Details of the Target
General Information of Target
Target ID | LDTP07054 | |||||
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Target Name | Exosome complex component MTR3 (EXOSC6) | |||||
Gene Name | EXOSC6 | |||||
Gene ID | 118460 | |||||
Synonyms |
MTR3; Exosome complex component MTR3; Exosome component 6; mRNA transport regulator 3 homolog; hMtr3; p11 |
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3D Structure | ||||||
Sequence |
MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGT
KVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEER ELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLV VGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEA VRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP |
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Target Bioclass |
Enzyme
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Family |
RNase PH family
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Subcellular location |
Cytoplasm
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Function |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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m-APA Probe Info |
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15.00 | LDD0402 | [1] | |
Probe 1 Probe Info |
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Y20(12.63); Y40(19.61) | LDD3495 | [2] | |
BTD Probe Info |
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C248(3.40); C117(1.14); C64(1.08) | LDD1700 | [3] | |
Sulforaphane-probe2 Probe Info |
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2.36 | LDD0160 | [4] | |
AHL-Pu-1 Probe Info |
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C117(7.70) | LDD0168 | [5] | |
HHS-475 Probe Info |
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Y20(0.76) | LDD0264 | [6] | |
DBIA Probe Info |
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C117(3.12) | LDD0080 | [7] | |
4-Iodoacetamidophenylacetylene Probe Info |
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C117(0.00); C248(0.00); C64(0.00) | LDD0038 | [8] | |
IA-alkyne Probe Info |
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C248(0.00); C64(0.00) | LDD0032 | [9] | |
Lodoacetamide azide Probe Info |
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C248(0.00); C64(0.00); C117(0.00) | LDD0037 | [8] | |
WYneO Probe Info |
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N.A. | LDD0022 | [10] | |
Compound 10 Probe Info |
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N.A. | LDD2216 | [11] | |
Compound 11 Probe Info |
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N.A. | LDD2213 | [11] | |
ENE Probe Info |
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N.A. | LDD0006 | [10] | |
IPM Probe Info |
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N.A. | LDD0005 | [10] | |
SF Probe Info |
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N.A. | LDD0028 | [12] | |
TFBX Probe Info |
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C117(0.00); C248(0.00) | LDD0148 | [13] | |
Phosphinate-6 Probe Info |
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N.A. | LDD0018 | [14] | |
1c-yne Probe Info |
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N.A. | LDD0228 | [15] | |
Acrolein Probe Info |
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C64(0.00); C117(0.00) | LDD0217 | [16] | |
Crotonaldehyde Probe Info |
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C248(0.00); C98(0.00); C64(0.00) | LDD0219 | [16] | |
Methacrolein Probe Info |
