Details of the Target

General Information of Target

Target ID LDTP01788
Target Name Adenylate kinase isoenzyme 1 (AK1)
Gene Name AK1
Gene ID 203
Synonyms
Adenylate kinase isoenzyme 1; AK 1; EC 2.7.4.10; EC 2.7.4.3; EC 2.7.4.6; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEI
MEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDA
GPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVD
SVFSQVCTHLDALK
Target Bioclass
Enzyme
Family
Adenylate kinase family, AK1 subfamily
Subcellular location
Cytoplasm
Function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Exhibits nucleoside diphosphate kinase activity, catalyzing the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and dTTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP. {|HAMAP-Rule:MF_03171}.
Uniprot ID
P00568
Ensemble ID
ENST00000373156.5
HGNC ID
HGNC:361
ChEMBL ID
CHEMBL4925

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		5.17  LDD0066  [1]
TH214
 Probe Info  		Y164(10.70)  LDD0258  [2]
STPyne
 Probe Info  		K21(6.31); K31(7.14); K56(8.24); K83(1.06)  LDD0277  [3]
AZ-9
 Probe Info  		E158(1.12); E103(1.04)  LDD2208  [4]
ONAyne
 Probe Info  		K27(10.00)  LDD0275  [3]
Probe 1
 Probe Info  		Y95(9.03); Y153(71.64); Y154(81.27)  LDD3495  [5]
DBIA
 Probe Info  		C187(2.51)  LDD3316  [6]
BTD
 Probe Info  		C25(1.09)  LDD2090  [7]
HHS-475
 Probe Info  		Y117(3.16)  LDD0264  [8]
HHS-465
 Probe Info  		Y32(10.00)  LDD2237  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K21(0.00); K27(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H189(0.00); H36(0.00)  LDD2231  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPM
 Probe Info  		C25(0.00); C187(0.00)  LDD0025  [13]
JW-RF-010
 Probe Info  		C25(0.00); C187(0.00)  LDD0026  [13]
NAIA_4
 Probe Info  		C25(0.00); 0.00  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
NHS
 Probe Info  		K166(0.00); K83(0.00)  LDD0010  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
1d-yne
 Probe Info  		N.A.  LDD0357  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		11.90  LDD0443  [19]
NAIA_5
 Probe Info  		C25(0.00); C187(0.00)  LDD2223  [14]
TER-AC
 Probe Info  		N.A.  LDD0426  [20]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C305
 Probe Info  		11.55  LDD1974  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C187(0.89)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C187(0.98)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C187(1.08)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C187(1.08)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C187(1.04)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C187(1.04)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C187(1.00)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C187(0.99)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C187(1.04)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C187(1.03)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C187(0.99)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C187(0.99)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C187(1.01)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C187(1.10)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C187(1.09)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C187(0.89)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C187(0.99)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C187(1.04)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C187(0.97)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C187(1.01)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C187(1.07)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C187(0.96)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C187(1.14)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C187(1.04)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C187(0.96)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C187(0.97)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C187(1.06)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C187(1.13)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C187(1.07)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C187(1.23)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C187(1.03)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C187(1.14)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C187(1.05)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C187(0.99)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C187(0.95)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C187(0.99)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C187(1.08)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C187(1.02)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C187(1.04)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C187(1.29)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C187(1.13)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C187(0.90)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C187(1.02)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C187(0.98)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C187(1.15)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C187(1.10)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C187(1.12)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C187(1.00)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C187(1.10)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C187(1.01)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C187(0.95)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C187(1.03)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C187(1.19)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C187(0.87)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C187(1.04)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C187(0.99)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C187(1.04)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C187(1.09)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C187(1.06)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C187(1.15)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C187(1.16)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C187(1.01)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C187(0.99)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C187(1.08)  LDD1514  [22]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C187(1.59); C25(1.25)  LDD2227  [14]
 LDCM0367  CL1 HEK-293T C187(0.98)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C187(1.22)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C187(0.94)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C187(0.94)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C187(0.99)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C187(1.13)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C187(0.99)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C187(0.86)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C187(0.93)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C187(1.07)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C187(1.01)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C187(0.82)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C187(1.29)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C187(1.16)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C187(0.99)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C187(1.02)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C187(0.91)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C187(0.96)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C187(1.10)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C187(1.02)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C187(1.00)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C187(0.91)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C187(1.18)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C187(1.31)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C187(1.01)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C187(0.85)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C187(1.09)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C187(1.00)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C187(0.98)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C187(0.96)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C187(1.02)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C187(1.05)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C187(1.05)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C187(0.84)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C187(1.13)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C187(1.00)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C187(1.12)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C187(0.96)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C187(1.04)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C187(1.15)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C187(1.20)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C187(1.10)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C187(0.97)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C187(1.16)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C187(1.44)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C187(1.25)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C187(0.92)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C187(0.94)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C187(1.11)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C187(1.09)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C187(0.95)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C187(1.05)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C187(1.16)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C187(1.20)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C187(1.14)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C187(1.09)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C187(1.22)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C187(1.35)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C187(1.24)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C187(0.88)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C187(1.18)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C187(0.97)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C187(1.08)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C187(0.97)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C187(1.14)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C187(1.27)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C187(1.15)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C187(1.14)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C187(1.24)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C187(1.34)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C187(1.43)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C187(0.89)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C187(0.96)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C187(1.39)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C187(1.04)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C187(0.97)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C187(0.96)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C187(1.12)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C187(1.24)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C187(1.14)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C187(1.22)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C187(1.40)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C187(0.87)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C187(1.33)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C187(1.00)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C187(1.34)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C187(1.09)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C187(1.04)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C187(1.02)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C187(1.00)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C187(1.19)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C187(1.15)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C187(1.15)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C187(1.02)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C187(1.32)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C187(1.33)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C187(1.20)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C187(0.76)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C187(1.12)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C187(1.04)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C187(0.88)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C187(1.07)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C187(1.10)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C187(0.95)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C187(1.24)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C187(1.07)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C187(1.21)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C187(1.30)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C187(1.17)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C187(0.88)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C187(1.43)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C187(1.05)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C187(1.07)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C187(1.03)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C187(1.16)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C187(0.91)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C187(1.24)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C187(1.08)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C187(1.12)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C187(1.17)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C187(0.73)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C187(1.08)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C187(0.83)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C187(1.04)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C187(1.10)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C187(1.25)  LDD1698  [22]
 LDCM0468  Fragment33 HEK-293T C187(1.09)  LDD1671  [22]
 LDCM0427  Fragment51 HEK-293T C187(0.97)  LDD1631  [22]
 LDCM0116  HHS-0101 DM93 Y117(3.16)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y117(2.26)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y117(1.07)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y117(1.54)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y117(0.77)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C187(1.02)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C187(1.02)  LDD1497  [22]
 LDCM0024  KB05 MEL167 C187(2.51)  LDD3316  [6]
 LDCM0109  NEM HeLa N.A.  LDD0225  [17]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C25(1.09)  LDD2090  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C25(0.74)  LDD2123  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C25(0.83); C25(0.77)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C25(0.77)  LDD2207  [23]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine Small molecular drug DB00640
Tenofovir Alafenamide Small molecular drug DB09299
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tenofovir Small molecular drug DB14126
Bis(Adenosine)-5'-pentaphosphate . DB01717

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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