Details of the Target

General Information of Target

Target ID LDTP05734
Target Name Protein flightless-1 homolog (FLII)
Gene Name FLII
Gene ID 2314
Synonyms
FLIL; Protein flightless-1 homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
WSAFCKALA
Target Bioclass
Other
Subcellular location
Nucleus
Function
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
Uniprot ID
Q13045
Ensemble ID
ENST00000327031.9
HGNC ID
HGNC:3750

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.Q1053H DBIA    Probe Info 
CCK81 SNV: p.L230R DBIA    Probe Info 
CHL1 SNV: p.A403T DBIA    Probe Info 
HCT15 SNV: p.S607I DBIA    Probe Info 
HUH1 SNV: p.S463N DBIA    Probe Info 
JURKAT SNV: p.A1267T Compound 10    Probe Info 
MDST8 SNV: p.D932G DBIA    Probe Info 
MFE319 SNV: p.C576F; p.I983V; p.S1213G; p.G1248S DBIA    Probe Info 
NCIH1048 Insertion: p.M897IfsTer75 DBIA    Probe Info 
NCIH716 SNV: p.A403T .
RKN SNV: p.D840E DBIA    Probe Info 
RKO SNV: p.Y929C; p.G1063S DBIA    Probe Info 
SHSY5Y SNV: p.R1069Q .
SKNSH SNV: p.E74D; p.R1069Q .
SNU1 SNV: p.E739K DBIA    Probe Info 
SNU423 SNV: p.Y571F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.84  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y1129(6.01)  LDD0260  [3]
ONAyne
 Probe Info  		K752(7.69)  LDD0274  [4]
STPyne
 Probe Info  		K1007(10.00); K290(5.57); K39(9.60); K456(0.29)  LDD0277  [4]
Probe 1
 Probe Info  		Y940(7.73); Y1057(109.37); Y1175(18.39)  LDD3495  [5]
BTD
 Probe Info  		C560(1.43)  LDD1700  [6]
YY4-yne
 Probe Info  		3.38  LDD0400  [7]
DA-P3
 Probe Info  		4.56  LDD0182  [8]
AHL-Pu-1
 Probe Info  		C46(2.44); C1265(2.03)  LDD0169  [9]
HHS-482
 Probe Info  		Y737(0.66)  LDD0285  [10]
HHS-475
 Probe Info  		Y737(0.97)  LDD0264  [11]
HHS-465
 Probe Info  		Y737(6.59)  LDD2237  [12]
DBIA
 Probe Info  		C46(1.00); C1257(0.95); C1265(0.95)  LDD0078  [13]
ATP probe
 Probe Info  		K631(0.00); K836(0.00); K1007(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C560(0.00); C119(0.00); C808(0.00); C264(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C241(0.00); C337(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		C264(0.00); C933(0.00)  LDD0030  [17]
Lodoacetamide azide
 Probe Info  		C1224(0.00); C560(0.00); C982(0.00); C119(0.00)  LDD0037  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
WYneN
 Probe Info  		C241(0.00); C46(0.00); C576(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C241(0.00); C46(0.00)  LDD0022  [19]
1d-yne
 Probe Info  		N.A.  LDD0356  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
IPM
 Probe Info  		C289(0.00); C46(0.00); C1067(0.00)  LDD0147  [22]
PF-06672131
 Probe Info  		C46(0.00); C289(0.00)  LDD0017  [23]
TFBX
 Probe Info  		C289(0.00); C1067(0.00); C46(0.00); C808(0.00)  LDD0148  [22]
VSF
 Probe Info  		N.A.  LDD0007  [19]
1c-yne
 Probe Info  		N.A.  LDD0228  [20]
Acrolein
 Probe Info  		C576(0.00); C232(0.00); C289(0.00); C119(0.00)  LDD0217  [24]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [24]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [24]
Methacrolein
 Probe Info  		C560(0.00); C289(0.00); C576(0.00)  LDD0218  [24]
W1
 Probe Info  		C46(0.00); C241(0.00); C576(0.00)  LDD0236  [25]
AOyne
 Probe Info  		10.20  LDD0443  [26]
NAIA_5
 Probe Info  		C808(0.00); C1224(0.00); C560(0.00); C119(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		30.70  LDD1793  [27]
C108
 Probe Info  		22.32  LDD1795  [27]
C176
 Probe Info  		5.13  LDD1855  [27]
C178
 Probe Info  		19.84  LDD1857  [27]
C194
 Probe Info  		9.78  LDD1870  [27]
C431
 Probe Info  		14.83  LDD2086  [27]
FFF probe13
 Probe Info  		20.00  LDD0475  [28]
FFF probe3
 Probe Info  		6.05  LDD0465  [28]
OEA-DA
 Probe Info  		12.72  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C560(0.95)  LDD2142  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1224(0.77)  LDD2095  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1224(1.23); C808(1.08); C560(1.06); C289(1.37)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1224(0.95); C560(0.94); C289(1.03)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C560(0.52)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C560(0.59); C289(0.58)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C576(4.90)  LDD0371  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C46(2.44); C1265(2.03)  LDD0169  [9]
 LDCM0561  Abegg_cp(-)-10 HeLa C289(2.14)  LDD0312  [22]
