Details of the Target

General Information of Target

Target ID LDTP15477
Target Name tRNA-uridine aminocarboxypropyltransferase 2 (DTWD2)
Gene Name DTWD2
Gene ID 285605
Synonyms
tRNA-uridine aminocarboxypropyltransferase 2; EC 2.5.1.25; DTW domain-containing protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSEQERIQECLRKEIRSLLISTKDGLSPQELEKEYLLMVGNHLPLRILGYRSTMELVLDM
PDVVRVCPGAGGTVILKAIPDESTKGIASLVAKQRSSHKLRNSMHKGRPSIYSGPRSHRR
VPYRGRVAPILPAVVKSELKDLLALSPVLLSDFEKAFAKRFGRSFQYMQYGFLSMFEVLN
AASDVISVEQTRAGSLLMLKKSVTEEKPRGCPAGKIFTQPFRMKQGSYSTGFPVAKPCFS
QPTSNMEPPKQIMSMEKTSKLNVVETSRLNHTEKLNQLENTFKSVIAQIGPGGTISSELK
HKIKFVVSKFPEGLFISKLLGEYEVIFKEQLSPKKLGFLNVTELVGALSDILHVEFRKGH
QDLLVFDADKKPLPPVQSDKKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQKEPQQKI
CKKPNLVVKPLQLQVETNKSELNLAMANHDIPPDAVPNKKLCRLPPLDTSSLIGVFVEYI
ISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRISEDK
WWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVE
EHWTSKAILQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVC
RENISSKGFSELNPLALYTTSSGGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRIL
DEIPTGMPCLESVTIGDDIWDENWLPLQAKMGKGGDAASHLFTASLGGKNQYSSCKEMPQ
KDWCFSTPKDTWDDSWQPSGLVNGTKVEVHKPEVLGAQEKNTGTNRTQKQLDINGSSDSS
TLPKLEEFCTSLTQSEQSADGSQSEPNNSQTQPKQIQLSTAAPCSTTAVDDSAEKPSGSV
ESSPEILKNEDFSSSRAITLYKDKRQESVDQLSLILSYECQISQKLYIPRSTATAALGAA
ARLATSRSLLHWYPSVKRMEA
Target Bioclass
Enzyme
Family
TDD superfamily, DTWD2 family
Subcellular location
Cytoplasm; Nucleus
Function
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)).
Uniprot ID
Q8NBA8
Ensemble ID
ENST00000304058.8
HGNC ID
HGNC:19334

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 SNV: p.C69R DBIA    Probe Info 
LU65 SNV: p.R130L .
UACC62 SNV: p.G154R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C69(5.35)  LDD1701  [1]
DBIA
 Probe Info  		C143(2.10)  LDD0080  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C143(0.00); C252(0.00); C117(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C252(0.00); C117(0.00); C143(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C252(0.00); C117(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
AOyne
 Probe Info  		12.70  LDD0443  [7]
NAIA_5
 Probe Info  		C143(0.00); C252(0.00); C117(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C143(0.81)  LDD0531  [2]
 LDCM0215  AC10 PaTu 8988t C143(0.91)  LDD1094  [2]
 LDCM0216  AC100 HCT 116 C143(1.79)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C143(1.31)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C143(1.06)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C143(1.31)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C143(1.21)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C143(1.42)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C143(1.62)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C143(1.30)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C143(1.54)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C143(0.97)  LDD0542  [2]
 LDCM0226  AC11 PaTu 8988t C143(0.98)  LDD1105  [2]
 LDCM0227  AC110 HCT 116 C143(1.33)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C143(1.58)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C143(1.45)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C143(0.44)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C143(0.53)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C143(0.75)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C143(0.61)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C143(0.70)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C143(0.73)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C143(0.59)  LDD0834  [2]
 LDCM0237  AC12 PaTu 8988t C143(0.88)  LDD1116  [2]
 LDCM0238  AC120 HEK-293T C143(0.79)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C143(0.66)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C143(0.65)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C143(0.70)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C143(0.60)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C143(0.77)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C143(0.86)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C143(0.93)  LDD0843  [2]
 LDCM0246  AC128 HCT 116 C143(0.43)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C143(0.79)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C143(0.67)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C143(0.60)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C143(0.74)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C143(0.72)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C143(0.84)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C143(0.66)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C143(0.68)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C143(0.77)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C143(0.72)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C143(0.82)  LDD0575  [2]
 LDCM0259  AC14 PaTu 8988t C143(0.82)  LDD1138  [2]
 LDCM0260  AC140 HCT 116 C143(0.81)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C143(0.76)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C143(0.65)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C143(1.04)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C143(1.04)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C143(0.97)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C143(1.09)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C143(1.09)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C143(0.96)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C143(1.14)  LDD0586  [2]
 LDCM0270  AC15 PaTu 8988t C143(0.85)  LDD1149  [2]
 LDCM0271  AC150 HCT 116 C143(0.88)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C143(0.97)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C143(0.81)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C143(0.93)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C143(0.98)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C143(1.13)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C143(1.15)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C143(0.88)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C143(1.20)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C143(0.86)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C143(0.93)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C143(1.10)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C143(1.28)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C143(1.21)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C143(1.16)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C143(1.06)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C143(0.99)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C143(0.85)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C143(0.79)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C143(0.92)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C143(0.83)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C143(0.92)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C143(1.18)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C143(0.86)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