Details of the Target

General Information of Target

Target ID LDTP09251
Target Name Atlastin-2 (ATL2)
Gene Name ATL2
Gene ID 64225
Synonyms
ARL6IP2; Atlastin-2; EC 3.6.5.-; ADP-ribosylation factor-like protein 6-interacting protein 2; ARL-6-interacting protein 2; Aip-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEGDEAARGQQPHQGLWRRRRTSDPSAAVNHVSSTTSLGENYEDDDLVNSDEVMKKPCP
VQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFRKGKSFLLDFMLRYMYN
KDSQSWIGGNNEPLTGFTWRGGCERETTGIQVWNEVFVIDRPNGTKVAVLLMDTQGAFDS
QSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYQKPFQTLM
FLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEELQNVRKHIHNCFSNLGCFLLPHPG
LKVATNPSFDGRLKDIDEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYI
KIYQGEELPHPKSMLQATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLD
LKEVAIKQFRSVKKMGGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFYAARTPATLFA
VMFAMYIISGLTGFIGLNSIAVLCNLVMGLALIFLCTWAYVKYSGEFREIGTVIDQIAET
LWEQVLKPLGDNLMEENIRQSVTNSIKAGLTDQVSHHARLKTD
Target Bioclass
Enzyme
Family
TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.
Uniprot ID
Q8NHH9
Ensemble ID
ENST00000378954.9
HGNC ID
HGNC:24047

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DEL SNV: p.Q124H .
HEC1 SNV: p.G493V .
LU65 SNV: p.D47G .
NALM6 SNV: p.Y232H .
NCIH1299 SNV: p.R430G .
RL SNV: p.F527L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH216
 Probe Info  		Y470(14.65)  LDD0259  [2]
STPyne
 Probe Info  		K314(9.40); K321(10.00); K567(6.27)  LDD0277  [3]
IPM
 Probe Info  		C441(0.00); C402(0.00)  LDD0241  [4]
P12
 Probe Info  		5.43  LDD0202  [5]
BTD
 Probe Info  		C441(1.27)  LDD1700  [6]
DA-P3
 Probe Info  		5.45  LDD0181  [7]
Acrolein
 Probe Info  		N.A.  LDD0221  [8]
DBIA
 Probe Info  		C287(0.94); C293(0.94); C441(1.08)  LDD0531  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
CY-1
 Probe Info  		N.A.  LDD0246  [11]
IA-alkyne
 Probe Info  		C441(0.00); C402(0.00)  LDD0162  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
W1
 Probe Info  		N.A.  LDD0236  [4]
AOyne
 Probe Info  		10.40  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 65 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.89  LDD1728  [16]
C040
 Probe Info  		9.92  LDD1740  [16]
C056
 Probe Info  		23.59  LDD1753  [16]
C070
 Probe Info  		9.00  LDD1766  [16]
C091
 Probe Info  		19.29  LDD1782  [16]
C092
 Probe Info  		32.90  LDD1783  [16]
C094
 Probe Info  		36.76  LDD1785  [16]
C100
 Probe Info  		6.45  LDD1789  [16]
C112
 Probe Info  		22.32  LDD1799  [16]
C134
 Probe Info  		27.28  LDD1816  [16]
C135
 Probe Info  		9.65  LDD1817  [16]
C141
 Probe Info  		9.58  LDD1823  [16]
C143
 Probe Info  		17.88  LDD1825  [16]
C159
 Probe Info  		7.26  LDD1839  [16]
C161
 Probe Info  		11.47  LDD1841  [16]
C169
 Probe Info  		22.16  LDD1849  [16]
C186
 Probe Info  		9.19  LDD1864  [16]
C201
 Probe Info  		35.75  LDD1877  [16]
C210
 Probe Info  		44.32  LDD1884  [16]
C216
 Probe Info  		5.17  LDD1890  [16]
C218
 Probe Info  		21.41  LDD1892  [16]
C220
 Probe Info  		14.22  LDD1894  [16]
C228
 Probe Info  		21.86  LDD1901  [16]
C229
 Probe Info  		8.88  LDD1902  [16]
C231
 Probe Info  		33.36  LDD1904  [16]
C232
 Probe Info  		59.30  LDD1905  [16]
C233
 Probe Info  		13.00  LDD1906  [16]
C234
 Probe Info  		7.16  LDD1907  [16]
C235
 Probe Info  		49.18  LDD1908  [16]
C238
 Probe Info  		11.24  LDD1911  [16]
C243
 Probe Info  		12.21  LDD1916  [16]
C246
 Probe Info  		17.75  LDD1919  [16]
C249
 Probe Info  		11.88  LDD1922  [16]
C264
 Probe Info  		17.63  LDD1935  [16]
C285
 Probe Info  		25.11  LDD1955  [16]
C287
 Probe Info  		11.39  LDD1957  [16]
C288
 Probe Info  		7.16  LDD1958  [16]
C289
 Probe Info  		64.45  LDD1959  [16]
C293
 Probe Info  		21.11  LDD1963  [16]
C296
 Probe Info  		14.12  LDD1966  [16]
C310
 Probe Info  		7.89  LDD1977  [16]
C343
 Probe Info  		14.22  LDD2005  [16]
C348
 Probe Info  		10.27  LDD2009  [16]
C349
 Probe Info  		14.12  LDD2010  [16]
C350
 Probe Info  		42.22  LDD2011  [16]
C355
 Probe Info  		27.47  LDD2016  [16]
C356
 Probe Info  		8.51  LDD2017  [16]
C362
 Probe Info  		69.55  LDD2023  [16]
C363
 Probe Info  		16.56  LDD2024  [16]
C364
 Probe Info  		20.53  LDD2025  [16]
C366
 Probe Info  		5.62  LDD2027  [16]
C388
 Probe Info  		56.89  LDD2047  [16]
C390
 Probe Info  		37.27  LDD2049  [16]
C399
 Probe Info  		6.82  LDD2058  [16]
C403
 Probe Info  		22.63  LDD2061  [16]
C407
 Probe Info  		17.27  LDD2064  [16]
C431
 Probe Info  		15.14  LDD2086  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe15
 Probe Info  		8.71  LDD0478  [17]
FFF probe2
 Probe Info  		20.00  LDD0463  [17]
STS-2
 Probe Info  		N.A.  LDD0138  [18]
Alk-rapa
 Probe Info  		2.42  LDD0213  [19]
OEA-DA
 Probe Info  		6.29  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C441(1.52); C402(1.02)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C441(1.68)  LDD2152  [6]