 LDCM0214  AC1 HCT 116 C241(0.75); C1067(1.45); C119(0.84); C1257(0.82)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C241(0.85); C1067(0.98); C119(1.41); C1257(0.74)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C241(1.06); C1067(1.09); C119(0.50); C1224(0.88)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C241(0.81); C1067(0.98); C119(0.79); C1224(0.88)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C241(0.85); C1067(0.97); C119(0.61); C1224(0.82)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C241(0.67); C1067(1.14); C119(0.82); C1224(1.01)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C241(0.78); C1067(1.09); C119(0.51); C1224(1.13)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C241(0.77); C1067(0.89); C119(0.61); C1224(1.03)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C241(0.83); C1067(1.12); C119(0.58); C1224(1.02)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C241(0.90); C1067(0.93); C119(0.71); C1224(0.90)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C241(0.88); C1067(1.11); C119(0.84); C1224(0.90)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C241(0.94); C1067(1.08); C119(0.67); C1224(1.07)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C241(0.72); C1067(0.99); C119(1.66); C1257(0.73)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C241(0.89); C1067(1.14); C119(0.68); C1224(1.06)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C241(0.82); C1067(1.03); C119(0.68); C1224(1.02)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C241(0.66); C1067(0.95); C119(0.53); C1224(1.00)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C241(0.84); C1067(0.96); C119(0.98); C1257(0.91)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C241(0.86); C1067(0.98); C119(0.93); C1257(0.70)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C241(0.67); C1067(0.95); C119(1.09); C1257(0.65)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C241(0.64); C1067(1.04); C119(0.96); C1257(0.62)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C241(0.81); C1067(1.04); C119(0.76); C1257(0.70)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C241(0.82); C1067(1.09); C119(0.86); C1257(0.71)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C241(0.74); C1067(0.95); C119(0.85); C1257(0.57)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C241(0.85); C1067(0.83); C119(1.42); C1257(0.79)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C241(0.83); C1067(0.85); C119(0.89); C1257(0.70)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C241(0.99); C1067(1.33); C119(1.08); C1257(0.92)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C241(0.69); C1067(1.07); C119(0.78); C1257(0.74)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C241(1.19); C1067(1.08); C119(1.26); C1257(1.04)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C241(1.05); C1067(1.21); C119(1.05); C1257(1.01)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C241(1.16); C1067(1.19); C119(0.92); C1257(0.74)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C241(0.89); C1067(1.16); C119(0.95); C1257(0.64)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C241(0.93); C1067(1.02); C119(0.97); C1257(0.65)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C241(0.98); C1067(0.99); C119(1.30); C1224(1.27)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C241(1.32); C1067(1.39); C119(1.41); C1224(1.42)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C241(0.73); C1067(1.10); C119(1.13); C1224(1.07)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C241(0.96); C1067(1.24); C119(0.89); C1224(1.03)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C241(1.38); C1067(1.08); C119(1.44); C1224(1.13)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C241(0.84); C1067(1.19); C119(1.25); C1224(1.28)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C241(0.88); C1067(1.10); C119(1.00); C1224(1.26)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C241(1.04); C1067(1.05); C119(1.36); C1224(1.14)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C241(1.24); C1067(1.34); C119(1.15); C1224(1.36)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C241(0.91); C1067(1.26); C119(1.33); C1224(1.13)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C241(1.23); C1067(0.86); C119(1.02); C1224(1.26)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C241(1.06); C1067(1.35); C119(1.39); C1224(1.09)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C241(0.84); C1067(0.85); C119(1.79); C1257(0.99)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C241(1.01); C1067(0.82); C119(1.21); C1224(1.20)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C241(0.92); C1067(0.99); C119(1.19); C1224(1.43)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C241(1.53); C1067(1.09); C119(1.10); C1224(1.22)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C241(0.68); C1067(0.79); C119(1.09); C1224(1.03)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C1224(0.62); C289(0.76); C1257(0.78); C241(0.80)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C1224(0.70); C289(0.83); C1257(0.83); C241(0.86)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C1224(0.64); C241(0.66); C289(0.68); C1257(0.78)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C1224(0.67); C1257(0.76); C289(0.80); C1265(0.84)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C241(0.61); C289(0.69); C1224(0.87); C1257(0.89)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C241(0.65); C289(0.68); C1224(0.69); C1257(0.73)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C1067(0.78); C1265(0.90); C1257(0.91); C289(0.92