C143(0.82)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C143(0.84)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C143(0.87)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C143(0.91)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C143(0.88)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C143(1.03)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C143(1.10)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C143(1.14)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C143(1.00)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C143(1.05)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C143(1.04)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C143(0.98)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C143(1.01)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C143(0.99)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C143(1.13)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C143(0.87)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C143(1.03)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C143(0.95)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C143(0.98)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C143(1.04)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C143(1.25)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C143(1.17)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C143(1.03)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C143(0.97)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C143(1.09)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C143(0.98)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C143(1.17)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C143(1.14)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C143(0.62)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C143(0.72)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C143(0.72)  LDD0639  [2]
 LDCM0323  AC6 PaTu 8988t C143(0.85)  LDD1202  [2]
 LDCM0324  AC60 HCT 116 C143(0.60)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C143(0.89)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C143(0.83)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C143(0.74)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C143(0.70)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C143(0.75)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C143(0.75)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C143(0.67)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C143(0.82)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C143(0.89)  LDD0650  [2]
 LDCM0334  AC7 PaTu 8988t C143(0.79)  LDD1213  [2]
 LDCM0335  AC70 HCT 116 C143(0.97)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C143(0.98)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C143(0.88)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C143(1.03)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C143(1.11)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C143(1.13)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C143(0.98)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C143(1.00)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C143(0.89)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C143(0.95)  LDD0661  [2]
 LDCM0345  AC8 PaTu 8988t C143(0.80)  LDD1224  [2]
 LDCM0346  AC80 HCT 116 C143(0.93)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C143(0.97)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C143(1.14)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C143(2.09)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C143(1.49)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C143(1.36)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C143(1.35)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C143(2.03)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C143(1.98)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C143(1.61)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C143(1.58)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C143(2.03)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C143(1.80)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C143(1.26)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C143(1.84)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C143(1.61)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C143(1.84)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C143(2.68)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C143(0.98)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C143(1.16)  LDD0683  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C143(0.87)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C143(0.87)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C143(0.88)  LDD1154  [2]
 LDCM0632  CL-Sc Hep-G2 C117(0.89); C252(0.15)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C143(1.02)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C143(0.93)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C143(0.99)  LDD0686  [2]
 LDCM0370  CL101 PaTu 8988t C143(0.91)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C143(0.83)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C143(0.95)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C143(0.88)  LDD1252  [2]
 LDCM0374  CL105 HCT 116 C143(0.90)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C143(1.01)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C143(0.94)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C143(1.00)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C143(1.06)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C143(0.92)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C143(0.93)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C143(0.98)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C143(0.73)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C143(0.79)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C143(0.75)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C143(0.91)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C143(0.88)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C143(1.09)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C143(0.90)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C143(1.00)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C143(1.10)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C143(1.04)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C143(0.94)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C143(0.96)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C143(1.04)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C143(1.05)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C143(0.62)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C143(0.54)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C143(0.61)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C143(0.83)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C143(0.93)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C143(1.05)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C143(0.95)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C143(0.82); C220(1.06); C226(1.06)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