Details of the Target

General Information of Target

Target ID LDTP10533
Target Name Sorting nexin-27 (SNX27)
Gene Name SNX27
Gene ID 81609
Synonyms
KIAA0488; Sorting nexin-27
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQP
FQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGV
PLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPA
GVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALH
VPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPAR
SSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQ
VHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKL
VRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKR
KKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEE
ANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCP
GDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK
FNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW
GPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQ
FFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWT
MVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKY
EHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPG
SSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLM
EEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQG
PLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTA
QASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVA
QPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTV
SQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQE
EKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPA
HSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRI
LRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLIL
SQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGI
NLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLI
REVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIA
RPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLT
PIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAEL
LTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKL
PPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNIL
LKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPN
WDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQL
YTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAE
RIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQP
QPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIA
GVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATT
QGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQ
QQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKM
QKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVA
NLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAG
ISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQI
TTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASI
QQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTP
GAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Early endosome membrane
Function
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Uniprot ID
Q96L92
Ensemble ID
ENST00000368843.8
HGNC ID
HGNC:20073

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.K97Q DBIA    Probe Info 
HT SNV: p.L78R .
NOMO1 SNV: p.V43G DBIA    Probe Info 
WM2664 Insertion: p.Y197VfsTer58 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K222(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y242(49.28); Y269(8.15); Y400(51.63)  LDD3495  [3]
BTD
 Probe Info  		C519(2.42)  LDD2090  [4]
AHL-Pu-1
 Probe Info  		C519(2.81)  LDD0169  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
DBIA
 Probe Info  		C30(1.16)  LDD0531  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C513(0.00); C456(0.00); C354(0.00); C30(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C513(0.00); C354(0.00); C30(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C513(0.00); C354(0.00); C456(0.00); C30(0.00)  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
IPM
 Probe Info  		C519(0.00); C30(0.00)  LDD0005  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		13.20  LDD0443  [16]
NAIA_5
 Probe Info  		C513(0.00); C30(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.54  LDD1725  [18]
C106
 Probe Info  		18.38  LDD1793  [18]
C108
 Probe Info  		33.59  LDD1795  [18]
C198
 Probe Info  		21.26  LDD1874  [18]
C201
 Probe Info  		26.35  LDD1877  [18]
C293
 Probe Info  		17.03  LDD1963  [18]
C314
 Probe Info  		15.78  LDD1981  [18]
C343
 Probe Info  		13.55  LDD2005  [18]
C350
 Probe Info  		34.30  LDD2011  [18]
C424
 Probe Info  		10.27  LDD2079  [18]
FFF probe11
 Probe Info  		7.99  LDD0471  [19]
FFF probe12
 Probe Info  		12.52  LDD0473  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]
FFF probe2
 Probe Info  		10.55  LDD0463  [19]
OEA-DA
 Probe Info  		5.79  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C519(1.45)  LDD2117  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C519(2.81)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C30(1.16)  LDD0531  [7]
 LDCM0215  AC10 HEK-293T C354(1.33); C432(0.80); C487(1.42); C30(1.32)  LDD0813  [7]
