Details of the Target

General Information of Target

Target ID LDTP05224
Target Name RNA-binding protein 10 (RBM10)
Gene Name RBM10
Gene ID 8241
Synonyms
DXS8237E; GPATC9; GPATCH9; KIAA0122; RNA-binding protein 10; G patch domain-containing protein 9; RNA-binding motif protein 10; RNA-binding protein S1-1; S1-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDS
SEEQSAEDSYEASPGSETQRRRRRRHRHSPTGPPGFPRDGDYRDQDYRTEQGEEEEEEED
EEEEEKASNIVMLRMLPQAATEDDIRGQLQSHGVQAREVRLMRNKSSGQSRGFAFVEFSH
LQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPK
SEAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENAND
TIILRNLNPHSTMDSILGALAPYAVLSSSNVRVIKDKQTQLNRGFAFIQLSTIVEAAQLL
QILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQG
GEGTWATSEEPPVDYSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGP
EASLEPGADSVSMQAFSRAQPGAAPGIYQQSAEASSSQGTAANSQSYTIMSPAVLKSELQ
SPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNA
QSQQYLYWDGERRTYVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIAKDMERWAR
SLNKQKENFKNSFQPISSLRDDERRESATADAGYAILEKKGALAERQHTSMDLPKLASDD
RPSPPRGLVAAYSGESDSEEEQERGGPEREEKLTDWQKLACLLCRRQFPSKEALIRHQQL
SGLHKQNLEIHRRAHLSENELEALEKNDMEQMKYRDRAAERREKYGIPEPPEPKRRKYGG
ISTASVDFEQPTRDGLGSDNIGSRMLQAMGWKEGSGLGRKKQGIVTPIEAQTRVRGSGLG
ARGSSYGVTSTESYKETLHKTMVTRFNEAQ
Target Bioclass
Other
Subcellular location
Nucleus
Function
May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A). May bind to specific miRNA hairpins.
Uniprot ID
P98175
Ensemble ID
ENST00000329236.8
HGNC ID
HGNC:9896

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.S562N .
COLO792 SNV: p.S897F .
HCT15 SNV: p.P725L .
HT1197 SNV: p.Y459C .
Ishikawa (Heraklio) 02 ER SNV: p.S151W .
LS123 SNV: p.S687P .
MCC13 SNV: p.W187Ter .
MELJUSO SNV: p.D300G; p.S687P .
MEWO SNV: p.S194F .
MFE319 SNV: p.A409V .
NCIH1944 Insertion: p.A618RfsTer10
SNV: p.V616F		 .
NCIH1975 Deletion: p.G840AfsTer7 .
NCIH2286 SNV: p.A552V .
NCIH2291 Deletion: p.I696SfsTer8 .
SNU1196 SNV: p.Q649Ter .
WM2664 Insertion: . .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K771(8.99)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
Probe 1
 Probe Info  		Y48(60.33); Y107(17.78); Y694(25.02); Y732(14.29)  LDD3495  [3]
BTD
 Probe Info  		C764(0.65)  LDD2123  [4]
Acrolein
 Probe Info  		H795(0.00); H152(0.00); H180(0.00)  LDD0221  [5]
DBIA
 Probe Info  		C222(0.96)  LDD1492  [6]
5E-2FA
 Probe Info  		H180(0.00); H152(0.00); H626(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		K699(0.00); K700(0.00)  LDD0199  [8]
m-APA
 Probe Info  		H180(0.00); H152(0.00); H34(0.00); H626(0.00)  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C222(0.00); C219(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C222(0.00); C219(0.00)  LDD0036  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
W1
 Probe Info  		N.A.  LDD0236  [2]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.50  LDD1714  [11]
C041
 Probe Info  		7.26  LDD1741  [11]
C052
 Probe Info  		6.41  LDD1750  [11]
C106
 Probe Info  		19.16  LDD1793  [11]
C108
 Probe Info  		8.82  LDD1795  [11]
C178
 Probe Info  		40.50  LDD1857  [11]
C187
 Probe Info  		18.38  LDD1865  [11]
C191
 Probe Info  		14.32  LDD1868  [11]
C193
 Probe Info  		5.86  LDD1869  [11]
C314
 Probe Info  		20.53  LDD1981  [11]
C338
 Probe Info  		10.20  LDD2001  [11]
C363
 Probe Info  		15.78  LDD2024  [11]
C431
 Probe Info  		18.51  LDD2086  [11]
FFF probe11
 Probe Info  		13.52  LDD0471  [12]
FFF probe13
 Probe Info  		20.00  LDD0475  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
FFF probe2
 Probe Info  		17.13  LDD0463  [12]
FFF probe3
 Probe Info  		20.00  LDD0465  [12]
JN0003
 Probe Info  		20.00  LDD0469  [12]
OEA-DA
 Probe Info  		20.00  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C219(0.82)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C219(0.87); C222(1.07)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C222(1.08)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C219(0.94); C222(1.07)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C219(0.99); C222(1.02)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C219(0.84)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C219(0.74); C222(0.70)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C219(0.99)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C222(1.04)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C222(0.94)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C219(0.93); C222(1.02)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C219(0.96); C222(1.10)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C219(0.97)  LDD1523  [6]
 LDCM0286  AC26 HEK-293T C219(0.98)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C219(0.89); C222(0.90)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C222(1.08)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C222(0.98)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C219(0.89); C222(1.03)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C219(0.97); C222(1.16)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C219(0.99); C222(1.05)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C219(1.03)  LDD1532  [6]
 LDCM0295  AC34 HEK-293T C219(0.89)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C219(0.95); C222(1.02)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C222(1.11)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C222(1.14)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C219(0.97); C222(1.02)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C219(1.01); C222(0.99)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C222(1.04)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C219(0.95)  LDD1541  [6]
 LDCM0304  AC42 HEK-293T C219(0.89)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C219(0.98); C222(0.96)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C222(1.12)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C222(0.98)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C219(1.05); C222(1.08)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C219(0.95); C222(1.05)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C219(0.98)  LDD1549  [6]
