Details of the Target

General Information of Target

Target ID LDTP10769
Target Name Intermembrane lipid transfer protein VPS13A (VPS13A)
Gene Name VPS13A
Gene ID 23230
Synonyms
CHAC; KIAA0986; Intermembrane lipid transfer protein VPS13A; Chorea-acanthocytosis protein; Chorein; Vacuolar protein sorting-associated protein 13A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPR
DGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRD
AQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFN
WAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQ
RTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWV
LQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRV
MVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGV
LELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHCSCSSQAS
PAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGA
QSGSVFQLLPGKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQD
VPSTLGPISQGHQHECSAGSSQDHPPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQ
EAPSTTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK
Target Bioclass
Transporter and channel
Family
VPS13 family
Subcellular location
Mitochondrion outer membrane
Function
Mediates the transfer of lipids between membranes at organelle contact sites. Binds phospholipids. Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria. Negatively regulates lipid droplet size and motility. Required for efficient lysosomal protein degradation.
Uniprot ID
Q96RL7
Ensemble ID
ENST00000360280.8
HGNC ID
HGNC:1908

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.F1871V DBIA    Probe Info 
CAL72 SNV: p.L1151F .
COLO792 SNV: p.K1391T DBIA    Probe Info 
CORL88 SNV: p.R13G DBIA    Probe Info 
DAOY SNV: p.E840V DBIA    Probe Info 
DU145 SNV: p.V805F DBIA    Probe Info 
EFO27 Deletion: p.K372SfsTer2
SNV: p.E1734D		 DBIA    Probe Info 
HEC1 Deletion: p.Y2885MfsTer20
SNV: p.R2700H		 DBIA    Probe Info 
HEC1B Deletion: p.Y2885MfsTer20
SNV: p.R2700H		 .
HEP3B217 SNV: p.N1099Y DBIA    Probe Info 
HT Deletion: p.S1752QfsTer10 DBIA    Probe Info 
HT115 SNV: p.R3037Q .
IGROV1 Deletion: p.Y2885MfsTer20
SNV: p.L1097P		 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Y1304C DBIA    Probe Info 
JURKAT Deletion: p.D2086IfsTer3 .
LUDLU1 SNV: p.V1605L DBIA    Probe Info 
MFE296 Insertion: p.Y2885LfsTer2 DBIA    Probe Info 
OVISE SNV: p.V948I DBIA    Probe Info 
SKN SNV: p.S2783T .
SKNAS SNV: p.I3014V DBIA    Probe Info 
SUPT1 SNV: p.P378L DBIA    Probe Info 
TKKK SNV: p.V305L DBIA    Probe Info 
WM1552C SNV: p.T535I DBIA    Probe Info 
WM2664 Insertion: p.V1653GfsTer20 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K2235(1.29)  LDD0277  [1]
BTD
 Probe Info  		C1608(0.97)  LDD2117  [2]
NAIA_5
 Probe Info  		C1626(20.00)  LDD2227  [3]
DBIA
 Probe Info  		C1608(1.11)  LDD0593  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
TFBX
 Probe Info  		C582(0.00); C1608(0.00); C1626(0.00); C1456(0.00)  LDD0148  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		10.70  LDD1728  [10]
C056
 Probe Info  		33.13  LDD1753  [10]
C063
 Probe Info  		15.45  LDD1760  [10]
C070
 Probe Info  		11.55  LDD1766  [10]
C106
 Probe Info  		25.11  LDD1793  [10]
C107
 Probe Info  		5.62  LDD1794  [10]
C108
 Probe Info  		11.16  LDD1795  [10]
C169
 Probe Info  		21.71  LDD1849  [10]
C201
 Probe Info  		29.24  LDD1877  [10]
C228
 Probe Info  		17.63  LDD1901  [10]
C304
 Probe Info  		14.52  LDD1973  [10]
C349
 Probe Info  		9.06  LDD2010  [10]
C362
 Probe Info  		25.28  LDD2023  [10]
C382
 Probe Info  		8.75  LDD2041  [10]
C388
 Probe Info  		43.71  LDD2047  [10]
C399
 Probe Info  		8.75  LDD2058  [10]
C403
 Probe Info  		27.28  LDD2061  [10]
C407
 Probe Info  		14.12  LDD2064  [10]
FFF probe11
 Probe Info  		20.00  LDD0471  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1608(0.97)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C1608(1.04)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C1456(1.13); C1608(0.98); C1626(1.13); C1848(0.58)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C1608(1.05); C1848(0.96)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C1608(1.21); C1848(1.15)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C1608(1.04); C1848(1.04)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C1608(1.18); C1848(0.98)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C1608(1.10); C1848(0.99)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C1608(1.30); C1848(1.06)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C1608(1.45); C1848(1.20)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C1608(0.95); C1848(0.91)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C1608(1.03); C1848(0.96)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C1608(0.89); C1848(0.78)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C1456(1.06); C1608(0.94); C1626(1.06); C1848(0.81)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C1608(0.81); C1848(0.77)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C1608(1.22); C1848(1.03)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C1608(1.05); C1848(0.91)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C1456(1.03); C1626(1.03); C1848(1.09)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C1456(1.00); C1626(1.00); C1848(1.34)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C1456(0.96); C1626(0.96); C1848(1.23)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C1456(0.95); C1626(0.95); C1848(0.97)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C1456(0.87); C1626(0.87); C1848(0.73)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C1456(0.74); C1626(0.74); C1848(0.65)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C1456(0.63); C1626(0.63); C1848(0.78)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C1456(0.77); C1608(0.92); C1626(0.77); C1848(0.83)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C1456(0.67); C1626(0.67); C1848(0.69)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C1456(0.68); C1626(0.68); C1848(0.81)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C1456(0.66); C1626(0.66); C1848(0.82)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C1456(0.61); C1626(0.61); C1848(0.95)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C1456(0.69); C1626(0.69); C1848(0.87)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C1456(0.63); C1626(0.63); C1848(0.81)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C1456(0.57); C1626(0.57); C1848(0.91)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C1456(0.60); C1626(0.60); C1848(0.86)  LDD0843  [4]