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C64(0.00); C248(0.00); C98(0.00) | LDD0218 | [16] | |
W1 Probe Info |
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N.A. | LDD0236 | [17] | |
AOyne Probe Info |
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12.40 | LDD0443 | [18] | |
NAIA_5 Probe Info |
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C98(0.00); C64(0.00); C117(0.00) | LDD2223 | [19] | |
HHS-465 Probe Info |
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N.A. | LDD2240 | [20] | |
HHS-482 Probe Info |
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Y20(0.77) | LDD2239 | [21] |
PAL-AfBPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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C305 Probe Info |
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9.58 | LDD1974 | [22] | |
C433 Probe Info |
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27.86 | LDD2088 | [22] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0548 | 1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one | MDA-MB-231 | C98(0.44); C117(1.14) | LDD2142 | [3] |
LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C98(0.54); C117(1.20); C64(0.79) | LDD2112 | [3] |
LDCM0537 | 2-Cyano-N,N-dimethylacetamide | MDA-MB-231 | C64(0.82) | LDD2130 | [3] |
LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C98(1.04); C117(1.13) | LDD2117 | [3] |
LDCM0558 | 2-Cyano-N-phenylacetamide | MDA-MB-231 | C64(1.14); C248(1.12) | LDD2152 | [3] |
LDCM0539 | 3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile | MDA-MB-231 | C64(0.52) | LDD2132 | [3] |
LDCM0538 | 4-(Cyanoacetyl)morpholine | MDA-MB-231 | C64(0.66) | LDD2131 | [3] |
LDCM0025 | 4SU-RNA | HEK-293T | C117(7.70) | LDD0168 | [5] |
LDCM0026 | 4SU-RNA+native RNA | HEK-293T | C117(3.19) | LDD0169 | [5] |
LDCM0214 | AC1 | HCT 116 | C117(0.99) | LDD0531 | [7] |
LDCM0215 | AC10 | HCT 116 | C117(1.09) | LDD0532 | [7] |
LDCM0216 | AC100 | HCT 116 | C117(1.21) | LDD0533 | [7] |
LDCM0217 | AC101 | HCT 116 | C117(1.26) | LDD0534 | [7] |
LDCM0218 | AC102 | HCT 116 | C117(1.08) | LDD0535 | [7] |
LDCM0219 | AC103 | HCT 116 | C117(1.13) | LDD0536 | [7] |
LDCM0220 | AC104 | HCT 116 | C117(0.89) | LDD0537 | [7] |
LDCM0221 | AC105 | HCT 116 | C117(1.09) | LDD0538 | [7] |
LDCM0222 | AC106 | HCT 116 | C117(1.07) | LDD0539 | [7] |
LDCM0223 | AC107 | HCT 116 | C117(1.01) | LDD0540 | [7] |
LDCM0224 | AC108 | HCT 116 | C117(1.03) | LDD0541 | [7] |
LDCM0225 | AC109 | HCT 116 | C117(0.76) | LDD0542 | [7] |
LDCM0226 | AC11 | HCT 116 | C117(1.11) | LDD0543 | [7] |
LDCM0227 | AC110 | HCT 116 | C117(1.06) | LDD0544 | [7] |
LDCM0228 | AC111 | HCT 116 | C117(1.15) | LDD0545 | [7] |
LDCM0229 | AC112 | HCT 116 | C117(1.10) | LDD0546 | [7] |
LDCM0230 | AC113 | HCT 116 | C117(0.98) | LDD0547 | [7] |
LDCM0231 | AC114 | HCT 116 | C117(1.03) | LDD0548 | [7] |
LDCM0232 | AC115 | HCT 116 | C117(0.92) | LDD0549 | [7] |
LDCM0233 | AC116 | HCT 116 | C117(1.04) | LDD0550 | [7] |
LDCM0234 | AC117 | HCT 116 | C117(1.07) | LDD0551 | [7] |
LDCM0235 | AC118 | HCT 116 | C117(1.04) | LDD0552 | [7] |
LDCM0236 | AC119 | HCT 116 | C117(1.04) | LDD0553 | [7] |
LDCM0237 | AC12 | HCT 116 | C117(0.96) | LDD0554 | [7] |
LDCM0238 | AC120 | HCT 116 | C117(1.14) | LDD0555 | [7] |
LDCM0239 | AC121 | HCT 116 | C117(0.98) | LDD0556 | [7] |
LDCM0240 | AC122 | HCT 116 | C117(1.03) | LDD0557 | [7] |
LDCM0241 | AC123 | HCT 116 | C117(0.95) | LDD0558 | [7] |
LDCM0242 | AC124 | HCT 116 | C117(1.00) | LDD0559 | [7] |
LDCM0243 | AC125 | HCT 116 | C117(1.18) | LDD0560 | [7] |
LDCM0244 | AC126 | HCT 116 | C117(1.03) | LDD0561 | [7] |
