Details of the Target

General Information of Target

Target ID LDTP10699
Target Name E3 ubiquitin-protein ligase NEDD4-like (NEDD4L)
Gene Name NEDD4L
Gene ID 23327
Synonyms
KIAA0439; NEDL3; E3 ubiquitin-protein ligase NEDD4-like; EC 2.3.2.26; EC 2.3.2.36; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; Nedd4-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFD
YDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLI
DPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKH
KSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWN
ELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKII
SVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQL
LCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSAST
ESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHG
RSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALN
CDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSS
HGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSG
TTKRPISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEG
PNFLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYI
MIPNEILQTLLDLFFPGYSKGR
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes. Involved in the regulation of TOR signaling. Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF. Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3.
Uniprot ID
Q96PU5
Ensemble ID
ENST00000256830.13
HGNC ID
HGNC:7728

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.V108L .
HLF SNV: p.L899V .
HT SNV: p.L764R .
IPC298 SNV: p.I558M .
LNCaP clone FGC SNV: p.W884Ter .
LS180 SNV: p.Y756C .
MDAMB231 SNV: p.P293Q .
NCIH146 SNV: p.P385Q .
RL952 SNV: p.I744M .
SNU869 SNV: p.G6R .
UACC62 SNV: p.Q491H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.93  LDD0402  [1]
STPyne
 Probe Info  		K143(10.00); K489(4.17); K531(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y593(8.31)  LDD3495  [3]
HHS-482
 Probe Info  		Y210(1.01)  LDD0285  [4]
HHS-475
 Probe Info  		Y210(1.05)  LDD0264  [5]
DBIA
 Probe Info  		C874(1.07)  LDD0078  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.36  LDD1714  [9]
C071
 Probe Info  		13.83  LDD1767  [9]
C092
 Probe Info  		25.11  LDD1783  [9]
C106
 Probe Info  		25.28  LDD1793  [9]
C134
 Probe Info  		39.95  LDD1816  [9]
C158
 Probe Info  		10.56  LDD1838  [9]
C159
 Probe Info  		9.92  LDD1839  [9]
C161
 Probe Info  		15.03  LDD1841  [9]
C178
 Probe Info  		37.27  LDD1857  [9]
C201
 Probe Info  		39.67  LDD1877  [9]
C206
 Probe Info  		35.51  LDD1881  [9]
C210
 Probe Info  		59.71  LDD1884  [9]
C243
 Probe Info  		19.03  LDD1916  [9]
C244
 Probe Info  		15.67  LDD1917  [9]
C249
 Probe Info  		12.64  LDD1922  [9]
C305
 Probe Info  		24.59  LDD1974  [9]
C310
 Probe Info  		9.78  LDD1977  [9]
C338
 Probe Info  		23.26  LDD2001  [9]
C350
 Probe Info  		26.54  LDD2011  [9]
C353
 Probe Info  		33.82  LDD2014  [9]
C363
 Probe Info  		19.16  LDD2024  [9]
C364
 Probe Info  		35.26  LDD2025  [9]
C366
 Probe Info  		6.41  LDD2027  [9]
C367
 Probe Info  		34.78  LDD2028  [9]
C378
 Probe Info  		8.40  LDD2037  [9]
C380
 Probe Info  		30.27  LDD2039  [9]
C383
 Probe Info  		12.73  LDD2042  [9]
C395
 Probe Info  		7.16  LDD2054  [9]
C419
 Probe Info  		13.83  LDD2074  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C874(0.86); C942(0.75)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C942(0.99)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C874(1.19); C942(1.02)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C874(1.50); C942(1.13)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C874(1.22); C942(1.29)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C874(1.52); C942(1.44)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C874(1.18); C942(1.19)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C874(1.22); C942(1.22)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C874(1.57); C942(1.29)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C874(1.35); C942(1.25)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C874(1.08); C942(1.18)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C874(0.82); C942(0.92)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C942(0.72)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C874(1.62); C942(1.17)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C874(1.25); C942(1.17)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C874(1.29); C942(1.05)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C874(0.85); C942(0.93)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C874(0.91); C942(1.22)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C874(0.95); C942(0.95)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C874(0.91); C942(1.43)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C874(0.89); C942(1.17)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C874(1.01); C942(0.96)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C874(1.13); C942(1.71)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C942(0.84)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C874(1.04); C942(1.92)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C874(1.05); C942(1.23)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C874(1.13); C942(1.27)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C874(0.94); C942(0.90)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C874(1.00); C942(1.16)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C874(1.03); C942(1.23)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C874(1.02); C942(1.18)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C874(0.91); C942(1.39)  LDD0562  [6]
 LDCM0246  AC128 PaTu 8988t C942(1.05)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C942(1.38)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C942(1.31)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C942(1.12)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C942(1.15)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C942(1.40)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C942(1.33)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C942(1.37)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C942(1.11)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C942(1.33)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C942(1.23)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C942(1.09)  LDD1137  [6]
 LDCM0259  AC14 HCT 116 C942(0.87)  LDD0576  [6]
 LDCM0260  AC140 PaTu 8988t C942(1.23)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C942(1.27)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C942(1.46)  LDD1141  [6]
 LDCM0263  AC143 HCT 116 C942(1.09)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C942(0.97)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C942(0.98)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C942(0.91)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C942(0.95)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C942(0.82)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C942(0.77)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C942(0.92)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C942(0.80)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C942(0.93)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C942(0.88)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C942(0.76)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C942(0.90)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C942(0.81)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C942(0.92)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C942(0.81)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C942(0.78); C874(1.01)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C942(0.61); C874(1.00)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C942(0.69); C874(1.13)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C874(0.88); C942(0.98)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