Details of the Target

General Information of Target

Target ID LDTP01380
Target Name Wolframin (WFS1)
Gene Name WFS1
Gene ID 7466
Synonyms
Wolframin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSNTAPLGPSCPQPPPAPQPQARSRLNATASLEQERSERPRAPGPQAGPGPGVRDAAAP
AEPQAQHTRSRERADGTGPTKGDMEIPFEEVLERAKAGDPKAQTEVGKHYLQLAGDTDEE
LNSCTAVDWLVLAAKQGRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERAVRKAA
LVMYWKLNPKKKKQVAVAELLENVGQVNEHDGGAQPGPVPKSLQKQRRMLERLVSSESKN
YIALDDFVEITKKYAKGVIPSSLFLQDDEDDDELAGKSPEDLPLRLKVVKYPLHAIMEIK
EYLIDMASRAGMHWLSTIIPTHHINALIFFFIVSNLTIDFFAFFIPLVIFYLSFISMVIC
TLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYAHFLLSVFFVIFSFP
IASKDCIPCSELAVITGFFTVTSYLSLSTHAEPYTRRALATEVTAGLLSLLPSMPLNWPY
LKVLGQTFITVPVGHLVVLNVSVPCLLYVYLLYLFFRMAQLRNFKGTYCYLVPYLVCFMW
CELSVVILLESTGLGLLRASIGYFLFLFALPILVAGLALVGVLQFARWFTSLELTKIAVT
VAVCSVPLLLRWWTKASFSVVGMVKSLTRSSMVKLILVWLTAIVLFCWFYVYRSEGMKVY
NSTLTWQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAI
NMLPFFIGDWMRCLYGEAYPACSPGNTSTAEEELCRLKLLAKHPCHIKKFDRYKFEITVG
MPFSSGADGSRSREEDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEGRLGSKWPVF
ELKAISCLNCMAQLSPTRRHVKIEHDWRSTVHGAVKFAFDFFFFPFLSAA
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum membrane
Function
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism.
Uniprot ID
O76024
Ensemble ID
ENST00000226760.5
HGNC ID
HGNC:12762

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
YN-4
 Probe Info  		100.00  LDD0445  [2]
STPyne
 Probe Info  		K762(2.78); K836(7.46)  LDD0277  [3]
BTD
 Probe Info  		C148(1.31)  LDD2091  [4]
DA-P3
 Probe Info  		5.40  LDD0179  [5]
DBIA
 Probe Info  		C847(1.45); C850(1.45)  LDD0078  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
ATP probe
 Probe Info  		N.A.  LDD0035  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
AOyne
 Probe Info  		14.40  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		8.40  LDD1728  [13]
C040
 Probe Info  		10.63  LDD1740  [13]
C056
 Probe Info  		17.75  LDD1753  [13]
C106
 Probe Info  		21.56  LDD1793  [13]
C108
 Probe Info  		7.94  LDD1795  [13]
C112
 Probe Info  		25.99  LDD1799  [13]
C134
 Probe Info  		22.01  LDD1816  [13]
C161
 Probe Info  		9.99  LDD1841  [13]
C169
 Probe Info  		23.75  LDD1849  [13]
C201
 Probe Info  		36.00  LDD1877  [13]
C210
 Probe Info  		48.84  LDD1884  [13]
C218
 Probe Info  		17.75  LDD1892  [13]
C219
 Probe Info  		5.54  LDD1893  [13]
C220
 Probe Info  		19.84  LDD1894  [13]
C228
 Probe Info  		18.64  LDD1901  [13]
C231
 Probe Info  		19.70  LDD1904  [13]
C232
 Probe Info  		41.07  LDD1905  [13]
C235
 Probe Info  		22.32  LDD1908  [13]
C243
 Probe Info  		13.36  LDD1916  [13]
C246
 Probe Info  		19.84  LDD1919  [13]
C249
 Probe Info  		12.38  LDD1922  [13]
C264
 Probe Info  		16.22  LDD1935  [13]
C277
 Probe Info  		10.06  LDD1947  [13]
C285
 Probe Info  		19.97  LDD1955  [13]
C287
 Probe Info  		11.16  LDD1957  [13]
C289
 Probe Info  		36.50  LDD1959  [13]
C293
 Probe Info  		17.75  LDD1963  [13]
C299
 Probe Info  		5.94  LDD1968  [13]
C310
 Probe Info  		8.00  LDD1977  [13]
C343
 Probe Info  		12.38  LDD2005  [13]
C350
 Probe Info  		22.01  LDD2011  [13]
C388
 Probe Info  		38.32  LDD2047  [13]
C390
 Probe Info  		29.04  LDD2049  [13]
C403
 Probe Info  		14.52  LDD2061  [13]
C407
 Probe Info  		11.79  LDD2064  [13]
OEA-DA
 Probe Info  		12.82  LDD0046  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C148(1.11)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C148(2.14)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C850(0.87)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C850(1.03)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C847(0.86); C850(0.86)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C847(0.96); C850(0.96)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C847(1.08); C850(1.08)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C847(0.93); C850(0.93)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C847(1.01); C850(1.01)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C847(0.93); C850(0.93)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C847(0.86); C850(0.86)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C847(0.87); C850(0.87)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C847(1.05); C850(1.05)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C847(0.85); C850(0.85)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C850(1.19)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C847(0.89); C850(0.89)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C847(0.97); C850(0.97)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C847(0.80); C850(0.80)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C847(0.95); C850(0.95)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C847(1.16); C850(0.73)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C847(1.45); C850(1.05)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C847(1.04); C850(0.98)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C847(1.21); C850(0.84)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C847(1.36); C850(0.92)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C847(1.32); C850(1.02)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C850(1.09)