Details of the Target

General Information of Target

Target ID LDTP14041
Target Name TRPM8 channel-associated factor 1 (TCAF1)
Gene Name TCAF1
Gene ID 9747
Synonyms
FAM115A; KIAA0738; TRPM8 channel-associated factor 1; TRP channel-associated factor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKD
LKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERIVQWPAITYKPLL
DKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE
SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIH
VEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEI
LLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTK
PDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPT
KASSKAELEIANPPELQKHLEHAPSPSDVSNAPEVKAGVNSDSPNNCSGKKVEPSALACR
SQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIV
AQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAI
GLWLPLTKNVVGIDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVRE
MCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENL
MPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKP
TLGAVLQQNPSVLEPAAVGGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQ
PTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGL
KNTPKILDDIFASLVQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNK
SNWNVFRECWKQGQPVMVSGVHHKLNSELWKPESFRKEFGEQEVDLVNCRTNEIITGATV
GDFWDGFEDVPNRLKNEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGK
LNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQC
EQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQEN
PADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKV
AEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGK
P
Target Bioclass
Other
Family
TCAF family
Subcellular location
Cell membrane
Function
Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.
Uniprot ID
Q9Y4C2
Ensemble ID
ENST00000355951.2
HGNC ID
HGNC:22201

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN18 Substitution: p.S97F DBIA    Probe Info 
MFE319 SNV: p.A24V DBIA    Probe Info 
NCIH1975 SNV: p.Y130Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.73  LDD0402  [1]
TH211
 Probe Info  		Y542(8.67)  LDD0257  [2]
TH216
 Probe Info  		Y542(20.00)  LDD0259  [2]
STPyne
 Probe Info  		K586(8.33)  LDD0277  [3]
BTD
 Probe Info  		C576(1.46)  LDD2117  [4]
HHS-475
 Probe Info  		Y542(1.10)  LDD0264  [5]
HHS-465
 Probe Info  		Y542(4.51)  LDD2237  [6]
DBIA
 Probe Info  		C487(1.03); C488(1.03)  LDD0078  [7]
ATP probe
 Probe Info  		K865(0.00); K194(0.00); K817(0.00)  LDD0199  [8]
IA-alkyne
 Probe Info  		C144(0.00); C576(0.00); C543(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
WYneN
 Probe Info  		C488(0.00); C576(0.00)  LDD0021  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
W1
 Probe Info  		C487(0.00); C488(0.00)  LDD0236  [14]
AOyne
 Probe Info  		12.90  LDD0443  [15]
NAIA_5
 Probe Info  		C576(0.00); C608(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C265
 Probe Info  		16.91  LDD1936  [17]
C277
 Probe Info  		21.71  LDD1947  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C576(1.46)  LDD2117  [4]
 LDCM0214  AC1 HCT 116 C487(1.18); C488(0.96); C144(0.92); C597(0.53)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C487(1.13); C488(1.16); C576(0.75); C597(1.13)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C487(1.08); C488(1.03); C576(0.87)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C487(1.17); C488(1.10); C576(0.63)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C487(1.16); C488(1.22); C576(0.78)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C487(1.50); C488(1.20); C576(0.35)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C487(1.26); C488(1.08); C576(0.48)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C487(1.24); C488(1.08); C576(0.33)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C487(1.35); C488(1.14); C576(0.31)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C487(1.16); C488(1.17); C576(0.30)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C487(1.28); C488(1.09); C576(0.87)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C487(1.10); C488(1.01); C576(0.72)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C487(1.07); C488(1.13); C576(0.67); C597(1.01)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C487(1.19); C488(1.08); C576(0.68)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C487(1.18); C488(1.19); C576(0.71)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C487(1.14); C488(1.16); C576(0.54)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C487(1.00); C488(0.91); C543(1.48)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C487(1.20); C488(1.02); C543(0.94)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C487(1.41); C488(1.27); C543(0.72)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C487(1.69); C488(1.49); C543(0.86)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C487(1.21); C488(1.15); C543(1.04)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C487(1.15); C488(1.13); C543(0.92)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C487(1.35); C488(1.32); C543(0.83)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C487(0.87); C488(0.89); C576(0.72); C597(1.05)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C487(1.19); C488(1.01); C543(0.80)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C487(1.08); C488(1.05); C543(1.11)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C487(1.07); C488(1.02); C543(0.68)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C487(1.14); C488(1.14); C543(1.16)