Details of the Target

General Information of Target

Target ID LDTP01335
Target Name Protein SCO1 homolog, mitochondrial (SCO1)
Gene Name SCO1
Gene ID 6341
Synonyms
SCOD1; Protein SCO1 homolog, mitochondrial
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAMLVLVPGRVMRPLGGQLWRFLPRGLEFWGPAEGTARVLLRQFCARQAEAWRASGRPGY
CLGTRPLSTARPPPPWSQKGPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKA
EKLEKERQRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKM
IQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARA
YRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKK
S
Target Bioclass
Enzyme
Family
SCO1/2 family
Subcellular location
Mitochondrion
Function
Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1.
Uniprot ID
O75880
Ensemble ID
ENST00000255390.10
HGNC ID
HGNC:10603

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.80  LDD0402  [1]
Probe 1
 Probe Info  		Y244(25.27); Y245(27.46)  LDD3495  [2]
HPAP
 Probe Info  		4.16  LDD0062  [3]
DBIA
 Probe Info  		C173(0.92)  LDD1575  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
ATP probe
 Probe Info  		K133(0.00); K283(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C169(0.00); C173(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
Lodoacetamide azide
 Probe Info  		C169(0.00); C173(0.00)  LDD0037  [7]
NHS
 Probe Info  		N.A.  LDD0010  [9]
1d-yne
 Probe Info  		N.A.  LDD0357  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 48 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		6.59  LDD1740  [12]
C055
 Probe Info  		11.71  LDD1752  [12]
C056
 Probe Info  		21.26  LDD1753  [12]
C091
 Probe Info  		10.63  LDD1782  [12]
C092
 Probe Info  		16.80  LDD1783  [12]
C094
 Probe Info  		25.11  LDD1785  [12]
C112
 Probe Info  		17.27  LDD1799  [12]
C134
 Probe Info  		42.22  LDD1816  [12]
C135
 Probe Info  		16.22  LDD1817  [12]
C138
 Probe Info  		5.03  LDD1820  [12]
C139
 Probe Info  		15.89  LDD1821  [12]
C140
 Probe Info  		9.99  LDD1822  [12]
C153
 Probe Info  		15.14  LDD1834  [12]
C169
 Probe Info  		24.93  LDD1849  [12]
C173
 Probe Info  		5.58  LDD1853  [12]
C201
 Probe Info  		25.81  LDD1877  [12]
C210
 Probe Info  		42.22  LDD1884  [12]
C228
 Probe Info  		22.16  LDD1901  [12]
C231
 Probe Info  		20.25  LDD1904  [12]
C232
 Probe Info  		47.84  LDD1905  [12]
C233
 Probe Info  		9.45  LDD1906  [12]
C235
 Probe Info  		27.47  LDD1908  [12]
C238
 Probe Info  		11.96  LDD1911  [12]
C264
 Probe Info  		18.38  LDD1935  [12]
C265
 Probe Info  		13.00  LDD1936  [12]
C278
 Probe Info  		55.72  LDD1948  [12]
C289
 Probe Info  		27.28  LDD1959  [12]
C343
 Probe Info  		12.55  LDD2005  [12]
C349
 Probe Info  		11.00  LDD2010  [12]
C350
 Probe Info  		26.54  LDD2011  [12]
C355
 Probe Info  		24.76  LDD2016  [12]
C362
 Probe Info  		99.73  LDD2023  [12]
C363
 Probe Info  		32.45  LDD2024  [12]
C364
 Probe Info  		36.76  LDD2025  [12]
C366
 Probe Info  		13.36  LDD2027  [12]
C367
 Probe Info  		10.63  LDD2028  [12]
C388
 Probe Info  		42.22  LDD2047  [12]
C390
 Probe Info  		26.72  LDD2049  [12]
C403
 Probe Info  		19.16  LDD2061  [12]
C407
 Probe Info  		12.73  LDD2064  [12]
C431
 Probe Info  		15.78  LDD2086  [12]
FFF probe11
 Probe Info  		20.00  LDD0471  [13]
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]
FFF probe2
 Probe Info  		20.00  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0464  [13]
FFF probe4
 Probe Info  		20.00  LDD0466  [13]
OEA-DA
 Probe Info  		17.90  LDD0046  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 11.73  LDD0403  [1]
 LDCM0371  CL102 HEK-293T C173(0.92)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C173(1.01)  LDD1579  [4]
 LDCM0380  CL110 HEK-293T C173(0.86)  LDD1584  [4]
 LDCM0384  CL114 HEK-293T C173(0.89)  LDD1588  [4]
 LDCM0388  CL118 HEK-293T C173(0.85)  LDD1592  [4]
 LDCM0393  CL122 HEK-293T C173(1.05)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C173(1.00)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C173(1.15)  LDD1605  [4]
 LDCM0407  CL2 HEK-293T C173(0.95)  LDD1611  [4]
 LDCM0414  CL26 HEK-293T C173(0.96)  LDD1618  [4]
 LDCM0441  CL50 HEK-293T C173(0.95)  LDD1645  [4]
 LDCM0454  CL62 HEK-293T C173(1.07)  LDD1657  [4]
 LDCM0467  CL74 HEK-293T C173(1.00)  LDD1670  [4]
 LDCM0480  CL86 HEK-293T C173(0.96)  LDD1683  [4]
 LDCM0493  CL98 HEK-293T C173(0.99)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C173(0.97)  LDD1631  [4]
 LDCM0014  Panhematin HEK-293T 4.16  LDD0062  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Cytochrome c oxidase copper chaperone (COX17) COX17 family Q14061

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570