)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C1224(0.69); C1257(0.74); C289(0.81); C1067(0.81)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C241(0.71); C1257(0.79); C289(0.80); C1224(0.83)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C241(0.69); C289(0.75); C1224(0.78); C1257(0.87)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C241(0.52); C289(0.72); C1257(0.76); C1224(0.85)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C241(0.82); C1067(1.07); C119(1.04); C1224(0.71)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C241(0.63); C1067(1.22); C119(1.22); C1224(0.59)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C241(0.81); C1067(0.84); C119(1.14); C1224(0.88)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C241(0.70); C1067(0.99); C119(1.17); C1224(1.04)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C1265(0.69); C1257(0.84); C241(0.98); C576(1.00)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C1265(0.66); C1257(0.66); C576(0.87); C289(0.96)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C1265(0.60); C1257(0.68); C576(0.84); C241(1.07)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C1257(0.67); C241(0.73); C289(0.77); C1265(0.82)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C1265(0.81); C1257(0.85); C119(0.88); C576(0.95)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C1265(0.63); C1257(0.74); C576(0.87); C119(0.96)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C808(0.62); C1257(0.93); C1265(0.94); C1067(0.95)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C1265(0.83); C1257(0.88); C576(0.96); C289(1.11)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C808(0.84); C576(0.88); C1067(0.98); C1265(1.05)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C1265(0.54); C241(0.64); C1257(0.66); C1224(0.86)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C1265(0.40); C1257(0.41); C1224(0.72); C241(0.73)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C1257(0.41); C1265(0.41); C1224(0.67); C289(0.86)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C1265(0.39); C1257(0.43); C1224(0.66); C1067(0.82)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C1257(0.43); C1265(0.49); C1224(0.68); C808(0.77)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C1257(0.71); C241(0.76); C1265(0.82); C289(0.85)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C1257(0.42); C1265(0.57); C1067(0.79); C1224(0.79)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C1265(0.47); C1257(0.49); C241(0.74); C1224(0.75)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C1257(0.34); C1265(0.53); C1224(0.64); C241(0.65)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C1257(0.55); C1265(0.67); C576(0.70); C241(0.70)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C576(0.69); C1067(0.72); C1265(0.74); C241(0.79)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C1067(0.94); C119(1.00); C289(1.03); C337(1.05)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C1067(0.83); C337(0.84); C1224(0.87); C1257(0.89)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C1257(0.83); C337(0.89); C1265(0.89); C1067(0.95)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C1067(0.79); C1265(0.88); C1257(0.89); C808(0.91)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C1265(0.68); C1067(0.78); C1257(0.79); C337(0.88)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C1265(0.79); C241(0.80); C1257(0.81); C289(0.83)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C1067(0.79); C289(0.91); C1257(0.92); C1265(0.93)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C1067(0.67); C808(0.69); C1257(0.78); C1265(0.84)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C808(0.73); C1067(0.78); C337(0.81); C1224(0.84)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C1224(0.63); C1067(0.68); C808(0.75); C1257(0.82)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C808(0.68); C1067(0.70); C289(0.91); C1257(0.92)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C1067(0.84); C1257(0.86); C337(0.88); C1265(0.88)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C1067(0.68); C1257(0.81); C808(0.82); C119(0.83)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C1257(0.75); C1067(0.76); C1265(0.77); C241(0.77)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C119(0.68); C1257(0.72); C1265(0.72); C241(0.77)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C576(0.69); C119(0.69); C1067(0.72); C808(0.91)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C1257(0.72); C241(0.76); C289(0.77); C1265(0.84)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C576(0.72); C241(0.78); C808(0.89); C119(0.89)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C119(0.75); C808(0.77); C1067(0.96); C1224(0.97)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C119(0.64); C808(0.82); C1224(0.83); C576(0.84)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C1067(0.75); C1224(0.79); C119(0.80); C576(0.87)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