Details of the Target

General Information of Target

Target ID LDTP03249
Target Name Plasma membrane calcium-transporting ATPase 4 (ATP2B4)
Gene Name ATP2B4
Gene ID 493
Synonyms
ATP2B2; MXRA1; Plasma membrane calcium-transporting ATPase 4; PMCA4; EC 7.2.2.10; Matrix-remodeling-associated protein 1; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKT
SPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLS
FYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGL
QCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLT
GESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKK
GKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLA
VQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVA
VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQA
YIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALL
GFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRK
CNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILT
ELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFL
CLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVV
AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSI
SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLL
KRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHY
TIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFS
CTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEID
HAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYI
KVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGT
RVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily
Subcellular location
Cell membrane
Function
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility.
Uniprot ID
P23634
Ensemble ID
ENST00000341360.7
HGNC ID
HGNC:817

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
ONAyne
 Probe Info  		K761(10.00)  LDD0275  [2]
IPM
 Probe Info  		C632(0.00); C537(0.00); C24(0.00)  LDD0241  [3]
HHS-465
 Probe Info  		Y216(1.14)  LDD2237  [4]
DBIA
 Probe Info  		C632(1.12)  LDD0078  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C55(0.00); C24(0.00); C537(0.00); C639(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C55(0.00); C537(0.00); C639(0.00); C632(0.00)  LDD0036  [7]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [8]
IPIAA_L
 Probe Info  		C24(0.00); C537(0.00)  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C55(0.00); C537(0.00); C639(0.00); C632(0.00)  LDD0037  [7]
STPyne
 Probe Info  		K761(0.00); K591(0.00)  LDD0009  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Acrolein
 Probe Info  		C537(0.00); C453(0.00)  LDD0217  [11]
NAIA_5
 Probe Info  		C55(0.00); C463(0.00); C453(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		10.56  LDD1782  [13]
C106
 Probe Info  		17.27  LDD1793  [13]
C108
 Probe Info  		8.28  LDD1795  [13]
C141
 Probe Info  		10.13  LDD1823  [13]
C153
 Probe Info  		21.71  LDD1834  [13]
C178
 Probe Info  		14.72  LDD1857  [13]
C231
 Probe Info  		14.52  LDD1904  [13]
C350
 Probe Info  		25.46  LDD2011  [13]
C407
 Probe Info  		13.18  LDD2064  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe13
 Probe Info  		19.77  LDD0475  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe3
 Probe Info  		20.00  LDD0465  [14]
STS-1
 Probe Info  		N.A.  LDD0137  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [15]
OEA-DA
 Probe Info  		5.06  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C632(0.78); C710(0.93); C721(0.93)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C710(0.72); C721(0.72)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C632(1.02); C710(0.60); C721(0.60)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C632(0.99); C710(0.58); C721(0.58)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C632(1.06); C710(0.61); C721(0.61)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C632(0.82); C710(0.53); C721(0.53)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C632(0.93); C710(0.54); C721(0.54)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C632(1.00); C710(0.66); C721(0.66)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C632(0.85); C710(0.67); C721(0.67)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C632(0.86); C710(0.79); C721(0.79)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C632(0.84); C710(0.57); C721(0.57)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C632(0.95); C710(0.50); C721(0.50)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C710(0.77); C721(0.77)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C632(0.83); C710(0.70); C721(0.70)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C632(1.16); C710(0.55); C721(0.55)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C632(1.21); C710(0.59); C721(0.59)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C632(0.73); C710(0.99); C721(0.99)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C632(1.28); C710(0.84); C721(0.84)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C632(1.44); C710(0.79); C721(0.79)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C632(1.26); C710(0.75); C721(0.75)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C632(1.01); C710(0.91); C721(0.91)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C632(1.01); C710(0.90); C721(0.90)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C632(1.30); C710(0.85); C721(0.85)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C710(0.81); C721(0.81)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C632(1.33); C710(0.77); C721(0.77)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C632(1.06); C710(1.01); C721(1.01)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C632(1.02); C710(1.10); C721(1.10)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C632(1.20); C710(0.91); C721(0.91)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C632(1.09); C710(0.92); C721(0.92)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C632(1.35); C710(0.89); C721(0.89)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C632(1.29); C710(0.77); C721(0.77)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C632(1.55); C710(0.79); C721(0.79)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C710(0.85); C721(0.85)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C710(1.13); C721(1.13)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C710(0.97); C721(0.97)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C710(1.05); C721(1.05)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C710(1.00); C721(1.00)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C710(1.11); C721(1.11)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C710(0.92); C721(0.92)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C710(0.93); C721(0.93)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C710(1.00); C721(1.00)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C710(1.03); C721(1.03)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C710(0.99); C721(0.99)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C710(1.20); C721(1.20)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C710(0.91); C721(0.91)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C710(1.03); C721(1.03)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C710(1.03); C721(1.03)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C710(1.27); C721(1.27)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C632(1.09); C710(0.86); C721(0.86)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C710(0.69); C721(0.69); C632(1.13)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C710(0.78); C721(0.78); C632(1.28)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C710(0.68); C721(0.68); C632(1.04)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C710(0.66); C721(0.66); C632(1.22)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C710(0.48); C721(0.48); C632(1.11)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C710(0.68); C721(0.68); C632(1.07)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C710(0.83); C721(0.83)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C710(0.77); C721(0.77); C632(1.12)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C710(0.74); C721(0.74); C632(1.20)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C710(0.58); C721(0.58); C632(1.17)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C710(0.46); C721(0.46); C632(1.02)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C632(1.07); C710(0.77); C721(0.77)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C632(1.11); C710(0.77); C721(0.77)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C632(0.93); C710(0.94); C721(0.94)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C632(0.81); C710(0.91); C721(0.91)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C710(0.95); C721(0.95)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C710(0.79); C721(0.79)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C710(1.11); C721(1.11)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C710(0.89); C721(0.89); C632(1.01)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C710(1.20); C721(1.20)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C710(1.52); C721(1.52)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C710(1.38); C721(1.38)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C710(1.02); C721(1.02)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C710(0.87); C721(0.87)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C710(1.03); C721(1.03)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C710(0.77); C721(0.77)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C710(0.85); C721(0.85)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C710(0.99); C721(0.99)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C710(0.91); C721(0.91)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C710(0.90); C721(0.90); C632(0.97)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C710(0.78); C721(0.78)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C710(1.01); C721(1.01)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C710(0.72); C721(0.72)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C710(0.89); C721(0.89)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C710(0.71); C721(0.71)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C537(1.06); C710(1.22); C721(1.22)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C537(1.02); C710(1.09); C721(1.09)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C710(1.10); C721(1.10); C537(1.12)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C710(1.14); C721(1.14); C537(1.19)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C537(0.81); C710(0.98); C721(0.98)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C710(0.78); C721(0.78); C632(0.84)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C537(0.76); C710(0.92); C721(0.92)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C537(0.95); C710(1.07); C721(1.07)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C537(0.94); C710(0.95); C721(0.95)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C537(0.91); C710(0.99); C721(0.99)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C537(0.92); C710(1.01); C721(1.01)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C537(0.73); C710(0.79); C721(0.79)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C632(1.05); C537(1.07)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C537(0.94); C632(1.37)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C537(0.97); C632(1.04)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C537(0.55); C632(1.04)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C710(0.77); C721(0.77); C632(0.95)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C537(0.60); C632(1.22)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C632(1.23); C537(1.30)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C537(1.01); C632(1.11)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C537(0.78); C632(1.24)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C537(0.72); C632(0.89)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C537(0.58); C632(1.34)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C537(0.50); C632(1.73)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C710(0.64); C721(0.64); C632(1.39)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C710(0.64); C721(0.64); C632(1.21)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C710(0.52); C721(0.52); C632(1.49)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C710(0.77); C721(0.77)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C710(0.68); C721(0.68); C632(1.49)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C710(0.63); C721(0.63); C632(1.41)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C710(0.48); C721(0.48); C632(1.35)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C710(0.63); C721(0.63); C632(1.40)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C710(0.43); C721(0.43); C632(1.40)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C710(0.42); C721(0.42); C632(1.66)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C710(0.48); C721(0.48); C632(1.68)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C710(0.25); C721(0.25); C632(1.42)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C710(0.98); C721(0.98)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C710(0.97); C721(0.97)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C710(0.85); C721(0.85)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C710(0.74); C721(0.74)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C710(0.86); C721(0.86)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C710(0.77); C721(0.77)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C710(0.74); C721(0.74)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