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C487(1.07); C488(1.03); C543(0.97)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C487(1.16); C488(1.07); C543(0.96)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C487(1.48); C488(1.15); C543(0.75)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C487(1.47); C488(1.24); C543(0.84)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C487(1.38); C488(0.91); C576(0.61); C597(1.23)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C487(0.97); C488(1.23); C576(1.43); C597(0.71)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C487(1.27); C488(1.19); C576(0.83); C597(1.13)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C487(1.04); C488(1.11); C576(1.32); C597(1.01)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C487(1.15); C488(1.43); C576(1.30); C597(0.94)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C487(1.16); C488(1.27); C576(1.03); C597(1.24)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C487(1.39); C488(1.42); C576(0.89); C597(1.17)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C487(1.33); C488(1.27); C576(0.76); C597(1.14)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C487(1.35); C488(1.43); C576(1.00); C597(1.37)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C487(1.12); C488(1.19); C576(1.30); C597(1.13)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C487(1.44); C488(1.61); C576(1.07); C597(1.30)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C487(1.34); C488(1.56); C576(1.17); C597(1.19)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C487(0.88); C488(0.89); C576(0.88); C597(1.29)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C487(1.64); C488(1.85); C576(0.87); C597(1.20)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C487(1.48); C488(1.60); C576(1.15); C597(1.08)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C487(1.11); C488(1.43); C576(1.68); C597(1.06)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C487(1.19); C488(1.06); C576(1.07); C597(1.30)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C576(0.56); C488(0.99); C597(1.25); C598(1.25)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C576(0.69); C488(1.02); C597(1.09); C598(1.09)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C576(0.76); C488(1.04); C597(1.18); C598(1.18)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C576(0.47); C488(0.99); C597(1.18); C598(1.18)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C576(0.42); C488(1.33); C597(1.41); C598(1.41)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C576(0.48); C597(1.25); C598(1.25); C488(1.32)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C576(0.73); C488(0.85); C487(0.87); C597(1.12)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C488(0.96); C576(1.02); C597(1.13); C598(1.13)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C488(0.97); C487(1.07); C597(1.07); C598(1.07)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C576(0.43); C488(0.89); C597(1.36); C598(1.36)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C576(0.45); C488(1.39); C597(1.44); C598(1.44)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C487(1.39); C488(0.96); C576(0.62); C597(1.27)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C487(1.30); C488(1.02); C576(0.59); C597(1.28)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C487(1.15); C488(1.07); C576(0.77); C597(1.08)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C487(0.93); C488(0.94); C576(0.76); C597(0.91)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C597(0.87); C598(0.88); C488(0.96); C487(1.04)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C576(0.64); C543(0.70); C488(1.06); C487(1.11)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C597(0.77); C576(0.81); C598(0.84); C488(1.00)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C598(0.43); C597(0.66); C488(0.94); C144(1.01)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C597(0.86); C598(0.90); C576(0.98); C543(1.16)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C576(0.74); C597(0.85); C598(0.92); C144(0.99)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C597(0.74); C598(0.74); C487(0.83); C144(0.99)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C598(0.74); C597(0.75); C576(0.90); C543(0.92)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C597(0.70); C598(0.72); C576(0.90); C144(1.09)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C597(0.84); C598(0.89); C576(0.96); C487(1.02)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C597(0.87); C576(0.87); C598(0.97); C488(1.17)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C576(0.81); C597(0.92); C598(1.08); C488(1.15)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C576(0.70); C597(0.79); C598(0.91); C144(1.19)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C576(0.76); C597(0.96); C598(1.03); C487(1.24)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C598(0.39); C597(0.61); C144(0.89); C488(0.98)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C576(0.75); C598(1.10); C597(1.11); C144(1.20)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C576(0.79); C597(0.89); C598(0.98); C488(1.17)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C576(0.49); C597(1.12); C598(1.29); C488(1.48)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C576(0.54); C597(1.08); C598(1.27); C488(1.33)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C576(0.38); C597(1.08); C144(1.21); C598(1.27)