C119(0.72); C576(0.74); C241(0.79); C1067(0.81)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C1067(0.75); C241(0.93); C289(0.94); C576(0.96)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C1067(0.68); C119(0.82); C576(0.87); C808(1.03)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C1257(0.67); C1265(0.75); C241(0.76); C289(0.84)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C1257(0.84); C289(0.85); C119(0.88); C576(0.89)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C241(0.59); C1257(0.62); C289(0.74); C1265(0.89)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C1257(0.75); C1265(0.81); C289(0.90); C241(0.93)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C241(0.60); C1257(0.70); C289(0.71); C1067(0.88)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C1257(0.72); C289(0.76); C1067(0.78); C1265(0.79)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C241(0.62); C1257(0.64); C1265(0.74); C289(0.76)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C241(0.60); C1257(0.69); C289(0.76); C1265(0.84)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C241(0.71); C289(0.73); C1257(0.76); C1265(0.87)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C1257(0.54); C241(0.70); C1265(0.76); C289(0.81)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C1257(0.70); C1067(0.81); C289(0.88); C576(0.93)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C241(0.55); C1257(0.57); C289(0.72); C1067(0.80)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C337(0.79); C576(0.79); C46(0.80); C289(0.92)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C576(0.75); C337(0.81); C46(0.85); C1224(0.98)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C1257(0.78); C1265(0.81); C289(0.92); C241(0.96)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C576(0.68); C241(0.81); C1224(0.85); C337(0.86)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C46(0.85); C289(1.02); C1224(1.04); C1265(1.04)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C576(0.69); C337(0.87); C241(0.90); C46(0.93)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C576(0.68); C241(0.86); C1224(0.95); C337(0.98)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C46(0.88); C576(0.88); C337(0.91); C289(1.08)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C576(0.68); C46(0.86); C337(0.99); C1224(1.03)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C46(0.77); C337(0.83); C576(0.95); C241(0.95)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C576(0.75); C1224(0.84); C1067(0.86); C337(0.87)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C337(0.79); C1067(0.87); C46(0.87); C1224(0.90)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C576(0.74); C1067(0.86); C46(0.88); C337(0.95)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C1257(0.74); C1265(0.80); C289(0.89); C241(0.94)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C337(0.78); C241(0.81); C46(0.81); C1224(0.92)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C337(0.65); C1224(0.73); C576(0.77); C46(0.84)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C46(0.80); C576(0.93); C241(0.94); C1224(0.97)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C1257(0.44); C576(0.77); C241(0.78); C289(0.86)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C1257(0.54); C241(0.74); C289(0.77); C576(0.79)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C1257(0.44); C241(0.68); C289(0.78); C576(0.85)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C1257(0.40); C241(0.77); C576(0.81); C232(0.81)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C1257(0.66); C576(0.91); C232(0.93); C1265(0.95)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C1257(0.45); C576(0.75); C1265(0.79); C808(0.84)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C1257(0.44); C241(0.78); C576(0.79); C1265(0.86)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C1257(0.53); C1265(0.58); C808(0.87); C576(0.90)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C1257(0.56); C241(0.77); C232(0.86); C289(0.88)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C1257(0.43); C232(0.72); C241(0.72); C1265(0.75)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C1257(0.46); C241(0.74); C1265(0.74); C576(0.78)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C241(0.66); C1257(0.73); C1265(0.83); C289(0.84)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C1257(0.62); C576(0.78); C808(0.87); C232(0.87)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C119(0.66); C241(0.72); C289(0.84); C232(0.86)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C1257(0.41); C576(0.62); C241(0.66); C1265(0.84)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C232(0.44); C576(0.45); C1257(0.51); C241(0.57)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C232(0.45); C576(0.57); C1257(0.65); C119(0.72)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C1224(1.05); C560(0.41)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C560(1.05); C289(0.47)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C241(0.97); C1067(0.82); C119(1.32); C1257(0.96)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C1257(0.65); C1265(0.72); C241(0.86); C289(0.88)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C1257(0.74); C1265(0.78); C241(0.82); C289(0.89)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C46(1.00); C1257(0.95); C1265(0.95)  LDD0078  [13]