C942(0.77); C874(1.27)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C942(0.74); C874(0.96)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C942(0.77); C874(1.04)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C942(0.72); C874(1.07)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C942(0.77); C874(1.20)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C942(0.85)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C942(0.89)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C942(0.84)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C942(0.78)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C942(1.25)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C874(0.78); C942(0.80)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C942(1.26)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C942(0.86)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C942(0.97)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C942(0.88)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C942(1.22)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C942(0.68)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C942(0.84)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C942(0.73)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C942(0.82)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C942(0.92)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C874(0.73); C942(0.74)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C942(0.81)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C942(0.86)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C942(0.77)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C942(0.82)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C942(0.80)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C942(0.67)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C942(1.15)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C942(1.09)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C942(1.26)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C942(1.52)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C942(0.85); C874(1.10)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C942(1.24)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C942(1.15)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C942(1.14)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C942(1.01)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C942(1.17)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C942(0.94)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C942(1.11)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C942(1.20)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C942(1.16)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C942(1.05)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C942(0.93)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C942(1.06)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C942(0.89)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C942(1.06)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C942(0.84)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C942(0.72)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C942(1.04)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C942(1.01)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C942(0.99)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C942(0.92)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C942(0.80)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C942(1.27)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C942(1.03)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C942(0.80)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C942(0.91)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C942(1.02)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C942(0.77)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C942(0.96)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C942(0.83)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C942(0.89)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C942(0.85)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C942(0.87)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C942(1.24)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C942(0.69)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C942(0.74)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C942(0.80)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C942(1.21)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C942(1.14)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C942(1.07)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C942(1.07)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C942(1.18)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C942(1.11)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C942(0.96)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C942(1.13)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C942(1.33)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C942(1.03)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C942(1.01)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C942(1.12)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C942(1.26)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C942(1.01)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C942(1.11)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C942(1.31); C874(1.81)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C942(1.15); C874(1.63)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C942(0.86)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C942(0.85)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C942(1.10)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 10.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C874(1.07)  LDD0078  [6]
 LDCM0367  CL1 HCT 116 C942(1.23)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C942(1.12)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C874(0.75); C942(0.85)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C942(0.88)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C942(0.74)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C942(0.75)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C942(1.04)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C942(0.60); C874(0.96)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C942(0.70); C874(0.79)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C942(0.77); C874(0.96)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C942(0.75); C874(0.91)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C942(0.76); C874(1.21)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C942(1.09)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C942(0.81); C874(0.85)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C942(0.96); C874(1.04)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C942(0.96)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C942(1.14)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C942(1.24)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C942(1.19)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C942(0.90)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C942(0.83)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C942(0.81)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C942(0.75)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C942(1.02)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C942(0.85)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C942(1.11)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C942(1.27)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C942(1.02)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C942(1.22)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C942(1.14)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C942(1.19)