Details of the Target

General Information of Target

Target ID LDTP06986
Target Name Rab-like protein 3 (RABL3)
Gene Name RABL3
Gene ID 285282
Synonyms
Rab-like protein 3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVHDYKEGTPEEKTY
YIELWDVGGSVGSASSVKSTRAVFYNSVNGIIFVHDLTNKKSSQNLRRWSLEALNRDLVP
TGVLVTNGDYDQEQFADNQIPLLVIGTKLDQIHETKRHEVLTRTAFLAEDFNPEEINLDC
TNPRYLAAGSSNAVKLSRFFDKVIEKRYFLREGNQIPGFPDRKRFGAGTLKSLHYD
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Function
Required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development.
TTD ID
T41075
Uniprot ID
Q5HYI8
DrugMap ID
TTYGK57
Ensemble ID
ENST00000273375.8
HGNC ID
HGNC:18072
ChEMBL ID
CHEMBL4105853

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		5.60  LDD0066  [1]
STPyne
 Probe Info  		K156(10.00); K231(4.32)  LDD0277  [2]
Probe 1
 Probe Info  		Y185(22.51)  LDD3495  [3]
DBIA
 Probe Info  		C180(2.41)  LDD3312  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
Phosphinate-6
 Probe Info  		C41(0.00); C180(0.00)  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
AOyne
 Probe Info  		13.90  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		12.04  LDD1740  [13]
C056
 Probe Info  		17.15  LDD1753  [13]
C063
 Probe Info  		10.56  LDD1760  [13]
C087
 Probe Info  		7.11  LDD1779  [13]
C161
 Probe Info  		12.82  LDD1841  [13]
C169
 Probe Info  		20.11  LDD1849  [13]
C201
 Probe Info  		30.06  LDD1877  [13]
C246
 Probe Info  		29.65  LDD1919  [13]
C285
 Probe Info  		41.64  LDD1955  [13]
C287
 Probe Info  		12.91  LDD1957  [13]
C288
 Probe Info  		8.34  LDD1958  [13]
C289
 Probe Info  		74.03  LDD1959  [13]
C290
 Probe Info  		5.03  LDD1960  [13]
C299
 Probe Info  		11.24  LDD1968  [13]
C304
 Probe Info  		5.50  LDD1973  [13]
C305
 Probe Info  		23.26  LDD1974  [13]
C310
 Probe Info  		14.32  LDD1977  [13]
C362
 Probe Info  		27.10  LDD2023  [13]
C390
 Probe Info  		23.59  LDD2049  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C27(1.10); C41(0.84)  LDD0812  [14]
 LDCM0215  AC10 PaTu 8988t C27(0.87); C41(0.87)  LDD1094  [14]
 LDCM0216  AC100 HEK-293T C27(1.34); C41(0.77)  LDD0814  [14]
 LDCM0217  AC101 HEK-293T C27(1.36); C41(0.86)  LDD0815  [14]
 LDCM0218  AC102 HEK-293T C27(1.35); C41(0.73)  LDD0816  [14]
 LDCM0219  AC103 HEK-293T C27(1.04); C41(0.67)  LDD0817  [14]
 LDCM0220  AC104 HEK-293T C27(1.28); C41(0.70)  LDD0818  [14]
 LDCM0221  AC105 HEK-293T C27(0.99); C41(0.97)  LDD0819  [14]
 LDCM0222  AC106 HEK-293T C27(1.04); C41(1.17)  LDD0820  [14]
 LDCM0223  AC107 HEK-293T C27(1.48); C41(0.78)  LDD0821  [14]