 LDCM0214  AC1 HCT 116 C287(0.94); C293(0.94); C441(1.08)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C287(0.87); C293(0.87); C441(1.00)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C287(0.81); C293(0.64); C441(1.13)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C287(0.94); C293(0.75); C441(0.96)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C287(1.00); C293(0.91); C441(0.95)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C287(0.77); C293(0.68); C441(0.96)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C287(0.96); C293(0.85); C441(0.98)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C287(0.88); C293(0.75); C441(0.97)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C287(0.86); C293(0.77); C441(0.94)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C287(1.01); C293(0.88); C441(0.91)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C287(0.70); C293(0.60); C441(0.90)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C287(0.80); C293(0.81); C441(0.89)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C287(0.93); C293(0.93); C441(1.05)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C287(0.86); C293(0.71); C441(1.07)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C287(0.80); C293(0.70); C441(0.97)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C287(0.84); C293(0.82); C441(1.02)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C287(1.05); C293(1.06); C441(1.19)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C287(0.90); C293(0.92); C441(1.07)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C287(0.83); C293(0.82); C441(1.11)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C287(0.80); C293(0.80); C441(1.12)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C287(0.92); C293(0.92); C441(1.21)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C287(0.95); C293(0.94); C441(1.09)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C287(0.89); C293(0.88); C441(1.21)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C287(0.99); C293(0.99); C441(1.03)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C287(1.04); C293(1.04); C441(1.08)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C287(0.99); C293(1.03); C441(1.17)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C287(0.92); C293(0.92); C441(1.10)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C287(1.05); C293(1.13); C441(1.11)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C287(1.02); C293(1.07); C441(1.27)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C287(0.96); C293(0.99); C441(1.14)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C287(0.87); C293(0.89); C441(1.10)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C287(0.88); C293(0.91); C441(1.10)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C287(0.75); C293(0.75); C441(0.92)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C287(0.93); C293(0.93); C441(1.07)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C287(0.76); C293(0.76); C441(1.07)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C287(1.09); C293(1.09); C441(0.94)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C287(0.80); C293(0.80); C441(1.18)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C287(0.82); C293(0.82); C441(1.05)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C287(0.67); C293(0.67); C441(0.99)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C287(0.67); C293(0.67); C441(1.04)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C287(0.80); C293(0.80); C441(1.05)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C287(0.84); C293(0.84); C441(1.10)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C287(0.72); C293(0.72); C441(1.09)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C287(0.70); C293(0.70); C441(1.25)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C287(1.05); C293(1.05); C441(1.00)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C287(0.62); C293(0.62); C441(1.06)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C287(0.67); C293(0.67); C441(1.06)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C287(0.94); C293(0.94); C441(1.35)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C287(0.92); C293(0.92); C441(0.96)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C293(0.71); C287(0.75); C441(0.82)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C293(0.82); C287(0.85); C441(0.92)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C293(0.82); C441(0.85); C287(0.86)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C287(0.69); C293(0.71); C441(0.88)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C293(0.68); C287(0.72); C441(0.73)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C293(0.68); C287(0.78); C441(0.94)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C287(0.95); C293(0.95); C441(1.03)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C441(0.84); C293(0.91); C287(0.93)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C293(0.83); C287(0.86); C441(1.00)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C293(0.80); C441(0.81); C287(0.83)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C293(0.67); C287(0.76); C441(0.84)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C287(0.88); C293(0.84); C441(0.91)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C287(0.82); C293(0.78); C441(0.83)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C287(1.03); C293(1.00); C441(0.90)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C287(1.00); C293(0.96); C441(0.87)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C287(0.95); C293(0.95); C441(1.04)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C287(0.83); C293(0.83); C441(0.97)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C287(0.93); C293(0.93); C441(0.96)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C287(0.82); C293(0.82); C441(1.12)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C441(0.80); C287(1.14); C293(1.14)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C441(1.00); C287(1.12); C293(1.12)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C287(0.92); C293(