Details of the Target

General Information of Target

Target ID LDTP03905
Target Name Peroxisomal biogenesis factor 19 (PEX19)
Gene Name PEX19
Gene ID 5824
Synonyms
HK33; PXF; Peroxisomal biogenesis factor 19; 33 kDa housekeeping protein; Peroxin-19; Peroxisomal farnesylated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAEEGCSVGAEADRELEELLESALDDFDKAKPSPAPPSTTTAPDASGPQKRSPGDTAK
DALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMT
SQQEFTSCLKETLSGLAKNATDLQNSSMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQ
NLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICEQFEAETPTDS
ETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGASGEQCLIM
Target Bioclass
Transporter and channel
Family
Peroxin-19 family
Subcellular location
Cytoplasm
Function
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Uniprot ID
P40855
Ensemble ID
ENST00000368072.10
HGNC ID
HGNC:9713

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURLMK1 SNV: p.R53K DBIA    Probe Info 
MCC13 SNV: p.E241K DBIA    Probe Info 
SKMEL24 SNV: p.G11R DBIA    Probe Info 
SUPT1 SNV: p.E197K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		20.00  LDD0122  [1]
STPyne
 Probe Info  		K130(1.82); K60(0.83)  LDD0277  [2]
m-APA
 Probe Info  		15.00  LDD0403  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
BTD
 Probe Info  		C128(0.79)  LDD2111  [5]
DA-P3
 Probe Info  		4.26  LDD0179  [6]
DBIA
 Probe Info  		C128(0.92)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0174  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
NAIA_4
 Probe Info  		C8(0.00); C128(0.00)  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
IPM
 Probe Info  		N.A.  LDD0005  [14]
PPMS
 Probe Info  		N.A.  LDD0008  [14]
VSF
 Probe Info  		C8(0.00); C128(0.00)  LDD0007  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
W1
 Probe Info  		C226(0.00); C229(0.00)  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C226(0.00); C8(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 55 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.78  LDD1740  [20]
C056
 Probe Info  		20.11  LDD1753  [20]
C087
 Probe Info  		10.41  LDD1779  [20]
C091
 Probe Info  		11.71  LDD1782  [20]
C092
 Probe Info  		29.65  LDD1783  [20]
C094
 Probe Info  		24.25  LDD1785  [20]
C106
 Probe Info  		23.10  LDD1793  [20]
C112
 Probe Info  		22.94  LDD1799  [20]
C134
 Probe Info  		26.72  LDD1816  [20]
C159
 Probe Info  		7.67  LDD1839  [20]
C178
 Probe Info  		14.72  LDD1857  [20]
C187
 Probe Info  		61.82  LDD1865  [20]
C191
 Probe Info  		27.47  LDD1868  [20]
C193
 Probe Info  		12.82  LDD1869  [20]
C201
 Probe Info  		41.64  LDD1877  [20]
C206
 Probe Info  		16.91  LDD1881  [20]
C210
 Probe Info  		57.68  LDD1884  [20]
C218
 Probe Info  		14.93  LDD1892  [20]
C220
 Probe Info  		13.18  LDD1894  [20]
C229
 Probe Info  		7.31  LDD1902  [20]
C231
 Probe Info  		19.16  LDD1904  [20]
C232
 Probe Info  		71.01  LDD1905  [20]
C233
 Probe Info  		8.82  LDD1906  [20]
C234
 Probe Info  		5.39  LDD1907  [20]
C235
 Probe Info  		29.45  LDD1908  [20]
C243
 Probe Info  		13.45  LDD1916  [20]
C244
 Probe Info  		14.42  LDD1917  [20]
C246
 Probe Info  		14.42  LDD1919  [20]
C249
 Probe Info  		14.32  LDD1922  [20]
C278
 Probe Info  		89.26  LDD1948  [20]
C282
 Probe Info  		19.70  LDD1952  [20]
C284
 Probe Info  		33.36  LDD1954  [20]
C293
 Probe Info  		21.26  LDD1963  [20]
C296
 Probe Info  		16.68  LDD1966  [20]
C299
 Probe Info  		6.28  LDD1968  [20]
C305
 Probe Info  		9.65  LDD1974  [20]
C310
 Probe Info  		9.65  LDD1977  [20]
C314
 Probe Info  		11.88  LDD1981  [20]
C343
 Probe Info  		11.08  LDD2005  [20]
C349
 Probe Info  		8.82  LDD2010  [20]
C350
 Probe Info  		31.78  LDD2011  [20]
C362
 Probe Info  		53.82  LDD2023  [20]
C364
 Probe Info  		17.39  LDD2025  [20]
C383
 Probe Info  		12.13  LDD2042  [20]
C388
 Probe Info  		50.21  LDD2047  [20]
C403
 Probe Info  		21.71  LDD2061  [20]
C407
 Probe Info  		19.16  LDD2064  [20]
C431
 Probe Info  		14.03  LDD2086  [20]
FFF probe11
 Probe Info  		20.00  LDD0471  [21]
FFF probe12
 Probe Info  		8.97  LDD0473  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe2
 Probe Info  		19.51  LDD0463  [21]
FFF probe3
 Probe Info  		18.07  LDD0464  [21]
JN0003
 Probe Info  		17.09  LDD0469  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C128(0.80)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C128(1.03)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C128(1.23)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C128(1.22)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C128(1.19)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C128(1.48)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C128(1.24)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C128(1.35)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C128(1.44)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C128(1.31)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C128(1.12)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C128(1.02)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C128(1.14)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C128(1.33)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C128(1.23)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C128(1.36)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C128(0.94)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C128(0.87)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C128(0.90)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C128(0.98)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C128(1.15)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C128(0.93)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C128(1.05)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C128(1.02)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C128(0.78)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C128(1.02)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C128(0.82)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C128(0.77)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C128(0.98)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C128(0.82)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C128(0.80)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C128(0.84)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C128(0.78)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C128(0.95)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C128(1.02)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C128(0.92)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C128(1.05)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C128(0.98)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C128(1.03)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C128(0.92)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C128(1.02)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C128(1.00)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C128(1.16)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C128(1.16)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C128(1.00)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C128(1.34)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C128(1.29)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C128(0.95)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C128(1.25)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C128(0.99)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C128(0.95)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C128(0.95)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C128(1.13)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C128(0.95)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C128(0.89)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C128(0.98)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C128(1.03)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C128(0.96)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C128(0.93)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C128(0.91)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C128(1.03)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C128(0.95)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C128(0.98)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C128(1.00)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C128(1.08)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C128(1.03