LDCM0245 | AC127 | HCT 116 | C117(0.99) | LDD0562 | [7] |
LDCM0246 | AC128 | HCT 116 | C117(1.22) | LDD0563 | [7] |
LDCM0247 | AC129 | HCT 116 | C117(1.28) | LDD0564 | [7] |
LDCM0249 | AC130 | HCT 116 | C117(1.61) | LDD0566 | [7] |
LDCM0250 | AC131 | HCT 116 | C117(1.37) | LDD0567 | [7] |
LDCM0251 | AC132 | HCT 116 | C117(1.87) | LDD0568 | [7] |
LDCM0252 | AC133 | HCT 116 | C117(1.45) | LDD0569 | [7] |
LDCM0253 | AC134 | HCT 116 | C117(1.79) | LDD0570 | [7] |
LDCM0254 | AC135 | HCT 116 | C117(1.44) | LDD0571 | [7] |
LDCM0255 | AC136 | HCT 116 | C117(1.60) | LDD0572 | [7] |
LDCM0256 | AC137 | HCT 116 | C117(1.74) | LDD0573 | [7] |
LDCM0257 | AC138 | HCT 116 | C117(2.24) | LDD0574 | [7] |
LDCM0258 | AC139 | HCT 116 | C117(1.83) | LDD0575 | [7] |
LDCM0259 | AC14 | HCT 116 | C117(0.89) | LDD0576 | [7] |
LDCM0260 | AC140 | HCT 116 | C117(2.16) | LDD0577 | [7] |
LDCM0261 | AC141 | HCT 116 | C117(2.02) | LDD0578 | [7] |
LDCM0262 | AC142 | HCT 116 | C117(1.74) | LDD0579 | [7] |
LDCM0263 | AC143 | HCT 116 | C117(1.26) | LDD0580 | [7] |
LDCM0264 | AC144 | HCT 116 | C117(1.32) | LDD0581 | [7] |
LDCM0265 | AC145 | HCT 116 | C117(1.12) | LDD0582 | [7] |
LDCM0266 | AC146 | HCT 116 | C117(1.31) | LDD0583 | [7] |
LDCM0267 | AC147 | HCT 116 | C117(1.36) | LDD0584 | [7] |
LDCM0268 | AC148 | HCT 116 | C117(2.00) | LDD0585 | [7] |
LDCM0269 | AC149 | HCT 116 | C117(1.47) | LDD0586 | [7] |
LDCM0270 | AC15 | HCT 116 | C117(0.96) | LDD0587 | [7] |
LDCM0271 | AC150 | HCT 116 | C117(1.12) | LDD0588 | [7] |
LDCM0272 | AC151 | HCT 116 | C117(1.12) | LDD0589 | [7] |
LDCM0273 | AC152 | HCT 116 | C117(1.38) | LDD0590 | [7] |
LDCM0274 | AC153 | HCT 116 | C117(2.07) | LDD0591 | [7] |
LDCM0621 | AC154 | HCT 116 | C117(1.32) | LDD2158 | [7] |
LDCM0622 | AC155 | HCT 116 | C117(1.24) | LDD2159 | [7] |
LDCM0623 | AC156 | HCT 116 | C117(1.08) | LDD2160 | [7] |
LDCM0624 | AC157 | HCT 116 | C117(0.87) | LDD2161 | [7] |
LDCM0276 | AC17 | HCT 116 | C117(1.19) | LDD0593 | [7] |
LDCM0277 | AC18 | HCT 116 | C117(1.10) | LDD0594 | [7] |
LDCM0278 | AC19 | HCT 116 | C117(1.17) | LDD0595 | [7] |
LDCM0279 | AC2 | HCT 116 | C117(1.02) | LDD0596 | [7] |
LDCM0280 | AC20 | HCT 116 | C117(1.07) | LDD0597 | [7] |
LDCM0281 | AC21 | HCT 116 | C117(1.18) | LDD0598 | [7] |
LDCM0282 | AC22 | HCT 116 | C117(1.22) | LDD0599 | [7] |
LDCM0283 | AC23 | HCT 116 | C117(1.38) | LDD0600 | [7] |
LDCM0284 | AC24 | HCT 116 | C117(1.05) | LDD0601 | [7] |
LDCM0285 | AC25 | HCT 116 | C117(1.15) | LDD0602 | [7] |
LDCM0286 | AC26 | HCT 116 | C117(1.26) | LDD0603 | [7] |
LDCM0287 | AC27 | HCT 116 | C117(1.20) | LDD0604 | [7] |
LDCM0288 | AC28 | HCT 116 | C117(1.06) | LDD0605 | [7] |
LDCM0289 | AC29 | HCT 116 | C117(1.31) | LDD0606 | [7] |
LDCM0290 | AC3 | HCT 116 | C117(1.00) | LDD0607 | [7] |
LDCM0291 | AC30 | HCT 116 | C117(1.43) | LDD0608 | [7] |
LDCM0292 | AC31 | HCT 116 | C117(1.12) | LDD0609 | [7] |
LDCM0293 | AC32 | HCT 116 | C117(1.23) | LDD0610 | [7] |
LDCM0294 | AC33 | HCT 116 | C117(1.08) | LDD0611 | [7] |
LDCM0295 | AC34 | HCT 116 | C117(1.12) | LDD0612 | [7] |
LDCM0296 | AC35 | HCT 116 | C117(1.04) | LDD0613 | [7] |
LDCM0297 | AC36 | HCT 116 | C117(1.07) | LDD0614 | [7] |
LDCM0298 | AC37 | HCT 116 | C117(0.89) | LDD0615 | [7] |
LDCM0299 | AC38 | HCT 116 | C117(1.04) | LDD0616 | [7] |
LDCM0300 | AC39 | HCT 116 | C117(1.09) | LDD0617 | [7] |
LDCM0301 | AC4 | HCT 116 | C117(1.10) | LDD0618 | [7] |
LDCM0302 | AC40 | HCT 116 | C117(1.12) | LDD0619 | [7] |
LDCM0303 | AC41 | HCT 116 | C117(1.03) | LDD0620 | [7] |
LDCM0304 | AC42 | HCT 116 | C117(1.20) | LDD0621 | [7] |