0.92); C441(0.98)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C287(0.94); C293(0.94); C441(0.95)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C441(0.97); C287(1.05); C293(1.05)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C287(0.71); C293(0.71); C441(1.08)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C287(0.65); C293(0.65); C441(1.11)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C287(0.82); C293(0.82); C441(1.07)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C287(0.67); C293(0.67); C441(1.14)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C287(0.77); C293(0.77); C441(0.97)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C287(0.88); C293(0.88); C441(1.07)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C287(0.70); C293(0.70); C441(1.07)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C287(0.65); C293(0.65); C441(1.14)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C287(0.60); C293(0.60); C441(1.08)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C287(0.74); C293(0.74); C441(1.01)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C287(0.61); C293(0.61); C441(0.94)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C441(1.15); C287(1.25); C293(1.25)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C441(1.09); C287(1.16); C293(1.16)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C287(0.94); C293(0.94); C441(1.27)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C441(0.99); C287(1.09); C293(1.09)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C287(0.85); C293(0.85); C441(1.10)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C287(0.95); C293(0.95); C441(1.07)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C287(0.79); C293(0.79); C441(1.00)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C287(0.85); C293(0.85); C441(1.09)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C287(0.82); C293(0.82); C441(0.99)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C287(0.89); C293(0.89); C441(1.13)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C287(0.82); C293(0.82); C441(0.99)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C287(0.70); C293(0.70); C441(0.95)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C287(0.81); C293(0.81); C441(1.02)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C287(0.73); C293(0.73); C441(1.21)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C287(0.75); C293(0.75); C441(1.24)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C287(0.68); C293(0.68); C441(0.92)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C287(0.88); C293(0.88); C441(1.09)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C287(0.59); C293(0.59); C441(0.87)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C287(0.86); C293(0.86); C441(1.04)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C287(0.84); C293(0.84); C441(1.01)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C287(0.70); C293(0.70); C441(0.89)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C287(0.78); C293(0.78); C441(0.86)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C287(0.78); C293(0.78); C441(0.98)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C287(0.83); C293(0.83); C441(1.04)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C287(0.94); C293(0.94); C441(1.01)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C287(0.86); C293(0.86); C441(0.99)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C441(1.01); C287(1.03); C293(1.03)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C287(0.94); C293(0.94); C441(0.99)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C441(1.02); C287(1.30); C293(1.30)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C287(0.87); C293(0.87); C441(1.19)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C441(1.01); C287(1.07); C293(1.07)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C287(1.16); C293(1.16); C441(1.16)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C441(0.92); C287(1.23); C293(1.23)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C287(0.87); C293(0.87); C441(1.08)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C287(0.80); C293(0.80); C441(1.16)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C441(0.99); C287(1.07); C293(1.07)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C293(0.88); C287(0.91); C441(0.95)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C293(0.86); C441(0.87); C287(0.89)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C287(0.99); C293(0.99); C441(1.12)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C293(0.58); C287(0.59); C441(0.90)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C293(1.03); C287(1.05); C441(1.10)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C293(0.72); C287(0.74); C441(1.08)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C293(0.69); C287(0.69); C441(1.00)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C287(0.75); C293(0.76); C441(0.99)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C293(0.73); C287(0.75); C441(1.02)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C293(0.69); C287(0.70); C441(0.95)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C293(0.67); C287(0.69); C441(0.92)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C293(0.95); C287(0.97); C441(1.03)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C293(0.81); C287(0.84); C441(0.99)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C287(0.95); C293(0.95); C441(1.00