 LDCM0246  AC128 PaTu 8988t C1626(1.04)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C1626(0.99)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C1626(1.13)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C1626(1.08)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C1626(1.11)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C1626(1.02)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C1626(1.04)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C1626(1.08)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C1626(1.05)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C1626(1.08)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C1626(1.07)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C1626(1.23)  LDD1137  [4]
 LDCM0259  AC14 HEK-293T C1456(0.92); C1608(1.16); C1626(0.92); C1848(0.63)  LDD0857  [4]
 LDCM0260  AC140 PaTu 8988t C1626(0.97)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C1626(1.04)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C1626(1.03)  LDD1141  [4]
 LDCM0263  AC143 HEK-293T C1608(0.74); C1848(0.61)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C1608(0.76); C1848(0.83)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C1608(0.70); C1848(0.91)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C1608(0.72); C1848(0.77)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C1608(0.66); C1848(0.63)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C1608(0.62); C1848(0.71)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C1608(0.76); C1848(0.75)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C1456(0.64); C1608(0.92); C1626(0.64); C1848(0.49)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C1608(0.68); C1848(0.77)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C1608(0.73); C1848(0.85)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C1608(0.68); C1848(0.73)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C1608(0.69); C1848(0.71)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C1608(0.79); C1848(0.91)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C1608(0.69); C1848(0.77)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C1608(0.78); C1848(0.91)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C1608(0.91); C1848(0.87)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C1608(1.11)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C1608(1.10)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C1608(0.99)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C1608(1.09)  LDD0877  [4]
 LDCM0280  AC20 HCT 116 C1608(1.00)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C1608(1.13)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C1608(1.10)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C1608(1.02)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C1608(1.05)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C1456(0.64); C1626(0.64)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C1456(0.53); C1626(0.53)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C1456(0.55); C1626(0.55)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C1456(0.77); C1626(0.77)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C1456(0.60); C1626(0.60)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C1608(1.07)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C1456(0.61); C1626(0.61)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C1456(0.83); C1626(0.83)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C1456(0.70); C1626(0.70)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C1456(0.67); C1626(0.67)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C1456(0.78); C1626(0.78)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C1608(0.92)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C1608(0.89)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C1608(0.90)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C1608(0.96)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C1608(1.02)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C1608(0.94)  LDD0899  [4]
 LDCM0302  AC40 HCT 116 C1608(1.02)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C1608(0.89)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C1608(1.01)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C1608(0.99)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C1608(1.04)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C1608(1.11)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C1608(1.00)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C1608(1.08)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C1608(1.07)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C1608(1.23)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C1608(1.03)  LDD0910  [4]
 LDCM0313  AC50 HCT 116 C1608(1.21)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C1608(0.89)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C1608(1.04)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C1608(1.09)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C1608(1.06)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C1608(1.15)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C1608(1.30)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C1608(1.06)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C1608(1.08)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C1608(1.25)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C1456(1.16); C1608(1.10); C1626(1.16); C1848(0.87)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C1608(1.05)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C1608(1.04)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C1608(1.19)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C1608(1.01)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C1608(1.19)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C1608(1.67)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C1608(1.65)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C1608(1.74)  LDD0648  [4]