 LDCM0216  AC100 HCT 116 C30(1.25); C421(0.80); C432(0.85); C434(0.94)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C30(0.90); C421(0.84); C432(0.77); C434(1.17)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C30(0.46); C421(0.87); C432(0.87); C434(1.00)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C30(1.12); C421(0.98); C432(0.94); C434(1.17)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C30(0.78); C421(0.81); C432(0.79); C434(0.93)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C30(1.30); C421(0.84); C432(0.78); C434(1.04)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C30(1.58); C421(0.80); C432(0.71); C434(1.15)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C30(1.15); C421(0.77); C432(0.79); C434(0.95)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C30(0.86); C421(0.71); C432(0.68); C434(0.93)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C30(0.69); C421(0.80); C432(0.74); C434(0.93)  LDD0542  [7]
 LDCM0226  AC11 HEK-293T C354(1.42); C432(0.75); C487(1.79); C30(1.20)  LDD0824  [7]
 LDCM0227  AC110 HCT 116 C30(0.56); C421(0.88); C432(0.91); C434(1.06)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C30(0.90); C421(0.82); C432(0.71); C434(1.22)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C30(0.80); C421(0.62); C432(0.74); C434(0.72)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C30(1.28); C421(0.80); C432(0.87); C434(0.87)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C30(2.12); C421(0.92); C432(0.83); C434(1.25)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C30(1.58); C421(1.05); C432(0.83); C434(0.96)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C30(1.64); C421(0.66); C432(0.70); C434(0.71)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C30(1.44); C421(0.92); C432(0.78); C434(0.83)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C30(1.73); C421(0.74); C432(0.80); C434(0.80)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C30(1.44); C421(0.82); C432(0.84); C434(0.72)  LDD0553  [7]
 LDCM0237  AC12 HEK-293T C354(1.56); C432(0.71); C487(2.70); C30(1.81)  LDD0835  [7]
 LDCM0238  AC120 HCT 116 C30(0.71); C421(0.99); C432(1.16); C434(0.97)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C30(1.17); C421(1.00); C432(1.07); C434(1.07)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C30(1.56); C421(0.70); C432(0.74); C434(0.83)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C30(1.50); C421(0.88); C432(0.88); C434(0.79)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C30(0.97); C421(0.94); C432(1.03); C434(0.97)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C30(1.41); C421(0.95); C432(0.94); C434(0.92)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C30(1.35); C421(1.36); C432(1.09); C434(1.29)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C30(2.49); C421(0.87); C432(0.93); C434(1.00)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C432(2.28); C434(2.28)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C432(2.56); C434(2.56)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C432(1.40); C434(1.40)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C432(1.63); C434(1.63)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C432(0.92); C434(0.92)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C432(1.52); C434(1.52)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C432(1.76); C434(1.76)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C432(1.58); C434(1.58)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C432(1.36); C434(1.36)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C432(1.53); C434(1.53)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C432(1.72); C434(1.72)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C432(1.29); C434(1.29)  LDD0575  [7]
 LDCM0259  AC14 HEK-293T C354(1.26); C432(0.46); C487(1.69); C30(1.36)  LDD0857  [7]
 LDCM0260  AC140 HCT 116 C432(1.42); C434(1.42)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C432(1.14); C434(1.14)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C432(1.34); C434(1.34)  LDD0579  [7]
 LDCM0263  AC143 HEK-293T C354(0.99); C432(0.90); C487(1.05); C30(0.93)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C354(1.50); C432(1.13); C487(1.16); C30(1.34)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C354(1.40); C432(1.16); C487(1.14); C30(1.12)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C354(1.29); C432(1.18); C487(1.06); C30(1.11)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C354(1.33); C432(0.95); C487(1.37); C30(1.28)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C354(0.92); C432(1.03); C487(1.07); C30(1.10)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C354(0.97); C432(1.15); C487(1.11); C30(1.29)  LDD0867  [7]
 LDCM0270  AC15 HEK-293T C354(1.56); C432(0.74); C487(2.74); C30(1.60)  LDD0868  [7]
 LDCM0271  AC150 HEK-293T C354(1.05); C432(1.15); C487(0.92); C30(1.12)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C354(1.26); C432(1.04); C487(1.09); C30(0.91)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C354(1.14); C432(1.08); C487(1.01); C30(1.25)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C354(1.07); C432(1.19); C487(1.08); C30(0.69)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C354(0.98); C432(1.10); C487(0.91); C30(0.69)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C354(1.42); C432(0.92); C487(1.14); C30(0.79)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C354(1.24); C432(0.89); C487(1.43); C30(1.68)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C354(1.67); C432(1.41); C487(1.06); C30(1.43)  LDD2165  [7]