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C847(1.16); C850(0.84)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C847(1.16); C850(0.89)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C847(1.08); C850(0.88)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C847(1.08); C850(0.94)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C847(0.92); C850(0.87)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C847(1.18); C850(0.90)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C847(1.04); C850(0.85)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C847(1.17); C850(0.97)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C850(1.15)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C850(1.04)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C850(1.15)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C850(1.37)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C850(1.40)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C850(1.27)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C850(1.51)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C850(1.40)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C850(1.41)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C850(1.49)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C850(1.54)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C850(1.74)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C850(0.96)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C850(1.96)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C850(1.94)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C850(1.52)  LDD0579  [6]
 LDCM0270  AC15 HCT 116 C850(0.92)  LDD0587  [6]
 LDCM0276  AC17 HCT 116 C847(1.08); C850(1.14)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C847(1.09); C850(1.30)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C847(1.02); C850(1.17)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C850(1.06)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C847(0.91); C850(0.99)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C850(1.16); C847(1.24)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C850(0.99); C847(1.01)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C847(1.04); C850(1.04)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C847(0.98); C850(1.07)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C850(0.72)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C850(0.69)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C850(0.67)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C850(0.68)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C850(0.56)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C850(0.94)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C850(0.59)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C850(0.69)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C850(0.61)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C850(0.77)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C850(0.65)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C850(0.96); C847(1.19)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C850(1.02); C847(1.23)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C850(0.85); C847(1.04)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C850(1.03); C847(1.06)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C847(0.89); C850(0.95)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C850(0.92)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C850(0.93); C847(1.08)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C850(0.95); C847(1.12)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C850(0.96); C847(1.06)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C847(1.03); C850(1.04)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C850(0.97); C847(1.13)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C850(0.84); C847(0.98)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C850(1.06)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C850(0.89)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C850(1.15)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C850(1.33)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C850(0.85)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C850(1.31)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C850(1.25)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C850(1.14)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C850(1.17)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C850(1.06)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C850(0.98)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C850(0.90)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C850(0.98)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C850(0.90)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C850(0.93)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C850(0.85)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C850(1.02)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C850(0.88)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C850(1.01)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C850(1.23)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C850(1.02)