)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C293(0.75); C287(0.78); C441(1.02)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C293(1.08); C287(1.10); C441(1.13)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C293(0.79); C287(0.81); C441(1.16)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C287(0.71); C293(0.71); C441(0.90)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C287(0.83); C293(0.83); C441(0.88)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C287(0.88); C293(0.88); C441(1.12)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C287(0.88); C293(0.88); C441(1.05)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C287(0.96); C293(0.96); C441(1.02)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C287(0.97); C293(0.97); C441(1.12)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C287(0.86); C293(0.86); C441(0.99)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C287(1.08); C293(1.08); C441(1.13)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C287(0.64); C293(0.64); C441(0.86)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C287(0.69); C293(0.69); C441(0.94)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C441(0.96); C287(0.98); C293(0.98)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C441(0.92); C287(1.05); C293(1.05)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C287(1.02); C293(1.02); C441(1.03)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C287(0.83); C293(0.83); C441(0.92)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C287(0.80); C293(0.80); C441(0.90)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C293(0.49); C287(0.65); C441(1.01)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C293(0.80); C441(0.90); C287(0.97)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C287(0.92); C293(0.92); C441(1.14)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C287(0.87); C293(0.87); C441(1.07)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C287(0.77); C293(0.77); C441(0.93)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C287(1.02); C293(1.02)  LDD2171  [9]
 LDCM0088  C45 HEK-293T 5.43  LDD0202  [5]
 LDCM0087  Capsaicin HEK-293T 12.65  LDD0185  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C287(0.86); C293(0.86); C441(1.00)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C287(0.55); C293(0.55); C441(1.23)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C287(0.86); C293(0.86); C441(1.09)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C441(0.98); C287(1.26); C293(1.26)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C441(0.98); C287(1.21); C293(1.21)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C441(1.04); C287(1.17); C293(1.17)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C441(1.00); C287(1.06); C293(1.06)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C287(0.86); C293(0.86); C441(1.10)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C287(0.92); C293(0.92); C441(1.19)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C287(0.81); C293(0.81); C441(0.99)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C287(0.83); C293(0.83); C441(1.15)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C287(0.91); C293(0.91); C441(1.09)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C287(0.63); C293(0.63); C441(1.11)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C287(0.83); C293(0.83); C441(1.21)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C287(0.94); C293(0.94); C441(1.23)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C287(0.80); C293(0.80); C441(0.90)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C287(0.65); C293(0.65); C441(0.95)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C287(0.66); C293(0.66); C441(1.09)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C287(0.69); C293(0.69); C441(1.00)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C287(0.66); C293(0.66); C441(1.09)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C287(0.75); C293(0.75); C441(1.00)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C287(0.84); C293(0.84); C441(1.02)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C287(0.90); C293(0.90); C441(1.03)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C287(0.57); C293(0.57); C441(1.19)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C287(0.87); C293(0.87); C441(1.21)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C441(1.21); C287(1.26); C293(1.26)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C287(0.93); C293(0.93); C441(1.11)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C287(0.74); C293(0.74); C441(0.84)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C287(0.63); C293(0.63); C441(0.91)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C287(0.75); C293(0.75); C441(1.06)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C441(1.01); C287(1.23); C293(1.23)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C287(0.85); C293(0.85); C441(1.02)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C287(0.96); C293(0.96); C441(0.98)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C287(0.69); C293(0.69); C441(1.16)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C287(0.67); C293(0.67); C441(1.12)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C287(1.07); C293(1.07); C441(1.11)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C287(0.67); C293(0.67); C441(1.01)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C287(0.51); C293(0.51); C441(1.12)