Details of the Target

General Information of Target

Target ID LDTP11326
Target Name FUN14 domain-containing protein 2 (FUNDC2)
Gene Name FUNDC2
Gene ID 65991
Synonyms
HCBP6; FUN14 domain-containing protein 2; Cervical cancer proto-oncogene 3 protein; HCC-3; Hepatitis C virus core-binding protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLT
AHRAGKKHLSSLQLFYGKKQPGKERKQNPKHQNELRREETKAEAPLLTQTRLITQSALHR
APHYNSCCRRKYRPEAPGPSVSLSPMPPSEVKLQSGKISREPEPAAGPQAEESATVSAPA
PMSPTRRRALDHYLTLRSSGWIPDGRGRWVKDENVEFDSDEEEPPDLPLD
Target Bioclass
Other
Family
FUN14 family
Subcellular location
Mitochondrion outer membrane
Function
Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways. May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes.
Uniprot ID
Q9BWH2
Ensemble ID
ENST00000369498.8
HGNC ID
HGNC:24925

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NHS
 Probe Info  		K150(0.00); K170(0.00)  LDD0010  [1]
STPyne
 Probe Info  		K68(0.00); K150(0.00); K170(0.00)  LDD0009  [1]
AOyne
 Probe Info  		10.00  LDD0443  [2]
PAL-AfBPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		6.87  LDD1740  [3]
C055
 Probe Info  		14.52  LDD1752  [3]
C056
 Probe Info  		25.63  LDD1753  [3]
C091
 Probe Info  		14.83  LDD1782  [3]
C092
 Probe Info  		30.70  LDD1783  [3]
C094
 Probe Info  		47.84  LDD1785  [3]
C106
 Probe Info  		28.44  LDD1793  [3]
C108
 Probe Info  		8.22  LDD1795  [3]
C112
 Probe Info  		20.25  LDD1799  [3]
C134
 Probe Info  		22.94  LDD1816  [3]
C153
 Probe Info  		16.80  LDD1834  [3]
C159
 Probe Info  		7.57  LDD1839  [3]
C161
 Probe Info  		10.41  LDD1841  [3]
C163
 Probe Info  		5.70  LDD1843  [3]
C201
 Probe Info  		34.06  LDD1877  [3]
C210
 Probe Info  		44.94  LDD1884  [3]
C218
 Probe Info  		11.55  LDD1892  [3]
C220
 Probe Info  		13.27  LDD1894  [3]
C228
 Probe Info  		19.16  LDD1901  [3]
C231
 Probe Info  		27.10  LDD1904  [3]
C232
 Probe Info  		63.12  LDD1905  [3]
C234
 Probe Info  		6.23  LDD1907  [3]
C235
 Probe Info  		38.32  LDD1908  [3]
C246
 Probe Info  		12.38  LDD1919  [3]
C277
 Probe Info  		8.17  LDD1947  [3]
C278
 Probe Info  		85.63  LDD1948  [3]
C280
 Probe Info  		9.58  LDD1950  [3]
C282
 Probe Info  		22.78  LDD1952  [3]
C284
 Probe Info  		27.28  LDD1954  [3]
C289
 Probe Info  		26.91  LDD1959  [3]
C293
 Probe Info  		22.01  LDD1963  [3]
C296
 Probe Info  		13.45  LDD1966  [3]
C343
 Probe Info  		12.55  LDD2005  [3]
C362
 Probe Info  		60.97  LDD2023  [3]
C363
 Probe Info  		25.63  LDD2024  [3]
C364
 Probe Info  		26.35  LDD2025  [3]
C366
 Probe Info  		9.92  LDD2027  [3]
C367
 Probe Info  		22.16  LDD2028  [3]
C388
 Probe Info  		85.63  LDD2047  [3]
C390
 Probe Info  		38.32  LDD2049  [3]
C403
 Probe Info  		18.90  LDD2061  [3]
C407
 Probe Info  		16.00  LDD2064  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Epidermal retinol dehydrogenase 2 (SDR16C5) Short-chain dehydrogenases/reductases (SDR) family Q8N3Y7
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Cytochrome c oxidase assembly protein COX20, mitochondrial (COX20) COX20 family Q5RI15
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Monocarboxylate transporter 10 (SLC16A10) Monocarboxylate porter (TC 2.A.1.13) family Q8TF71
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Solute carrier family 66 member 2 (SLC66A2) . Q8N2U9
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Synaptotagmin-2 (SYT2) Synaptotagmin family Q8N9I0
Transmembrane protein 154 (TMEM154) . Q6P9G4

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587