Details of the Target

General Information of Target

Target ID LDTP12982
Target Name Mitochondrial import receptor subunit TOM7 homolog (TOMM7)
Gene Name TOMM7
Gene ID 54543
Synonyms
TOM7; TOMM07; Mitochondrial import receptor subunit TOM7 homolog; Translocase of outer membrane 7 kDa subunit homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVE
PMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPD
AYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHK
MLS
Target Bioclass
Other
Family
Tom7 family
Subcellular location
Mitochondrion outer membrane
Function
Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.
Uniprot ID
Q9P0U1
Ensemble ID
ENST00000358435.9
HGNC ID
HGNC:21648

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K17(1.19)  LDD0277  [1]
NHS
 Probe Info  		N.A.  LDD0010  [2]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		13.09  LDD1752  [3]
C056
 Probe Info  		29.04  LDD1753  [3]
C094
 Probe Info  		23.10  LDD1785  [3]
C112
 Probe Info  		20.25  LDD1799  [3]
C134
 Probe Info  		25.81  LDD1816  [3]
C210
 Probe Info  		41.07  LDD1884  [3]
C218
 Probe Info  		19.43  LDD1892  [3]
C231
 Probe Info  		25.63  LDD1904  [3]
C232
 Probe Info  		53.82  LDD1905  [3]
C234
 Probe Info  		7.62  LDD1907  [3]
C235
 Probe Info  		69.55  LDD1908  [3]
C238
 Probe Info  		12.30  LDD1911  [3]
C243
 Probe Info  		16.45  LDD1916  [3]
C246
 Probe Info  		27.67  LDD1919  [3]
C249
 Probe Info  		12.73  LDD1922  [3]
C285
 Probe Info  		84.45  LDD1955  [3]
C287
 Probe Info  		20.53  LDD1957  [3]
C288
 Probe Info  		7.06  LDD1958  [3]
C289
 Probe Info  		99.73  LDD1959  [3]
C299
 Probe Info  		8.40  LDD1968  [3]
C355
 Probe Info  		23.26  LDD2016  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) Tom22 family Q9NS69

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587