716(1.57)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C1116(0.57); C1120(0.57); C1131(1.08); C716(0.91)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C1116(0.53); C1120(0.53); C1131(1.09); C716(0.83)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C1116(1.17); C1120(1.17); C1131(1.15); C716(0.92)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C1116(1.27); C1120(1.27); C1131(1.03); C716(0.92)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C1116(0.70); C1120(0.70); C817(0.82); C810(0.93)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C1131(0.68); C657(0.88); C1116(0.98); C1120(0.98)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C1131(0.80); C1116(0.81); C1120(0.81); C657(0.90)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C1116(0.76); C1120(0.76); C657(0.88); C716(0.93)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C1116(0.75); C1120(0.75); C817(0.90); C1131(0.93)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C1116(0.78); C1120(0.78); C657(0.83); C1131(0.90)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C1131(0.77); C1116(0.88); C1120(0.88); C657(0.94)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C1131(0.84); C657(0.87); C1116(0.97); C1120(0.97)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C1116(0.84); C1120(0.84); C1131(0.90); C817(0.99)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C1116(0.81); C1120(0.81); C716(0.87); C1131(0.99)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C1116(0.78); C1120(0.78); C817(0.97); C716(0.97)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C1116(0.74); C1120(0.74); C817(0.99); C810(1.01)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C1116(0.74); C1120(0.74); C716(1.00); C1131(1.11)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C1116(0.82); C1120(0.82); C716(0.92); C817(1.03)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C657(0.80); C1116(0.84); C1120(0.84); C716(0.94)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C1116(0.80); C1120(0.80); C716(0.91); C817(0.92)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C1116(0.75); C1120(0.75); C817(1.05); C810(1.08)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C1116(0.74); C1120(0.74); C1131(0.97); C716(1.06)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C1116(0.80); C1120(0.80); C716(0.87); C817(0.96)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C1131(0.86); C1116(0.88); C1120(0.88); C817(1.04)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C1116(0.89); C1120(0.89); C810(1.01); C817(1.01)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C1116(0.80); C1120(0.80); C810(1.10); C817(1.10)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C1116(1.05); C1120(1.05); C810(1.25); C817(1.25)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C810(0.99); C817(0.99); C1116(1.02); C1120(1.02)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C1116(0.97); C1120(0.97); C810(1.16); C817(1.16)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C657(0.79); C1131(0.81); C1116(0.82); C1120(0.82)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C1116(1.17); C1120(1.17); C810(1.69); C817(1.69)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C1116(0.94); C1120(0.94); C810(1.14); C817(1.14)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C1116(0.92); C1120(0.92); C810(1.12); C817(1.12)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C1116(0.75); C1120(0.75); C810(1.22); C817(1.22)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C1116(0.86); C1120(0.86); C810(1.02); C817(1.02)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C1116(0.94); C1120(0.94); C810(1.31); C817(1.31)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C716(1.00); C1131(1.21); C810(1.23); C817(1.23)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C810(1.06); C817(1.06); C1116(1.07); C1120(1.07)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C1116(1.10); C1120(1.10); C810(1.12); C817(1.12)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C1116(1.21); C1120(1.21); C810(1.28); C817(1.28)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C1116(0.66); C1120(0.66); C657(0.85); C1131(0.92)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C1131(0.93); C810(1.03); C817(1.03); C716(1.24)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C1131(0.78); C716(0.99); C810(1.02); C817(1.02)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C1116(0.97); C1120(0.97); C1131(0.98); C810(0.99)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C1131(0.86); C1116(1.05); C1120(1.05); C716(1.12)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C1131(1.09); C810(1.11); C817(1.11); C1116(1.11)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C1131(1.04); C1116(1.10); C1120(1.10); C716(1.35)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C1131(0.78); C1116(1.32); C1120(1.32); C810(1.51)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C716(0.87); C810(0.99); C817(0.99); C1131(1.02)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C1131(0.84); C716(0.89); C810(0.97); C817(0.97)