C710(0.63); C721(0.63)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C710(0.72); C721(0.72)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C710(0.97); C721(0.97)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C710(0.86); C721(0.86)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C710(0.88); C721(0.88)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C710(0.97); C721(0.97)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C710(0.69); C721(0.69)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C710(0.99); C721(0.99)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C710(0.76); C721(0.76)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C710(0.61); C721(0.61)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C710(0.64); C721(0.64)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C710(0.72); C721(0.72)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C710(0.80); C721(0.80)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C710(0.89); C721(0.89)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C710(1.14); C721(1.14)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C710(0.95); C721(0.95)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C710(0.83); C721(0.83)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C710(1.21); C721(1.21)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C710(0.69); C721(0.69)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C710(0.76); C721(0.76)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C710(0.90); C721(0.90)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C710(0.82); C721(0.82)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C710(1.35); C721(1.35)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C710(0.93); C721(0.93)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C710(0.84); C721(0.84)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C710(0.33); C721(0.33); C632(0.93)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C710(0.62); C721(0.62); C632(0.72)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C710(1.11); C721(1.11)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C710(0.87); C721(0.87)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C710(0.60); C721(0.60)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C632(1.12)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa H762(0.00); C537(0.00)  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C710(1.28); C721(1.28)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C710(0.82); C721(0.82)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C710(0.74); C721(0.74); C632(0.91)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C710(0.81); C721(0.81)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C710(0.97); C721(0.97)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C710(0.90); C721(0.90)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C710(0.92); C721(0.92)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C710(0.94); C721(0.94)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C710(0.77); C721(0.77)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C710(1.10); C721(1.10)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C710(0.67); C721(0.67)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C710(0.99); C721(0.99)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C710(0.78); C721(0.78)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C710(0.97); C721(0.97)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C710(1.07); C721(1.07)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C710(0.92); C721(0.92)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C710(0.71); C721(0.71)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C710(0.83); C721(0.83)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C710(1.10); C721(1.10)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C710(0.79); C721(0.79)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C537(0.56); C710(0.57); C721(0.57)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C537(0.87); C710(0.98); C721(0.98)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C537(0.82); C710(0.94); C721(0.94)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C710(0.75); C721(0.75)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C537(0.98); C710(1.10); C721(1.10)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C537(0.64); C632(1.27)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C537(0.87); C632(1.31)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C537(0.73); C632(1.12)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C537(0.63); C632(1.42)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C710(0.97); C721(0.97); C632(1.22)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C710(1.04); C721(1.04); C632(1.18)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C710(0.77); C721(0.77); C632(1.29)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C710(0.80); C721(0.80); C632(1.45)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C710(0.93); C721(0.93)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C710(1.15); C721(1.15)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C710(1.05); C721(1.05)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C710(0.81); C721(0.81)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C710(0.76); C721(0.76)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C710(0.76); C721(0.76)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C710(0.73); C721(0.73)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C710(1.33); C721(1.33)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C710(0.64); C721(0.64)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C710(0.53); C721(0.53)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C710(0.39); C721(0.39)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C710(0.79); C721(0.79)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C710(0.54); C721(0.54)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C710(0.65); C721(0.65)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C710(0.77); C721(0.77)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C710(0.85); C721(0.85)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C710(0.69); C721(0.69)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C710(0.67); C721(0.67)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C710(1.18); C721(1.18)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C710(0.88); C721(0.88)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C537(0.78); C710(0.69); C721(0.69)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C537(0.71); C710(0.60); C721(0.60)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C537(0.79); C710(0.71); C721(0.71)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C537(0.82); C710(0.45); C721(0.45)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