 LDCM0498  BS-3668 MDA-MB-231 C1224(0.92); C560(0.51); C289(0.96); C1067(1.35)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C289(0.00); C560(0.00); C119(0.00); C576(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C241(1.19); C46(1.03); C808(0.63); C560(0.45)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C1224(0.73); C808(0.82); C289(0.87); C46(0.94)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C1224(0.66); C241(0.79); C808(0.80); C289(0.81)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C1257(0.62); C289(0.70); C1265(0.83); C241(0.84)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C241(0.78); C289(0.86); C1257(0.97); C808(1.09)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C241(0.73); C1067(0.95); C289(0.96); C808(1.10)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C289(0.95); C241(1.02); C1257(1.04); C808(1.08)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C241(0.82); C289(0.93); C808(1.02); C1067(1.05)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C1265(0.56); C1257(0.60); C808(0.71); C576(0.82)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C1265(0.51); C1257(0.59); C808(0.80); C576(0.93)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C1257(0.45); C1265(0.45); C808(0.83); C576(0.86)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C1265(0.48); C1257(0.61); C808(0.83); C241(0.94)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C1257(0.57); C1265(0.59); C289(0.89); C576(0.93)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C1224(0.60); C241(0.88); C232(0.99); C119(1.00)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C808(0.65); C1265(0.70); C1257(0.74); C289(0.96)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C1257(0.65); C1265(0.72); C119(0.81); C1067(0.86)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C1265(0.78); C119(0.82); C1257(0.82); C808(0.91)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C1257(0.46); C1265(0.58); C241(0.78); C808(0.78)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C241(0.59); C808(0.73); C119(0.82); C1067(0.83)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C1257(0.64); C1265(0.73); C289(0.76); C241(0.78)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C1265(0.57); C1257(0.62); C241(0.73); C289(0.80)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C1067(0.69); C576(0.88); C808(1.00); C1224(1.02)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C1067(0.69); C1224(0.75); C1265(0.83); C1257(0.83)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C1224(0.77); C1067(0.77); C337(0.88); C1257(0.88)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C1224(0.71); C808(0.76); C241(0.79); C289(0.97)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C1257(0.68); C1265(0.72); C1067(0.74); C1224(0.77)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C241(0.62); C119(0.68); C1067(0.69); C289(0.71)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C1067(0.74); C119(0.82); C808(0.93); C1257(0.95)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C1067(0.64); C576(0.80); C1224(0.85); C808(0.87)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C1067(0.70); C576(0.76); C119(0.86); C808(0.89)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C1257(0.68); C241(0.72); C1265(0.73); C289(0.84)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C241(0.82); C289(0.83); C119(0.85); C1257(0.88)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C1257(0.73); C289(0.76); C241(0.87); C808(0.89)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C1257(0.69); C289(0.78); C241(0.80); C1265(0.90)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C1224(0.79); C289(0.89); C241(0.90); C119(0.92)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C808(0.70); C1224(0.71); C289(0.86); C241(0.94)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C808(0.57); C1224(0.80); C232(1.02); C289(1.02)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C232(0.63); C576(0.72); C289(0.78); C119(0.80)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C119(0.72); C232(0.75); C1067(0.76); C241(0.78)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C232(0.60); C241(0.65); C119(0.66); C289(0.80)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C576(0.70); C241(0.76); C119(0.79); C1067(0.82)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C808(0.45); C1224(0.69); C289(0.90); C241(0.95)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C576(0.48); C241(0.61); C1067(0.76); C232(0.78)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C576(0.52); C232(0.66); C241