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C716(0.98); C810(0.99); C817(0.99); C1131(1.06)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1116(0.80); C1120(0.80); C1131(1.10); C716(1.18)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C716(0.88); C810(1.05); C817(1.05); C1116(1.35)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C810(0.96); C817(0.96); C1116(1.07); C1120(1.07)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C1131(0.92); C716(0.97); C810(1.14); C817(1.14)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C1131(0.81); C716(0.96); C1116(1.22); C1120(1.22)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C810(0.98); C817(0.98); C716(1.07); C1131(1.10)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C810(1.02); C817(1.02); C1131(1.06); C716(1.14)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C1131(0.86); C810(0.94); C817(0.94); C1116(1.12)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C810(1.07); C817(1.07); C1131(1.11); C1116(1.20)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C1131(0.97); C716(0.97); C810(0.98); C817(0.98)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C716(0.97); C810(1.16); C817(1.16); C1131(1.18)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C1116(0.76); C1120(0.76); C716(1.06); C1131(1.29)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C810(0.79); C817(0.79); C716(1.08); C1131(1.19)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C810(1.01); C817(1.01); C1131(1.13); C716(1.15)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C810(1.03); C817(1.03); C716(1.08); C1131(1.16)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C1131(0.98); C810(1.11); C817(1.11); C716(1.71)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C1131(1.01); C810(1.33); C817(1.33); C716(1.67)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C1131(1.13); C810(1.22); C817(1.22); C716(2.15)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C810(0.89); C817(0.89); C1131(1.03); C716(1.28)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C810(1.03); C817(1.03); C1131(1.03); C716(1.05)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C810(0.93); C817(0.93); C1131(0.95); C716(1.22)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C1131(1.05); C810(1.07); C817(1.07); C716(1.08)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C1116(0.67); C1120(0.67); C716(0.98); C817(1.29)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C810(0.90); C817(0.90); C1131(1.09); C716(1.20)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C716(0.98); C810(1.14); C817(1.14); C1131(1.20)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C1131(1.02); C810(1.36); C817(1.36); C716(1.94)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C1131(0.62); C810(0.89); C817(0.89)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C1131(0.47); C810(0.89); C817(0.89)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C1131(0.50); C810(1.04); C817(1.04)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C1131(0.85); C810(1.10); C817(1.10)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C1131(0.75); C810(1.01); C817(1.01)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C1131(0.66); C810(0.98); C817(0.98)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C1131(0.84); C810(0.95); C817(0.95)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C1131(0.53); C810(0.97); C817(0.97)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C1131(0.65); C810(0.83); C817(0.83)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C1131(0.66); C810(0.84); C817(0.84)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C1131(0.46); C810(0.89); C817(0.89)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C1131(0.63); C810(0.86); C817(0.86)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1131(0.64); C810(0.99); C817(0.99)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C1131(0.55); C810(1.21); C817(1.21)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C1131(0.66); C810(3.25); C817(3.25)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C1116(0.38); C1120(0.38); C810(1.39); C817(1.39)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C1116(0.38); C1120(0.38); C810(1.18); C817(1.18)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C810(1.52); C817(1.08); C1116(0.73); C1120(0.73)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C1116(0.76); C1120(0.76); C810(1.14); C716(1.20)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C1116(0.86); C1120(0.86); C1131(1.20); C716(1.45)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C1116(1.25); C1120(1.25); C731(1.08); C657(0.90)  LDD0078  [7]