)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C128(0.92)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C128(1.22)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C128(1.01)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C128(1.05)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C128(1.03)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C128(1.08)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C128(0.95)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C128(0.99)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C128(1.19)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C128(0.99)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C128(1.22)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C128(1.23)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C128(0.94)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C128(1.52)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C128(1.17)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C128(1.49)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C128(1.00)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C128(0.99)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C128(0.81)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C128(0.93)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C128(1.04)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C128(1.03)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C128(1.12)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C128(0.92)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C128(1.02)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C128(1.19)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C128(0.99)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C128(1.06)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C128(0.98)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C128(1.16)  LDD0624  [7]
 LDCM0308  AC46 HEK-293T C128(0.92)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C128(1.10)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C128(1.05)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C128(1.01)  LDD0909  [7]
 LDCM0312  AC5 HCT 116 C128(0.88)  LDD0629  [7]
 LDCM0313  AC50 HEK-293T C128(1.11)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C128(1.06)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C128(1.07)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C128(1.20)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C128(1.17)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C128(1.22)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C128(0.99)  LDD0917  [7]
 LDCM0320  AC57 HCT 116 C128(1.14)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C128(1.27)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C128(1.29)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C128(0.99)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C128(1.42)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C128(1.20)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C128(1.14)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C128(1.01)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C128(1.11)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C128(1.21)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C128(0.94)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C128(1.36)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C128(0.92)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C128(0.96)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C128(1.04)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C128(1.21)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C128(1.12)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C128(1.15)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C128(1.30)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C128(1.44)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C128(0.98)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C128(1.00)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C128(0.78)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C128(0.92)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C128(0.94)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C128(0.93)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C128(1.14)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C128(1.05)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C128(1.02)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C128(1.38)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C128(1.48)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C128(1.27)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C128(1.24)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C128(1.24)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C128(1.30)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C128(1.22)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C128(0.94)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C128(1.50)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C128(1.45)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C128(1.23)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C128(1.27)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C128(1.16)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C128(1.20)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C128(1.35)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C128(1.77)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C128(1.27)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C128(1.17)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C128(1.08)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C128(1.16)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [3]
 LDCM0020  ARS-1620 HCC44 C128(0.92)  LDD0078  [7]
 LDCM0632  CL-Sc Hep-G2 C128(1.14)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C128(1.03)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C128(0.88)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C128(0.89)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C128(1.06)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C128(0.97)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C128(0.89)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C128(1.04)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C128(1.10)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C128(1.16)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C128(1.25)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C128(1.30)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C128(1.10)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C128(0.98)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C128(1.18)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C128(1.13)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C128(1.00)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C128(1.15)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C128(1.62)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C128(1.22)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C128(1.03)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C128(1.38)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C128(0.98)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C128(0.93)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C128(0.96)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C128(1.05)  LDD0708  [7]
 LDCM0392  CL121 HEK-293T C128(1.04)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C128(1.21)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C128(1.15)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C128(1.02)  LDD0993  [7]