(0.67); C119(0.74)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C576(0.53); C119(0.78); C289(0.83); C232(0.84)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C576(0.67); C119(0.69); C232(0.70); C1257(0.81)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C576(0.54); C232(0.61); C241(0.70); C119(0.75)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C241(0.71); C1067(0.76); C119(0.74); C1257(0.76)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C241(0.73); C1067(0.83); C119(0.67); C1257(0.82)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C241(0.78); C1067(0.71); C119(0.78); C1257(0.79)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C241(0.71); C1067(0.85); C119(0.77); C1257(0.90)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C241(0.87); C1067(1.03); C119(0.79); C1257(0.87)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C241(0.92); C1067(1.16); C119(0.92); C1224(0.69)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C241(1.16); C1067(0.82); C119(0.75); C1257(0.93)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C241(0.86); C1067(1.01); C119(0.83); C1257(0.86)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C241(0.85); C1067(0.94); C119(0.76); C1257(0.64)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C241(0.78); C1067(0.86); C119(0.76); C1257(1.10)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C241(0.72); C1067(0.81); C119(0.95); C1257(1.15)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C241(0.73); C1067(1.05); C119(0.79); C1257(0.67)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C241(0.74); C1067(1.04); C119(0.82); C1257(1.47)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C241(0.78); C1067(1.02); C119(0.88); C1257(0.75)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C241(1.02); C1067(0.97); C119(0.97); C1257(0.79)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C241(0.93); C1067(0.89); C119(0.94); C1224(0.72)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C241(0.87); C1067(0.88); C119(0.78); C1257(0.82)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C241(0.91); C1067(0.93); C119(0.82); C1257(1.19)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C241(1.07); C1067(0.87); C119(1.00); C1257(1.28)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C241(0.97); C1067(0.78); C119(0.92); C1257(0.89)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C241(1.14); C1067(0.97); C119(0.87); C1257(0.73)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C241(1.01); C1067(0.92); C119(0.80); C1257(0.62)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C241(4.88); C1067(0.93); C119(1.26); C1224(1.09)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C241(1.18); C1067(0.98); C119(1.12); C1224(1.07)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C241(1.32); C1067(1.04); C119(1.12); C1224(1.10)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C241(1.19); C1067(1.61); C119(1.16); C1224(1.29)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C241(0.93); C1067(1.13); C119(1.05); C1224(0.79)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C241(1.13); C1067(1.27); C119(1.08); C1224(1.20)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C241(1.14); C1067(1.55); C119(1.43); C1224(1.05)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C241(1.05); C1067(1.10); C119(1.23); C1224(1.19)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C241(1.25); C1067(0.99); C119(1.16); C1224(1.08)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C241(1.40); C1067(1.10); C119(0.87); C1224(1.02)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C241(1.37); C1067(1.02); C119(1.11); C1224(1.24)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C241(1.17); C1067(1.01); C119(1.03); C1224(1.53)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C241(1.24); C1067(1.02); C119(0.96); C1224(1.12)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C241(1.22); C1067(0.94); C119(1.14); C1224(1.09)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C241(1.09); C1067(1.06); C119(1.18); C1224(1.62)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C241(0.83); C1067(1.10); C119(1.01); C1224(0.73)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C241(1.09); C1067(1.00); C119(1.12); C1224(1.12)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C241(0.86); C1067(1.14); C119(1.13); C1224(0.92)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C241(0.91); C1067(0.93); C119(0.94); C1224(0.87)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C241(0.82); C1067(1.18); C119(0.74); C1224(1.47)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C241(0.87); C1067(1.07); C119(0.95); C1224(1.09)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C241(0.92); C1067(1.19); C119(1.01); C1224(1.15)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C241(0.70); C1067(1.29); C119(0.85); C1224(1.02)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C241(0.93); C1067(1.13); C119(0.84); C1224(1.21)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