 LDCM0224  AC108 HEK-293T C27(1.57); C41(0.93)  LDD0822  [14]
 LDCM0225  AC109 HEK-293T C27(0.94); C41(0.98)  LDD0823  [14]
 LDCM0226  AC11 PaTu 8988t C27(1.33); C41(1.33)  LDD1105  [14]
 LDCM0227  AC110 HEK-293T C27(1.27); C41(0.58)  LDD0825  [14]
 LDCM0228  AC111 HEK-293T C27(1.61); C41(0.64)  LDD0826  [14]
 LDCM0229  AC112 HEK-293T C27(1.73); C41(0.59)  LDD0827  [14]
 LDCM0230  AC113 HEK-293T C41(1.14)  LDD0828  [14]
 LDCM0231  AC114 HEK-293T C41(1.00)  LDD0829  [14]
 LDCM0232  AC115 HEK-293T C41(1.09)  LDD0830  [14]
 LDCM0233  AC116 HEK-293T C41(0.98)  LDD0831  [14]
 LDCM0234  AC117 HEK-293T C41(0.85)  LDD0832  [14]
 LDCM0235  AC118 HEK-293T C41(0.83)  LDD0833  [14]
 LDCM0236  AC119 HEK-293T C41(0.79)  LDD0834  [14]
 LDCM0237  AC12 PaTu 8988t C27(0.77); C41(0.77)  LDD1116  [14]
 LDCM0238  AC120 HEK-293T C41(0.79)  LDD0836  [14]
 LDCM0239  AC121 HEK-293T C41(0.74)  LDD0837  [14]
 LDCM0240  AC122 HEK-293T C41(0.60)  LDD0838  [14]
 LDCM0241  AC123 HEK-293T C41(0.59)  LDD0839  [14]
 LDCM0242  AC124 HEK-293T C41(0.78)  LDD0840  [14]
 LDCM0243  AC125 HEK-293T C41(0.59)  LDD0841  [14]
 LDCM0244  AC126 HEK-293T C41(0.58)  LDD0842  [14]
 LDCM0245  AC127 HEK-293T C41(0.65)  LDD0843  [14]
 LDCM0246  AC128 HEK-293T C41(1.11)  LDD0844  [14]
 LDCM0247  AC129 HEK-293T C41(0.61)  LDD0845  [14]
 LDCM0249  AC130 HEK-293T C41(1.24)  LDD0847  [14]
 LDCM0250  AC131 HEK-293T C41(1.03)  LDD0848  [14]
 LDCM0251  AC132 HEK-293T C41(0.61)  LDD0849  [14]
 LDCM0252  AC133 HEK-293T C41(0.64)  LDD0850  [14]
 LDCM0253  AC134 HEK-293T C41(0.75)  LDD0851  [14]
 LDCM0254  AC135 HEK-293T C41(0.98)  LDD0852  [14]
 LDCM0255  AC136 HEK-293T C41(0.90)  LDD0853  [14]
 LDCM0256  AC137 HEK-293T C41(0.55)  LDD0854  [14]
 LDCM0257  AC138 HEK-293T C41(0.57)  LDD0855  [14]
 LDCM0258  AC139 HEK-293T C41(0.61)  LDD0856  [14]
 LDCM0259  AC14 PaTu 8988t C27(1.25); C41(1.25)  LDD1138  [14]
 LDCM0260  AC140 HEK-293T C41(0.70)  LDD0858  [14]
 LDCM0261  AC141 HEK-293T C41(0.63)  LDD0859  [14]
 LDCM0262  AC142 HEK-293T C41(0.73)  LDD0860  [14]
 LDCM0263  AC143 HEK-293T C27(0.52)  LDD0861  [14]
 LDCM0264  AC144 HEK-293T C27(0.70)  LDD0862  [14]
 LDCM0265  AC145 HEK-293T C27(0.67)  LDD0863  [14]
 LDCM0266  AC146 HEK-293T C27(0.55)  LDD0864  [14]
 LDCM0267  AC147 HEK-293T C27(0.39)  LDD0865  [14]
 LDCM0268  AC148 HEK-293T C27(0.33)  LDD0866  [14]
 LDCM0269  AC149 HEK-293T C27(0.49)  LDD0867  [14]
 LDCM0270  AC15 PaTu 8988t C27(1.44); C41(1.44)  LDD1149  [14]
 LDCM0271  AC150 HEK-293T C27(0.54)  LDD0869  [14]
 LDCM0272  AC151 HEK-293T C27(0.65)  LDD0870  [14]
