Details of the Target

General Information of Target

Target ID LDTP08981
Target Name Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18)
Gene Name COX18
Gene ID 285521
Synonyms
OXA1L2; Cytochrome c oxidase assembly protein COX18, mitochondrial; COX18Hs; Cytochrome c oxidase assembly protein 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLCRLGGRWLRPLPALQLWARDLPLAPVPTSGAKRPTLPVWAVAPVSAVHANGWYEALAA
SSPVRVAEEVLLGVHAATGLPWWGSILLSTVALRGAVTLPLAAYQHYILAKVENLQPEIK
TIARHLNQEVAVRANQLGWSKRDARLTYLKNMRRLISELYVRDNCHPFKATVLVWIQLPM
WIFMSFALRNLSTGAAHSEGFSVQEQLATGGILWFPDLTAPDSTWILPISVGVINLLIVE
ICALQKIGMSRFQTYITYFVRAMSVLMIPIAATVPSSIVLYWLCSSFVGLSQNLLLRSPG
FRQLCRIPSTKSDSETPYKDIFAAFNTKFISRK
Target Bioclass
Transporter and channel
Family
OXA1/ALB3/YidC family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).
Uniprot ID
Q8N8Q8
Ensemble ID
ENST00000295890.8
HGNC ID
HGNC:26801

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K141(3.03); K328(0.90)  LDD0277  [1]
Curcusone 37
 Probe Info  		3.88  LDD0188  [2]
DBIA
 Probe Info  		C165(0.86)  LDD1492  [3]
Acrolein
 Probe Info  		N.A.  LDD0233  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		28.64  LDD1752  [6]
C056
 Probe Info  		27.86  LDD1753  [6]
C091
 Probe Info  		51.63  LDD1782  [6]
C092
 Probe Info  		54.95  LDD1783  [6]
C094
 Probe Info  		64.45  LDD1785  [6]
C106
 Probe Info  		21.56  LDD1793  [6]
C107
 Probe Info  		5.66  LDD1794  [6]
C112
 Probe Info  		52.35  LDD1799  [6]
C134
 Probe Info  		20.82  LDD1816  [6]
C186
 Probe Info  		8.11  LDD1864  [6]
C201
 Probe Info  		73.52  LDD1877  [6]
C206
 Probe Info  		32.67  LDD1881  [6]
C207
 Probe Info  		20.53  LDD1882  [6]
C216
 Probe Info  		5.90  LDD1890  [6]
C218
 Probe Info  		58.49  LDD1892  [6]
C219
 Probe Info  		14.42  LDD1893  [6]
C220
 Probe Info  		42.81  LDD1894  [6]
C264
 Probe Info  		21.86  LDD1935  [6]
C265
 Probe Info  		14.83  LDD1936  [6]
C266
 Probe Info  		9.25  LDD1937  [6]
C278
 Probe Info  		81.57  LDD1948  [6]
C282
 Probe Info  		18.25  LDD1952  [6]
C285
 Probe Info  		26.17  LDD1955  [6]
C287
 Probe Info  		11.08  LDD1957  [6]
C288
 Probe Info  		6.41  LDD1958  [6]
C289
 Probe Info  		56.89  LDD1959  [6]
C293
 Probe Info  		26.72  LDD1963  [6]
C296
 Probe Info  		14.03  LDD1966  [6]
C299
 Probe Info  		10.20  LDD1968  [6]
C305
 Probe Info  		12.73  LDD1974  [6]
C314
 Probe Info  		13.27  LDD1981  [6]
C362
 Probe Info  		74.54  LDD2023  [6]
C363
 Probe Info  		26.54  LDD2024  [6]
C364
 Probe Info  		26.54  LDD2025  [6]
C366
 Probe Info  		13.00  LDD2027  [6]
C367
 Probe Info  		7.67  LDD2028  [6]
C383
 Probe Info  		11.47  LDD2042  [6]
C388
 Probe Info  		76.11  LDD2047  [6]
OEA-DA
 Probe Info  		20.00  LDD0046  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C165(0.95)  LDD1507  [3]
 LDCM0259  AC14 HEK-293T C165(1.02)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C165(0.95)  LDD1515  [3]
 LDCM0282  AC22 HEK-293T C165(0.95)  LDD1521  [3]
 LDCM0285  AC25 HEK-293T C165(0.88)  LDD1524  [3]
 LDCM0291  AC30 HEK-293T C165(0.93)  LDD1530  [3]
 LDCM0294  AC33 HEK-293T C165(1.09)  LDD1533  [3]
 LDCM0299  AC38 HEK-293T C165(0.98)  LDD1538  [3]
 LDCM0303  AC41 HEK-293T C165(1.06)  LDD1542  [3]
 LDCM0308  AC46 HEK-293T C165(0.94)  LDD1547  [3]
 LDCM0311  AC49 HEK-293T C165(0.94)  LDD1550  [3]
 LDCM0317  AC54 HEK-293T C165(0.93)  LDD1556  [3]
 LDCM0320  AC57 HEK-293T C165(1.09)  LDD1559  [3]
 LDCM0323  AC6 HEK-293T C165(1.00)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C165(0.92)  LDD1565  [3]
 LDCM0356  AKOS034007680 HEK-293T C165(0.99)  LDD1570  [3]
 LDCM0368  CL10 HEK-293T C165(1.92)  LDD1572  [3]
 LDCM0404  CL17 HEK-293T C165(1.49)  LDD1608  [3]
 LDCM0410  CL22 HEK-293T C165(1.08)  LDD1614  [3]
 LDCM0417  CL29 HEK-293T C165(0.92)  LDD1621  [3]
 LDCM0423  CL34 HEK-293T C165(1.09)  LDD1627  [3]
 LDCM0431  CL41 HEK-293T C165(1.06)  LDD1635  [3]
 LDCM0436  CL46 HEK-293T C165(1.02)  LDD1640  [3]
 LDCM0440  CL5 HEK-293T C165(1.20)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C165(1.29)  LDD1647  [3]
 LDCM0449  CL58 HEK-293T C165(1.17)  LDD1652  [3]
 LDCM0457  CL65 HEK-293T C165(1.02)  LDD1660  [3]
 LDCM0463  CL70 HEK-293T C165(1.02)  LDD1666  [3]
 LDCM0470  CL77 HEK-293T C165(1.23)  LDD1673  [3]
 LDCM0476  CL82 HEK-293T C165(0.99)  LDD1679  [3]
 LDCM0483  CL89 HEK-293T C165(1.08)  LDD1686  [3]
 LDCM0489  CL94 HEK-293T C165(1.06)  LDD1692  [3]
 LDCM0033  Curcusone1d MCF-7 3.88  LDD0188  [2]
 LDCM0022  KB02 HEK-293T C165(0.86)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C165(0.91)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C165(0.68)  LDD1502  [3]
 LDCM0109  NEM HeLa N.A.  LDD0233  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570