 LDCM0367  CL1 HCT 116 C1131(0.94); C1116(1.33); C1120(1.33); C810(5.03)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C1131(1.05); C1116(1.49); C1120(1.49); C810(4.09)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C1116(0.63); C1120(0.63); C1131(0.80); C657(0.84)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C1116(0.66); C1120(0.66); C716(0.99); C1131(1.06)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C1116(0.74); C1120(0.74); C716(1.09); C1131(1.34)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C1116(0.72); C1120(0.72); C716(0.94); C817(1.42)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C716(1.08); C1116(1.19); C1120(1.19); C1131(1.53)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C1116(0.63); C1120(0.63); C657(0.84); C1131(0.92)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C1116(0.66); C1120(0.66); C1131(0.67); C657(0.78)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C1116(0.67); C1120(0.67); C1131(0.83); C657(0.83)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C1116(0.71); C1120(0.71); C1131(0.78); C657(0.80)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C1116(0.64); C1120(0.64); C657(0.78); C1131(0.81)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C1131(0.94); C1116(1.13); C1120(1.13); C810(4.80)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C1116(0.79); C1120(0.79); C657(0.80); C1131(1.03)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C1131(0.77); C1116(0.81); C1120(0.81); C657(0.91)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C1116(0.77); C1120(0.77); C716(0.94); C1131(0.96)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C1116(0.73); C1120(0.73); C716(0.83); C817(0.92)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C1116(0.72); C1120(0.72); C716(0.91); C1131(1.41)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C1116(0.74); C1120(0.74); C1131(0.91); C817(0.99)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C1116(0.82); C1120(0.82); C817(1.03); C810(1.07)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C1116(1.16); C1120(1.16); C810(1.59); C817(1.59)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C1116(0.71); C1120(0.71); C810(1.17); C817(1.17)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C1116(0.88); C1120(0.88); C810(1.25); C817(1.25)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C1116(1.17); C1120(1.17); C1131(1.34); C810(1.82)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C1116(0.71); C1120(0.71); C810(1.11); C817(1.11)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C716(0.62); C1116(1.31); C1120(1.31); C1131(1.67)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C1131(0.96); C1116(1.04); C1120(1.04); C716(1.15)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C1116(0.97); C1120(0.97); C1131(1.13); C716(1.20)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C1131(1.07); C716(1.22); C1116(1.26); C1120(1.26)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C716(0.86); C810(1.00); C817(1.00); C1131(1.00)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C716(0.73); C1131(0.75); C810(1.10); C817(1.10)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C716(0.80); C1131(1.04); C810(1.06); C817(1.06)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C810(0.83); C817(0.83); C716(0.93); C1116(1.23)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C1131(1.05); C1116(1.20); C1120(1.20); C810(1.65)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C1131(0.82); C1116(1.05); C1120(1.05); C810(1.51)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C1131(0.98); C1116(1.23); C1120(1.23); C810(4.71)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C657(0.85); C1116(0.88); C1120(0.88); C1131(1.12)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C657(0.69); C1116(0.92); C1120(0.92); C810(3.37)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C810(0.95); C817(0.95); C657(1.17); C1116(1.40)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C1116(0.87); C1120(0.87); C810(0.92); C817(0.92)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C1131(0.88); C1116(0.96); C1120(0.96); C810(1.28)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C1116(0.77); C1120(0.77); C657(0.98); C810(1.03)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C657(1.16); C1116(1.23); C1120(1.23); C810(3.59)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C1116(1.53); C1120(1.53); C657(1.71); C810(1.81)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C810(1.04); C817(1.04); C1116(1.05); C1120(1.05)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C1116(1.06); C1120(1.06); C657(1.16); C810(1.19)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C810(2.64); C817(2.64); C1116(0.84); C1120(0.84)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C810(1.17); C817(1.17); C1116(0.89); C1120(0.89)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C810(1.11); C817(1.11); C1116(0.78); C1120(0.78)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C810(2.26); C817(2.26); C1116(1.01); C1120(1.01)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C810(1.02); C817(1.02); C1116(0.88); C1120(0.88)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C810(1.77); C817(1.77); C1116(0.84); C1120(0.84)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C810(0.92); C817(0.92); C1116(1.06); C1120(1.06)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C810(0.97); C817(0.97); C1131(1.44)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C810(3.48); C817(3.48); C1131(1.44)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