Details of the Target

General Information of Target

Target ID LDTP11041
Target Name Calcium uptake protein 1, mitochondrial (MICU1)
Gene Name MICU1
Gene ID 10367
Synonyms
CALC; CBARA1; Calcium uptake protein 1, mitochondrial; Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; allergen Hom s 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAERRLLSIKEAFRLAQQPHQNQAKLVVALSRTYRTMDDKTVFHEEFIHYLKYVMVVYK
REPAVERVIEFAAKFVTSFHQSDMEDDEEEEDGGLLNYLFTFLLKSHEANSNAVRFRVCL
LINKLLGSMPENAQIDDDVFDKINKAMLIRLKDKIPNVRIQAVLALSRLQDPKDDECPVV
NAYATLIENDSNPEVRRAVLSCIAPSAKTLPKIVGRTKDVKEAVRKLAYQVLAEKVHMRA
MSIAQRVMLLQQGLNDRSDAVKQAMQKHLLQGWLRFSEGNILELLHRLDVENSSEVAVSV
LNALFSITPLSELVGLCKNNDGRKLIPVETLTPEIALYWCALCEYLKSKGDEGEEFLEQI
LPEPVVYADYLLSYIQSIPVVNEEHRGDFSYIGNLMTKEFIGQQLILIIKSLDTSEEGGR
KKLLAVLQEILILPTIPISLVSFLVERLLHIIIDDNKRTQIVTEIISEIRAPIVTVGVNN
DPADVRKKELKMAEIKVKLIEAKEALENCITLQDFNRASELKEEIKALEDARINLLKETE
QLEIKEVHIEKNDAETLQKCLILCYELLKQMSISTGLSATMNGIIESLILPGIISIHPVV
RNLAVLCLGCCGLQNQDFARKHFVLLLQVLQIDDVTIKISALKAIFDQLMTFGIEPFKTK
KIKTLHCEGTEINSDDEQESKEVEETATAKNVLKLLSDFLDSEVSELRTGAAEGLAKLMF
SGLLVSSRILSRLILLWYNPVTEEDVQLRHCLGVFFPVFAYASRTNQECFEEAFLPTLQT
LANAPASSPLAEIDITNVAELLVDLTRPSGLNPQAKTSQDYQALTVHDNLAMKICNEILT
SPCSPEIRVYTKALSSLELSSHLAKDLLVLLNEILEQVKDRTCLRALEKIKIQLEKGNKE
FGDQAEAAQDATLTTTTFQNEDEKNKEVYMTPLRGVKATQASKSTQLKTNRGQRKVTVSA
RTNRRCQTAEADSESDHEVPEPESEMKMRLPRRAKTAALEKSKLNLAQFLNEDLS
Target Bioclass
Transporter and channel
Family
MICU1 family, MICU1 subfamily
Subcellular location
Mitochondrion inner membrane
Function
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains . MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Uniprot ID
Q9BPX6
Ensemble ID
ENST00000361114.10
HGNC ID
HGNC:1530

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C83(9.12)  LDD0171  [2]
DBIA
 Probe Info  		C275(12.98)  LDD0209  [3]
5E-2FA
 Probe Info  		H95(0.00); H85(0.00)  LDD2235  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C275(0.00); C83(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C83(0.00); C275(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		C83(0.00); C275(0.00)  LDD0148  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Acrolein
 Probe Info  		C83(0.00); C62(0.00)  LDD0217  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
Methacrolein
 Probe Info  		C62(0.00); C83(0.00)  LDD0218  [9]
AOyne
 Probe Info  		13.30  LDD0443  [10]
NAIA_5
 Probe Info  		C83(0.00); C275(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.26  LDD1728  [12]
C070
 Probe Info  		14.93  LDD1766  [12]
C091
 Probe Info  		13.64  LDD1782  [12]
C106
 Probe Info  		17.27  LDD1793  [12]
C108
 Probe Info  		8.82  LDD1795  [12]
C112
 Probe Info  		18.13  LDD1799  [12]
C141
 Probe Info  		9.51  LDD1823  [12]
C216
 Probe Info  		6.02  LDD1890  [12]
C231
 Probe Info  		12.55  LDD1904  [12]
C232
 Probe Info  		34.54  LDD1905  [12]
C233
 Probe Info  		10.78  LDD1906  [12]
C235
 Probe Info  		16.80  LDD1908  [12]
C290
 Probe Info  		5.82  LDD1960  [12]
C292
 Probe Info  		4.92  LDD1962  [12]
C314
 Probe Info  		12.13  LDD1981  [12]
C338
 Probe Info  		11.24  LDD2001  [12]
C356
 Probe Info  		8.51  LDD2017  [12]
C362
 Probe Info  		26.72  LDD2023  [12]
C390
 Probe Info  		22.63  LDD2049  [12]
C391
 Probe Info  		22.16  LDD2050  [12]
C424
 Probe Info  		12.91  LDD2079  [12]
FFF probe11
 Probe Info  		16.27  LDD0471  [13]
FFF probe13
 Probe Info  		18.41  LDD0475  [13]
FFF probe2
 Probe Info  		15.36  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0465  [13]
OEA-DA
 Probe Info  		17.90  LDD0046  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C83(9.12)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C275(1.02); C422(1.00)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C83(1.02); C275(0.94); C463(1.10); C422(0.98)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C83(1.03); C275(0.94); C422(0.91)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C83(1.10); C275(0.95); C422(1.02)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C83(1.16); C275(0.94); C422(0.90)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C83(1.14); C275(0.94); C422(1.10)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C275(0.94); C422(0.86)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C83(1.01); C275(0.85); C463(1.04); C422(0.92)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C83(2.28); C275(0.86); C422(0.84)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C83(0.98); C275(0.85); C463(1.05); C422(0.87)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C83(1.01); C275(0.98); C422(1.19)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C83(1.01); C275(0.92); C422(1.01)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C83(1.04); C275(1.01); C422(1.08)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C83(0.99); C275(1.00); C422(1.07)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C83(0.96); C275(0.87); C422(1.03)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C275(1.04); C422(0.85)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C83(0.95); C275(0.92); C463(1.04); C422(0.98)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C83(1.04); C275(0.91); C422(1.00)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C83(1.06); C275(0.92); C422(1.20)