 LDCM0273  AC152 HEK-293T C27(0.56)  LDD0871  [14]
 LDCM0274  AC153 HEK-293T C27(0.62)  LDD0872  [14]
 LDCM0621  AC154 HEK-293T C27(0.45)  LDD2162  [14]
 LDCM0622  AC155 HEK-293T C27(0.59)  LDD2163  [14]
 LDCM0623  AC156 HEK-293T C27(0.65)  LDD2164  [14]
 LDCM0624  AC157 HEK-293T C27(0.71)  LDD2165  [14]
 LDCM0276  AC17 HEK-293T C41(1.10)  LDD0874  [14]
 LDCM0277  AC18 HEK-293T C41(1.46)  LDD0875  [14]
 LDCM0278  AC19 HEK-293T C41(1.47)  LDD0876  [14]
 LDCM0279  AC2 HEK-293T C27(0.98); C41(0.98)  LDD0877  [14]
 LDCM0280  AC20 HEK-293T C41(1.19)  LDD0878  [14]
 LDCM0281  AC21 HEK-293T C41(1.57)  LDD0879  [14]
 LDCM0282  AC22 HEK-293T C41(1.50)  LDD0880  [14]
 LDCM0283  AC23 HEK-293T C41(1.26)  LDD0881  [14]
 LDCM0284  AC24 HEK-293T C41(2.09)  LDD0882  [14]
 LDCM0285  AC25 HEK-293T C27(2.20); C41(1.08)  LDD0883  [14]
 LDCM0286  AC26 HEK-293T C27(1.80); C41(1.13)  LDD0884  [14]
 LDCM0287  AC27 HEK-293T C27(1.40); C41(1.07)  LDD0885  [14]
 LDCM0288  AC28 HEK-293T C27(1.77); C41(0.72)  LDD0886  [14]
 LDCM0289  AC29 HEK-293T C27(2.00); C41(0.96)  LDD0887  [14]
 LDCM0290  AC3 HEK-293T C27(0.83); C41(1.13)  LDD0888  [14]
 LDCM0291  AC30 HEK-293T C27(1.75); C41(1.09)  LDD0889  [14]
 LDCM0292  AC31 HEK-293T C27(1.82); C41(1.00)  LDD0890  [14]
 LDCM0293  AC32 HEK-293T C27(1.77); C41(0.98)  LDD0891  [14]
 LDCM0294  AC33 HEK-293T C27(2.04); C41(1.04)  LDD0892  [14]
 LDCM0295  AC34 HEK-293T C27(2.65); C41(1.07)  LDD0893  [14]
 LDCM0296  AC35 PaTu 8988t C27(0.62); C41(0.62)  LDD1175  [14]
 LDCM0297  AC36 PaTu 8988t C27(0.47); C41(0.47)  LDD1176  [14]
 LDCM0298  AC37 PaTu 8988t C27(0.62); C41(0.62)  LDD1177  [14]
 LDCM0299  AC38 PaTu 8988t C27(0.60); C41(0.60)  LDD1178  [14]
 LDCM0300  AC39 PaTu 8988t C27(0.86); C41(0.86)  LDD1179  [14]
 LDCM0301  AC4 HEK-293T C27(1.04); C41(1.17)  LDD0899  [14]
 LDCM0302  AC40 PaTu 8988t C27(0.60); C41(0.60)  LDD1181  [14]
 LDCM0303  AC41 PaTu 8988t C27(0.75); C41(0.75)  LDD1182  [14]
 LDCM0304  AC42 PaTu 8988t C27(0.81); C41(0.81)  LDD1183  [14]
 LDCM0305  AC43 PaTu 8988t C27(0.63); C41(0.63)  LDD1184  [14]
 LDCM0306  AC44 PaTu 8988t C27(0.87); C41(0.87)  LDD1185  [14]
 LDCM0307  AC45 PaTu 8988t C27(0.82); C41(0.82)  LDD1186  [14]
 LDCM0308  AC46 HEK-293T C27(0.58); C41(1.00)  LDD0906  [14]
 LDCM0309  AC47 HEK-293T C27(0.63); C41(0.97)  LDD0907  [14]
 LDCM0310  AC48 HEK-293T C27(0.69); C41(0.98)  LDD0908  [14]
 LDCM0311  AC49 HEK-293T C27(0.93); C41(0.89)  LDD0909  [14]
 LDCM0312  AC5 HEK-293T C27(1.49); C41(0.98)  LDD0910  [14]
 LDCM0313  AC50 HEK-293T C27(0.65); C41(0.88)  LDD0911  [14]