C810(4.09); C817(4.09); C1131(1.06)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C810(2.97); C817(2.97); C1131(1.40)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C810(1.58); C817(1.58); C1131(1.36)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C810(2.15); C817(2.15); C1131(0.95)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C810(0.81); C817(0.81); C1131(1.21)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C810(1.23); C817(1.23); C1131(1.13)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C810(4.06); C817(4.06); C1116(1.06); C1120(1.06)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C810(3.15); C817(3.15); C1131(1.10)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C810(3.52); C817(3.52); C1131(1.31)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C810(1.02); C817(1.02); C1131(1.26)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C810(1.08); C817(1.08); C1131(1.41)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C810(1.28); C817(1.28); C1131(1.29)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C810(1.85); C817(1.85); C1131(1.20)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C810(3.47); C817(3.47); C1116(1.28); C1120(1.28)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C810(1.82); C817(1.82); C1116(1.11); C1120(1.11)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C810(1.10); C817(1.10); C1116(1.43); C1120(1.43)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C810(0.87); C817(0.87); C1116(1.05); C1120(1.05)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C810(0.95); C817(0.95); C1116(1.07); C1120(1.07)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C810(1.49); C817(1.49); C1116(1.05); C1120(1.05)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C810(1.30); C817(1.30); C1116(1.04); C1120(1.04)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C810(1.89); C817(1.89); C1116(1.09); C1120(1.09)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C810(0.97); C817(0.97); C1116(1.01); C1120(1.01)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C810(5.82); C817(5.82); C1116(1.22); C1120(1.22)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C810(4.45); C817(4.45); C1116(1.15); C1120(1.15)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C810(1.20); C817(1.20); C1116(0.78); C1120(0.78)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C810(0.90); C817(0.90); C1116(1.04); C1120(1.04)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C810(3.37); C817(3.37); C1116(1.24); C1120(1.24)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C810(1.01); C817(1.01); C1116(0.88); C1120(0.88)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C810(3.58); C817(3.58); C1116(1.00); C1120(1.00)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C810(1.27); C817(1.27); C1116(1.00); C1120(1.00)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C810(1.39); C817(1.39); C1116(0.63); C1120(0.63)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C810(1.07); C817(1.07); C1116(0.61); C1120(0.61)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C810(2.67); C817(2.67); C1116(0.53); C1120(0.53)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C810(1.03); C817(1.03); C1116(0.52); C1120(0.52)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C810(1.87); C817(1.87); C1116(0.54); C1120(0.54)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C810(1.17); C817(1.17); C1116(0.51); C1120(0.51)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C810(0.96); C817(0.96); C1116(0.56); C1120(0.56)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C810(1.92); C817(1.92); C1116(0.72); C1120(0.72)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C810(4.07); C817(4.07); C1116(1.19); C1120(1.19)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C810(1.43); C817(1.43); C1116(1.20); C1120(1.20)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C810(1.92); C817(1.92); C1116(0.75); C1120(0.75)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C810(1.20); C817(1.20); C1116(0.54); C1120(0.54)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C810(1.02); C817(1.02); C1116(0.67); C1120(0.67)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C810(2.40); C817(2.40); C1116(1.04); C1120(1.04)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C810(1.67); C817(1.67); C1116(0.71); C1120(0.71)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C810(1.33); C817(1.33); C1116(1.41); C1120(1.41)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C810(2.29); C817(2.29); C1116(2.46); C1120(2.46)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C810(1.58); C817(1.58); C1116(0.73); C1120(0.73)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C810(0.92); C817(0.92); C1116(0.95); C1120(0.95)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C810(6.49); C817(6.49); C1116(1.95); C1120(1.95)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C810(0.94); C817(0.94); C1116(1.74); C1120(1.74)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C810(1.13); C817(1.13); C1116(0.75); C1120(0.75)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