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C83(1.10); C275(0.85); C422(0.98)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C83(1.04); C275(0.86); C422(0.84)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C83(1.05); C275(1.01); C422(1.05)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C83(0.96); C275(0.96); C422(0.92)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C83(1.07); C275(0.97); C422(1.12)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C275(0.89); C422(0.91)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C83(0.97); C275(0.91); C463(0.98); C422(0.89)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C83(1.08); C275(0.85); C422(0.92)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C83(1.01); C275(0.92); C422(1.16)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C83(0.98); C275(0.87); C422(1.07)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C83(0.99); C275(0.83); C422(0.84)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C83(1.06); C275(0.95); C422(1.05)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C83(1.04); C275(0.95); C422(1.07)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C83(0.95); C275(0.91); C422(0.99)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C275(1.22); C422(0.88)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C83(1.00); C275(0.93); C463(1.13); C422(0.85)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C83(1.02); C275(0.96); C422(0.95)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C83(0.99); C275(0.98); C422(1.02)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C83(1.05); C275(0.84); C422(1.04)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C83(0.95); C275(0.85); C422(0.91)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C83(1.01); C275(0.95); C422(1.00)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C83(0.89); C275(0.94); C422(1.29)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C275(0.86); C422(0.98)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C83(1.06); C275(0.92); C422(0.96)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C83(0.96); C275(0.89); C463(1.12); C422(0.87)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C83(1.07); C275(1.01); C422(0.89)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C83(1.11); C275(0.94); C422(1.04)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C83(1.02); C275(0.82); C422(0.93)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C83(1.03); C275(0.84); C422(1.10)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C83(1.08); C275(0.96); C422(1.02)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C83(0.95); C275(0.94); C422(0.91)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C275(1.06); C422(0.97)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C83(0.98); C275(0.89); C463(0.97); C422(0.97)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C83(1.00); C275(0.92); C422(0.87)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C83(1.01); C275(0.91); C422(0.85)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C83(1.04); C275(0.96); C422(1.01)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C83(1.02); C275(0.93); C422(0.98)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C83(0.96); C275(1.11); C422(0.95)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C83(1.06); C275(1.01); C422(1.00)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C83(0.95); C275(0.90); C422(0.98)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C83(1.09); C275(1.07); C422(0.93)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C83(0.98); C275(1.01); C422(1.14)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C83(1.03); C275(0.88); C422(0.94)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C275(1.05); C422(0.95)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C83(1.04); C275(0.93); C422(1.00)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 11.13  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C83(0.30)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C83(0.99); C275(0.70); C422(0.96)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C83(0.80); C275(0.89); C422(0.96)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C83(0.91); C275(0.81); C422(0.90)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C83(1.18); C275(0.67); C422(0.93)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C83(1.00); C275(0.95); C422(1.02)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C83(1.26); C275(1.02); C422(1.08)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C83(0.92); C275(0.87); C422(0.97)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C83(1.11); C275(0.76); C422(0.96)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C83(1.03); C275(1.01); C422(0.97)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C83(1.04); C275(1.09); C422(1.04)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C83(0.92); C275(0.81); C422(1.01)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C83(1.04); C275(1.00); C422(0.93)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C83(0.95); C275(1.02); C422(1.20)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C83(0.99); C275(0.97); C422(0.91)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C83(1.00); C275(0.81); C422(1.08)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C83(0.87); C275(0.76); C422(0.98)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C83(1.10); C275(0.81); C422(0.94)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C83(0.97); C275(0.91); C422(0.91)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C83(0.93); C275(0.72); C422(1.11)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C83(0.95); C275(0.74); C422(1.01)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C83(1.13); C275(0.71); C422(0.87)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C83(1.13); C275(0.90); C422(0.97)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C83(1.05); C275(0.88); C422(1.03)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C83(0.92); C275(1.00); C422(1.01)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C83(0.98); C275(0.84); C422(0.92)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C83(1.16); C275(0.67); C422(0.83)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C83(1.08); C275(0.93); C422(0.93)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C83(1.03); C275(0.80); C422(0.99)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C83(0.98); C275(0.83); C422(0.94)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C83(1.13); C275(0.92); C422(0.88)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C83(0.97); C275(0.96); C422(0.96)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C83(1.01); C275(0.92); C422(0.96)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C83(0.90); C275(0.85); C422(0.99)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C83(1.31); C275(0.70); C422(0.86)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C83(0.99); C275(0.92); C422(0.91)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C83(1.07); C275(0.92); C422(0.94)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C83(1.01); C275(0.85); C422(1.12)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C275(0.93); C422(0.84)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C83(1.02); C275(0.89); C463(1.01); C422(0.96)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C83(1.08); C275(0.85); C422(0.96)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C83(0.98); C275(0.95); C422(1.06)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C83(0.89); C275(0.99); C422(1.31)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C83(0.96); C275(1.09); C422(0.93)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C83(0.88); C275(0.94); C422(0.91)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C83(0.97); C275(1.05); C422(1.30)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C83(0.90); C275(0.97); C422(1.01)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C83(1.09); C275(0.72); C422(1.01)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C83(1.01); C275(0.92); C422(1.18)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C83(1.18); C275(1.05); C422(0.97)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C83(0.86); C275(0.92); C422(0.92)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C275(0.98); C422(0.97)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C83(1.03); C275(1.18); C422(1.10)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C83(1.03); C275(0.93); C463(0.91); C422(0.97)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C83(1.06); C275(0.95); C422(1.14)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C83(0.94); C275(0.94); C422(1.01)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C83(0.94); C275(0.75); C422(0.78)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C83(1.01); C275(1.16); C422(0.89)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C83(0.93); C275(1.17); C422(1.17)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C83(0.93); C275(0.89); C422(1.10)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C83(0.95); C275(0.70); C422(0.91)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C83(1.04); C275(1.10); C422(1.08)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C83(0.92); C275(0.92); C422(0.97)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C83(0.89); C275(0.96); C422(0.89)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C275(1.10); C422(0.90)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C83(1.03); C275(0.95); C463(0.90); C422(0.89)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C83(1.00); C275(0.86); C422(1.02)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C83(0.95); C275(1.04); C422(1.10)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C83(0.97); C275(0.87); C422(0.93)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C83(0.88); C275(0.99); C422(1.26)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C83(0.93); C275(1.03); C422(1.05)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C83(0.86); C275(0.93); C422(1.03)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C83(1.11); C275(0.76); C422(0.88)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C275(1.07); C422(0.93)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C83(0.97); C275(0.94); C422(0.93)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C83(0.99); C275(0.81); C422(1.02)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C275(1.10); C422