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C287(0.76); C293(0.76); C441(1.26)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C287(0.89); C293(0.89); C441(1.08)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C287(0.94); C293(0.94); C441(1.00)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C287(0.88); C293(0.88); C441(0.99)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C287(0.93); C293(0.93); C441(1.13)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C441(1.14); C287(1.16); C293(1.16)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C287(0.87); C293(0.87); C441(1.14)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C287(0.73); C293(0.73); C441(1.18)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C287(0.50); C293(0.50); C441(1.09)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C287(0.70); C293(0.70); C441(1.19)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C287(0.66); C293(0.66); C441(1.04)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C287(0.70); C293(0.70); C441(1.07)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C287(0.74); C293(0.74); C441(1.05)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C287(0.78); C293(0.78); C441(1.06)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C287(0.67); C293(0.67); C441(1.23)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C287(0.87); C293(0.87); C441(1.13)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C287(1.00); C293(1.00); C441(1.01)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C287(1.08); C293(1.08); C441(0.80)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C287(0.69); C293(0.69); C441(0.93)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C287(0.65); C293(0.65); C441(1.02)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C287(0.61); C293(0.61); C441(0.79)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C287(0.50); C293(0.50); C441(1.14)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C287(0.55); C293(0.55); C441(0.89)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C287(0.98); C293(0.98); C441(0.95)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C287(0.65); C293(0.65); C441(0.93)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C287(0.62); C293(0.62); C441(0.85)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C287(0.64); C293(0.64); C441(1.01)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C287(0.67); C293(0.67); C441(0.96)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C287(0.78); C293(0.78); C441(0.94)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C287(0.63); C293(0.63); C441(1.04)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C287(0.75); C293(0.79); C441(0.99)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C287(0.79); C293(0.80); C441(0.87)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C287(0.79); C293(0.81); C441(0.91)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C287(0.82); C293(0.91); C441(0.91)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C287(0.95); C293(0.95); C441(1.08)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C287(0.81); C293(0.87); C441(0.93)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C287(0.71); C293(0.77); C441(1.00)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C287(0.69); C293(0.73); C441(1.13)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C287(1.20); C293(1.25); C441(0.86)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C287(0.87); C293(0.87); C441(0.85)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C287(1.03); C293(1.02); C441(1.04)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C287(0.97); C293(0.99); C441(0.93)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C287(1.15); C293(1.15); C441(0.94)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C287(0.82); C293(0.85); C441(0.95)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C287(0.92); C293(0.91); C441(0.93)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C287(0.89); C293(0.89); C441(1.16)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C287(0.77); C293(0.79); C441(0.90)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C287(0.85); C293(0.85); C441(1.01)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C287(0.85); C293(0.85); C441(1.07)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C287(0.93); C293(0.93); C441(1.01)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C287(0.85); C293(0.85); C441(1.02)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C287(1.05); C293(1.05); C441(1.07)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C287(1.08); C293(1.08); C441(1.02)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C287(1.19); C293(1.19); C441(0.98)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C287(1.46); C293(1.46); C441(1.07)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C287(1.01); C293(1.01); C441(0.98)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C287(0.60); C293(0.60); C441(1.28)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C287(1.07); C293(1.07); C441(1.02)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C287(1.08); C293(1.08); C441(0.89)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C287(1.03); C293(1.03); C441(1.07)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C287(1.14); C293(1.14); C441(1.05)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C287(1.17); C293(1.17); C441(0.93)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C287(1.08); C293(1.08); C441(1.33)