C537(0.78); C710(0.52); C721(0.52)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C537(0.87); C710(0.51); C721(0.51)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C537(0.76); C710(0.51); C721(0.51)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C537(0.69); C710(0.62); C721(0.62)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C710(1.16); C721(1.16)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C537(0.70); C710(0.48); C721(0.48)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C537(0.93); C710(0.60); C721(0.60)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C537(0.58); C710(0.29); C721(0.29)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C537(0.69); C710(0.34); C721(0.34)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C537(0.72); C710(0.55); C721(0.55)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C537(0.69); C710(0.44); C721(0.44)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C537(1.03); C632(0.95); C710(1.13); C721(1.13)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C537(1.07); C632(0.81); C710(1.22); C721(1.22)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C537(1.07); C632(0.78); C710(1.06); C721(1.06)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C537(1.06); C632(0.89); C710(0.98); C721(0.98)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C710(1.16); C721(1.16)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C537(1.15); C632(1.06); C710(1.34); C721(1.34)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C537(1.22); C632(1.15); C710(1.64); C721(1.64)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C537(1.06); C632(1.12); C710(1.08); C721(1.08)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C537(1.13); C632(0.86); C710(1.07); C721(1.07)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C537(1.16); C632(0.96); C710(1.29); C721(1.29)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C537(1.10); C632(0.97); C710(1.36); C721(1.36)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C537(1.09); C632(0.85); C710(0.93); C721(0.93)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C537(1.12); C632(1.09); C710(1.46); C721(1.46)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C537(1.08); C632(0.97); C710(1.30); C721(1.30)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C537(1.13); C632(0.92); C710(1.05); C721(1.05)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C710(0.93); C721(0.93)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C537(0.76); C632(0.76); C710(0.99); C721(0.99)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C710(0.77); C721(0.77)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C710(0.95); C721(0.95)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C710(0.64); C721(0.64)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C710(0.64); C721(0.64)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C710(0.68); C721(0.68)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C710(0.49); C721(0.49)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C710(0.54); C721(0.54)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C710(0.58); C721(0.58)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C710(1.23); C721(1.23)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C710(0.89); C721(0.89)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C710(0.70); C721(0.70)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C710(0.73); C721(0.73)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C710(0.84); C721(0.84)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C710(0.62); C721(0.62)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C710(0.66); C721(0.66)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C710(0.82); C721(0.82)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C710(0.71); C721(0.71)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C710(0.71); C721(0.71)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C710(0.61); C721(0.61)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C710(0.68); C721(0.68)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C710(0.96); C721(0.96)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C710(0.70); C721(0.70)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C710(0.47); C721(0.47)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C710(0.47); C721(0.47)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C710(0.32); C721(0.32)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C710(0.63); C721(0.63)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C710(0.75); C721(0.75)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C710(0.68); C721(0.68)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C710(0.52); C721(0.52)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C710(0.32); C721(0.32)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C710(1.05); C721(1.05)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C710(0.78); C721(0.78)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C632(1.02); C710(0.87); C721(0.87)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C632(0.67); C710(0.83); C721(0.83)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C632(0.89); C710(0.98); C721(0.98)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C632(0.94); C710(0.81); C721(0.81)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C632(0.58); C710(0.84); C721(0.84)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C632(0.84); C710(0.86); C721(0.86)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C632(1.16); C710(0.77); C721(0.77)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C632(0.95); C710(0.82); C721(0.82)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C632(0.86); C710(0.85); C721(0.85)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C632(0.86); C639(1.08); C537(1.09); C463(1.01)  LDD1698  [17]
 LDCM0468  Fragment33 HCT 116 C710(0.71); C721(0.71)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C537(0.65); C710(0.35); C721(0.35)  LDD0744  [5]
 LDCM0107  IAA HeLa H762(0.00); C537(0.00)  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C710(5.07); C721(5.07); C632(1.30)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C710(16.52); C721(16.52); C632(1.21)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C710(9.41); C721(9.41); C632(1.16)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0021  THZ1 HCT 116 C453(0.83); C463(0.83)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Renalase (RNLS) Renalase family Q5VYX0
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcitonin (CALCA) Calcitonin family P01258

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Desflurane Small molecular drug DB01189
Halothane Small molecular drug DB01159
Ritodrine Small molecular drug DB00867
Sevoflurane Small molecular drug DB01236

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402