Details of the Target

General Information of Target

Target ID LDTP04980
Target Name U6 snRNA-associated Sm-like protein LSm6 (LSM6)
Gene Name LSM6
Gene ID 11157
Synonyms
U6 snRNA-associated Sm-like protein LSm6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKY
GDAFIRGNNVLYISTQKRRM
Target Bioclass
Other
Family
SnRNP Sm proteins family, SmF/LSm6 subfamily
Subcellular location
Cytoplasm
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable).
Uniprot ID
P62312
Ensemble ID
ENST00000296581.11
HGNC ID
HGNC:17017

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.37  LDD0402  [1]
C-Sul
 Probe Info  		2.99  LDD0066  [2]
TH211
 Probe Info  		Y40(20.00)  LDD0257  [3]
STPyne
 Probe Info  		K5(6.25)  LDD0277  [4]
DBIA
 Probe Info  		C36(0.94)  LDD1492  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
HHS-482
 Probe Info  		Y40(1.14)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		20.68  LDD1816  [9]
C305
 Probe Info  		9.71  LDD1974  [9]
C423
 Probe Info  		10.41  LDD2078  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C36(1.07)  LDD1507  [5]
 LDCM0237  AC12 HEK-293T C36(0.87)  LDD1510  [5]
 LDCM0276  AC17 HEK-293T C36(0.94)  LDD1515  [5]
 LDCM0280  AC20 HEK-293T C36(1.10)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C36(0.96)  LDD1520  [5]
 LDCM0284  AC24 HEK-293T C36(1.07)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C36(0.97)  LDD1524  [5]
 LDCM0288  AC28 HEK-293T C36(0.85)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C36(1.00)  LDD1528  [5]
 LDCM0293  AC32 HEK-293T C36(0.99)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C36(1.09)  LDD1533  [5]
 LDCM0297  AC36 HEK-293T C36(0.97)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C36(1.08)  LDD1537  [5]
 LDCM0301  AC4 HEK-293T C36(1.15)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C36(0.97)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C36(0.94)  LDD1542  [5]
 LDCM0306  AC44 HEK-293T C36(0.85)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C36(1.03)  LDD1546  [5]
 LDCM0310  AC48 HEK-293T C36(1.01)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C36(0.97)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C36(0.96)  LDD1551  [5]
 LDCM0315  AC52 HEK-293T C36(1.11)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C36(0.92)  LDD1555  [5]
 LDCM0319  AC56 HEK-293T C36(1.03)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C36(1.09)  LDD1559  [5]
 LDCM0324  AC60 HEK-293T C36(0.79)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C36(1.01)  LDD1564  [5]
 LDCM0328  AC64 HEK-293T C36(0.97)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C36(0.89)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C36(1.09)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C36(1.05)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C36(1.11)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C36(1.01)  LDD1571  [5]
 LDCM0369  CL100 HEK-293T C36(0.87)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C36(0.80)  LDD1574  [5]
 LDCM0373  CL104 HEK-293T C36(1.26)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C36(1.10)  LDD1578  [5]
 LDCM0377  CL108 HEK-293T C36(0.91)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C36(1.06)  LDD1582  [5]
 LDCM0382  CL112 HEK-293T C36(0.95)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C36(1.20)  LDD1587  [5]
 LDCM0386  CL116 HEK-293T C36(0.97)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C36(0.85)  LDD1591  [5]
 LDCM0390  CL12 HEK-293T C36(0.66)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C36(1.11)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C36(1.21)  LDD1596  [5]
 LDCM0395  CL124 HEK-293T C36(1.19)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C36(0.82)  LDD1600  [5]
 LDCM0399  CL128 HEK-293T C36(1.32)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C36(0.97)  LDD1604  [5]
 LDCM0403  CL16 HEK-293T C36(0.96)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C36(0.88)  LDD1608  [5]
 LDCM0408  CL20 HEK-293T C36(1.07)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C36(0.79)  LDD1613  [5]
 LDCM0412  CL24 HEK-293T C36(0.66)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C36(0.78)  LDD1617  [5]
 LDCM0416  CL28 HEK-293T C36(0.85)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C36(1.01)  LDD1621  [5]
 LDCM0421  CL32 HEK-293T C36(0.73)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C36(0.77)  LDD1626  [5]
 LDCM0425  CL36 HEK-293T C36(0.66)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C36(0.92)  LDD1630  [5]
 LDCM0429  CL4 HEK-293T C36(0.98)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C36(1.02)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C36(0.89)  LDD1635  [5]
 LDCM0434  CL44 HEK-293T C36(0.89)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C36(0.96)  LDD1639  [5]
 LDCM0438  CL48 HEK-293T C36(0.55)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C36(1.09)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C36(0.89)  LDD1644  [5]
 LDCM0443  CL52 HEK-293T C36(0.88)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C36(0.89)  LDD1647  [5]
 LDCM0447  CL56 HEK-293T C36(0.89)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C36(0.78)  LDD1651  [5]
 LDCM0452  CL60 HEK-293T C36(0.64)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C36(0.85)  LDD1656  [5]
 LDCM0456  CL64 HEK-293T C36(0.90)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C36(0.92)  LDD1660  [5]
 LDCM0460  CL68 HEK-293T C36(0.96)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C36(0.88)  LDD1664  [5]
 LDCM0465  CL72 HEK-293T C36(0.68)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C36(1.36)  LDD1669  [5]
 LDCM0469  CL76 HEK-293T C36(1.09)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C36(0.78)  LDD1673  [5]
 LDCM0473  CL8 HEK-293T C36(0.79)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C36(0.85)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C36(0.98)  LDD1678  [5]
 LDCM0478  CL84 HEK-293T C36(0.97)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C36(1.36)  LDD1682  [5]
 LDCM0482  CL88 HEK-293T C36(0.95)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C36(0.91)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C36(0.95)  LDD1687  [5]
 LDCM0487  CL92 HEK-293T C36(0.72)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C36(0.92)  LDD1691  [5]
 LDCM0491  CL96 HEK-293T C36(0.87)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C36(0.92)  LDD1695  [5]
 LDCM0022  KB02 HEK-293T C36(0.94)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C36(1.20)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C36(1.00)  LDD1502  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methylosome subunit pICln (CLNS1A) PICln (TC 1.A.47) family P54105
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein PAT1 homolog 1 (PATL1) PAT1 family Q86TB9
Small nuclear ribonucleoprotein Sm D2 (SNRPD2) SnRNP core protein family P62316
U6 snRNA-associated Sm-like protein LSm1 (LSM1) SnRNP Sm proteins family O15116
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
U6 snRNA-associated Sm-like protein LSm3 (LSM3) SnRNP Sm proteins family P62310
U6 snRNA-associated Sm-like protein LSm5 (LSM5) SnRNP Sm proteins family Q9Y4Y9
U6 snRNA-associated Sm-like protein LSm7 (LSM7) SnRNP Sm proteins family Q9UK45
U6 snRNA-associated Sm-like protein LSm8 (LSM8) SnRNP Sm proteins family O95777

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Citric Acid Small molecular drug DB04272
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Uridine Small molecular drug DB02745
Uridine Monophosphate Small molecular drug DB03685

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587