 LDCM0276  AC17 HEK-293T C354(1.63); C432(1.04); C421(1.04); C434(1.26)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C354(1.57); C432(0.67); C421(0.67); C434(0.76)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C354(1.51); C432(0.93); C421(0.93); C434(1.19)  LDD0876  [7]
 LDCM0279  AC2 HCT 116 C30(1.04)  LDD0596  [7]
 LDCM0280  AC20 HEK-293T C354(1.40); C432(0.57); C421(0.57); C434(0.68)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C354(2.71); C432(0.71); C421(0.71); C434(0.95)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C354(1.63); C432(0.58); C421(0.58); C434(0.70)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C354(2.06); C432(0.62); C421(0.62); C434(0.75)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C354(1.15); C432(0.96); C421(0.96); C434(1.31)  LDD0882  [7]
 LDCM0285  AC25 HCT 116 C421(0.92); C432(0.92); C434(0.92)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C421(0.46); C432(0.46); C434(0.46)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C421(0.58); C432(0.58); C434(0.58)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C421(0.44); C432(0.44); C434(0.44)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C421(0.50); C432(0.50); C434(0.50)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C30(1.65)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C421(0.42); C432(0.42); C434(0.42)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C421(0.59); C432(0.59); C434(0.59)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C421(0.30); C432(0.30); C434(0.30)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C421(0.91); C432(0.91); C434(0.91)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C421(2.12); C432(2.12); C434(2.12)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C421(1.48); C432(1.48)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C421(0.78); C432(0.78)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C421(0.72); C432(0.72)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C421(1.28); C432(1.28)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C421(1.26); C432(1.26)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C30(1.17)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C421(1.35); C432(1.35)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C421(0.75); C432(0.75)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C421(0.92); C432(0.92)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C421(0.54); C432(0.54)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C421(1.41); C432(1.41)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C421(0.96); C432(0.96)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C421(0.55); C432(0.55); C434(0.55); C30(0.91)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C421(0.51); C432(0.51); C434(0.51); C30(0.89)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C421(0.61); C432(0.61); C434(0.61); C30(0.91)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C421(0.46); C432(0.46); C434(0.46); C30(1.11)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C30(1.03)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C421(0.44); C432(0.44); C434(0.44); C30(1.99)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C421(0.56); C432(0.56); C434(0.56); C30(0.74)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C421(0.60); C432(0.60); C434(0.60); C30(1.13)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C421(0.79); C432(0.79); C434(0.79); C30(1.52)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C421(0.74); C432(0.74); C434(0.74); C30(0.95)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C421(0.67); C432(0.67); C434(0.67); C30(1.30)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C421(0.53); C432(0.53); C434(0.53); C30(1.89)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C421(1.32); C432(1.32); C434(1.32)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C421(1.40); C432(1.40); C434(1.40)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C421(1.37); C432(1.37); C434(1.37)  LDD0639  [7]
 LDCM0323  AC6 HEK-293T C354(2.51); C432(0.96); C487(1.29); C30(1.04)  LDD0921  [7]
 LDCM0324  AC60 HCT 116 C421(1.87); C432(1.87); C434(1.87)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C421(0.86); C432(0.86); C434(0.86)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C421(1.36); C432(1.36); C434(1.36)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C421(1.72); C432(1.72); C434(1.72)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C421(1.44); C432(1.44); C434(1.44)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C421(0.60); C432(0.60); C434(0.60)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C421(0.68); C432(0.68); C434(0.68)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C421(1.83); C432(1.83); C434(1.83)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C434(1.16); C421(1.17); C432(1.17); C30(1.21)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C30(0.77); C434(1.04); C421(1.05); C432(1.05)  LDD0650  [7]
 LDCM0334  AC7 HEK-293T C354(1.57); C432(1.11); C487(1.20); C30(0.97)  LDD0932  [7]
