Details of the Target

General Information of Target

Target ID LDTP01560
Target Name NADH dehydrogenase 1 subunit C2 (NDUFC2)
Gene Name NDUFC2
Gene ID 4718
Synonyms
NADH dehydrogenase [ubiquinone] 1 subunit C2; Complex I-B14.5b; CI-B14.5b; Human lung cancer oncogene 1 protein; HLC-1; NADH-ubiquinone oxidoreductase subunit B14.5b
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQ
LLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR
Target Bioclass
Enzyme
Family
Complex I NDUFC2 subunit family
Subcellular location
Mitochondrion inner membrane
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot ID
O95298
Ensemble ID
ENST00000281031.5
HGNC ID
HGNC:7706
ChEMBL ID
CHEMBL2363065

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 Substitution: p.L42W .
KU1919 SNV: p.M89L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K114(6.93)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
DBIA
 Probe Info  		C39(1.33)  LDD1511  [3]
1c-yne
 Probe Info  		N.A.  LDD0228  [4]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		14.32  LDD1782  [5]
C092
 Probe Info  		32.45  LDD1783  [5]
C094
 Probe Info  		30.91  LDD1785  [5]
C231
 Probe Info  		12.21  LDD1904  [5]
C238
 Probe Info  		29.86  LDD1911  [5]
C243
 Probe Info  		10.70  LDD1916  [5]
C246
 Probe Info  		17.03  LDD1919  [5]
C407
 Probe Info  		13.93  LDD2064  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C39(0.72)  LDD1520  [3]
 LDCM0289  AC29 HEK-293T C39(1.22)  LDD1528  [3]
 LDCM0298  AC37 HEK-293T C39(1.05)  LDD1537  [3]
 LDCM0307  AC45 HEK-293T C39(0.81)  LDD1546  [3]
 LDCM0312  AC5 HEK-293T C39(0.66)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C39(1.30)  LDD1555  [3]
 LDCM0325  AC61 HEK-293T C39(0.85)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C39(1.33)  LDD1511  [3]
 LDCM0409  CL21 HEK-293T C39(1.39)  LDD1613  [3]
 LDCM0422  CL33 HEK-293T C39(0.74)  LDD1626  [3]
 LDCM0435  CL45 HEK-293T C39(1.19)  LDD1639  [3]
 LDCM0448  CL57 HEK-293T C39(0.39)  LDD1651  [3]
 LDCM0461  CL69 HEK-293T C39(0.62)  LDD1664  [3]
 LDCM0475  CL81 HEK-293T C39(0.75)  LDD1678  [3]
 LDCM0484  CL9 HEK-293T C39(0.78)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C39(0.83)  LDD1691  [3]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Carvedilol Small molecular drug DB01136
Nadh Small molecular drug DB00157

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587