 LDCM0332  AC68 HEK-293T C1456(1.11); C1626(1.11); C1848(1.02)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C1456(1.06); C1626(1.06); C1848(1.05)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C1456(0.74); C1608(1.20); C1626(0.74); C1848(0.84)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C1456(0.75); C1626(0.75); C1848(0.90)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C1456(0.99); C1626(0.99); C1848(0.86)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C1456(0.90); C1626(0.90); C1848(1.07)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C1456(0.88); C1626(0.88); C1848(0.78)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C1456(0.81); C1626(0.81); C1848(0.89)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C1456(0.67); C1626(0.67); C1848(0.76)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C1456(0.84); C1626(0.84); C1848(0.86)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C1456(0.69); C1626(0.69); C1848(0.98)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C1456(0.70); C1626(0.70); C1848(1.01)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C1456(1.00); C1626(1.00); C1848(0.88)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C1456(0.60); C1608(1.23); C1626(0.60); C1848(0.79)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C1456(0.54); C1626(0.54); C1848(0.78)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C1456(0.72); C1626(0.72); C1848(0.84)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C1456(0.35); C1626(0.35); C1848(0.84)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C1456(0.96); C1626(0.96); C1848(0.91)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C1456(0.51); C1626(0.51); C1848(0.75)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C1456(0.62); C1626(0.62); C1848(0.90)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C1456(0.72); C1626(0.72); C1848(0.89)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C1456(0.61); C1626(0.61); C1848(0.70)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C1456(0.49); C1626(0.49); C1848(0.79)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C1456(0.45); C1626(0.45); C1848(0.63)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C1456(0.45); C1626(0.45); C1848(0.92)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C1456(0.56); C1626(0.56); C1848(0.95)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C1456(0.59); C1626(0.59); C1848(0.83)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C1456(0.54); C1626(0.54); C1848(0.76)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C1456(0.36); C1626(0.36); C1848(0.64)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C1456(0.47); C1626(0.47); C1848(0.66)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C1456(0.42); C1626(0.42); C1848(0.66)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C1456(0.39); C1626(0.39); C1848(0.61)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C1608(0.91); C1848(0.86)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C1608(1.71); C1848(1.30)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C1456(0.77); C1608(1.06); C1626(0.77); C1848(0.76)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C1456(0.51); C1608(1.06); C1626(0.51); C1848(0.44)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C1456(0.60); C1608(0.85); C1626(0.60); C1848(0.71)  LDD0873  [4]
 LDCM0632  CL-Sc Hep-G2 C1626(20.00)  LDD2227  [3]
 LDCM0367  CL1 HCT 116 C1608(1.04)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C1608(1.09)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C1608(0.95)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C1456(0.62); C1608(1.24); C1626(0.62); C1848(0.71)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C1456(0.51); C1608(1.00); C1626(0.51); C1848(0.61)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C1456(0.57); C1608(1.38); C1626(0.57); C1848(0.69)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C1456(0.71); C1608(1.25); C1626(0.71); C1848(0.57)  LDD0971  [4]
 LDCM0374  CL105 HCT 116 C1608(1.06)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C1608(1.15)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C1608(1.28)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C1608(1.38)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C1608(1.06)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C1608(1.20)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C1608(1.02)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C1608(1.02)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C1456(0.51); C1626(0.51)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C1456(0.69); C1626(0.69)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C1456(0.30); C1626(0.30)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C1456(0.58); C1626(0.58)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C1456(0.51); C1626(0.51)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C1608(1.18)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C1608(1.03)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C1608(0.96)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C1608(1.28)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C1608(0.98)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C1608(0.60)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C1608(1.07)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C1608(1.14)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C1608(1.12)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C1608(1.14)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C1608(0.94)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C1608(0.89)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C1608(1.16)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C1608(1.06)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C1608(1.06)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C1608(1.05)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C1608(1.13); C1626(1.28); C1848(1.25)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C1608(1.45); C1626(0.75); C1848(1.21)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C1608(1.08); C1626(0.81); C1848(0.98)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C1608(1.05); C1626(1.04); C1848(1.22)  LDD1004  [4]