 LDCM0335  AC70 HCT 116 C30(0.78); C434(0.88); C421(0.91); C432(0.91)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C30(0.85); C421(1.37); C432(1.37); C434(1.43)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C30(0.85); C434(1.01); C421(1.03); C432(1.03)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C30(0.72); C434(0.76); C421(0.77); C432(0.77)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C30(1.03); C421(1.14); C432(1.14); C434(1.17)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C421(0.69); C432(0.69); C434(0.72); C30(1.20)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C30(1.10); C421(1.23); C432(1.23); C434(1.34)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C30(1.10); C434(1.26); C421(1.28); C432(1.28)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C30(0.96); C421(1.02); C432(1.02); C434(1.04)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C30(0.78); C421(1.02); C432(1.02); C434(1.06)  LDD0661  [7]
 LDCM0345  AC8 HEK-293T C354(2.95); C432(1.27); C487(1.09); C30(1.19)  LDD0943  [7]
 LDCM0346  AC80 HCT 116 C421(0.97); C432(0.97); C434(1.00); C30(1.13)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C30(0.86); C421(1.01); C432(1.01); C434(1.04)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C30(0.81); C421(1.15); C432(1.15); C434(1.28)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C30(1.58)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C30(1.18)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C30(0.96)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C30(1.00)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C30(0.94)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C30(0.80)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C30(1.67)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C30(0.53)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C30(1.92)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C30(1.55)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C30(0.67)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C30(0.78)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C30(1.12)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C30(1.10)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C30(1.20)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C432(0.83); C421(0.85); C434(1.08); C30(1.36)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C30(0.60); C421(0.89); C432(0.91); C434(1.09)  LDD0683  [7]
 LDCM0248  AKOS034007472 HEK-293T C354(1.71); C432(0.78); C487(1.16); C30(1.31)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C354(1.48); C432(0.62); C487(1.55); C30(1.43)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C354(1.79); C432(0.48); C487(1.30); C30(1.30)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 11.62  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C30(0.55)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C432(0.91); C487(0.96); C30(3.28); C421(1.02)  LDD0965  [7]
 LDCM0368  CL10 HEK-293T C432(1.19); C487(1.30); C30(1.56); C421(0.63)  LDD0966  [7]
 LDCM0369  CL100 HCT 116 C30(1.14)  LDD0686  [7]
 LDCM0370  CL101 HEK-293T C354(1.70); C432(0.86); C487(1.46); C30(1.42)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C354(1.77); C432(0.71); C487(1.60); C30(1.65)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C354(2.03); C432(0.98); C487(1.39); C30(1.65)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C354(2.02); C432(1.80); C487(1.58); C30(1.11)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C354(1.94); C432(0.58); C421(0.58); C434(0.69)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C354(1.01); C432(0.71); C421(0.71); C434(0.99)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C354(1.60); C432(0.59); C421(0.59); C434(0.83)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C354(1.14); C432(1.15); C421(1.15); C434(1.57)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C354(1.34); C432(0.59); C421(0.59); C434(0.73)  LDD0976  [7]
 LDCM0379  CL11 HEK-293T C432(1.10); C487(1.51); C30(2.15); C421(0.68)  LDD0977  [7]
 LDCM0380  CL110 HEK-293T C354(1.87); C432(0.62); C421(0.62); C434(0.76)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C354(1.50); C432(0.53); C421(0.53); C434(0.64)  LDD0979  [7]
 LDCM0382  CL112 HCT 116 C421(0.85); C432(0.85); C434(0.85)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C421(0.65); C432(0.65); C434(0.65)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C421(1.43); C432(1.43); C434(1.43)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C421(1.68); C432(1.68); C434(1.68)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C421(1.05); C432(1.05); C434(1.05)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C421(1.77); C432(1.77)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C421(0.69); C432(0.69)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C421(0.68); C432(0.68)  LDD0706  [7]
 LDCM0390  CL12 HEK-293T C432(1.09); C487(1.12); C30(1.09); C421(0.68)  LDD0988  [7]
 LDCM0391  CL120 HCT 116 C421(0.73); C432(0.73)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C30(0.73); C421(0.94); C432(0.94); C434(0.94)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C421(0.80); C432(0.80); C434(0.80); C30(1.16)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C421(0.72); C432(0.72); C434(0.72); C30(1.37)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C421(0.54); C432(0.54); C434(0.54); C30(1.58)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C421(0.72); C432(0.72); C434(0.72)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C421(0.73); C432(0.73); C434(0.73)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C421(1.07); C432(1.07); C434(1.07)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C421(1.19); C432(1.19); C434(1.19)  LDD0716  [7]