 LDCM0396  CL125 HCT 116 C128(1.19)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C128(1.18)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C128(1.24)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C128(0.93)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C128(0.98)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C128(0.99)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C128(0.98)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C128(1.05)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C128(1.12)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C128(1.02)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C128(1.21)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C128(0.99)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C128(1.12)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C128(1.21)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C128(1.51)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C128(1.13)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C128(1.28)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C128(1.46)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C128(1.06)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C128(1.16)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C128(1.28)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C128(1.23)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C128(0.95)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C128(1.04)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C128(1.34)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C128(1.24)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C128(1.17)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C128(1.78)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C128(1.42)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C128(1.37)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C128(1.46)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C128(1.32)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C128(1.23)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C128(1.28)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C128(1.14)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C128(1.97)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C128(1.68)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C128(1.35)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C128(1.69)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C128(0.91)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C128(0.84)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C128(0.77)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C128(0.83)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C128(0.96)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C128(0.85)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C128(0.94)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C128(0.88)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C128(0.84)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C128(0.78)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C128(0.74)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C128(0.92)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C128(0.83)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C128(0.86)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C128(0.93)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C128(1.05)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C128(0.82)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C128(1.07)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C128(1.02)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C128(1.20)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C128(0.95)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C128(1.01)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C128(1.13)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C128(0.98)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C128(0.96)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C128(0.99)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C128(0.97)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C128(1.16)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C128(1.07)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C128(1.10)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C128(0.98)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C128(1.06)  LDD0784  [7]
 LDCM0469  CL76 HEK-293T C128(1.06)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C128(0.99)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C128(1.05)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C128(1.17)  LDD1070  [7]
 LDCM0473  CL8 HCT 116 C128(1.02)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C128(1.30)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C128(1.04)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C128(0.93)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C128(1.41)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C128(1.23)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C128(1.36)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C128(1.26)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C128(1.13)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C128(1.58)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C128(1.05)  LDD1081  [7]
 LDCM0484  CL9 HCT 116 C128(0.98)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C128(1.53)  LDD1083  [7]
 LDCM0486  CL91 HCT 116 C128(1.18)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C128(1.01)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C128(0.76)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C128(0.75)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C128(1.15)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C128(0.96)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C128(1.27)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C128(1.15)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C128(1.05)  LDD0811  [7]
 LDCM0027  Dopamine HEK-293T 4.26  LDD0179  [6]
 LDCM0495  E2913 HEK-293T C226(1.10); C128(1.09); C229(1.09)  LDD1698  [22]
 LDCM0625  F8 Ramos C128(1.04)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C128(2.18)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C128(0.49)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C128(2.98)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C128(1.14)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C128(2.20)  LDD2193  [23]
 LDCM0580  Fragment21 Ramos C128(1.07)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C128(2.07)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C128(1.00)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C128(0.91)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C128(1.30)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C128(1.68)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C128(2.43)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C128(1.00)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C128(1.45)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C128(1.00)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C128(1.99)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C128(1.43)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C128(1.26)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C128(1.59)  LDD2186  [23]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HCT 116 C128(1.66); C226(1.41)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C128(2.62); C226(1.45)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C128(2.28); C226(1.43)  LDD0082  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C128(0.79)  LDD2111  [5]
 LDCM0131  RA190 MM1.R C128(1.99)  LDD0304  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-binding cassette sub-family D member 1 (ABCD1) ABCD family P33897
ATP-binding cassette sub-family D member 3 (ABCD3) ABCD family P28288
N-acetylaspartate synthetase (NAT8L) Camello family Q8N9F0
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
Peroxisome biogenesis factor 2 (PEX2) Pex2/pex10/pex12 family P28328
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 11 (BCL2L11) Bcl-2 family O43521
Peroxisomal membrane protein PMP34 (SLC25A17) Mitochondrial carrier (TC 2.A.29) family O43808
Peroxisomal membrane protein PEX13 (PEX13) Peroxin-13 family Q92968
Peroxisomal membrane protein PEX14 (PEX14) Peroxin-14 family O75381
Peroxisomal membrane protein PEX16 (PEX16) Peroxin-16 family Q9Y5Y5
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
Peroxisomal biogenesis factor 3 (PEX3) Peroxin-3 family P56589
Peroxisomal membrane protein 2 (PXMP2) Peroxisomal membrane protein PXMP2/4 family Q9NR77
Peroxisome assembly protein 12 (PEX12) Pex2/pex10/pex12 family O00623
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon beta (IFNB1) Alpha/beta interferon family P01574
Interleukin-23 subunit alpha (IL23A) IL-6 superfamily Q9NPF7
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal membrane protein 11B (PEX11B) Peroxin-11 family O96011
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.