C143(0.91); C220(0.94); C226(0.94)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C143(0.80); C220(1.08); C226(1.08)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C143(0.90); C220(1.09); C226(1.09)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C143(1.04)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C143(0.84); C220(0.84); C226(0.84)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C143(1.17); C220(0.76); C226(0.76)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C143(1.03); C220(0.84); C226(0.84)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C143(0.97); C220(0.73); C226(0.73)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C143(0.96); C220(0.76); C226(0.76)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C143(0.84); C220(0.74); C226(0.74)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C143(0.87); C220(0.84); C226(0.84)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C143(1.06); C220(0.83); C226(0.83)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C143(1.01); C220(0.79); C226(0.79)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C143(1.13); C220(0.86); C226(0.86)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C143(1.05)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C143(1.04); C220(0.85); C226(0.85)  LDD1017  [2]
 LDCM0420  CL31 HCT 116 C143(1.14)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C143(0.98)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C143(0.83)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C143(0.86)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C143(1.00)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C143(1.01)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C143(1.09)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C143(1.08)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C143(1.02)  LDD1027  [2]
 LDCM0430  CL40 HCT 116 C143(0.98)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C143(0.96)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C143(1.01)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C143(1.17)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C143(1.02)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C143(0.84)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C143(1.18)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C143(1.03)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C143(1.11)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C143(1.14)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C143(1.00)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C143(1.11)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C143(1.33)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C143(1.32)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C143(0.88)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C143(1.09)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C143(1.07)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C143(1.11)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C143(1.07)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C143(1.36)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C143(1.11)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C143(1.10)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C143(1.30)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C143(0.77); C220(1.34); C226(1.34)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C143(0.85); C220(0.88); C226(0.88)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C143(0.72); C220(0.92); C226(0.92)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C143(0.97); C220(0.91); C226(0.91)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C143(0.83); C220(0.93); C226(0.93)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C143(0.78); C220(0.86); C226(0.86)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C143(0.88); C220(0.88); C226(0.88)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C143(1.00); C220(0.79); C226(0.79)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C143(0.92); C220(1.02); C226(1.02)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C143(1.11)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C143(0.91); C220(1.00); C226(1.00)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C143(0.97); C220(0.79); C226(0.79)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C143(0.84); C220(1.07); C226(1.07)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C143(1.05); C220(0.88); C226(0.88)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C143(0.90); C220(0.83); C226(0.83)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C143(1.02); C220(0.83); C226(0.83)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C143(1.24); C220(0.70); C226(0.70)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C143(0.66); C220(0.66); C226(0.66)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C143(0.69); C220(0.69); C226(0.69)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C143(0.85)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C143(1.01); C220(0.66); C226(0.66)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C143(0.83); C220(0.75); C226(0.75)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C143(1.07); C220(0.92); C226(0.92)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C143(1.00); C220(0.99); C226(0.99)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C143(1.00); C220(0.70); C226(0.70)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C143(0.78); C220(0.63); C226(0.63)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C143(0.67); C220(0.57); C226(0.57)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C143(0.86); C220(0.78); C226(0.78)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C143(1.13); C220(0.70); C226(0.70)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C143(0.92); C220(0.76); C226(0.76)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C143(0.88)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C143(1.60); C220(0.76); C226(0.76)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C143(0.86)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C143(0.90)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C143(0.95)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C143(1.09)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C143(1.08)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C143(0.86)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C143(0.97)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C143(1.03)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C143(1.20)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C252(1.82); C117(0.83); C220(1.05)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C69(1.23)  LDD1702  [1]
 LDCM0202  EV-93 T cell C220, C226(4.06)  LDD0514  [9]
 LDCM0468  Fragment33 HEK-293T C143(0.78); C220(0.74); C226(0.74)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C143(1.30)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C143(2.10)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C143(2.30)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C143(2.14)  LDD0082  [2]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.