Details of the Target

General Information of Target

Target ID LDTP06275
Target Name Lysosomal-associated transmembrane protein 4A (LAPTM4A)
Gene Name LAPTM4A
Gene ID 9741
Synonyms
KIAA0108; LAPTM4; MBNT; MTRP; Lysosomal-associated transmembrane protein 4A; Golgi 4-transmembrane-spanning transporter MTP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAV
NIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDF
VLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLI
NCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYLPA
Target Bioclass
Transporter and channel
Family
LAPTM4/LAPTM5 transporter family
Subcellular location
Endomembrane system
Function May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.
Uniprot ID
Q15012
Ensemble ID
ENST00000175091.5
HGNC ID
HGNC:6924

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		5.05  LDD0318  [1]
TG42
 Probe Info  		7.37  LDD0326  [2]
STPyne
 Probe Info  		K7(6.17)  LDD0277  [3]
Curcusone 37
 Probe Info  		5.48  LDD0188  [4]
Jackson_14
 Probe Info  		2.08  LDD0123  [5]
DBIA
 Probe Info  		C19(0.84)  LDD1512  [6]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C049
 Probe Info  		10.20  LDD1747  [7]
C055
 Probe Info  		15.89  LDD1752  [7]
C056
 Probe Info  		25.28  LDD1753  [7]
C285
 Probe Info  		34.06  LDD1955  [7]
C286
 Probe Info  		5.86  LDD1956  [7]
C287
 Probe Info  		31.56  LDD1957  [7]
C288
 Probe Info  		18.64  LDD1958  [7]
C289
 Probe Info  		80.45  LDD1959  [7]
C290
 Probe Info  		7.57  LDD1960  [7]
C299
 Probe Info  		29.04  LDD1968  [7]
C302
 Probe Info  		5.70  LDD1971  [7]
C303
 Probe Info  		5.62  LDD1972  [7]
C304
 Probe Info  		5.50  LDD1973  [7]
C305
 Probe Info  		25.81  LDD1974  [7]
C307
 Probe Info  		9.65  LDD1975  [7]
C310
 Probe Info  		30.06  LDD1977  [7]
C362
 Probe Info  		99.73  LDD2023  [7]
C363
 Probe Info  		99.73  LDD2024  [7]
C364
 Probe Info  		99.04  LDD2025  [7]
C366
 Probe Info  		20.68  LDD2027  [7]
C367
 Probe Info  		13.27  LDD2028  [7]
A-DA
 Probe Info  		3.41  LDD0332  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C19(0.84)  LDD1512  [6]
 LDCM0282  AC22 HEK-293T C19(0.95)  LDD1521  [6]
 LDCM0284  AC24 HEK-293T C19(0.92)  LDD1523  [6]
 LDCM0291  AC30 HEK-293T C19(0.98)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C19(0.97)  LDD1532  [6]
 LDCM0299  AC38 HEK-293T C19(1.04)  LDD1538  [6]
 LDCM0302  AC40 HEK-293T C19(1.06)  LDD1541  [6]
 LDCM0308  AC46 HEK-293T C19(1.16)  LDD1547  [6]
 LDCM0310  AC48 HEK-293T C19(0.90)  LDD1549  [6]
 LDCM0317  AC54 HEK-293T C19(0.62)  LDD1556  [6]
 LDCM0319  AC56 HEK-293T C19(1.04)  LDD1558  [6]
 LDCM0323  AC6 HEK-293T C19(0.73)  LDD1562  [6]
 LDCM0326  AC62 HEK-293T C19(1.13)  LDD1565  [6]
 LDCM0328  AC64 HEK-293T C19(0.99)  LDD1567  [6]
 LDCM0345  AC8 HEK-293T C19(0.89)  LDD1569  [6]
 LDCM0275  AKOS034007705 HEK-293T C19(0.93)  LDD1514  [6]
 LDCM0368  CL10 HEK-293T C19(1.52)  LDD1572  [6]
 LDCM0390  CL12 HEK-293T C19(0.91)  LDD1594  [6]
 LDCM0410  CL22 HEK-293T C19(0.88)  LDD1614  [6]
 LDCM0412  CL24 HEK-293T C19(0.85)  LDD1616  [6]
 LDCM0423  CL34 HEK-293T C19(1.13)  LDD1627  [6]
 LDCM0425  CL36 HEK-293T C19(1.24)  LDD1629  [6]
 LDCM0436  CL46 HEK-293T C19(1.11)  LDD1640  [6]
 LDCM0438  CL48 HEK-293T C19(0.92)  LDD1642  [6]
 LDCM0449  CL58 HEK-293T C19(1.27)  LDD1652  [6]
 LDCM0452  CL60 HEK-293T C19(1.10)  LDD1655  [6]
 LDCM0463  CL70 HEK-293T C19(0.97)  LDD1666  [6]
 LDCM0465  CL72 HEK-293T C19(0.99)  LDD1668  [6]
 LDCM0476  CL82 HEK-293T C19(1.01)  LDD1679  [6]
 LDCM0478  CL84 HEK-293T C19(1.12)  LDD1681  [6]
 LDCM0489  CL94 HEK-293T C19(1.01)  LDD1692  [6]
 LDCM0491  CL96 HEK-293T C19(1.23)  LDD1694  [6]
 LDCM0033  Curcusone1d MCF-7 5.48  LDD0188  [4]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.08  LDD0123  [5]
 LDCM0137  SR-4995 HEK-293T 3.41  LDD0332  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome b-c1 complex subunit 7 (UQCRB) UQCRB/QCR7 family P14927
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Protein TMED8 (TMED8) . Q6PL24
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570