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C487(0.84); C488(0.87); C597(0.90); C598(0.90)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C144(0.93); C487(0.95); C597(0.96); C598(0.96)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C597(0.78); C598(0.78); C487(0.86); C488(0.95)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C597(0.91); C598(0.91); C487(0.98); C144(1.08)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C597(0.98); C598(0.98); C488(1.02); C487(1.13)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C598(0.38); C597(0.58); C488(0.87); C144(1.13)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C576(0.81); C597(0.87); C598(0.87); C488(1.02)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C597(0.72); C598(0.72); C487(1.11); C576(1.16)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C597(0.73); C598(0.73); C576(0.98); C488(1.03)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C597(0.73); C598(0.73); C487(1.11); C488(1.13)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C597(0.72); C598(0.72); C576(0.96); C488(0.97)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C597(0.70); C598(0.70); C576(0.80); C488(1.05)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C487(1.12); C488(1.17); C576(1.21); C597(1.29)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C576(0.99); C597(1.00); C488(1.10); C487(1.17)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C597(1.03); C488(1.14); C487(1.25); C576(1.37)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C576(0.72); C597(0.95); C488(1.41); C487(1.67)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C598(0.39); C597(0.57); C488(0.92); C144(1.17)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C576(0.68); C597(0.87); C488(1.24); C487(1.42)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C597(0.83); C488(0.99); C487(1.14); C576(1.95)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C597(0.66); C576(0.99); C488(1.15); C487(1.38)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C597(0.62); C576(0.73); C488(1.36); C487(1.43)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C576(0.69); C597(0.73); C488(1.18); C487(1.26)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C597(0.74); C576(0.76); C488(1.40); C487(1.43)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C597(0.74); C576(0.98); C488(1.49); C487(1.62)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C543(0.64); C576(0.76); C488(1.30); C144(1.35)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C543(0.57); C576(0.79); C488(1.40); C144(1.64)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C543(0.59); C576(0.65); C144(1.53); C597(1.83)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C576(0.66); C487(1.04); C488(1.09); C597(1.27)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C543(0.60); C576(0.90); C488(1.43); C487(1.58)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C543(0.49); C576(0.86); C597(1.39); C488(1.46)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C543(0.45); C576(0.60); C144(1.63); C597(1.83)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C576(0.73); C543(0.74); C488(1.39); C144(1.48)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C543(0.47); C576(0.73); C488(1.27); C144(1.52)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C543(0.61); C576(0.81); C488(1.54); C597(1.55)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C543(0.73); C576(0.89); C488(1.38); C597(1.43)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C543(0.24); C576(0.72); C597(1.56); C144(1.65)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C576(0.77); C487(1.07); C488(1.12); C597(1.36)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C576(0.69); C487(1.06); C488(1.14); C597(1.15)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C576(0.79); C597(1.07); C598(1.07); C488(1.48)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C576(0.57); C597(1.07); C598(1.07); C144(1.11)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C576(0.90); C597(0.92); C598(0.92); C487(1.02)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C576(0.60); C597(1.15); C598(1.15); C144(1.18)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C576(0.62); C597(1.23); C598(1.23); C487(1.38)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C576(0.64); C597(1.18); C598(1.18); C487(1.34)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C576(0.71); C597(1.31); C598(1.31); C487(1.61)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C576(0.60); C597(1.11); C598(1.11); C487(1.21)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C576(0.56); C487(1.14); C597(1.19); C598(1.19)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C576(0.90); C597(1.02); C598(1.02); C487(1.14)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C576(0.78); C597(1.06); C598(1.06); C487(1.12)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C576(0.65); C488(0.93); C487(0.97); C597(1.18)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C576(0.60); C597(1.03); C598(1.03); C487(1.08)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C576(0.88); C487(1.05); C488(1.14); C144(1.23)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C576(0.72); C597(1.25); C598(1.25); C487(1.73)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C576(0.61); C144(0.94); C488(1.55); C487(1.60)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C576(0.66); C144(0.95); C488(1.38); C487(1.49)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