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C850(1.01)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C850(0.86)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C850(1.08)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C847(0.98); C850(0.98)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C847(0.82); C850(0.82)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C850(1.02)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C847(1.16); C850(1.16)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C847(0.77); C850(0.77)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C847(0.87); C850(0.87)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C847(1.24); C850(1.24)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C847(1.42); C850(1.42)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C847(1.18); C850(1.18)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C847(0.89); C850(0.89)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C847(0.96); C850(0.96)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C847(0.95); C850(0.95)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C847(1.08); C850(1.08)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C850(1.09)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C847(1.05); C850(1.05)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C847(0.89); C850(0.89)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C847(1.17); C850(1.17)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C850(1.25)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C850(1.12)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C850(1.38)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C850(1.10)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C850(1.12)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C850(1.15)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C850(1.23)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C850(1.46)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C850(1.11)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C850(1.31)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C850(1.34)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C850(1.00)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C850(1.11)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C850(1.04)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C850(1.24)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C847(1.07); C850(1.07)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C847(0.85); C850(0.85)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C850(1.11)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C850(1.24)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C850(0.84)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.59  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C847(1.45); C850(1.45)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C148(1.31)  LDD2091  [4]
 LDCM0087  Capsaicin HEK-293T 4.92  LDD0185  [5]
 LDCM0367  CL1 HCT 116 C850(0.98)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C850(0.79)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C850(0.99)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C850(0.97)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C850(0.91)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C850(1.10)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C850(1.12)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C847(1.11); C850(1.20)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C847(1.04); C850(1.46)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C847(1.02); C850(1.30)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C847(1.06); C850(1.54)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C847(1.22); C850(1.31)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C850(0.65)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C847(0.95); C850(1.08)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C847(1.05); C850(1.23)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C850(0.54)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C850(0.58)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C850(0.54)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C850(0.50)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C850(0.61)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C850(0.95); C847(1.00)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C850(1.00); C847(1.11)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C850(0.98); C847(1.15)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C850(0.73)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C850(0.98); C847(1.03)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C850(1.04)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C850(1.31)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C850(0.87)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C850(1.02)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C850(0.87)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C850(0.82)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C850(0.91)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C850(0.89)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