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C942(0.89)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C942(1.03)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C942(1.06)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C942(1.03)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C942(1.31)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C942(1.19)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C942(0.98)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C942(1.26)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C942(1.32)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C942(1.17)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C942(1.03)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C942(1.35)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C942(1.28)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C942(1.19)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C942(1.25)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C942(1.35)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C942(1.33)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C942(1.42)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C942(1.18)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C942(1.41)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C942(1.15)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C942(1.34)  LDD1298  [6]
 LDCM0420  CL31 HCT 116 C942(1.07)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C942(1.29)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C942(1.47)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C942(1.26)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C942(1.29)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C942(1.24)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C942(1.27)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C942(1.20)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C942(1.12)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C942(1.15)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C942(1.09)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C942(1.31)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C942(1.07)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C942(1.13)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C942(0.91)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C942(0.77)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C942(0.72)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C942(0.94)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C942(0.84)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C942(0.96)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C942(1.10)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C942(0.61)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C942(0.79)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C942(0.79)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C942(1.09)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C942(1.05)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C942(1.21)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C942(0.66)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C942(1.02)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C942(0.75)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C942(0.93)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C942(0.96)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C942(0.79)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C942(0.75)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C942(0.87)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C942(0.91)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C942(0.94)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C942(0.90)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C942(0.92)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C942(1.33)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C942(0.79)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C942(0.84)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C942(0.90)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C942(0.93)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C942(1.05)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C942(0.89)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C942(0.87)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C874(1.41); C942(1.03)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C874(2.72); C942(1.18)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C874(1.16); C942(1.03)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C874(1.21); C942(1.35)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C942(1.11)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C874(1.10); C942(1.45)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C874(1.15); C942(0.74)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C874(1.10); C942(0.77)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C874(1.36); C942(0.85)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C874(1.14); C942(1.22)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C874(1.30); C942(1.30)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C874(1.20); C942(0.96)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C874(1.34); C942(1.01)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C874(1.43); C942(1.07)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C874(0.97); C942(0.63)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C942(1.27)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C874(4.26); C942(1.45)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C874(1.07); C942(1.02)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C874(1.43); C942(1.22)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C874(1.05); C942(0.80)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C874(1.41); C942(0.79)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C874(1.48); C942(1.11)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C874(0.98); C942(0.96)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C874(1.44); C942(0.96)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C874(0.96); C942(0.87)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C874(0.87); C942(0.82)  LDD0811  [6]
 LDCM0468  Fragment33 HCT 116 C942(1.06)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C942(1.64)  LDD0744  [6]
 LDCM0116  HHS-0101 DM93 Y210(1.05)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y210(0.89)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y210(0.93)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y210(0.74)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y210(0.82); Y485(1.72)  LDD0268  [5]
 LDCM0123  JWB131 DM93 Y210(1.01)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y210(1.05)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y210(0.99)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y210(2.11)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y210(1.48)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y210(1.29)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y210(0.93)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y210(1.11)  LDD0292  [4]
 LDCM0022  KB02 22RV1 C341(1.75)  LDD2243  [10]
 LDCM0023  KB03 Jurkat C874(25.37)  LDD0209  [11]
 LDCM0024  KB05 NCI-H2052 C853(1.33)  LDD3353  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4) Commissureless family Q9BZD6
Transmembrane gamma-carboxyglutamic acid protein 2 (PRRG2) . O14669
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Natural resistance-associated macrophage protein 2 (SLC11A2) NRAMP family P49281
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 7 (SMAD7) Dwarfin/SMAD family O15105
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492
DAZ-associated protein 2 (DAZAP2) . Q15038

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.