Details of the Target

General Information of Target

Target ID LDTP05741
Target Name Large ribosomal subunit protein bL28m (MRPL28)
Gene Name MRPL28
Gene ID 10573
Synonyms
MAAT1; Large ribosomal subunit protein bL28m; 39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28; Melanoma antigen p15; Melanoma-associated antigen recognized by T-lymphocytes
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPLHKYPVWLWKRLQLREGICSRLPGHYLRSLEEERTPTPVHYRPHGAKFKINPKNGQRE
RVEDVPIPIYFPPESQRGLWGGEGWILGQIYANNDKLSKRLKKVWKPQLFEREFYSEILD
KKFTVTVTMRTLDLIDEAYGLDFYILKTPKEDLCSKFGMDLKRGMLLRLARQDPQLHPED
PERRAAIYDKYKEFAIPEEEAEWVGLTLEEAIEKQRLLEEKDPVPLFKIYVAELIQQLQQ
QALSEPAVVQKRASGQ
Target Bioclass
Other
Family
Bacterial ribosomal protein bL28 family
Subcellular location
Mitochondrion
Uniprot ID
Q13084
Ensemble ID
ENST00000199706.13
HGNC ID
HGNC:14484

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C154(525.89); C21(1,746.96)  LDD0209  [1]
IA-alkyne
 Probe Info  		C154(0.00); C21(0.00)  LDD0165  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
IPM
 Probe Info  		N.A.  LDD0147  [3]
Phosphinate-6
 Probe Info  		C21(0.00); C154(0.00)  LDD0018  [4]
Ox-W18
 Probe Info  		N.A.  LDD2175  [5]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]
1d-yne
 Probe Info  		N.A.  LDD0357  [6]
Acrolein
 Probe Info  		H46(0.00); C154(0.00)  LDD0217  [7]
AOyne
 Probe Info  		14.80  LDD0443  [8]
TER-AC
 Probe Info  		N.A.  LDD0426  [9]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		16.68  LDD1793  [10]
C107
 Probe Info  		5.74  LDD1794  [10]
C108
 Probe Info  		8.34  LDD1795  [10]
C112
 Probe Info  		18.13  LDD1799  [10]
C278
 Probe Info  		73.52  LDD1948  [10]
C280
 Probe Info  		8.94  LDD1950  [10]
C282
 Probe Info  		14.42  LDD1952  [10]
C284
 Probe Info  		23.75  LDD1954  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [11]
FFF probe14
 Probe Info  		20.00  LDD0477  [11]
FFF probe3
 Probe Info  		13.60  LDD0464  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H27(0.00); C154(0.00)  LDD0222  [7]
 LDCM0625  F8 Ramos C154(1.70)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C154(0.85)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C154(3.36)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C154(0.92)  LDD2191  [12]
 LDCM0576  Fragment14 Ramos C154(1.48)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C154(0.63)  LDD2194  [12]
 LDCM0582  Fragment23 Ramos C154(1.07)  LDD2196  [12]
 LDCM0586  Fragment28 Ramos C154(0.75)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C154(1.18)  LDD2199  [12]
 LDCM0590  Fragment32 Ramos C154(1.04)  LDD2201  [12]
 LDCM0468  Fragment33 Ramos C154(1.24)  LDD2202  [12]
 LDCM0596  Fragment38 Ramos C154(0.80)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C154(0.73)  LDD2184  [12]
 LDCM0569  Fragment7 Ramos C154(0.98)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C154(0.74)  LDD2188  [12]
 LDCM0022  KB02 Ramos C154(1.07)  LDD2182  [12]
 LDCM0023  KB03 Jurkat C154(525.89); C21(1,746.96)  LDD0209  [1]
 LDCM0024  KB05 MEWO C154(2.68)  LDD3319  [13]
 LDCM0109  NEM HeLa H46(0.00); H27(0.00)  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
E3 ubiquitin ligase TRAF3IP2 (TRAF3IP2) . O43734
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thyrotroph embryonic factor (TEF) BZIP family Q10587
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Periplakin (PPL) Plakin or cytolinker family O60437
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840