C850(0.88)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C850(0.89)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C850(0.90)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C850(1.38); C847(1.80)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C847(1.61); C850(1.61)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C847(2.41); C850(2.41)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C847(1.64); C850(1.64)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C850(0.96)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C847(2.00); C850(2.00)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C847(1.54); C850(1.54)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C847(1.53); C850(1.53)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C847(1.56); C850(1.56)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C847(1.93); C850(1.93)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C847(1.95); C850(1.95)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C847(2.53); C850(2.53)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C847(2.17); C850(2.17)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C847(2.05); C850(2.05)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C847(1.80); C850(1.80)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C850(0.84)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C847(1.93); C850(1.93)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C850(0.82)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C850(0.92)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C850(0.91)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C850(0.95)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C850(1.17)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C850(0.91)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C850(1.00)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C850(0.91)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C850(0.91)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C850(0.83)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C850(1.05)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C850(0.92)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C850(0.91)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C850(0.88)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C850(1.03)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C850(0.64)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C850(0.80)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C850(0.59)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C850(0.74)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C850(0.91)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C850(0.66)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C850(0.59)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C850(0.73)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C850(0.69)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C850(0.55)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C850(0.70)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C850(0.77)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C850(0.81)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C850(0.66)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C850(0.80)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C850(0.88)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C850(0.81)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C847(1.01); C850(0.78)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C847(1.06); C850(0.68)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C847(1.05); C850(0.65)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C847(1.32); C850(0.77)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C847(1.22); C850(0.71)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C847(1.13); C850(0.77)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C847(1.26); C850(0.83)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C847(1.33); C850(0.84)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C847(0.94); C850(0.83)  LDD1059  [6]
 LDCM0462  CL7 HCT 116 C850(0.84)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C847(0.96); C850(0.86)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C847(1.04); C850(0.74)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C847(0.93); C850(0.80)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C847(1.08); C850(0.74)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C847(1.31); C850(0.76)  LDD1065  [6]
