Details of the Target

General Information of Target

Target ID LDTP05871
Target Name Protein OS-9 (OS9)
Gene Name OS9
Gene ID 10956
Synonyms
Protein OS-9; Amplified in osteosarcoma 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV
VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY
EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK
CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA
PQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGAS
PTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIR
SPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDED
EDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGL
KKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHR
VRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWA
EGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTG
DLDEFDF
Target Bioclass
Transporter and channel
Family
OS-9 family
Subcellular location
Endoplasmic reticulum lumen
Function
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.
Uniprot ID
Q13438
Ensemble ID
ENST00000257966.13
HGNC ID
HGNC:16994

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K266N .
HT SNV: p.Y255C .
OVCAR5 SNV: p.Q262K .
SKMEL30 SNV: p.L227F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K163(4.55); K373(6.51)  LDD0277  [1]
ONAyne
 Probe Info  		K373(1.37)  LDD0275  [1]
DBIA
 Probe Info  		C181(3.27)  LDD3311  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_5
 Probe Info  		C181(0.00); C228(0.00); C73(0.00); C246(0.00)  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.84  LDD1725  [6]
C106
 Probe Info  		35.51  LDD1793  [6]
C107
 Probe Info  		7.11  LDD1794  [6]
C108
 Probe Info  		10.06  LDD1795  [6]
C210
 Probe Info  		39.95  LDD1884  [6]
C289
 Probe Info  		30.48  LDD1959  [6]
C362
 Probe Info  		30.48  LDD2023  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C110(0.99)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C110(1.03)  LDD1508  [7]
 LDCM0276  AC17 HEK-293T C110(0.88)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C110(1.03)  LDD1516  [7]
 LDCM0279  AC2 HEK-293T C110(1.02)  LDD1518  [7]
 LDCM0281  AC21 HEK-293T C110(0.98)  LDD1520  [7]
 LDCM0285  AC25 HEK-293T C110(0.96)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C110(1.03)  LDD1525  [7]
 LDCM0289  AC29 HEK-293T C110(0.98)  LDD1528  [7]
 LDCM0294  AC33 HEK-293T C110(0.99)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C110(1.07)  LDD1534  [7]
 LDCM0298  AC37 HEK-293T C110(1.17)  LDD1537  [7]
 LDCM0303  AC41 HEK-293T C110(1.03)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C110(1.10)  LDD1543  [7]
 LDCM0307  AC45 HEK-293T C110(1.11)  LDD1546  [7]
 LDCM0311  AC49 HEK-293T C110(0.95)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C110(1.07)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C110(1.09)  LDD1552  [7]
 LDCM0316  AC53 HEK-293T C110(0.98)  LDD1555  [7]
 LDCM0320  AC57 HEK-293T C110(0.93)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C110(0.99)  LDD1560  [7]
 LDCM0325  AC61 HEK-293T C110(1.02)  LDD1564  [7]
 LDCM0248  AKOS034007472 HEK-293T C110(1.00)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C110(1.02)  LDD1570  [7]
 LDCM0404  CL17 HEK-293T C110(0.94)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C110(1.05)  LDD1609  [7]
 LDCM0409  CL21 HEK-293T C110(1.15)  LDD1613  [7]
 LDCM0417  CL29 HEK-293T C110(0.94)  LDD1621  [7]
 LDCM0419  CL30 HEK-293T C110(0.98)  LDD1623  [7]
 LDCM0422  CL33 HEK-293T C110(1.30)  LDD1626  [7]
 LDCM0431  CL41 HEK-293T C110(0.94)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C110(1.12)  LDD1636  [7]
 LDCM0435  CL45 HEK-293T C110(1.10)  LDD1639  [7]
 LDCM0440  CL5 HEK-293T C110(0.94)  LDD1644  [7]
 LDCM0444  CL53 HEK-293T C110(1.08)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C110(1.31)  LDD1648  [7]
 LDCM0448  CL57 HEK-293T C110(1.18)  LDD1651  [7]
 LDCM0451  CL6 HEK-293T C110(1.17)  LDD1654  [7]
 LDCM0457  CL65 HEK-293T C110(0.97)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C110(1.09)  LDD1661  [7]
 LDCM0461  CL69 HEK-293T C110(1.24)  LDD1664  [7]
 LDCM0470  CL77 HEK-293T C110(1.19)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C110(0.99)  LDD1674  [7]
 LDCM0475  CL81 HEK-293T C110(1.14)  LDD1678  [7]
 LDCM0483  CL89 HEK-293T C110(0.98)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C110(1.13)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C110(1.24)  LDD1688  [7]
 LDCM0488  CL93 HEK-293T C110(1.19)  LDD1691  [7]
 LDCM0022  KB02 A2058 C181(2.89)  LDD2253  [2]
 LDCM0023  KB03 A2058 C181(3.46)  LDD2670  [2]
 LDCM0024  KB05 G361 C181(3.27)  LDD3311  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Egl nine homolog 1 (EGLN1) . Q9GZT9
Prolyl hydroxylase EGLN3 (EGLN3) . Q9H6Z9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein sel-1 homolog 1 (SEL1L) Sel-1 family Q9UBV2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402