 LDCM0407  CL2 HCT 116 C1608(1.09)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C1608(1.56); C1626(0.82); C1848(1.29)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C1608(0.95); C1626(0.71); C1848(0.86)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C1608(1.04); C1626(0.84); C1848(1.08)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C1608(1.34); C1626(1.07); C1848(1.21)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C1608(1.32); C1626(0.70); C1848(1.13)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C1608(1.28); C1626(0.91); C1848(1.12)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C1608(1.05); C1626(0.87); C1848(1.03)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C1608(1.19); C1626(1.28); C1848(1.23)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C1608(1.42); C1626(0.80); C1848(1.21)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C1608(1.45); C1626(0.76); C1848(1.24)  LDD1015  [4]
 LDCM0418  CL3 HCT 116 C1608(1.02)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C1608(1.02); C1626(0.90); C1848(1.13)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C1848(0.90)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C1848(0.83)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C1848(0.62)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C1848(0.67)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C1848(0.80)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C1848(0.71)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C1848(0.83)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C1848(0.52)  LDD1026  [4]
 LDCM0429  CL4 HCT 116 C1608(1.00)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C1848(0.67)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C1848(0.48)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C1848(0.53)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C1848(0.45)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C1848(0.70)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C1848(0.53)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C1456(0.65); C1626(0.78); C1848(1.02)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C1456(0.93); C1626(0.96); C1848(0.99)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C1456(1.07); C1626(1.00); C1848(1.25)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C1456(0.76); C1626(1.04); C1848(1.00)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C1608(1.06)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C1456(0.57); C1626(0.75); C1848(0.74)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C1456(0.70); C1626(0.83); C1848(0.69)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C1456(1.41); C1626(1.32); C1848(1.20)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C1456(1.01); C1626(1.12); C1848(0.82)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C1456(0.75); C1626(0.87); C1848(0.79)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C1456(0.87); C1626(0.91); C1848(0.73)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C1456(1.27); C1626(1.17); C1848(1.06)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C1456(0.82); C1626(0.96); C1848(0.70)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C1456(1.13); C1626(1.10); C1848(0.72)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C1456(0.71); C1626(0.87); C1848(0.78)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C1608(1.07)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C1456(0.59); C1626(0.71); C1848(0.74)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C1848(1.15)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C1848(0.85)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C1848(0.86)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C1848(0.84)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C1848(0.74)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C1848(0.97)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C1848(0.72)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C1848(0.64)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C1848(0.74)  LDD1059  [4]
 LDCM0462  CL7 HCT 116 C1608(1.16)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C1848(0.69)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C1848(0.64)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C1848(1.21)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C1848(0.73)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C1848(0.69)  LDD1065  [4]
 LDCM0469  CL76 PaTu 8988t C1626(0.94)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C1626(0.92)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C1626(0.94)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C1626(0.87)  LDD1351  [4]
 LDCM0473  CL8 HCT 116 C1608(1.26)  LDD0790  [4]
 LDCM0474  CL80 PaTu 8988t C1626(0.87)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C1626(0.99)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C1626(0.96)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C1626(0.83)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C1626(0.99)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C1626(0.91)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C1626(0.89)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C1626(1.08)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C1626(0.93)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C1626(0.95)  LDD1362  [4]
 LDCM0484  CL9 HCT 116 C1608(1.13)  LDD0801  [4]
 LDCM0485  CL90 PaTu 8988t C1626(1.08)  LDD1364  [4]
 LDCM0486  CL91 HEK-293T C1608(0.92)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C1608(0.86)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C1608(1.04)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C1608(0.85)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C1608(0.95)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C1608(0.97)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C1608(0.96)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C1608(0.98)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C1608(0.99)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C1070(1.18); C1608(1.04); C1626(1.02); C2343(0.80)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1608(1.61)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C1848(0.53)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C1848(0.67)  LDD1025  [4]
 LDCM0022  KB02 HEK-293T C1070(1.08); C1608(0.94); C1626(0.91); C2343(1.05)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C1070(1.02); C1608(0.93); C1626(0.94); C2343(1.02)  LDD1497  [12]
 LDCM0024  KB05 G361 C1608(3.91); C1070(2.28); C1626(3.01); C2377(1.25)  LDD3311  [13]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1608(0.95)  LDD2120  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1608(0.99)  LDD2143  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840