 LDCM0469  CL76 HCT 116 C847(1.67); C850(1.67)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C847(1.36); C850(1.36)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C847(1.27); C850(1.27)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C847(1.40); C850(1.40)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C850(0.68)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C847(1.52); C850(1.52)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C847(1.27); C850(1.27)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C847(1.40); C850(1.40)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C847(1.27); C850(1.27)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C847(1.36); C850(1.36)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C847(1.50); C850(1.50)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C847(1.52); C850(1.52)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C847(1.44); C850(1.44)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C847(1.45); C850(1.45)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C847(1.36); C850(1.36)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C850(0.79)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C847(1.29); C850(1.29)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C850(1.07)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C850(0.97)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C850(1.06)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C850(1.03)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C850(0.98)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C850(0.93)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C850(1.14)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C850(0.95)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C850(1.08)  LDD0811  [6]
 LDCM0028  Dobutamine HEK-293T 5.73  LDD0180  [5]
 LDCM0027  Dopamine HEK-293T 5.40  LDD0179  [5]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.44  LDD0183  [5]
 LDCM0468  Fragment33 HEK-293T C847(1.14); C850(0.77)  LDD1066  [6]
 LDCM0427  Fragment51 HCT 116 C850(0.93)  LDD0744  [6]
 LDCM0022  KB02 A2780 C690(1.82)  LDD2254  [15]
 LDCM0023  KB03 A2780 C690(2.82)  LDD2671  [15]
 LDCM0024  KB05 OVCAR-5 C690(2.68)  LDD3383  [15]
 LDCM0030  Luteolin HEK-293T 4.18  LDD0182  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C148(1.46)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C148(1.27)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C148(0.81)  LDD2109  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C148(0.91)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C148(1.04)  LDD2125  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C148(1.52)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C148(1.64)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C148(0.84)  LDD2137  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C148(2.06)  LDD2144  [4]
 LDCM0032  Oleacein HEK-293T 4.31  LDD0184  [5]
 LDCM0029  Quercetin HEK-293T 6.01  LDD0181  [5]
 LDCM0021  THZ1 HCT 116 C847(1.08); C850(1.08)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 85 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 10B (PSMC6) AAA ATPase family P62333
Phosphatidylcholine-sterol acyltransferase (LCAT) Lipase family P04180
ATP-binding cassette sub-family G member 4 (ABCG4) ABCG family Q9H172
GTP:AMP phosphotransferase AK3, mitochondrial (AK3) Adenylate kinase family Q9UIJ7
Aldo-keto reductase family 1 member A1 (AKR1A1) Aldo/keto reductase family P14550
Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) ATP:guanido phosphotransferase family P12532
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) Cation transport ATPase (P-type) (TC 3.A.3) family P16615
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) C5-methyltransferase family Q9Y6K1
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (TRMT61B) TRM61 family Q9BVS5
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Cytochrome b5 (CYB5A) Cytochrome b5 family P00167
ATP-dependent RNA helicase DDX39A (DDX39A) DEAD box helicase family O00148
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
DNA polymerase beta (POLB) DNA polymerase type-X family P06746
5' exonuclease Apollo (DCLRE1B) DNA repair metallo-beta-lactamase (DRMBL) family Q9H816
Deoxyribonuclease-1-like 1 (DNASE1L1) DNase I family P49184
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
DNA-directed RNA polymerase III subunit RPC6 (POLR3F) Eukaryotic RPC34/RPC39 RNA polymerase subunit family Q9H1D9
Serine protease FAM111B (FAM111B) FAM111 family Q6SJ93
FAST kinase domain-containing protein 1, mitochondrial (FASTKD1) FAST kinase family Q53R41
L-amino-acid oxidase (IL4I1) Flavin monoamine oxidase family Q96RQ9
Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1) Gfo/Idh/MocA family Q9NXC2
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) Glucose-6-phosphatase family P35575
Polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6) Glycosyltransferase 2 family Q8NCL4
Eyes absent homolog 3 (EYA3) EYA family Q99504
F-box DNA helicase 1 (FBH1) Helicase family Q8NFZ0
Hexokinase-3 (HK3) Hexokinase family P52790
Interleukin-18 receptor accessory protein (IL18RAP) Interleukin-1 receptor family O95256
X-ray repair cross-complementing protein 6 (XRCC6) Ku70 family P12956
Phosphatidate phosphatase LPIN1 (LPIN1) Lipin family Q14693
Lysyl oxidase homolog 4 (LOXL4) Lysyl oxidase family Q96JB6
Dihydropyrimidinase-related protein 4 (DPYSL4) Hydantoinase/dihydropyrimidinase family O14531
Dihydropyrimidinase-related protein 5 (DPYSL5) Hydantoinase/dihydropyrimidinase family Q9BPU6
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) Methylthiotransferase family Q5VV42
THUMP domain-containing protein 2 (THUMPD2) Methyltransferase superfamily Q9BTF0
Peptidoglycan recognition protein 3 (PGLYRP3) N-acetylmuramoyl-L-alanine amidase 2 family Q96LB9
