Details of the Target

General Information of Target

Target ID LDTP12790
Target Name Glutaminyl-peptide cyclotransferase-like protein (QPCTL)
Gene Name QPCTL
Gene ID 54814
Synonyms
Glutaminyl-peptide cyclotransferase-like protein; EC 2.3.2.5; Golgi-resident glutaminyl-peptide cyclotransferase; isoQC; gQC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREE
QMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILE
RRSLELDTPSQPVNNHHAHSHTPVEKRKYNPTSHHTTTDHIPEKKFKSEALLSTLTSDAS
KENTLGCRNNNSTASSNNAYNVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMK
EGRRTSSLKASYEAFKNNDFQLGKEFSMARETVGYSSSSALMTTLTQNASSSAADSRSGR
KSKNNNKSSSQQSSSSSSSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEP
RYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
Target Bioclass
Enzyme
Family
Glutaminyl-peptide cyclotransferase family
Subcellular location
Golgi apparatus membrane
Function Responsible for the biosynthesis of pyroglutamyl peptides.
Uniprot ID
Q9NXS2
Ensemble ID
ENST00000012049.10
HGNC ID
HGNC:25952
ChEMBL ID
CHEMBL3638349

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.V312M .
SUPT1 SNV: p.T285M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		H252(0.00); H162(0.00)  LDD0227  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		66.26  LDD1793  [4]
C107
 Probe Info  		20.97  LDD1794  [4]
C108
 Probe Info  		16.56  LDD1795  [4]
C252
 Probe Info  		11.08  LDD1925  [4]
C388
 Probe Info  		79.34  LDD2047  [4]
VE-P
 Probe Info  		N.A.  LDD0396  [5]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [6]
OEA-DA
 Probe Info  		20.00  LDD0046  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa H252(0.00); H162(0.00)  LDD0227  [1]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Olfactomedin-4 (OLFM4) . Q6UX06
TPA-induced transmembrane protein (TTMP) . Q5BVD1

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
6 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
7 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570