 LDCM0400  CL13 HEK-293T C432(1.29); C487(0.92); C30(1.34); C421(1.20)  LDD0998  [7]
 LDCM0401  CL14 HEK-293T C432(1.00); C487(0.86); C30(1.98); C421(1.30)  LDD0999  [7]
 LDCM0402  CL15 HEK-293T C432(1.10); C487(1.48); C30(1.41); C421(1.03)  LDD1000  [7]
 LDCM0403  CL16 HEK-293T C432(1.22); C421(1.22); C434(1.22)  LDD1001  [7]
 LDCM0404  CL17 HCT 116 C421(0.67); C432(0.67); C434(0.67); C30(1.56)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C421(0.86); C432(0.86); C434(0.86); C30(1.27)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C421(0.84); C432(0.84); C434(0.84); C30(1.18)  LDD0723  [7]
 LDCM0407  CL2 HEK-293T C432(1.03); C487(1.24); C30(1.49); C421(0.93)  LDD1005  [7]
 LDCM0408  CL20 HCT 116 C421(0.65); C432(0.65); C434(0.65); C30(1.28)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C421(0.85); C432(0.85); C434(0.85); C30(1.54)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C30(0.91); C421(1.04); C432(1.04); C434(1.04)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C421(0.67); C432(0.67); C434(0.67); C30(1.09)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C30(1.31); C421(1.02); C432(1.02); C434(1.02)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C30(1.09); C421(0.87); C432(0.87); C434(0.87)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C30(1.57); C421(1.00); C432(1.00); C434(1.00)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C30(1.18); C421(1.06); C432(1.06); C434(1.06)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C30(1.55); C421(0.69); C432(0.69); C434(0.69)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C30(1.37); C421(1.05); C432(1.05); C434(1.05)  LDD0734  [7]
 LDCM0418  CL3 HEK-293T C432(1.01); C487(1.01); C30(1.03); C421(0.95)  LDD1016  [7]
 LDCM0419  CL30 HCT 116 C30(0.80); C421(0.95); C432(0.95); C434(0.95)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C30(1.05); C421(0.81); C432(0.81); C434(0.81)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C30(0.75)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C30(0.95)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C30(0.89)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C30(1.48)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C30(1.44)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C30(1.83)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C30(0.93)  LDD0745  [7]
 LDCM0429  CL4 HEK-293T C432(1.36); C487(1.25); C30(0.93); C421(1.16)  LDD1027  [7]
 LDCM0430  CL40 HCT 116 C30(1.18)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C30(0.88)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C30(1.45)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C30(0.69)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C30(0.79)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C30(0.71)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C421(3.08); C432(3.08); C434(3.08)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C421(0.83); C432(0.83); C434(0.83)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C421(1.37); C432(1.37); C434(1.37)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C421(0.90); C432(0.90); C434(0.90)  LDD0756  [7]
 LDCM0440  CL5 HEK-293T C432(0.96); C487(1.32); C30(0.91); C421(0.86)  LDD1038  [7]
 LDCM0441  CL50 HCT 116 C421(1.06); C432(1.06); C434(1.06)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C421(1.15); C432(1.15); C434(1.15)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C421(1.37); C432(1.37); C434(1.37)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C421(1.25); C432(1.25); C434(1.25)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C421(1.54); C432(1.54); C434(1.54)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C421(2.24); C432(2.24); C434(2.24)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C421(1.50); C432(1.50); C434(1.50)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C421(1.79); C432(1.79); C434(1.79)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C421(1.03); C432(1.03); C434(1.03)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C421(1.48); C432(1.48); C434(1.48)  LDD0767  [7]
 LDCM0451  CL6 HEK-293T C432(1.05); C487(0.97); C30(1.15); C421(1.17)  LDD1049  [7]
 LDCM0452  CL60 HCT 116 C421(1.49); C432(1.49); C434(1.49)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C354(1.25); C432(1.17); C487(0.81); C421(1.09)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C354(1.26); C432(0.79); C487(1.16); C421(0.88)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C354(1.57); C432(1.24); C487(1.10); C421(0.91)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C354(0.96); C432(1.06); C487(0.91); C421(1.09)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C354(1.41); C432(0.65); C487(1.22); C421(0.92)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C354(1.17); C432(0.97); C487(0.94); C421(1.29)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C354(0.86); C432(1.29); C487(1.09); C421(1.09)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C354(1.07); C432(0.59); C487(1.27); C421(0.85)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C354(1.33); C432(0.87); C487(0.78); C421(0.90)  LDD1059  [7]