LDCM0305 | AC43 | HCT 116 | C117(1.03) | LDD0622 | [7] |
LDCM0306 | AC44 | HCT 116 | C117(1.01) | LDD0623 | [7] |
LDCM0307 | AC45 | HCT 116 | C117(1.15) | LDD0624 | [7] |
LDCM0308 | AC46 | HCT 116 | C117(1.05) | LDD0625 | [7] |
LDCM0309 | AC47 | HCT 116 | C117(1.07) | LDD0626 | [7] |
LDCM0310 | AC48 | HCT 116 | C117(1.10) | LDD0627 | [7] |
LDCM0311 | AC49 | HCT 116 | C117(1.36) | LDD0628 | [7] |
LDCM0312 | AC5 | HCT 116 | C117(1.02) | LDD0629 | [7] |
LDCM0313 | AC50 | HCT 116 | C117(1.41) | LDD0630 | [7] |
LDCM0314 | AC51 | HCT 116 | C117(0.96) | LDD0631 | [7] |
LDCM0315 | AC52 | HCT 116 | C117(1.03) | LDD0632 | [7] |
LDCM0316 | AC53 | HCT 116 | C117(1.40) | LDD0633 | [7] |
LDCM0317 | AC54 | HCT 116 | C117(1.11) | LDD0634 | [7] |
LDCM0318 | AC55 | HCT 116 | C117(1.37) | LDD0635 | [7] |
LDCM0319 | AC56 | HCT 116 | C117(1.72) | LDD0636 | [7] |
LDCM0320 | AC57 | HCT 116 | C117(1.41) | LDD0637 | [7] |
LDCM0321 | AC58 | HCT 116 | C117(1.31) | LDD0638 | [7] |
LDCM0322 | AC59 | HCT 116 | C117(1.37) | LDD0639 | [7] |
LDCM0323 | AC6 | HCT 116 | C117(1.14) | LDD0640 | [7] |
LDCM0324 | AC60 | HCT 116 | C117(1.34) | LDD0641 | [7] |
LDCM0325 | AC61 | HCT 116 | C117(1.33) | LDD0642 | [7] |
LDCM0326 | AC62 | HCT 116 | C117(1.55) | LDD0643 | [7] |
LDCM0327 | AC63 | HCT 116 | C117(1.52) | LDD0644 | [7] |
LDCM0328 | AC64 | HCT 116 | C117(1.63) | LDD0645 | [7] |
LDCM0329 | AC65 | HCT 116 | C117(1.48) | LDD0646 | [7] |
LDCM0330 | AC66 | HCT 116 | C117(1.44) | LDD0647 | [7] |
LDCM0331 | AC67 | HCT 116 | C117(1.98) | LDD0648 | [7] |
LDCM0332 | AC68 | HCT 116 | C117(0.93) | LDD0649 | [7] |
LDCM0333 | AC69 | HCT 116 | C117(0.89) | LDD0650 | [7] |
LDCM0334 | AC7 | HCT 116 | C117(1.06) | LDD0651 | [7] |
LDCM0335 | AC70 | HCT 116 | C117(1.22) | LDD0652 | [7] |
LDCM0336 | AC71 | HCT 116 | C117(0.92) | LDD0653 | [7] |
LDCM0337 | AC72 | HCT 116 | C117(1.06) | LDD0654 | [7] |
LDCM0338 | AC73 | HCT 116 | C117(1.13) | LDD0655 | [7] |
LDCM0339 | AC74 | HCT 116 | C117(0.99) | LDD0656 | [7] |
LDCM0340 | AC75 | HCT 116 | C117(1.04) | LDD0657 | [7] |
LDCM0341 | AC76 | HCT 116 | C117(0.94) | LDD0658 | [7] |
LDCM0342 | AC77 | HCT 116 | C117(0.84) | LDD0659 | [7] |
LDCM0343 | AC78 | HCT 116 | C117(0.90) | LDD0660 | [7] |
LDCM0344 | AC79 | HCT 116 | C117(1.00) | LDD0661 | [7] |
LDCM0345 | AC8 | HCT 116 | C117(1.04) | LDD0662 | [7] |
LDCM0346 | AC80 | HCT 116 | C117(1.11) | LDD0663 | [7] |
LDCM0347 | AC81 | HCT 116 | C117(1.06) | LDD0664 | [7] |
LDCM0348 | AC82 | HCT 116 | C117(1.04) | LDD0665 | [7] |
LDCM0349 | AC83 | HCT 116 | C117(1.13) | LDD0666 | [7] |
LDCM0350 | AC84 | HCT 116 | C117(1.14) | LDD0667 | [7] |
LDCM0351 | AC85 | HCT 116 | C117(1.18) | LDD0668 | [7] |
LDCM0352 | AC86 | HCT 116 | C117(1.13) | LDD0669 | [7] |
LDCM0353 | AC87 | HCT 116 | C117(1.03) | LDD0670 | [7] |
LDCM0354 | AC88 | HCT 116 | C117(1.10) | LDD0671 | [7] |
LDCM0355 | AC89 | HCT 116 | C117(1.15) | LDD0672 | [7] |
LDCM0357 | AC90 | HCT 116 | C117(1.15) | LDD0674 | [7] |
LDCM0358 | AC91 | HCT 116 | C117(1.05) | LDD0675 | [7] |
LDCM0359 | AC92 | HCT 116 | C117(1.21) | LDD0676 | [7] |
LDCM0360 | AC93 | HCT 116 | C117(1.12) | LDD0677 | [7] |
LDCM0361 | AC94 | HCT 116 | C117(1.15) | LDD0678 | [7] |
LDCM0362 | AC95 | HCT 116 | C117(1.11) | LDD0679 | [7] |
LDCM0363 | AC96 | HCT 116 | C117(1.17) | LDD0680 | [7] |
LDCM0364 | AC97 | HCT 116 | C117(1.35) | LDD0681 | [7] |
LDCM0365 | AC98 | HCT 116 | C117(1.28) | LDD0682 | [7] |
LDCM0366 | AC99 | HCT 116 | C117(1.24) | LDD0683 | [7] |
LDCM0545 | Acetamide | MDA-MB-231 | C64(0.41) | LDD2138 | [3] |