C576(0.76); C144(0.96); C597(1.23); C488(1.26)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C576(0.74); C597(1.07); C144(1.18); C598(1.20)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C144(0.92); C597(0.92); C576(0.94); C598(1.00)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C576(0.75); C144(0.97); C597(0.99); C598(1.06)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C576(0.67); C144(1.06); C597(1.16); C598(1.22)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C598(0.89); C597(0.94); C144(0.96); C488(1.03)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C576(0.61); C144(1.05); C597(1.42); C488(1.46)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C576(0.54); C144(1.02); C597(1.31); C488(1.35)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C576(0.77); C144(0.97); C598(1.00); C597(1.06)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C576(0.89); C597(0.96); C598(1.05); C488(1.06)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C597(0.80); C576(0.89); C598(1.01); C144(1.05)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C576(0.74); C144(0.98); C597(1.11); C488(1.12)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C576(0.60); C144(1.15); C597(1.17); C598(1.32)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C576(0.34); C488(1.51); C487(1.89)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C576(0.76); C487(1.12); C488(1.13)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C487(0.93); C488(0.98); C576(0.93); C597(1.10)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C576(0.69); C597(1.01); C598(1.01); C487(1.05)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C576(0.34); C487(1.08); C488(1.09); C597(1.61)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C487(1.03); C488(1.03)  LDD0078  [7]
 LDCM0367  CL1 HCT 116 C576(0.81); C597(0.89); C598(0.89); C144(1.09)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C597(0.80); C598(0.80); C576(0.87); C144(1.45)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C598(0.44); C597(0.60); C144(0.86); C488(1.08)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C576(0.58); C597(1.41); C598(1.41); C487(1.46)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C576(0.99); C597(1.09); C598(1.09); C487(1.98)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C576(0.75); C597(1.06); C598(1.06); C488(1.22)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C576(0.73); C597(1.19); C598(1.19); C488(1.32)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C576(0.81); C543(0.93); C597(1.11); C598(1.20)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C543(0.50); C576(0.67); C487(1.24); C597(1.24)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C576(0.71); C543(0.83); C487(1.01); C488(1.06)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C576(0.66); C543(0.73); C487(1.09); C488(1.18)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C576(0.58); C543(0.85); C597(0.93); C598(0.95)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C576(0.60); C597(0.77); C598(0.77); C144(1.44)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C576(0.63); C543(0.69); C597(1.17); C598(1.18)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C576(0.68); C543(0.87); C597(0.95); C598(0.97)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C576(0.88); C144(0.92); C597(1.05); C598(1.07)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C576(0.51); C597(0.97); C598(1.07); C144(1.10)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C576(0.61); C597(0.97); C598(1.06); C144(1.21)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C576(0.71); C597(1.03); C598(1.07); C144(1.23)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C576(0.96); C597(0.96); C598(1.05); C488(1.22)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C597(0.82); C598(0.82); C576(0.85); C144(0.91)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C597(0.76); C598(0.76); C144(1.08); C576(1.10)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C597(0.71); C598(0.71); C144(0.92); C576(1.00)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C597(0.67); C598(0.67); C576(1.09); C144(1.47)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C597(0.76); C598(0.76); C487(1.13); C488(1.26)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C576(0.67); C487(0.90); C597(1.01); C488(1.46)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C576(1.08); C597(1.09); C488(1.51); C487(1.73)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C576(0.62); C597(0.80); C487(2.77); C488(3.06)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C576(0.71); C597(0.84); C488(2.59); C487(2.81)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C576(0.94); C597(1.08); C543(1.09); C598(1.09)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C576(0.77); C543(0.86); C597(1.27); C598(1.46)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C576(0.85); C543(0.93); C144(1.26); C597(1.27)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C576(0.67); C543(0.68); C144(1.49); C597(1.51)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C597(0.74); C598(0.74); C576(1.10); C144(1.54)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C597(0.81); C598(0.81); C576(0.91); C144(1.02)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C597(0.73); C598(0.73); C576(0.84); C144(1.61)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C597(1.10); C598(1.10); C488(1.48); C487(1.58)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