C241(0.83); C1067(1.13); C119(0.76); C1224(1.49)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C241(1.44); C1067(0.96); C119(0.67); C1224(0.73)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C241(0.85); C1067(1.01); C119(1.05); C1224(0.68)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C241(0.87); C1067(1.10); C119(0.82); C1224(1.02)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C241(0.92); C1067(1.11); C119(0.73); C1224(0.89)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C241(1.00); C1067(1.02); C119(0.93); C1224(0.94)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C241(2.21); C1067(1.14); C119(0.85); C1224(0.94)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C241(1.23); C1067(1.02); C119(0.88); C1224(1.08)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C241(1.08); C1067(0.96); C119(0.71); C1224(1.08)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C241(3.13); C1067(1.00); C119(0.84); C1224(1.10)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C241(0.81); C1067(1.03); C119(0.93); C1224(0.95)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C241(1.02); C1067(0.90); C119(0.60); C1224(1.03)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C241(0.96); C1067(1.02); C119(0.91); C1224(1.07)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C241(0.89); C1067(1.00); C119(1.16); C1224(0.99)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C241(0.94); C1067(1.10); C119(1.02); C1224(0.86)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C241(1.04); C1067(1.08); C119(0.98); C1224(0.90)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C241(1.12); C1067(1.18); C119(0.71); C1224(1.11)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C241(1.09); C1067(0.99); C119(1.01); C1224(0.97)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C241(0.99); C1067(0.81); C119(0.64); C1224(1.24)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C241(1.02); C1067(1.03); C119(0.77); C1224(1.07)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C241(1.16); C1067(1.01); C119(0.64); C1224(1.19)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C241(1.14); C1067(1.08); C119(0.69); C1224(1.05)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C241(0.92); C1067(0.99); C119(0.84); C1224(0.69)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C241(0.90); C1067(1.08); C119(1.13); C1224(0.78)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C241(1.32); C1067(0.97); C119(0.76); C1224(0.91)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C241(0.86); C1067(1.19); C119(0.80); C1257(1.16)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C241(1.47); C1067(1.09); C119(0.83); C1257(1.22)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C241(1.11); C1067(1.26); C119(0.86); C1257(0.96)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C241(1.00); C1067(1.36); C119(0.84); C1257(0.75)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C241(0.94); C1067(1.61); C119(0.75); C1257(1.18)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C241(0.72); C1067(1.34); C119(0.84); C1257(0.94)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C241(0.71); C1067(1.19); C119(0.77); C1257(0.91)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C241(0.63); C1067(1.17); C119(0.80); C1257(0.73)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C241(0.77); C1067(1.17); C119(0.87); C1257(0.75)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C46(1.55)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C560(1.53); C289(1.05); C241(1.10); C46(1.13)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C289(2.60); C808(2.08); C560(2.02)  LDD1702  [6]
 LDCM0625  F8 Ramos C46(0.96)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C46(0.97)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C46(0.61)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C46(1.01)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C46(1.20)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C46(1.59)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C46(0.92)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C46(1.26)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C46(1.08)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C46(1.13)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C46(0.51)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C46(1.23)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C46(1.17)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C46(1.33)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C241(0.85); C1067(1.32); C119(0.77); C1224(0.96)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C46(1.42)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C46(0.86)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C241(1.08); C1067(0.96); C119(0.80); C1257(1.05)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C46(1.26)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C46(1.65)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C46(0.86)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C46(0.81)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y737(0.97)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y737(0.85)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y737(0.84)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y737(0.81)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y737(0.71)  LDD0268  [11]