 LDCM0314  AC51 HEK-293T C27(0.86); C41(0.83)  LDD0912  [14]
 LDCM0315  AC52 HEK-293T C27(0.97); C41(0.88)  LDD0913  [14]
 LDCM0316  AC53 HEK-293T C27(0.83); C41(0.94)  LDD0914  [14]
 LDCM0317  AC54 HEK-293T C27(0.81); C41(0.91)  LDD0915  [14]
 LDCM0318  AC55 HEK-293T C27(0.90); C41(1.00)  LDD0916  [14]
 LDCM0319  AC56 HEK-293T C27(0.83); C41(1.06)  LDD0917  [14]
 LDCM0320  AC57 HEK-293T C180(0.97); C41(1.01)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C180(1.21); C27(0.83); C41(0.86)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C180(1.01); C27(0.88); C41(0.98)  LDD1561  [15]
 LDCM0323  AC6 PaTu 8988t C27(0.75); C41(0.75)  LDD1202  [14]
 LDCM0324  AC60 HEK-293T C180(1.15); C27(0.90); C41(1.47)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C180(1.11); C27(1.01); C41(1.15)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C180(1.12); C27(0.89); C41(1.01)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C180(1.04); C27(1.02); C41(1.07); C27(1.13)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C180(1.10); C27(1.28); C41(0.99)  LDD1567  [15]
 LDCM0332  AC68 HEK-293T C27(1.06)  LDD0930  [14]
 LDCM0333  AC69 HEK-293T C27(1.07)  LDD0931  [14]
 LDCM0334  AC7 PaTu 8988t C27(1.14); C41(1.14)  LDD1213  [14]
 LDCM0335  AC70 HEK-293T C27(1.31)  LDD0933  [14]
 LDCM0336  AC71 HEK-293T C27(1.65)  LDD0934  [14]
 LDCM0337  AC72 HEK-293T C27(1.32)  LDD0935  [14]
 LDCM0338  AC73 HEK-293T C27(0.83)  LDD0936  [14]
 LDCM0339  AC74 HEK-293T C27(1.14)  LDD0937  [14]
 LDCM0340  AC75 HEK-293T C27(1.30)  LDD0938  [14]
 LDCM0341  AC76 HEK-293T C27(1.12)  LDD0939  [14]
 LDCM0342  AC77 HEK-293T C27(1.29)  LDD0940  [14]
 LDCM0343  AC78 HEK-293T C27(1.15)  LDD0941  [14]
 LDCM0344  AC79 HEK-293T C27(1.22)  LDD0942  [14]
 LDCM0345  AC8 PaTu 8988t C27(1.28); C41(1.28)  LDD1224  [14]
 LDCM0346  AC80 HEK-293T C27(1.73)  LDD0944  [14]
 LDCM0347  AC81 HEK-293T C27(1.33)  LDD0945  [14]
 LDCM0348  AC82 HEK-293T C27(2.15)  LDD0946  [14]
 LDCM0349  AC83 HEK-293T C27(1.06)  LDD0947  [14]
 LDCM0350  AC84 HEK-293T C27(1.03)  LDD0948  [14]
 LDCM0351  AC85 HEK-293T C27(0.93)  LDD0949  [14]
 LDCM0352  AC86 HEK-293T C27(1.03)  LDD0950  [14]
 LDCM0353  AC87 HEK-293T C27(0.98)  LDD0951  [14]
 LDCM0354  AC88 HEK-293T C27(0.74)  LDD0952  [14]
 LDCM0355  AC89 HEK-293T C27(0.87)  LDD0953  [14]
 LDCM0357  AC90 HEK-293T C27(1.01)  LDD0955  [14]
 LDCM0358  AC91 HEK-293T C27(0.84)  LDD0956  [14]
 LDCM0359  AC92 HEK-293T C27(1.00)  LDD0957  [14]
 LDCM0360  AC93 HEK-293T C27(0.82)  LDD0958  [14]
 LDCM0361  AC94 HEK-293T C27(0.96)  LDD0959  [14]