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (AGA) Ntn-hydrolase family P20933
Diphosphoinositol polyphosphate phosphohydrolase 2 (NUDT4) Nudix hydrolase family Q9NZJ9
Phospholipid phosphatase-related protein type 1 (PLPPR1) PA-phosphatase related phosphoesterase family Q8TBJ4
Signal peptide peptidase-like 2A (SPPL2A) Peptidase A22B family Q8TCT8
Sentrin-specific protease 3 (SENP3) Peptidase C48 family Q9H4L4
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
N-acetylated-alpha-linked acidic dipeptidase 2 (NAALAD2) Peptidase M28 family Q9Y3Q0
MPN domain-containing protein (MPND) Peptidase M67 family Q8N594
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Group XIIA secretory phospholipase A2 (PLA2G12A) Phospholipase A2 family Q9BZM1
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Protein phosphatase PTC7 homolog (PPTC7) PP2C family Q8NI37
Protein prune homolog 2 (PRUNE2) PPase class C family Q8WUY3
26S proteasome non-ATPase regulatory subunit 5 (PSMD5) Proteasome subunit S5B/HSM3 family Q16401
Myosin light chain kinase 2, skeletal/cardiac muscle (MYLK2) CAMK Ser/Thr protein kinase family Q9H1R3
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G) CAMK Ser/Thr protein kinase family Q96NX5
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) STE Ser/Thr protein kinase family P52564
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
Dual specificity protein phosphatase 16 (DUSP16) Protein-tyrosine phosphatase family Q9BY84
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Ribose-phosphate pyrophosphokinase 2 (PRPS2) Ribose-phosphate pyrophosphokinase family P11908
E3 ubiquitin-protein ligase RNF10 (RNF10) RNF10 family Q8N5U6
E3 ubiquitin-protein ligase RNF168 (RNF168) RNF168 family Q8IYW5
Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1) RXYLT1 family Q9Y2B1
3-ketodihydrosphingosine reductase (KDSR) Short-chain dehydrogenases/reductases (SDR) family Q06136
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Ras-related protein Rab-11B (RAB11B) Rab family Q15907
DNA excision repair protein ERCC-6-like (ERCC6L) SNF2/RAD54 helicase family Q2NKX8
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) STT3 family P46977
Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2) Sulfatase-modifying factor family Q8NBJ7
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Kinesin-like protein KIF1A (KIF1A) Kinesin family Q12756
Septin-6 (SEPTIN6) Septin GTPase family Q14141
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
Ubiquitin-conjugating enzyme E2 J2 (UBE2J2) Ubiquitin-conjugating enzyme family Q8N2K1
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
G/T mismatch-specific thymine DNA glycosylase (TDG) TDG/mug family Q13569
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
E3 ubiquitin-protein transferase RMND5A (RMND5A) . Q9H871
Eukaryotic translation initiation factor 5B (EIF5B) . O60841
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3) . Q7L622
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
RING finger protein 208 (RNF208) . Q9H0X6
Transporter and channel
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A5 (ANXA5) Annexin family P08758
Amyloid-beta precursor protein (APP) APP family P05067
V-type proton ATPase subunit B, brain isoform (ATP6V1B2) ATPase alpha/beta chains family P21281
V-type proton ATPase subunit B, kidney isoform (ATP6V1B1) ATPase alpha/beta chains family P15313
Stomatin-like protein 2, mitochondrial (STOML2) Band 7/mec-2 family Q9UJZ1
Beclin-1 (BECN1) Beclin family Q14457
Clathrin interactor 1 (CLINT1) Epsin family Q14677
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Calcium-activated potassium channel subunit beta-2 (KCNMB2) KCNMB (TC 8.A.14.1) family Q9Y691
Monocarboxylate transporter 7 (SLC16A6) Monocarboxylate porter (TC 2.A.1.13) family O15403
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Aquaporin-8 (AQP8) MIP/aquaporin (TC 1.A.8) family O94778
BOS complex subunit NCLN (NCLN) Nicastrin family Q969V3
Secretory carrier-associated membrane protein 4 (SCAMP4) SCAMP family Q969E2
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Solute carrier family 13 member 2 (SLC13A2) SLC13A/DASS transporter family Q13183
Serine incorporator 3 (SERINC3) TDE1 family Q13530
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) Tim17/Tim22/Tim23 family O60830
p53 apoptosis effector related to PMP-22 (PERP) TMEM47 family Q96FX8
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) X(+)/potassium ATPases subunit beta family P05026
Barttin (BSND) . Q8WZ55
Membrane protein MLC1 (MLC1) . Q15049
Syntenin-1 (SDCBP) . O00560
Uncharacterized protein CXorf38 (CXorf38) . Q8TB03
Transcription factor
Click To Hide/Show 39 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Fos-related antigen 1 (FOSL1) BZIP family P15407
Doublesex- and mab-3-related transcription factor A1 (DMRTA1) DMRT family Q5VZB9
Krueppel-like factor 3 (KLF3) Krueppel C2H2-type zinc-finger protein family P57682
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 138 (ZNF138) Krueppel C2H2-type zinc-finger protein family P52744
Zinc finger protein 225 (ZNF225) Krueppel C2H2-type zinc-finger protein family Q9UK10
Zinc finger protein 239 (ZNF239) Krueppel C2H2-type zinc-finger protein family Q16600