(0.87)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C83(1.10); C275(0.89); C463(1.15); C422(0.79)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C83(1.00); C275(0.86); C422(0.94)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C83(0.89); C275(0.96); C422(1.06)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C83(1.05); C275(0.81); C422(0.84)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C83(0.87); C275(0.94); C422(0.78)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C83(0.99); C275(0.98); C422(1.07)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C83(0.97); C275(0.90); C463(1.14); C422(0.79)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C83(0.89); C275(0.90); C422(0.98)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C83(1.05); C275(0.72); C422(0.92)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C83(0.97); C275(0.89); C422(0.97)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C83(1.11); C275(1.03); C422(0.97)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C83(0.96); C275(0.76); C422(0.99)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C275(1.01); C422(0.96)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C83(1.01); C275(0.89); C463(1.03); C422(0.85)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C83(1.03); C275(1.05); C422(0.91)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C83(0.85); C275(0.94); C422(1.13)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C83(0.91); C275(0.82); C422(0.95)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C83(1.01); C275(1.00); C422(1.06)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C83(0.94); C275(1.05); C422(1.10)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C83(1.04); C275(0.99); C422(1.24)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C83(0.96); C275(0.95); C422(0.96)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C83(1.06); C275(0.88); C422(0.90)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C83(0.97); C275(0.95); C422(1.10)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C83(0.93); C275(0.78); C422(0.97)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C275(1.17); C422(0.86)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C83(0.95); C275(0.84); C463(1.02); C422(1.02)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C83(1.05); C275(0.97); C422(1.02)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C83(0.86); C275(1.12); C422(0.96)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C83(0.84); C275(0.93); C422(0.99)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C83(1.01); C275(0.91); C422(0.91)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C83(1.01); C275(1.10); C422(0.90)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C83(0.97); C275(1.04); C422(1.13)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C83(0.91); C275(0.97); C422(0.94)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C83(1.06); C275(0.89); C422(0.97)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C83(1.02); C275(0.92); C422(0.97)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C83(1.04); C275(0.98); C422(1.01)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C83(0.88); C275(1.00); C422(1.04)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C275(0.93); C422(0.95)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C83(0.92); C275(0.90); C422(0.96)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C83(0.98); C275(0.77); C463(1.08); C422(0.73)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C83(1.05); C275(0.89); C422(0.88)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C83(0.96); C275(0.93); C422(1.04)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C83(0.97); C275(0.98); C422(0.88)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C83(0.91); C275(0.98); C422(0.81)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C83(1.07); C275(1.20); C422(0.97)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C83(0.86); C275(0.98); C422(0.87)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C83(1.05); C275(0.72); C422(0.84)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C83(0.98); C275(0.89); C422(1.08)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C83(0.94); C275(0.82); C422(1.10)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C83(0.93); C275(0.92); C422(1.16)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C62(1.71)  LDD1702  [16]
 LDCM0468  Fragment33 HEK-293T C83(1.12); C275(1.04); C422(1.01)  LDD1671  [15]
 LDCM0427  Fragment51 HEK-293T C83(1.01); C275(0.91); C422(1.00)  LDD1631  [15]
 LDCM0022  KB02 HEK-293T C83(0.93); C275(0.91); C422(1.11)  LDD1492  [15]
 LDCM0023  KB03 Jurkat C275(12.98)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C83(1.07)  LDD3310  [17]
 LDCM0109  NEM HeLa N.A.  LDD0227  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium uptake protein 1, mitochondrial (MICU1) MICU1 family Q9BPX6
Calcium uptake protein 2, mitochondrial (MICU2) MICU1 family Q8IYU8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium uniporter protein, mitochondrial (MCU) MCU (TC 1.A.77) family Q8NE86
Mitochondrial intermembrane space import and assembly protein 40 (CHCHD4) . Q8N4Q1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840