Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name EN219-alkyne  Probe Info 
Probe concentration 2 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name EN219  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast cancer [ICD-11:2C82]
Model Name Human breast cancer cell lysate (231MFP)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 5.3
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 4.5
 LDTP03540  Heme oxygenase 2 (HMOX2) 3.9
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 3.5
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 4.9
 LDTP06302  Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (ACAP2) 4.2
 LDTP01522  Reticulon-3 (RTN3) 3.5

References

1 Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.