Zinc finger protein 436 (ZNF436) Krueppel C2H2-type zinc-finger protein family Q9C0F3
Zinc finger protein 440 (ZNF440) Krueppel C2H2-type zinc-finger protein family Q8IYI8
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 524 (ZNF524) Krueppel C2H2-type zinc-finger protein family Q96C55
Zinc finger protein 57 (ZNF57) Krueppel C2H2-type zinc-finger protein family Q68EA5
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 64 (ZFP64) Krueppel C2H2-type zinc-finger protein family Q9NTW7
Zinc finger protein 670 (ZNF670) Krueppel C2H2-type zinc-finger protein family Q9BS34
Zinc finger protein 696 (ZNF696) Krueppel C2H2-type zinc-finger protein family Q9H7X3
Zinc finger protein 697 (ZNF697) Krueppel C2H2-type zinc-finger protein family Q5TEC3
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 791 (ZNF791) Krueppel C2H2-type zinc-finger protein family Q3KP31
Zinc finger protein GLI4 (GLI4) Krueppel C2H2-type zinc-finger protein family P10075
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
Nuclear receptor subfamily 1 group D member 2 (NR1D2) Nuclear hormone receptor family Q14995
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
PHD finger-like domain-containing protein 5A (PHF5A) PHF5 family Q7RTV0
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
TATA box-binding protein-like 1 (TBPL1) TBP family P62380
Ribosome quality control complex subunit TCF25 (TCF25) TCF25 family Q9BQ70
TSC22 domain family protein 4 (TSC22D4) TSC-22/Dip/Bun family Q9Y3Q8
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Zinc finger protein ZXDC (ZXDC) ZXD family Q2QGD7
Achaete-scute homolog 4 (ASCL4) . Q6XD76
Hematopoietically-expressed homeobox protein HHEX (HHEX) . Q03014
LIM/homeobox protein Lhx6 (LHX6) . Q9UPM6
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Zinc finger and SCAN domain-containing protein 26 (ZSCAN26) . Q16670
Zinc finger protein 366 (ZNF366) . Q8N895
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
P2Y purinoceptor 6 (P2RY6) G-protein coupled receptor 1 family Q15077
Probable G-protein coupled receptor 141 (GPR141) G-protein coupled receptor 1 family Q7Z602
Golgi pH regulator B (GPR89B) Golgi pH regulator (TC 1.A.38) family P0CG08
Immunoglobulin
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Semaphorin-4C (SEMA4C) Semaphorin family Q9C0C4
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Coiled-coil domain-containing protein 141 (CCDC141) . Q6ZP82
Other
Click To Hide/Show 157 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A8 (ANXA8) Annexin family P13928
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) ANP32 family Q92688
Anaphase-promoting complex subunit 13 (ANAPC13) APC13 family Q9BS18
Ashwin (C2orf49) Ashwin family Q9BVC5
Augurin (ECRG4) Augurin family Q9H1Z8
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Bcl-2-modifying factor (BMF) Bcl-2 family Q96LC9
Nuclear nucleic acid-binding protein C1D (C1D) C1D family Q13901
Fatty acid-binding protein, brain (FABP7) Fatty-acid binding protein (FABP) family O15540
Protein canopy homolog 3 (CNPY3) Canopy family Q9BT09
Cbp/p300-interacting transactivator 2 (CITED2) CITED family Q99967
Protein CMSS1 (CMSS1) CMS1 family Q9BQ75
Cysteine-rich PDZ-binding protein (CRIPT) CRIPT family Q9P021
COP9 signalosome complex subunit 2 (COPS2) CSN2 family P61201
G1/S-specific cyclin-E2 (CCNE2) Cyclin family O96020
Cytoplasmic FMR1-interacting protein 1 (CYFIP1) CYFIP family Q7L576
Cystatin-A (CSTA) Cystatin family P01040
Protein dispatched homolog 1 (DISP1) Dispatched family Q96F81
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Dynein light chain Tctex-type 1 (DYNLT1) Dynein light chain Tctex-type family P63172
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2) EPS8 family Q9H6S3
Epithelial splicing regulatory protein 1 (ESRP1) ESRP family Q6NXG1
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Protein FAM163A (FAM163A) FAM163 family Q96GL9
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM74A4/A6 (FAM74A4; FAM74A6) FAM74 family Q5TZK3
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Protein FAM98C (FAM98C) FAM98 family Q17RN3
Ferritin light chain (FTL) Ferritin family P02792
Fibulin-5 (FBLN5) Fibulin family Q9UBX5
Putative golgin subfamily A member 2B (GOLGA2P5) GOLGA2 family Q9HBQ8
Iron-sulfur cluster assembly 2 homolog, mitochondrial (ISCA2) HesB/IscA family Q86U28
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Histone H3.3C (H3-5) Histone H3 family Q6NXT2
Inhibitor of growth protein 4 (ING4) ING family Q9UNL4
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin-like protein KRT222 (KRT222) Intermediate filament family Q8N1A0
Syncoilin (SYNC) Intermediate filament family Q9H7C4
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Lebercilin-like protein (LCA5L) LCA5 family O95447
Late cornified envelope protein 1B (LCE1B) LCE family Q5T7P3
Late cornified envelope protein 2A (LCE2A) LCE family Q5TA79
Repressor of RNA polymerase III transcription MAF1 homolog (MAF1) MAF1 family Q9H063
Protein PALS1 (PALS1) MAGUK family Q8N3R9
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Protein Mis18-beta (OIP5) Mis18 family O43482
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