C810(0.93); C817(0.93); C1116(1.20); C1120(1.20)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C810(2.88); C817(2.88); C1116(1.10); C1120(1.10)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C810(2.39); C817(2.39); C1116(1.37); C1120(1.37)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C810(1.20); C817(1.20); C1116(0.79); C1120(0.79)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C810(1.15); C817(1.15); C1116(0.80); C1120(0.80)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C810(1.35); C817(1.35); C1116(0.81); C1120(0.81)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C810(1.02); C817(1.02); C1116(1.39); C1120(1.39)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C810(1.17); C817(1.17); C1116(1.58); C1120(1.58)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C810(3.12); C817(3.12); C1116(0.88); C1120(0.88)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C810(4.31); C817(4.31); C1116(0.88); C1120(0.88)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C1116(0.74); C1120(0.74); C1131(1.18); C657(0.79)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C1116(0.87); C1120(0.87); C1131(0.99); C657(0.83)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C1116(0.80); C1120(0.80); C1131(0.87); C657(0.84)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C1116(0.73); C1120(0.73); C1131(1.13); C657(0.79)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C1116(0.69); C1120(0.69); C1131(0.94); C657(0.75)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C1116(0.79); C1120(0.79); C1131(1.06); C657(0.86)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C1116(0.64); C1120(0.64); C1131(1.03); C657(0.73)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C1116(0.67); C1120(0.67); C1131(1.05); C657(0.68)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C1116(0.71); C1120(0.71); C1131(0.92); C657(0.73)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C716(0.95); C944(0.73); C169(0.89); C827(0.65)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C810(12.53); C257(9.17); C716(6.08); C169(2.42)  LDD1702  [4]
 LDCM0202  EV-93 T cell C810, C817, C818(10.73)  LDD0514  [20]
 LDCM0625  F8 Ramos C988(0.81); C1131(1.04); C944(3.64); C61(1.26)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C988(0.95); C1131(1.11); C61(0.54)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C988(20.00); C1131(0.65); C944(1.55); C61(1.56)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C988(1.26); C1131(0.73); C944(0.54); C61(0.80)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C988(1.21); C1131(0.72); C944(1.01); C257(1.13)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C988(1.21); C1131(1.66); C944(1.54); C74(0.95)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C61(0.80)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C988(1.02); C1131(0.65); C944(1.43); C257(1.34)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C988(0.76); C1131(1.05); C257(1.35); C61(0.88)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C988(0.96); C1131(0.66); C944(0.92); C257(0.88)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C988(0.87); C1131(0.82); C944(0.75); C257(0.68)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C988(0.97); C1131(0.77); C944(1.07); C257(1.11)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C988(0.99); C1131(0.68); C944(1.63); C257(0.99)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C988(0.82); C1131(0.63); C944(2.24); C257(2.34)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C810(1.56); C817(1.56); C1116(0.61); C1120(0.61)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C988(0.75); C1131(1.13); C944(0.96); C257(1.18)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C1131(1.32); C944(1.45); C61(2.11)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C810(1.40); C817(1.40); C1131(1.73)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C257(0.78); C61(0.71); C74(0.54)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C988(1.22); C1131(0.80); C944(2.07); C257(1.09)  LDD2205  [21]
 LDCM0616  Fragment61 Jurkat _(7.89)  LDD1489  [6]
 LDCM0569  Fragment7 Jurkat _(13.02)  LDD1485  [6]
 LDCM0571  Fragment9 Ramos C944(0.76); C61(0.66)  LDD2188  [21]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 HCT 116 C1116(2.55); C1120(2.55); C1131(1.78)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C1116(6.95); C1120(6.95); C1131(2.55)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C1116(3.01); C1120(3.01); C1131(1.91)  LDD0082  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C988(1.73); C257(0.72)  LDD2109  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C988(1.27)  LDD2125  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C257(0.89)  LDD2141  [4]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.27  LDD0123  [5]
 LDCM0021  THZ1 HCT 116 C1131(2.08)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Tyrosine-protein kinase JAK2 (JAK2) Tyr protein kinase family O60674
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 1-alpha/beta (STAT1) Transcription factor STAT family P42224