LDCM0520 | AKOS000195272 | MDA-MB-231 | C98(1.03); C248(2.25) | LDD2113 | [3] |
LDCM0248 | AKOS034007472 | HCT 116 | C117(1.01) | LDD0565 | [7] |
LDCM0356 | AKOS034007680 | HCT 116 | C117(1.25) | LDD0673 | [7] |
LDCM0275 | AKOS034007705 | HCT 116 | C117(1.10) | LDD0592 | [7] |
LDCM0156 | Aniline | NCI-H1299 | 13.41 | LDD0403 | [1] |
LDCM0102 | BDHI 8 | Jurkat | C64(18.22) | LDD0204 | [23] |
LDCM0498 | BS-3668 | MDA-MB-231 | C98(0.64); C64(0.57) | LDD2091 | [3] |
LDCM0108 | Chloroacetamide | HeLa | C64(0.00); C117(0.00); C248(0.00); C98(0.00) | LDD0222 | [16] |
LDCM0367 | CL1 | HCT 116 | C117(1.23) | LDD0684 | [7] |
LDCM0368 | CL10 | HCT 116 | C117(1.36) | LDD0685 | [7] |
LDCM0369 | CL100 | HCT 116 | C117(1.05) | LDD0686 | [7] |
LDCM0370 | CL101 | HCT 116 | C117(1.03) | LDD0687 | [7] |
LDCM0371 | CL102 | HCT 116 | C117(1.14) | LDD0688 | [7] |
LDCM0372 | CL103 | HCT 116 | C117(1.00) | LDD0689 | [7] |
LDCM0373 | CL104 | HCT 116 | C117(0.94) | LDD0690 | [7] |
LDCM0374 | CL105 | HCT 116 | C117(1.24) | LDD0691 | [7] |
LDCM0375 | CL106 | HCT 116 | C117(1.07) | LDD0692 | [7] |
LDCM0376 | CL107 | HCT 116 | C117(1.08) | LDD0693 | [7] |
LDCM0377 | CL108 | HCT 116 | C117(1.06) | LDD0694 | [7] |
LDCM0378 | CL109 | HCT 116 | C117(1.38) | LDD0695 | [7] |
LDCM0379 | CL11 | HCT 116 | C117(1.76) | LDD0696 | [7] |
LDCM0380 | CL110 | HCT 116 | C117(1.32) | LDD0697 | [7] |
LDCM0381 | CL111 | HCT 116 | C117(1.54) | LDD0698 | [7] |
LDCM0382 | CL112 | HCT 116 | C117(1.09) | LDD0699 | [7] |
LDCM0383 | CL113 | HCT 116 | C117(1.34) | LDD0700 | [7] |
LDCM0384 | CL114 | HCT 116 | C117(1.76) | LDD0701 | [7] |
LDCM0385 | CL115 | HCT 116 | C117(1.27) | LDD0702 | [7] |
LDCM0386 | CL116 | HCT 116 | C117(1.23) | LDD0703 | [7] |
LDCM0387 | CL117 | HCT 116 | C117(1.39) | LDD0704 | [7] |
LDCM0388 | CL118 | HCT 116 | C117(1.13) | LDD0705 | [7] |
LDCM0389 | CL119 | HCT 116 | C117(1.14) | LDD0706 | [7] |
LDCM0390 | CL12 | HCT 116 | C117(1.34) | LDD0707 | [7] |
LDCM0391 | CL120 | HCT 116 | C117(1.03) | LDD0708 | [7] |
LDCM0392 | CL121 | HCT 116 | C117(0.85) | LDD0709 | [7] |
LDCM0393 | CL122 | HCT 116 | C117(1.21) | LDD0710 | [7] |
LDCM0394 | CL123 | HCT 116 | C117(1.63) | LDD0711 | [7] |
LDCM0395 | CL124 | HCT 116 | C117(1.57) | LDD0712 | [7] |
LDCM0396 | CL125 | HCT 116 | C117(1.12) | LDD0713 | [7] |
LDCM0397 | CL126 | HCT 116 | C117(1.01) | LDD0714 | [7] |
LDCM0398 | CL127 | HCT 116 | C117(1.11) | LDD0715 | [7] |
LDCM0399 | CL128 | HCT 116 | C117(1.38) | LDD0716 | [7] |
LDCM0400 | CL13 | HCT 116 | C117(1.34) | LDD0717 | [7] |
LDCM0401 | CL14 | HCT 116 | C117(1.38) | LDD0718 | [7] |
LDCM0402 | CL15 | HCT 116 | C117(1.48) | LDD0719 | [7] |
LDCM0403 | CL16 | HCT 116 | C117(1.42) | LDD0720 | [7] |
LDCM0404 | CL17 | HCT 116 | C117(2.51) | LDD0721 | [7] |
LDCM0405 | CL18 | HCT 116 | C117(1.14) | LDD0722 | [7] |
LDCM0406 | CL19 | HCT 116 | C117(1.10) | LDD0723 | [7] |
LDCM0407 | CL2 | HCT 116 | C117(1.06) | LDD0724 | [7] |
LDCM0408 | CL20 | HCT 116 | C117(1.71) | LDD0725 | [7] |
LDCM0409 | CL21 | HCT 116 | C117(1.70) | LDD0726 | [7] |
LDCM0410 | CL22 | HCT 116 | C117(2.46) | LDD0727 | [7] |
LDCM0411 | CL23 | HCT 116 | C117(1.37) | LDD0728 | [7] |
LDCM0412 | CL24 | HCT 116 | C117(1.37) | LDD0729 | [7] |
LDCM0413 | CL25 | HCT 116 | C117(1.61) | LDD0730 | [7] |
LDCM0414 | CL26 | HCT 116 | C117(1.45) | LDD0731 | [7] |
LDCM0415 | CL27 | HCT 116 | C117(1.03) | LDD0732 | [7] |
LDCM0416 | CL28 | HCT 116 | C117(1.19) | LDD0733 | [7] |
LDCM0417 | CL29 | HCT 116 | C117(1.18) | LDD0734 | [7] |
LDCM0418 | CL3 | HCT 116 | C117(1.05) | LDD0735 | [7] |