 LDCM0462  CL7 HEK-293T C432(1.20); C487(1.05); C30(1.41); C421(1.16)  LDD1060  [7]
 LDCM0463  CL70 HEK-293T C354(0.84); C432(0.86); C487(1.44); C421(1.07)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C354(1.31); C432(0.98); C487(1.20); C421(0.93)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C354(1.21); C432(0.86); C487(1.01); C421(0.85)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C354(0.87); C432(0.86); C487(1.29); C421(1.10)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C354(1.39); C432(1.39); C487(1.32); C421(1.05)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C354(1.22); C432(0.84); C421(0.81); C434(0.84)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C354(1.20); C432(0.75); C421(0.86); C434(0.75)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C354(1.79); C432(0.86); C421(1.16); C434(0.86)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C354(1.23); C432(0.86); C421(0.83); C434(0.86)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C432(1.15); C30(0.86); C421(0.85); C434(1.22)  LDD1071  [7]
 LDCM0474  CL80 HEK-293T C354(1.20); C432(0.87); C421(0.92); C434(0.87)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C354(1.28); C432(0.85); C421(0.87); C434(0.85)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C354(0.86); C432(0.82); C421(0.83); C434(0.82)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C354(0.92); C432(0.87); C421(0.92); C434(0.87)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C354(1.59); C432(0.88); C421(1.33); C434(0.88)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C354(1.84); C432(0.76); C421(0.79); C434(0.76)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C354(1.47); C432(0.74); C421(0.95); C434(0.74)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C354(1.42); C432(0.63); C421(0.75); C434(0.63)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C354(1.37); C432(0.74); C421(0.92); C434(0.74)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C354(1.40); C432(0.76); C421(0.86); C434(0.76)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C432(1.22); C30(1.53); C421(0.76); C434(0.97)  LDD1082  [7]
 LDCM0485  CL90 HEK-293T C354(1.07); C432(0.76); C421(0.83); C434(0.76)  LDD1083  [7]
 LDCM0486  CL91 HCT 116 C30(0.80)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C30(0.97)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C30(0.96)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C30(1.84)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C30(1.29)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C30(1.29)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C30(1.10)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C30(1.02)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C30(1.09)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C30(0.72); C456(1.13); C513(1.02)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C519(0.95)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0625  F8 Ramos C30(1.70)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C30(1.75)  LDD2189  [22]
 LDCM0574  Fragment12 Ramos C30(0.49)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C30(0.75)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C30(0.58)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C30(0.65)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C30(0.86)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C30(0.76)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C30(0.74)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C30(0.89)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C30(0.88)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C30(0.57)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C30(1.57)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C354(1.46); C432(1.46); C487(1.48); C421(1.27)  LDD1066  [7]
 LDCM0596  Fragment38 Ramos C30(0.71)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C30(0.73)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C30(1.70)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C30(0.88)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C30(1.17)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C30(0.98)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C30(0.82)  LDD2188  [22]
 LDCM0022  KB02 HEK-293T C30(0.92); C354(0.96); C513(1.07); C434(1.27)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C30(0.92); C354(1.01); C513(1.01); C434(1.09)  LDD1497  [21]
 LDCM0024  KB05 COLO792 C513(1.97); C354(1.64)  LDD3310  [23]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C519(2.42)  LDD2090  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C519(1.20)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C519(0.61)  LDD2109  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C519(0.82)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C519(0.83)  LDD2127  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C519(1.00)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C519(0.96)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C519(1.08)  LDD2140  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiotensin-converting enzyme 2 (ACE2) Peptidase M2 family Q9BYF1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840