 LDCM0362  AC95 HEK-293T C27(0.89)  LDD0960  [14]
 LDCM0363  AC96 HEK-293T C27(0.81)  LDD0961  [14]
 LDCM0364  AC97 HEK-293T C27(1.06)  LDD0962  [14]
 LDCM0365  AC98 HEK-293T C27(0.89); C41(0.83)  LDD0963  [14]
 LDCM0366  AC99 HEK-293T C27(1.09); C41(0.99)  LDD0964  [14]
 LDCM0248  AKOS034007472 PaTu 8988t C27(1.13); C41(1.13)  LDD1127  [14]
 LDCM0356  AKOS034007680 PaTu 8988t C27(0.95); C41(0.95)  LDD1235  [14]
 LDCM0275  AKOS034007705 PaTu 8988t C27(0.86); C41(0.86)  LDD1154  [14]
 LDCM0108  Chloroacetamide HeLa C180(0.00); H158(0.00)  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C180(0.92); C41(0.99)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C180(0.85); C27(1.11); C41(1.01)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C27(0.95); C41(0.88)  LDD0967  [14]
 LDCM0370  CL101 PaTu 8988t C27(1.15); C41(1.15)  LDD1249  [14]
 LDCM0371  CL102 PaTu 8988t C27(0.84); C41(0.84)  LDD1250  [14]
 LDCM0372  CL103 PaTu 8988t C27(1.25); C41(1.25)  LDD1251  [14]
 LDCM0373  CL104 PaTu 8988t C27(1.22); C41(1.22)  LDD1252  [14]
 LDCM0374  CL105 HEK-293T C41(1.18)  LDD0972  [14]
 LDCM0375  CL106 HEK-293T C41(1.30)  LDD0973  [14]
 LDCM0376  CL107 HEK-293T C41(1.22)  LDD0974  [14]
 LDCM0377  CL108 HEK-293T C41(1.38)  LDD0975  [14]
 LDCM0378  CL109 HEK-293T C41(1.71)  LDD0976  [14]
 LDCM0379  CL11 HEK-293T C180(1.09); C27(0.94); C41(1.01); C27(0.98)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C41(1.72)  LDD0978  [14]
 LDCM0381  CL111 HEK-293T C41(1.79)  LDD0979  [14]
 LDCM0382  CL112 HEK-293T C27(1.66); C41(0.91)  LDD0980  [14]
 LDCM0383  CL113 HEK-293T C27(2.27); C41(1.06)  LDD0981  [14]
 LDCM0384  CL114 HEK-293T C27(2.29); C41(0.80)  LDD0982  [14]
 LDCM0385  CL115 HEK-293T C27(2.84); C41(0.98)  LDD0983  [14]
 LDCM0386  CL116 HEK-293T C27(1.85); C41(0.95)  LDD0984  [14]
 LDCM0387  CL117 PaTu 8988t C27(0.73); C41(0.73)  LDD1266  [14]
 LDCM0388  CL118 PaTu 8988t C27(0.91); C41(0.91)  LDD1267  [14]
 LDCM0389  CL119 PaTu 8988t C27(0.61); C41(0.61)  LDD1268  [14]
 LDCM0390  CL12 HEK-293T C180(1.02); C27(1.44); C41(0.85)  LDD1594  [15]
 LDCM0391  CL120 PaTu 8988t C27(0.67); C41(0.67)  LDD1270  [14]
 LDCM0392  CL121 HEK-293T C27(0.79); C41(0.87)  LDD0990  [14]
 LDCM0393  CL122 HEK-293T C27(0.94); C41(1.04)  LDD0991  [14]
 LDCM0394  CL123 HEK-293T C27(0.82); C41(0.94)  LDD0992  [14]
 LDCM0395  CL124 HEK-293T C27(0.98); C41(1.05)  LDD0993  [14]