LDCM0419 | CL30 | HCT 116 | C117(1.43) | LDD0736 | [7] |
LDCM0420 | CL31 | HCT 116 | C117(1.21) | LDD0737 | [7] |
LDCM0421 | CL32 | HCT 116 | C117(1.07) | LDD0738 | [7] |
LDCM0422 | CL33 | HCT 116 | C117(1.21) | LDD0739 | [7] |
LDCM0423 | CL34 | HCT 116 | C117(0.97) | LDD0740 | [7] |
LDCM0424 | CL35 | HCT 116 | C117(0.98) | LDD0741 | [7] |
LDCM0425 | CL36 | HCT 116 | C117(0.99) | LDD0742 | [7] |
LDCM0426 | CL37 | HCT 116 | C117(1.07) | LDD0743 | [7] |
LDCM0428 | CL39 | HCT 116 | C117(1.07) | LDD0745 | [7] |
LDCM0429 | CL4 | HCT 116 | C117(1.32) | LDD0746 | [7] |
LDCM0430 | CL40 | HCT 116 | C117(1.31) | LDD0747 | [7] |
LDCM0431 | CL41 | HCT 116 | C117(0.94) | LDD0748 | [7] |
LDCM0432 | CL42 | HCT 116 | C117(0.85) | LDD0749 | [7] |
LDCM0433 | CL43 | HCT 116 | C117(1.04) | LDD0750 | [7] |
LDCM0434 | CL44 | HCT 116 | C117(1.06) | LDD0751 | [7] |
LDCM0435 | CL45 | HCT 116 | C117(1.09) | LDD0752 | [7] |
LDCM0436 | CL46 | HCT 116 | C117(1.01) | LDD0753 | [7] |
LDCM0437 | CL47 | HCT 116 | C117(1.26) | LDD0754 | [7] |
LDCM0438 | CL48 | HCT 116 | C117(1.06) | LDD0755 | [7] |
LDCM0439 | CL49 | HCT 116 | C117(0.94) | LDD0756 | [7] |
LDCM0440 | CL5 | HCT 116 | C117(1.08) | LDD0757 | [7] |
LDCM0441 | CL50 | HCT 116 | C117(1.07) | LDD0758 | [7] |
LDCM0442 | CL51 | HCT 116 | C117(1.15) | LDD0759 | [7] |
LDCM0443 | CL52 | HCT 116 | C117(1.08) | LDD0760 | [7] |
LDCM0444 | CL53 | HCT 116 | C117(1.03) | LDD0761 | [7] |
LDCM0445 | CL54 | HCT 116 | C117(1.05) | LDD0762 | [7] |
LDCM0446 | CL55 | HCT 116 | C117(1.07) | LDD0763 | [7] |
LDCM0447 | CL56 | HCT 116 | C117(1.01) | LDD0764 | [7] |
LDCM0448 | CL57 | HCT 116 | C117(1.12) | LDD0765 | [7] |
LDCM0449 | CL58 | HCT 116 | C117(0.96) | LDD0766 | [7] |
LDCM0450 | CL59 | HCT 116 | C117(1.04) | LDD0767 | [7] |
LDCM0451 | CL6 | HCT 116 | C117(1.22) | LDD0768 | [7] |
LDCM0452 | CL60 | HCT 116 | C117(1.07) | LDD0769 | [7] |
LDCM0453 | CL61 | HCT 116 | C117(1.24) | LDD0770 | [7] |
LDCM0454 | CL62 | HCT 116 | C117(1.35) | LDD0771 | [7] |
LDCM0455 | CL63 | HCT 116 | C117(1.41) | LDD0772 | [7] |
LDCM0456 | CL64 | HCT 116 | C117(1.66) | LDD0773 | [7] |
LDCM0457 | CL65 | HCT 116 | C117(1.30) | LDD0774 | [7] |
LDCM0458 | CL66 | HCT 116 | C117(1.41) | LDD0775 | [7] |
LDCM0459 | CL67 | HCT 116 | C117(1.43) | LDD0776 | [7] |
LDCM0460 | CL68 | HCT 116 | C117(1.39) | LDD0777 | [7] |
LDCM0461 | CL69 | HCT 116 | C117(1.25) | LDD0778 | [7] |
LDCM0462 | CL7 | HCT 116 | C117(1.21) | LDD0779 | [7] |
LDCM0463 | CL70 | HCT 116 | C117(1.23) | LDD0780 | [7] |
LDCM0464 | CL71 | HCT 116 | C117(1.68) | LDD0781 | [7] |
LDCM0465 | CL72 | HCT 116 | C117(1.25) | LDD0782 | [7] |
LDCM0466 | CL73 | HCT 116 | C117(1.58) | LDD0783 | [7] |
LDCM0467 | CL74 | HCT 116 | C117(1.62) | LDD0784 | [7] |
LDCM0469 | CL76 | HCT 116 | C117(1.12) | LDD0786 | [7] |
LDCM0470 | CL77 | HCT 116 | C117(1.26) | LDD0787 | [7] |
LDCM0471 | CL78 | HCT 116 | C117(1.25) | LDD0788 | [7] |
LDCM0472 | CL79 | HCT 116 | C117(1.12) | LDD0789 | [7] |
LDCM0473 | CL8 | HCT 116 | C117(1.97) | LDD0790 | [7] |
LDCM0474 | CL80 | HCT 116 | C117(0.98) | LDD0791 | [7] |
LDCM0475 | CL81 | HCT 116 | C117(1.00) | LDD0792 | [7] |
LDCM0476 | CL82 | HCT 116 | C117(1.09) | LDD0793 | [7] |
LDCM0477 | CL83 | HCT 116 | C117(1.07) | LDD0794 | [7] |
LDCM0478 | CL84 | HCT 116 | C117(1.11) | LDD0795 | [7] |
LDCM0479 | CL85 | HCT 116 | C117(1.14) | LDD0796 | [7] |
LDCM0480 | CL86 | HCT 116 | C117(1.29) | LDD0797 | [7] |
LDCM0481 | CL87 | HCT 116 | C117(1.30) | LDD0798 | [7] |
LDCM0482 | CL88 | HCT 116 | C117(1.20) | LDD0799 | [7] |