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C287(1.39); C293(1.39); C441(1.15)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C287(0.97); C293(0.97); C441(1.25)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C287(0.88); C293(0.88); C441(1.09)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C287(1.05); C293(1.05); C441(0.97)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C287(1.06); C293(1.06); C441(1.14)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C287(0.91); C293(0.91); C441(1.36)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C287(1.04); C293(1.04); C441(1.17)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C287(0.82); C293(0.82); C441(1.04)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C287(1.46); C293(1.46); C441(1.33)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C287(1.03); C293(1.03); C441(1.42)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C287(1.07); C293(1.07); C441(1.45)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C287(1.10); C293(1.10); C441(1.24)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C287(1.11); C293(1.11); C441(1.11)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C287(1.00); C293(1.00); C441(1.28)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C287(0.69); C293(0.69); C441(1.18)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C287(1.05); C293(1.05); C441(1.00)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C287(1.06); C293(1.06); C441(0.95)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C287(1.16); C293(1.16); C441(0.98)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C287(0.97); C293(0.97); C441(0.89)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C287(1.01); C293(1.01); C441(0.93)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C287(0.98); C293(0.98); C441(1.00)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C287(0.99); C293(0.99); C441(1.03)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C287(0.86); C293(0.86); C441(1.10)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C287(0.85); C293(0.85); C441(0.90)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C287(0.92); C293(0.92); C441(1.04)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C402(1.05); C441(0.91); C187(1.05); C293(1.04)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C441(1.20)  LDD1702  [6]
 LDCM0625  F8 Ramos C441(0.91); C349(0.94)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C441(0.75); C349(0.34)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C441(9.72); C349(15.32)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C441(0.78); C349(1.16)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C441(0.81); C349(0.44)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C441(0.99); C349(1.85)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C441(0.71)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C441(0.80)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C441(0.85)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C441(0.91)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C441(0.66); C349(1.13)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C441(1.08); C349(0.46)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C441(1.00); C349(0.60)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C441(0.75); C349(0.43)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C287(0.96); C293(0.96); C441(0.95)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C441(0.96)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C441(0.78); C349(1.50)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C287(0.69); C293(0.69); C441(0.95)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C441(1.98); C349(0.60)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C441(0.82)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C441(0.53); C349(1.93)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C441(0.61)  LDD2188  [22]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C402(1.21); C441(0.96); C59(1.16); C287(1.04)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C402(1.02); C441(1.00); C59(1.19); C287(1.12)  LDD1497  [21]
 LDCM0024  KB05 NCI-H1975 C402(1.20)  LDD3352  [23]
 LDCM0109  NEM HeLa N.A.  LDD0227  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C441(1.76)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C402(0.64)  LDD2100  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C441(1.21)  LDD2107  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C441(1.52)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C441(1.43)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C441(1.32)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C441(1.54)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C441(0.53)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C441(1.58)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C441(1.84); C402(1.39)  LDD2136  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C441(1.27)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C441(1.14)  LDD2140  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C441(2.06)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C441(1.60)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C441(0.96)  LDD2148  [6]
 LDCM0029  Quercetin HEK-293T 5.45  LDD0181  [7]
 LDCM0090  Rapamycin JHH-7 2.42  LDD0213  [19]
 LDCM0021  THZ1 HCT 116 C287(1.02); C293(1.02)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protrudin (ZFYVE27) . Q5T4F4

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840