 LDCM0396  CL125 HEK-293T C180(1.14); C41(0.87)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C180(0.98); C41(0.93)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C180(1.05); C27(0.69); C41(0.82)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C180(1.02); C27(0.73); C41(0.69)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C180(0.95); C41(0.81)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C180(0.98); C41(1.00)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C180(0.92); C27(0.83); C41(1.08)  LDD1606  [15]
 LDCM0403  CL16 PaTu 8988t C27(0.95); C41(0.95)  LDD1282  [14]
 LDCM0404  CL17 PaTu 8988t C27(1.03); C41(1.03)  LDD1283  [14]
 LDCM0405  CL18 PaTu 8988t C27(0.89); C41(0.89)  LDD1284  [14]
 LDCM0406  CL19 PaTu 8988t C27(1.16); C41(1.16)  LDD1285  [14]
 LDCM0407  CL2 HEK-293T C180(1.03); C41(0.98)  LDD1611  [15]
 LDCM0408  CL20 PaTu 8988t C27(0.97); C41(0.97)  LDD1287  [14]
 LDCM0409  CL21 PaTu 8988t C27(1.11); C41(1.11)  LDD1288  [14]
 LDCM0410  CL22 PaTu 8988t C27(0.87); C41(0.87)  LDD1289  [14]
 LDCM0411  CL23 PaTu 8988t C27(1.16); C41(1.16)  LDD1290  [14]
 LDCM0412  CL24 PaTu 8988t C27(1.09); C41(1.09)  LDD1291  [14]
 LDCM0413  CL25 PaTu 8988t C27(0.78); C41(0.78)  LDD1292  [14]
 LDCM0414  CL26 PaTu 8988t C27(1.09); C41(1.09)  LDD1293  [14]
 LDCM0415  CL27 PaTu 8988t C27(1.08); C41(1.08)  LDD1294  [14]
 LDCM0416  CL28 PaTu 8988t C27(1.18); C41(1.18)  LDD1295  [14]
 LDCM0417  CL29 PaTu 8988t C27(1.55); C41(1.55)  LDD1296  [14]
 LDCM0418  CL3 HEK-293T C180(0.98); C27(0.86); C41(1.12)  LDD1622  [15]
 LDCM0419  CL30 PaTu 8988t C27(1.01); C41(1.01)  LDD1298  [14]
 LDCM0420  CL31 PaTu 8988t C27(0.73); C41(0.73)  LDD1299  [14]
 LDCM0421  CL32 PaTu 8988t C27(0.61); C41(0.61)  LDD1300  [14]
 LDCM0422  CL33 PaTu 8988t C27(0.59); C41(0.59)  LDD1301  [14]
 LDCM0423  CL34 PaTu 8988t C27(0.67); C41(0.67)  LDD1302  [14]
 LDCM0424  CL35 PaTu 8988t C27(0.72); C41(0.72)  LDD1303  [14]
 LDCM0425  CL36 PaTu 8988t C27(0.71); C41(0.71)  LDD1304  [14]
 LDCM0426  CL37 PaTu 8988t C27(0.56); C41(0.56)  LDD1305  [14]
 LDCM0428  CL39 PaTu 8988t C27(0.57); C41(0.57)  LDD1307  [14]
 LDCM0429  CL4 HEK-293T C180(1.17); C27(0.84); C41(0.79)  LDD1633  [15]
 LDCM0430  CL40 PaTu 8988t C27(0.80); C41(0.80)  LDD1309  [14]
 LDCM0431  CL41 PaTu 8988t C27(0.62); C41(0.62)  LDD1310  [14]
 LDCM0432  CL42 PaTu 8988t C27(0.67); C41(0.67)  LDD1311  [14]
 LDCM0433  CL43 PaTu 8988t C27(0.78); C41(0.78)  LDD1312  [14]
 LDCM0434  CL44 PaTu 8988t C27(0.64); C41(0.64)  LDD1313  [14]
 LDCM0435  CL45 PaTu 8988t C27(0.77); C41(0.77)  LDD1314  [14]
 LDCM0436  CL46 HEK-293T C41(0.75)  LDD1034  [14]
 LDCM0437  CL47 HEK-293T C41(0.80)  LDD1035  [14]
 LDCM0438  CL48 HEK-293T C41(0.78)  LDD1036  [14]