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon alpha/beta receptor 2 (IFNAR2) Type II cytokine receptor family P48551

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Baricitinib Small molecular drug D0Y7IC
Fedratinib Small molecular drug DB12500
Fostamatinib Small molecular drug DB12010
Ruxolitinib Small molecular drug D04LKS
Tofacitinib Small molecular drug DB08895
Abrocitinib . DB14973
Filgotinib . DB14845
Pralsetinib . DB15822
Upadacitinib . D07JAG
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Asp-015k Small molecular drug D06EIC
Phase 2
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ati-501 Small molecular drug D6INZ9
Ati-502 Small molecular drug D6N5UC
Ctp-543 Small molecular drug DU10JI
Glpg-0634 Small molecular drug D0SG7B
Incb039110 Small molecular drug D09AFI
Cerdulatinib . D0BI3N
Gsk2586184 . D06HZA
Incb54707 . D0HJ1R
Pf-06700841 . D0V4DX
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-tert-butyl-9-fluoro-16-dihydrobenzo[H]Imidazo[45-f]Isoquinolin-7-one Small molecular drug DB04716
Myricetin Small molecular drug DB02375
Pmid24359159c19a Small molecular drug D0US9O
Whi-p154 Small molecular drug D0E5IP
Zm-39923 Small molecular drug D0YX5U
Ivarmacitinib . DB16756
Patented
Click To Hide/Show 58 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aminooxazole Carboxamide Derivative 1 Small molecular drug D05AXE
Aminotriazolopyridine Derivative 1 Small molecular drug D09ALF
Benzimidazole Derivative 7 Small molecular drug D01CRX
Bipyrazole Derivative 1 Small molecular drug D0H3KF
Bis-aminopyrimidine Derivative 2 Small molecular drug D0LR6J
Bis-aminopyrimidine Derivative 3 Small molecular drug D0S6XT
Bis-aminopyrimidine Derivative 4 Small molecular drug D0SJ1Q
Cyanomethyl Pypazole Carboxamide Derivative 1 Small molecular drug D0K2RW
Cyclic Cyanoethypypazole Derivative 1 Small molecular drug D05GEL
Cycloalkyl Nitrile Pyrazole Carboxamide Derivative 1 Small molecular drug D0V0KI
Cycloalkyl Nitrile Pyrazolo Pyridone Derivative 1 Small molecular drug D0PB5X
Cycloalkyl Nitrile Pyrazolo Pyridone Derivative 2 Small molecular drug D0S4TH
Cyclohexyl Azetidine Derivative 1 Small molecular drug D00GJY
Five-and-six-membered Heterocyclic Compound 1 Small molecular drug D08WPB
Geminally-substituted Cyanoethylpypazolo Pyridone Derivative 1 Small molecular drug D0H6XN
Geminally-substituted Cyanoethylpypazolo Pyridone Derivative 2 Small molecular drug D0KI5F
Imidazopyridazine Derivative 1 Small molecular drug D07BND
Imidazopyridazine Derivative 2 Small molecular drug D00PTE
Imidazo[4,5-c]Pyridine Derivative 1 Small molecular drug D07PTU
Imidazo[4,5-c]Pyridine Derivative 2 Small molecular drug D0VJ1R
Isoxazole Derivative 1 Small molecular drug D0G9MM
Isoxazole Derivative 2 Small molecular drug D0TX2G
N-(Cyanomethyl)-4-(2-(Phenylamino)Pyrimidin-4-yl)Benzamide Derivative 1 Small molecular drug D0Y2IM
N-methylmethanesulfonamide Derivative 1 Small molecular drug D0XH7H
Pmid27774822-compound-figure11example5 Small molecular drug D0RJ3W
Pmid27774822-compound-figure1example20 Small molecular drug D0M3CB
Pmid27774822-compound-figure7example63 Small molecular drug D04OCD
Pmid27774824-compound-figure11example1up Small molecular drug D0YR8S
Pmid27774824-compound-figure2example4 Small molecular drug D0A6RG
Pmid27774824-compound-figure3example18 Small molecular drug D0U1HA
Pmid27774824-compound-figure6example12 Small molecular drug D0GB7G
Pmid27774824-compound-figure6example6 Small molecular drug D0F3BK
Pmid27774824-compound-figure9example2down Small molecular drug D01DBB
Pmid27774824-compound-figure9example2up Small molecular drug D0WZ8N
Pyrazolopyridine Derivative 3 Small molecular drug D03QAY
Pyrimidopyridazinone Derivative 2 Small molecular drug D0WA1V
Pyrrole Derivative 7 Small molecular drug D0YJ4D
Pyrrole Six-membered Heteroaryl Ring Derivative 1 Small molecular drug D09UBE
Pyrrolo-pyridine Derivative 3 Small molecular drug D0VR6E
Pyrrolo-pyridone Derivative 1 Small molecular drug D06MQB
Pyrrolo-pyridone Derivative 2 Small molecular drug D03PBI
Pyrrolo-pyridone Derivative 3 Small molecular drug D0T6CY
Pyrrolo[2,3-d]Pyrimidine Derivative 11 Small molecular drug D0VQ7P
Pyrrolo[2,3-d]Pyrimidine Derivative 6 Small molecular drug D0FQ4Z
Pyrrolo[2,3-d]Pyrimidine Derivative 7 Small molecular drug D0U5FZ
Pyrrolo[2,3-d]Pyrimidine Derivative 8 Small molecular drug D0KL3B
Ruxolitinib Derivative 2 Small molecular drug D01EYJ
Triazolo-pyridine Derivative 1 Small molecular drug D00JUI
Tricyclic Compound 1 Small molecular drug D0G0FK
Tricyclic Compound 11 Small molecular drug D0LS1O
Tricyclic Compound 3 Small molecular drug D0OS1N
Tricyclic Heterocycle Derivative 1 Small molecular drug D0X1FD
Tricyclic Heterocycle Derivative 5 Small molecular drug D0M2WA
Tricyclic Pyrrolopyridine Compound 1 Small molecular drug D04BOW
Bis-aminopyrimidine Derivative 1 . D01FVC
Pmid27774824-compound-figure7example10 . D0PM8K
Pyrazolopyridine Derivative 4 . D09RUN
Pyrazolo[4,3-c]Pyridine Derivative 2 . D09PIS
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Incb47986 . D0HB4E

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578