LDCM0483 | CL89 | HCT 116 | C117(1.01) | LDD0800 | [7] |
LDCM0484 | CL9 | HCT 116 | C117(1.25) | LDD0801 | [7] |
LDCM0485 | CL90 | HCT 116 | C117(1.91) | LDD0802 | [7] |
LDCM0486 | CL91 | HCT 116 | C117(1.30) | LDD0803 | [7] |
LDCM0487 | CL92 | HCT 116 | C117(0.97) | LDD0804 | [7] |
LDCM0488 | CL93 | HCT 116 | C117(0.95) | LDD0805 | [7] |
LDCM0489 | CL94 | HCT 116 | C117(0.91) | LDD0806 | [7] |
LDCM0490 | CL95 | HCT 116 | C117(1.17) | LDD0807 | [7] |
LDCM0491 | CL96 | HCT 116 | C117(1.03) | LDD0808 | [7] |
LDCM0492 | CL97 | HCT 116 | C117(1.29) | LDD0809 | [7] |
LDCM0493 | CL98 | HCT 116 | C117(1.28) | LDD0810 | [7] |
LDCM0494 | CL99 | HCT 116 | C117(1.05) | LDD0811 | [7] |
LDCM0495 | E2913 | HEK-293T | C117(1.02); C64(1.01) | LDD1698 | [24] |
LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C117(1.19) | LDD1702 | [3] |
LDCM0625 | F8 | Ramos | C117(1.77) | LDD2187 | [25] |
LDCM0572 | Fragment10 | Ramos | C117(20.00) | LDD2189 | [25] |
LDCM0574 | Fragment12 | Ramos | C117(1.83) | LDD2191 | [25] |
LDCM0575 | Fragment13 | Ramos | C117(1.60) | LDD2192 | [25] |
LDCM0576 | Fragment14 | Ramos | C117(1.03) | LDD2193 | [25] |
LDCM0579 | Fragment20 | Ramos | C117(1.73) | LDD2194 | [25] |
LDCM0580 | Fragment21 | Ramos | C117(1.60) | LDD2195 | [25] |
LDCM0582 | Fragment23 | Ramos | C117(0.85) | LDD2196 | [25] |
LDCM0578 | Fragment27 | Ramos | C117(0.91) | LDD2197 | [25] |
LDCM0586 | Fragment28 | Ramos | C117(0.78) | LDD2198 | [25] |
LDCM0588 | Fragment30 | Ramos | C117(1.25) | LDD2199 | [25] |
LDCM0589 | Fragment31 | Ramos | C117(1.05) | LDD2200 | [25] |
LDCM0590 | Fragment32 | Ramos | C117(2.94) | LDD2201 | [25] |
LDCM0468 | Fragment33 | HCT 116 | C117(1.42) | LDD0785 | [7] |
LDCM0596 | Fragment38 | Ramos | C117(0.83) | LDD2203 | [25] |
LDCM0566 | Fragment4 | Ramos | C117(0.74) | LDD2184 | [25] |
LDCM0427 | Fragment51 | HCT 116 | C117(1.36) | LDD0744 | [7] |
LDCM0610 | Fragment52 | Ramos | C117(1.35) | LDD2204 | [25] |
LDCM0614 | Fragment56 | Ramos | C117(1.36) | LDD2205 | [25] |
LDCM0569 | Fragment7 | Ramos | C117(1.13) | LDD2186 | [25] |
LDCM0571 | Fragment9 | Ramos | C117(2.05) | LDD2188 | [25] |
LDCM0116 | HHS-0101 | DM93 | Y20(0.76) | LDD0264 | [6] |
LDCM0118 | HHS-0301 | DM93 | Y20(0.82) | LDD0266 | [6] |
LDCM0119 | HHS-0401 | DM93 | Y20(0.33) | LDD0267 | [6] |
LDCM0120 | HHS-0701 | DM93 | Y20(0.91) | LDD0268 | [6] |
LDCM0107 | IAA | HeLa | C64(0.00); C98(0.00) | LDD0221 | [16] |
LDCM0022 | KB02 | HCT 116 | C117(3.12) | LDD0080 | [7] |
LDCM0023 | KB03 | HCT 116 | C117(1.48) | LDD0081 | [7] |
LDCM0024 | KB05 | HCT 116 | C117(1.47) | LDD0082 | [7] |
LDCM0509 | N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide | MDA-MB-231 | C98(1.67) | LDD2102 | [3] |
LDCM0528 | N-(4-bromophenyl)-2-cyano-N-phenylacetamide | MDA-MB-231 | C64(0.70) | LDD2121 | [3] |
LDCM0109 | NEM | HeLa | C64(0.00); C98(0.00) | LDD0223 | [16] |
LDCM0496 | Nucleophilic fragment 11a | MDA-MB-231 | C64(0.69) | LDD2089 | [3] |
LDCM0497 | Nucleophilic fragment 11b | MDA-MB-231 | C98(1.18); C117(0.95) | LDD2090 | [3] |
LDCM0499 | Nucleophilic fragment 12b | MDA-MB-231 | C117(0.76) | LDD2092 | [3] |
LDCM0500 | Nucleophilic fragment 13a | MDA-MB-231 | C64(0.96); C248(1.04) | LDD2093 | [3] |
LDCM0504 | Nucleophilic fragment 15a | MDA-MB-231 | C64(0.97) | LDD2097 | [3] |
LDCM0505 | Nucleophilic fragment 15b | MDA-MB-231 | C98(1.41) | LDD2098 | [3] |
LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C98(0.98); C117(1.02); C64(0.84) | LDD2099 | [3] |
LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C98(0.38); C117(1.14) | LDD2100 | [3] |
LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C98(0.38) | LDD2104 | [3] |
LDCM0512 | Nucleophilic fragment 19a | MDA-MB-231 | C98(1.57) | LDD2105 | [3] |
LDCM0513 | Nucleophilic fragment 19b | MDA-MB-231 | C117(1.04) | LDD2106 | [3] |
LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C117(0.87); C64(0.91) | LDD2107 | [3] |
LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C98(0.68); C117(1.01); C64(0.55) | LDD2108 | [3] |
LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C117(1.01); C248(0.47) | LDD2109 | [3] |
LDCM0518 | Nucleophilic fragment 22a | MDA-MB-231 | C117(1.02); C64(0.82); C248(0.92) | LDD2111 | [3] |
LDCM0521 | Nucleophilic fragment 23b | MDA-MB-231 | C117(1.07) | LDD2114 | [3] |
LDCM0522 | Nucleophilic fragment 24a | MDA-MB-231 | C64(0.51); C248(1.99) | LDD2115 | [3] |
LDCM0526 | Nucleophilic fragment 26a | MDA-MB-231 | C98(2.44); C64(2.04); C248(1.78) | LDD2119 | [3] |
LDCM0527 | Nucleophilic fragment 26b | MDA-MB-231 | C64(0.79) | LDD2120 | [3] |
LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C98(0.96); C117(0.78); C64(0.72); C248(0.71) | LDD2123 | [3] |
LDCM0531 | Nucleophilic fragment 28b | MDA-MB-231 | C117(1.68) | LDD2124 | [3] |
LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C98(0.95); C117(0.86); C64(0.69); C248(1.14) | LDD2125 | [3] |
LDCM0533 | Nucleophilic fragment 29b | MDA-MB-231 | C117(0.81) | LDD2126 | [3] |
LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C98(1.21); C117(1.02); C64(0.82) | LDD2127 | [3] |
LDCM0535 | Nucleophilic fragment 30b | MDA-MB-231 | C64(0.83) | LDD2128 | [3] |
LDCM0536 | Nucleophilic fragment 31 | MDA-MB-231 | C98(1.39); C117(1.03); C64(0.90); C248(0.86) | LDD2129 | [3] |
LDCM0540 | Nucleophilic fragment 35 | MDA-MB-231 | C64(0.62); C248(3.06) | LDD2133 | [3] |
LDCM0541 | Nucleophilic fragment 36 | MDA-MB-231 | C98(0.62); C64(0.51) | LDD2134 | [3] |
LDCM0542 | Nucleophilic fragment 37 | MDA-MB-231 | C98(1.43); C117(0.54); C64(0.93); C248(0.97) | LDD2135 | [3] |
LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C98(1.06); C117(1.06); C248(0.90) | LDD2136 | [3] |
LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C98(0.82); C117(0.98); C64(0.76) | LDD2137 | [3] |
LDCM0211 | Nucleophilic fragment 3b | MDA-MB-231 | C248(3.40); C117(1.14); C64(1.08) | LDD1700 | [3] |
LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C117(1.02) | LDD2140 | [3] |
LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C117(0.88); C64(0.61) | LDD2141 | [3] |
LDCM0549 | Nucleophilic fragment 43 | MDA-MB-231 | C64(0.83) | LDD2143 | [3] |
LDCM0550 | Nucleophilic fragment 5a | MDA-MB-231 | C64(2.37); C248(2.39) | LDD2144 | [3] |
LDCM0551 | Nucleophilic fragment 5b | MDA-MB-231 | C98(0.43); C117(5.89); C64(0.60); C248(0.15) | LDD2145 | [3] |
LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C98(1.00); C117(0.91); C64(0.82); C248(0.66) | LDD2146 | [3] |
LDCM0553 | Nucleophilic fragment 6b | MDA-MB-231 | C117(1.91); C64(2.02) | LDD2147 | [3] |
LDCM0554 | Nucleophilic fragment 7a | MDA-MB-231 | C64(0.47); C248(2.93) | LDD2148 | [3] |
LDCM0556 | Nucleophilic fragment 8a | MDA-MB-231 | C117(0.74); C64(0.46) | LDD2150 | [3] |
LDCM0559 | Nucleophilic fragment 9b | MDA-MB-231 | C117(0.90) | LDD2153 | [3] |
LDCM0627 | NUDT7-COV-1 | HEK-293T | C117(0.91) | LDD2206 | [26] |
LDCM0628 | OTUB2-COV-1 | HEK-293T | C117(1.64); C117(0.14) | LDD2207 | [26] |
LDCM0131 | RA190 | MM1.R | C117(1.18) | LDD0304 | [27] |
LDCM0003 | Sulforaphane | MDA-MB-231 | 2.36 | LDD0160 | [4] |
LDCM0112 | W16 | Hep-G2 | C117(0.59) | LDD0239 | [17] |
References