 LDCM0312  AC5 HEK-293T C222(0.94)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C219(0.86)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C219(0.81); C222(0.99)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C222(1.17)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C222(1.01)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C219(0.98); C222(1.11)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C219(0.95); C222(1.13)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C219(0.98)  LDD1558  [6]
 LDCM0321  AC58 HEK-293T C219(0.91)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C219(0.95); C222(1.01)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C219(0.96); C222(1.08)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C222(1.09)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C222(0.96)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C219(0.98); C222(1.08)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C219(0.95); C222(0.97)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C219(0.98)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C219(0.94); C222(1.06)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C219(1.02)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C222(1.04)  LDD1511  [6]
 LDCM0275  AKOS034007705 HEK-293T C219(1.05)  LDD1514  [6]
 LDCM0108  Chloroacetamide HeLa H152(0.00); H180(0.00); H795(0.00)  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C219(0.75)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C219(0.74); C222(0.98)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C219(0.96)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C219(0.91)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C219(0.90)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C219(0.97); C222(1.16)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C219(0.94)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C219(0.91)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C219(0.86)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C219(1.04); C222(1.02)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C219(1.02)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C219(0.92)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C219(0.93); C222(1.01)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C219(0.91)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C219(0.96); C222(0.93)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C219(0.90)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C219(0.97)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C219(0.93)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C219(0.99); C222(0.88)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C219(1.11)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C219(0.93)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C219(1.05)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C219(1.04); C222(1.13)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C219(1.00)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C219(1.07)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C219(1.03)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C219(0.95)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C219(0.92); C222(0.90)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C219(1.01)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C219(0.89)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C219(0.92)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C219(0.95); C222(0.98)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C219(1.01)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C219(0.96)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C219(1.00)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C219(0.89); C222(1.13)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C219(0.99)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C219(0.90)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C219(1.05); C222(1.16)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C219(0.93)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C222(1.02)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C222(0.95)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C219(0.96); C222(1.03)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C219(0.97); C222(1.03)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C219(0.97)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C219(0.91)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C219(1.01)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C219(0.95); C222(0.95)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C219(0.94)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C219(1.00); C222(0.96)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C219(0.85)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C219(0.95); C222(0.89)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C222(1.15)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C222(0.98)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C219(0.88); C222(1.16)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C219(0.90); C222(1.02)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C219(0.92)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C219(0.88)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C219(0.92); C222(1.02)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C219(1.04)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C219(0.93)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C219(0.86)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C219(0.99); C222(0.97)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C222(1.10)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C222(0.92)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C219(0.87); C222(1.05)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C219(0.90); C222(1.13)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C219(1.10)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C219(0.97)  LDD1643  [6]