NADH dehydrogenase 1 alpha subcomplex assembly factor 4 (NDUFAF4) NDUFAF4 family Q9P032
Palmdelphin (PALMD) Paralemmin family Q9NP74
Perilipin-2 (PLIN2) Perilipin family Q99541
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Polyadenylate-binding protein 3 (PABPC3) Polyadenylate-binding protein type-1 family Q9H361
Rhophilin-1 (RHPN1) RHPN family Q8TCX5
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Protein S100-P (S100P) S-100 family P25815
E-selectin (SELE) Selectin/LECAM family P16581
Ski-like protein (SKIL) SKI family P12757
SLIT and NTRK-like protein 3 (SLITRK3) SLITRK family O94933
Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) Small Tim family O60220
snRNA-activating protein complex subunit 3 (SNAPC3) SNAPC3/SRD2 family Q92966
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Synaptotagmin-3 (SYT3) Synaptotagmin family Q9BQG1
Syndecan-2 (SDC2) Syndecan proteoglycan family P34741
T-complex protein 1 subunit beta (CCT2) TCP-1 chaperonin family P78371
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
Transcription elongation factor A protein-like 4 (TCEAL4) TFS-II family Q96EI5
Transcription elongation factor A protein-like 8 (TCEAL8) TFS-II family Q8IYN2
Toll-like receptor 10 (TLR10) Toll-like receptor family Q9BXR5
Troponin I, cardiac muscle (TNNI3) Troponin I family P19429
Tubulin beta-6 chain (TUBB6) Tubulin family Q9BUF5
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) Ubiquitin family; Eukaryotic ribosomal protein eS31 family P62979
Large ribosomal subunit protein uL3 (RPL3) Universal ribosomal protein uL3 family P39023
Small ribosomal subunit protein uS17m (MRPS17) Universal ribosomal protein uS17 family Q9Y2R5
Small ribosomal subunit protein uS2 (RPSA) Universal ribosomal protein uS2 family P08865
Small ribosomal subunit protein uS8 (RPS15A) Universal ribosomal protein uS8 family P62244
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
WD40 repeat-containing protein SMU1 (SMU1) WD repeat SMU1 family Q2TAY7
Protein YIF1A (YIF1A) YIF1 family O95070
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
C-type lectin domain family 11 member A (CLEC11A) . Q9Y240
CAP-Gly domain-containing linker protein 3 (CLIP3) . Q96DZ5
Cell cycle and apoptosis regulator protein 2 (CCAR2) . Q8N163
Cell division cycle-associated protein 7 (CDCA7) . Q9BWT1
Chromatin complexes subunit BAP18 (BAP18) . Q8IXM2
Coiled-coil domain-containing protein 9 (CCDC9) . Q9Y3X0
DENN domain-containing protein 2B (DENND2B) . P78524
DnaJ homolog subfamily C member 4 (DNAJC4) . Q9NNZ3
Endothelial cell-specific molecule 1 (ESM1) . Q9NQ30
Ephexin-1 (NGEF) . Q8N5V2
Erythroid differentiation-related factor 1 (EDRF1) . Q3B7T1
F-box only protein 4 (FBXO4) . Q9UKT5
F-box only protein 42 (FBXO42) . Q6P3S6
F-box/WD repeat-containing protein 1A (BTRC) . Q9Y297
Fanconi anemia group G protein (FANCG) . O15287
Fibronectin type 3 and ankyrin repeat domains protein 1 (FANK1) . Q8TC84
FMR1-interacting protein NUFIP2 (NUFIP2) . Q7Z417
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Galectin-8 (LGALS8) . O00214
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) . O14979
Huntingtin-interacting protein M (H2AP) . O75409
Insulin-like growth factor-binding protein 4 (IGFBP4) . P22692
IQ domain-containing protein F2 (IQCF2) . Q8IXL9
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Ligand of Numb protein X 2 (LNX2) . Q8N448
Male-specific lethal 3 homolog (MSL3) . Q8N5Y2
Melanoma-associated antigen B18 (MAGEB18) . Q96M61
Methyl-CpG-binding protein 2 (MECP2) . P51608
Methylosome protein WDR77 (WDR77) . Q9BQA1
Myosin regulatory light chain 11 (MYL11) . Q96A32
Necdin (NDN) . Q99608
Period circadian protein homolog 1 (PER1) . O15534
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) . Q6ZR37
Protein FAM117B (FAM117B) . Q6P1L5
Protein SIX6OS1 (SIX6OS1) . Q8N1H7
Pumilio homolog 1 (PUM1) . Q14671
Putative BPES syndrome breakpoint region protein (BPESC1) . Q9GZL8
Putative insulin-like growth factor 2-associated protein . P09565
Putative uncharacterized protein RUSC1-AS1 (RUSC1-AS1) . Q66K80
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3
Ribonuclease inhibitor (RNH1) . P13489
RNA-binding protein 14 (RBM14) . Q96PK6
SAP domain-containing ribonucleoprotein (SARNP) . P82979
Serine protease inhibitor Kazal-type 2 (SPINK2) . P20155
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) . Q96B97
Shieldin complex subunit 1 (SHLD1) . Q8IYI0
Spermatogenesis-associated protein 8 (SPATA8) . Q6RVD6
Splicing factor 45 (RBM17) . Q96I25
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698
Sterile alpha motif domain-containing protein 7 (SAMD7) . Q7Z3H4
Steroid receptor-associated and regulated protein (SRARP) . Q8NEQ6
Synaptonemal complex central element protein 3 (SYCE3) . A1L190
Telomeric repeat-binding factor 1 (TERF1) . P54274
Testis-expressed protein 19 (TEX19) . Q8NA77
Tetratricopeptide repeat protein 1 (TTC1) . Q99614
Transmembrane protein 61 (TMEM61) . Q8N0U2
Ubiquitin-associated domain-containing protein 1 (UBAC1) . Q9BSL1
Uncharacterized protein C7orf50 (C7orf50) . Q9BRJ6
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52
Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1) . Q8TBF4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840