C597(1.67); C598(1.67); C488(8.22); C487(11.15)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C487(1.07); C488(1.08); C597(1.44); C598(1.44)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C487(1.19); C488(1.20); C597(1.24); C598(1.24)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C597(0.70); C598(0.70); C576(0.87); C144(0.91)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C488(1.38); C487(1.41); C597(1.43); C598(1.43)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C597(2.31); C598(2.31); C488(3.62); C487(3.69)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C597(2.04); C598(2.04); C488(2.21); C487(2.26)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C597(1.08); C598(1.08); C488(1.14); C487(1.14)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C488(1.32); C487(1.32); C597(1.66); C598(1.66)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C487(2.64); C488(2.68); C597(1.86); C598(1.86)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C487(1.42); C488(1.34); C597(1.38); C598(1.38)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C487(1.32); C488(1.31); C597(1.16); C598(1.16)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C487(1.96); C488(1.88); C597(1.41); C598(1.41)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C487(1.24); C488(1.23); C597(1.47); C598(1.47)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C487(2.13); C488(2.04); C144(1.02); C576(1.07)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C487(1.19); C488(1.09); C597(1.20); C598(1.20)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C487(3.30); C488(3.05); C144(1.17); C543(1.19)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C487(1.62); C488(1.49); C144(1.09); C543(0.71)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C487(2.14); C488(1.87); C144(0.94); C543(0.70)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C487(2.28); C488(2.22); C144(0.94); C543(0.66)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C487(2.30); C488(2.12); C144(1.24); C543(0.68)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C487(5.04); C488(3.97); C144(1.45); C543(0.92)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C487(2.68); C488(2.38); C144(2.51); C543(0.61)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C487(2.91); C488(2.19); C144(1.33); C543(0.72)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C487(1.63); C488(1.64); C144(1.04); C576(0.89)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C487(3.88); C488(2.65); C144(1.48); C543(1.26)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C487(1.94); C488(1.38); C144(1.08); C543(1.14)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C487(3.48); C488(2.43); C144(1.25); C543(0.50)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C487(2.40); C488(1.69); C144(1.35); C543(0.49)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C487(2.26); C488(1.77); C144(1.36); C543(0.52)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C487(4.17); C488(2.50); C144(1.14); C543(0.54)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C487(1.16); C488(1.27); C144(1.17); C597(0.67)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C487(2.03); C488(1.96); C144(0.94); C597(0.81)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C487(1.08); C488(1.28); C144(0.97); C597(0.76)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C487(1.06); C488(1.11); C144(1.09); C597(0.70)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C487(1.18); C488(1.09); C144(1.14); C576(0.96)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C487(1.24); C488(1.25); C144(0.97); C597(0.80)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C487(1.52); C488(1.36); C144(1.05); C597(0.77)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C487(1.68); C488(2.17); C144(1.16); C597(0.75)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C487(1.06); C488(1.08); C144(1.09); C597(0.89)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C487(0.92); C488(1.00); C144(1.10); C597(0.78)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C487(0.87); C488(0.92); C144(1.05); C597(0.85)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C487(1.11); C488(1.12); C144(0.98); C597(0.93)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C487(1.59); C488(1.63); C144(1.23); C597(0.84)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C487(0.91); C488(0.99); C144(1.19); C597(0.73)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C487(0.88); C488(0.92); C144(1.11); C597(0.82)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C487(4.01); C488(3.55); C144(1.03); C576(0.92)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C487(1.78); C488(1.73); C144(1.21); C597(0.79)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C487(1.41); C488(1.13); C597(0.97); C598(0.75)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C487(1.23); C488(1.17); C597(0.96); C598(0.78)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C487(1.62); C488(2.89); C597(1.03); C598(0.91)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C487(1.38); C488(1.08); C597(0.96); C598(0.82)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C487(3.05); C488(2.38); C597(0.78); C598(0.69)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C487(1.78); C488(1.46); C597(0.76); C598(0.72)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C487(1.43); C488(1.15); C597(0.69); C598(0.61)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C487(2.10); C488(2.12); C597(0.83); C598(0.78)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C487(1.42); C488(1.40); C597(0.76); C598(0.69)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C487(1.73); C488(1.33); C144(1.12); C576(1.16)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C487(1.15); C488(1.27); C597(0.71); C598(0.70)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C487(1.36); C488(1.16); C597(0.74); C598(0.64)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C487(1.16); C488(1.14); C597(0.63); C598(0.57)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C487(2.76); C488(2.82); C597(0.79); C598(0.70)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C487(1.63); C488(1.43); C597(0.69); C598(0.60)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C487(1.23); C488(1.18); C144(1.04); C597(1.45)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C487(3.95); C488(3.67); C144(0.98); C597(1.73)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C487(1.53); C488(1.58); C144(0.97); C597(1.10)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C487(1.86); C488(1.56); C144(0.96); C597(1.23)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C487(4.08); C488(2.84); C144(1.23); C576(0.72)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C487(1.25); C488(1.09); C144(1.09); C597(0.99)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C487(1.41); C488(1.34); C144(0.97); C597(0.99)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C487(2.21); C488(1.86); C144(1.00); C597(0.76)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C487(2.72); C488(2.05); C144(1.05); C597(1.07)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C487(4.78); C488(4.05); C144(1.32); C597(1.02)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C487(1.54); C488(1.57); C144(1.10); C597(1.15)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C487(1.24); C488(1.19); C144(0.86); C597(1.13)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C487(1.72); C488(1.60); C144(1.14); C597(0.97)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C487(2.50); C488(2.46); C144(1.11); C597(1.02)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C487(3.02); C488(2.95); C144(1.29); C597(0.90)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C487(3.52); C488(2.38); C144(1.05); C576(0.91)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C487(2.86); C488(2.42); C144(0.82); C597(1.21)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C487(2.22); C488(1.16); C144(0.75); C597(0.87)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C487(2.55); C488(1.21); C144(0.75); C597(0.83)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C487(1.69); C488(1.06); C144(1.21); C597(0.73)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C487(1.56); C488(1.09); C144(0.86); C597(0.79)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C487(1.98); C488(1.76); C144(0.83); C597(0.72)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C487(1.79); C488(1.37); C144(0.87); C597(0.74)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C487(3.12); C488(1.72); C144(0.79); C597(0.73)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C487(2.88); C488(1.21); C144(0.82); C597(0.68)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C487(1.49); C488(1.19); C144(0.92); C597(0.61)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C576(0.96); C144(0.91); C335(1.06)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C576(1.94)  LDD1702  [4]
 LDCM0202  EV-93 T cell C487, C488(5.59)  LDD0514  [19]
 LDCM0468  Fragment33 HCT 116 C487(1.83); C488(1.87); C597(0.69); C598(0.64)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C487(3.03); C488(2.41); C144(1.36); C543(0.53)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y542(1.10)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y542(2.21)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y542(0.78)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y542(1.14)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y542(1.34)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C487(20.00); C488(20.00)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C487(2.06); C488(2.06)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C487(1.44); C488(1.44)  LDD0082  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C576(1.31)  LDD2125  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C576(0.80); C487(0.07)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C487(0.99)  LDD2207  [20]
 LDCM0021  THZ1 HCT 116 C488(1.08); C487(1.05)  LDD2173  [7]
 LDCM0112  W16 Hep-G2 C487(0.76); C488(0.76)  LDD0239  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Baculoviral IAP repeat-containing protein 2 (BIRC2) IAP family Q13490
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 143 (ZNF143) GLI C2H2-type zinc-finger protein family P52747
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein Eos (IKZF4) Ikaros C2H2-type zinc-finger protein family Q9H2S9
RB-associated KRAB zinc finger protein (RBAK) Krueppel C2H2-type zinc-finger protein family Q9NYW8
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
Zinc finger protein 263 (ZNF263) Krueppel C2H2-type zinc-finger protein family O14978
Zinc finger protein 592 (ZNF592) Krueppel C2H2-type zinc-finger protein family Q92610
Transcription factor E2-alpha (TCF3) . P15923
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Connector enhancer of kinase suppressor of ras 1 (CNKSR1) CNKSR family Q969H4
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.