Details of the Target

General Information of Target

Target ID LDTP14181
Target Name Peroxisomal membrane protein PEX16 (PEX16)
Gene Name PEX16
Gene ID 9409
Synonyms
Peroxisomal membrane protein PEX16; Peroxin-16; Peroxisomal biogenesis factor 16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
Target Bioclass
Transporter and channel
Family
Peroxin-16 family
Subcellular location
Peroxisome membrane
Function
Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3.
Uniprot ID
Q9Y5Y5
Ensemble ID
ENST00000241041.7
HGNC ID
HGNC:8857
ChEMBL ID
CHEMBL3774297

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.D154Y; p.N161K .
FUOV1 SNV: p.L282R .
HCT15 SNV: p.R109H .
IM95 Deletion: p.L213WfsTer42 .
LS180 SNV: p.L35R .
MCC13 SNV: p.R241K .
NCIH446 SNV: p.E106K .
RH30 SNV: p.R241W .
RL952 SNV: p.R170W .
TOV21G SNV: p.P228S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y166(20.00)  LDD0260  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]
PAL-AfBPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		32.45  LDD1799  [3]
C159
 Probe Info  		9.92  LDD1839  [3]
C160
 Probe Info  		7.36  LDD1840  [3]
C161
 Probe Info  		17.51  LDD1841  [3]
C169
 Probe Info  		40.50  LDD1849  [3]
C218
 Probe Info  		11.39  LDD1892  [3]
C220
 Probe Info  		13.93  LDD1894  [3]
C229
 Probe Info  		10.34  LDD1902  [3]
C231
 Probe Info  		47.18  LDD1904  [3]
C232
 Probe Info  		93.70  LDD1905  [3]
C233
 Probe Info  		17.51  LDD1906  [3]
C234
 Probe Info  		7.67  LDD1907  [3]
C235
 Probe Info  		52.71  LDD1908  [3]
C246
 Probe Info  		18.13  LDD1919  [3]
C264
 Probe Info  		19.03  LDD1935  [3]
C265
 Probe Info  		20.97  LDD1936  [3]
C270
 Probe Info  		8.75  LDD1940  [3]
C278
 Probe Info  		56.10  LDD1948  [3]
C282
 Probe Info  		26.35  LDD1952  [3]
C284
 Probe Info  		27.86  LDD1954  [3]
C285
 Probe Info  		23.75  LDD1955  [3]
C287
 Probe Info  		15.56  LDD1957  [3]
C288
 Probe Info  		7.36  LDD1958  [3]
C289
 Probe Info  		45.57  LDD1959  [3]
C296
 Probe Info  		12.91  LDD1966  [3]
C299
 Probe Info  		8.11  LDD1968  [3]
C305
 Probe Info  		14.62  LDD1974  [3]
C314
 Probe Info  		26.72  LDD1981  [3]
FFF probe11
 Probe Info  		20.00  LDD0471  [4]
FFF probe13
 Probe Info  		20.00  LDD0475  [4]
FFF probe14
 Probe Info  		20.00  LDD0477  [4]
FFF probe2
 Probe Info  		20.00  LDD0463  [4]
BD-F
 Probe Info  		A41(0.00); S43(0.00)  LDD0024  [5]
LD-F
 Probe Info  		L46(0.00); A41(0.00); D42(0.00); E45(0.00)  LDD0015  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855
Peroxisomal biogenesis factor 3 (PEX3) Peroxin-3 family P56589
Optineurin (OPTN) . Q96CV9
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) . Q02223
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dexamethasone-induced protein (DEXI) DEXI family O95424
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
C-type lectin domain family 10 member A (CLEC10A) . Q8IUN9
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) . O00559

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
5 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652