 LDCM0439  CL49 HEK-293T C41(0.75)  LDD1037  [14]
 LDCM0440  CL5 HEK-293T C180(1.08); C41(1.00)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C41(0.53)  LDD1039  [14]
 LDCM0442  CL51 HEK-293T C41(0.65)  LDD1040  [14]
 LDCM0443  CL52 HEK-293T C41(1.00)  LDD1041  [14]
 LDCM0444  CL53 HEK-293T C41(0.90)  LDD1042  [14]
 LDCM0445  CL54 HEK-293T C41(0.71)  LDD1043  [14]
 LDCM0446  CL55 HEK-293T C41(0.75)  LDD1044  [14]
 LDCM0447  CL56 HEK-293T C41(0.95)  LDD1045  [14]
 LDCM0448  CL57 HEK-293T C41(0.91)  LDD1046  [14]
 LDCM0449  CL58 HEK-293T C41(0.87)  LDD1047  [14]
 LDCM0450  CL59 HEK-293T C41(0.61)  LDD1048  [14]
 LDCM0451  CL6 HEK-293T C180(1.13); C27(0.75); C41(0.87)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C41(0.51)  LDD1050  [14]
 LDCM0453  CL61 HEK-293T C27(1.51); C41(1.06)  LDD1051  [14]
 LDCM0454  CL62 HEK-293T C27(1.48); C41(1.29)  LDD1052  [14]
 LDCM0455  CL63 HEK-293T C27(1.60); C41(1.16)  LDD1053  [14]
 LDCM0456  CL64 HEK-293T C27(1.33); C41(1.67)  LDD1054  [14]
 LDCM0457  CL65 HEK-293T C27(1.40); C41(1.71)  LDD1055  [14]
 LDCM0458  CL66 HEK-293T C27(1.33); C41(1.72)  LDD1056  [14]
 LDCM0459  CL67 HEK-293T C27(1.15); C41(1.86)  LDD1057  [14]
 LDCM0460  CL68 HEK-293T C27(1.18); C41(1.64)  LDD1058  [14]
 LDCM0461  CL69 HEK-293T C27(1.35); C41(1.50)  LDD1059  [14]
 LDCM0462  CL7 HEK-293T C180(1.17); C27(0.99); C41(0.94)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C27(1.22); C41(1.81)  LDD1061  [14]
 LDCM0464  CL71 HEK-293T C27(1.11); C41(1.49)  LDD1062  [14]
 LDCM0465  CL72 HEK-293T C27(1.56); C41(1.66)  LDD1063  [14]
 LDCM0466  CL73 HEK-293T C27(1.05); C41(1.74)  LDD1064  [14]
 LDCM0467  CL74 HEK-293T C27(1.42); C41(1.07)  LDD1065  [14]
 LDCM0469  CL76 HEK-293T C27(0.44)  LDD1067  [14]
 LDCM0470  CL77 HEK-293T C27(0.96)  LDD1068  [14]
 LDCM0471  CL78 HEK-293T C27(1.00)  LDD1069  [14]
 LDCM0472  CL79 HEK-293T C27(0.61)  LDD1070  [14]
 LDCM0473  CL8 HEK-293T C180(0.86); C27(0.88); C41(0.97)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C27(0.84)  LDD1072  [14]
 LDCM0475  CL81 HEK-293T C27(1.30)  LDD1073  [14]
 LDCM0476  CL82 HEK-293T C27(0.93)  LDD1074  [14]
 LDCM0477  CL83 HEK-293T C27(0.88)  LDD1075  [14]
 LDCM0478  CL84 HEK-293T C27(0.98)  LDD1076  [14]
 LDCM0479  CL85 HEK-293T C27(0.99)  LDD1077  [14]
 LDCM0480  CL86 HEK-293T C27(0.83)  LDD1078  [14]
 LDCM0481  CL87 HEK-293T C27(1.06)  LDD1079  [14]
 LDCM0482  CL88 HEK-293T C27(0.85)  LDD1080  [14]
 LDCM0483  CL89 HEK-293T C27(0.67)  LDD1081  [14]
 LDCM0484  CL9 HEK-293T C180(0.88); C27(1.11); C41(0.92)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C27(1.03)  LDD1083  [14]