 LDCM0441  CL50 HEK-293T C219(0.95)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C219(1.03)  LDD1646  [6]
 LDCM0445  CL54 HEK-293T C219(0.86)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C219(0.94); C222(1.06)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C222(1.01)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C222(0.92)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C219(0.92); C222(1.06)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C219(0.96); C222(1.14)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C219(0.85)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C219(1.04)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C219(0.95)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C219(0.95)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C219(1.02); C222(0.98)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C219(0.97)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C219(0.89)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C219(0.93); C222(1.07)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C222(1.13)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C222(1.11)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C219(1.02); C222(1.04)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C219(0.94); C222(1.13)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C219(0.98); C222(0.94)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C219(1.04)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C219(0.88)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C219(0.92)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C219(0.94)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C219(0.82)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C219(0.93); C222(1.03)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C222(0.80)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C222(1.25)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C222(0.97)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C219(0.95); C222(1.07)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C219(0.93); C222(1.00)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C219(1.00)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C219(0.88)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C219(0.90)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C219(1.00); C222(0.99)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C219(1.08)  LDD1685  [6]
 LDCM0484  CL9 HEK-293T C222(0.92)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C219(0.64)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C219(0.95); C222(1.03)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C222(1.05)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C222(1.07)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C219(0.89); C222(1.12)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C219(0.85); C222(0.86)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C219(1.00)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C219(0.92)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C219(1.00)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C219(0.96); C222(0.80)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C219(0.97); C222(1.12)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C219(0.97); C222(1.01)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C219(0.92)  LDD1631  [6]
 LDCM0107  IAA HeLa H795(0.00); H152(0.00); H180(0.00)  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C222(0.96)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C222(0.99)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C222(0.96)  LDD1502  [6]
 LDCM0109  NEM HeLa H180(0.00); H152(0.00); H795(0.00)  LDD0223  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C764(0.65)  LDD2123  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Probable ATP-dependent RNA helicase DDX17 (DDX17) DEAD box helicase family Q92841
ATP-dependent RNA helicase DHX15 (DHX15) DEAD box helicase family O43143
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38) DEAD box helicase family Q92620
E3 ubiquitin-protein ligase Hakai (CBLL1) Hakai family Q75N03
Pre-mRNA-processing factor 19 (PRPF19) WD repeat PRP19 family Q9UMS4
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 1 (KLF1) Krueppel C2H2-type zinc-finger protein family Q13351
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger protein 275 (ZNF275) Krueppel C2H2-type zinc-finger protein family Q9NSD4
Zinc finger protein 317 (ZNF317) Krueppel C2H2-type zinc-finger protein family Q96PQ6
Zinc finger protein 473 (ZNF473) Krueppel C2H2-type zinc-finger protein family Q8WTR7
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 64 (ZFP64) Krueppel C2H2-type zinc-finger protein family Q9NTW7
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Zinc finger protein 408 (ZNF408) . Q9H9D4
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Red (IK) RED family Q13123
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Proline-rich protein 20E (PRR20E) PRR20 family P86478
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
U2 snRNP-associated SURP motif-containing protein (U2SURP) Splicing factor SR family O15042
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Methyl-CpG-binding domain protein 6 (MBD6) . Q96DN6
Polypyrimidine tract-binding protein 1 (PTBP1) . P26599
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
RNA-binding protein 10 (RBM10) . P98175
Splicing factor 3A subunit 1 (SF3A1) . Q15459
SURP and G-patch domain-containing protein 1 (SUGP1) . Q8IWZ8
TAR DNA-binding protein 43 (TARDBP) . Q13148
TBC1 domain family member 22B (TBC1D22B) . Q9NU19

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570