 LDCM0015  HNE MDA-MB-231 C46(1.20)  LDD0346  [31]
 LDCM0107  IAA HeLa H113(0.00); C119(0.00); C560(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y737(0.66)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y737(0.64)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y737(1.06)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y737(1.26)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y737(1.51)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y737(0.05)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y737(0.38)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y737(0.90)  LDD0292  [10]
 LDCM0022  KB02 HCT 116 C46(1.69); C1265(1.33); C576(1.36)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C46(1.81); C1265(0.92); C576(1.40)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C46(1.49); C1265(1.42); C576(1.36)  LDD0082  [13]
 LDCM0030  Luteolin HEK-293T 4.56  LDD0182  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C289(0.94)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1224(1.15)  LDD2121  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C560(0.52); C289(0.75)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C560(1.04)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C560(0.95); C289(1.05)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C560(1.04)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C560(0.50)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C560(1.66); C289(0.65)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C560(0.96)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1224(1.20); C808(1.05); C560(1.07)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C289(0.65)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C560(0.87)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C560(1.03)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1224(1.26); C808(1.18); C560(0.68); C289(1.13)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C560(1.23)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1224(0.59); C808(0.80); C560(0.68); C289(0.68)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C560(0.71)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C808(1.11); C560(0.95)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C560(1.01)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C289(0.53)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C560(0.74)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C560(0.62)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C808(1.98); C560(1.73)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1224(0.85); C560(0.94); C289(0.96)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C560(0.82)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1224(0.89); C808(1.11); C560(0.94); C289(1.18)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1224(0.79); C808(0.93); C560(0.82); C289(0.89)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C560(0.95)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C808(0.79); C560(1.01); C289(1.06); C1067(0.70)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C560(1.18)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C808(1.00); C560(0.90)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C560(0.76); C289(0.56)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C560(1.08); C289(1.69)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C808(1.54); C560(1.36); C1067(0.78); C119(1.36)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C808(0.96); C560(0.95); C289(1.08); C1067(0.92)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C560(1.43)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C808(1.32); C560(0.87); C289(0.80); C1067(0.74)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C560(1.00); C289(6.95)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C560(0.98); C289(0.76)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1224(1.27); C808(2.43)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C808(1.11); C560(0.85); C289(0.77)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C560(2.31)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C560(0.91)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C560(0.97)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1224(0.79); C560(0.42)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C560(0.75)  LDD2151  [6]
 LDCM0131  RA190 MM1.R C46(1.76)  LDD0304  [32]
 LDCM0021  THZ1 HCT 116 C46(1.06)  LDD2173  [13]
 LDCM0154  YY4 T cell 3.38  LDD0400  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) LRRFIP family Q32MZ4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.