 LDCM0486  CL91 HEK-293T C27(1.37); C41(1.18)  LDD1084  [14]
 LDCM0487  CL92 HEK-293T C27(1.02); C41(1.04)  LDD1085  [14]
 LDCM0488  CL93 HEK-293T C27(1.55); C41(0.94)  LDD1086  [14]
 LDCM0489  CL94 HEK-293T C27(1.32); C41(0.88)  LDD1087  [14]
 LDCM0490  CL95 HEK-293T C27(1.72); C41(0.67)  LDD1088  [14]
 LDCM0491  CL96 HEK-293T C27(1.79); C41(0.99)  LDD1089  [14]
 LDCM0492  CL97 HEK-293T C27(1.47); C41(0.96)  LDD1090  [14]
 LDCM0493  CL98 HEK-293T C27(0.96); C41(1.02)  LDD1091  [14]
 LDCM0494  CL99 HEK-293T C27(0.94); C41(1.16)  LDD1092  [14]
 LDCM0495  E2913 HEK-293T C180(1.22); C27(0.70); C41(0.90)  LDD1698  [15]
 LDCM0625  F8 Ramos C180(0.64)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C180(1.02)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C180(0.71)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C180(1.24)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C180(0.83)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C180(1.39)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C180(0.85)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C180(0.82)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C180(0.75)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C180(0.78)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C180(0.34)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C180(0.87)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C180(1.41)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C180(0.79)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C27(1.35); C41(1.40)  LDD1066  [14]
 LDCM0596  Fragment38 Ramos C180(0.91)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C180(0.72)  LDD2184  [16]
 LDCM0427  Fragment51 PaTu 8988t C27(0.70); C41(0.70)  LDD1306  [14]
 LDCM0610  Fragment52 Ramos C180(0.97)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C180(0.99)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C180(0.30)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C180(1.28)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C180(1.03); C41(0.92); C27(1.01); C41(1.01)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C180(1.06); C41(0.89); C27(1.00); C41(1.00)  LDD1497  [15]
 LDCM0024  KB05 HMCB C180(2.41)  LDD3312  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C180(0.96)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C180(2.04)  LDD2207  [17]
 LDCM0131  RA190 MM1.R C180(1.11)  LDD0304  [18]

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
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