Details of the Target

General Information of Target

Target ID LDTP12979
Target Name Transmembrane protein 14C (TMEM14C)
Gene Name TMEM14C
Gene ID 51522
Synonyms
C6orf53; Transmembrane protein 14C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFFSVPVAWTLTNIIHNLGM
YVFLHAVKGTPFETPDQGKARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYD
PTHFILNTASLLSVLIPKMPQLHGVRIFGINKY
Target Bioclass
Transporter and channel
Family
TMEM14 family
Subcellular location
Mitochondrion membrane
Function Required for normal heme biosynthesis.
Uniprot ID
Q9P0S9
Ensemble ID
ENST00000229563.6
HGNC ID
HGNC:20952

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y81(20.00)  LDD0260  [1]
Probe 1
 Probe Info  		Y81(15.88)  LDD3495  [2]
HPAP
 Probe Info  		3.77  LDD0063  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		10.93  LDD1740  [5]
C041
 Probe Info  		5.54  LDD1741  [5]
C056
 Probe Info  		20.82  LDD1753  [5]
C091
 Probe Info  		11.79  LDD1782  [5]
C092
 Probe Info  		22.16  LDD1783  [5]
C094
 Probe Info  		93.70  LDD1785  [5]
C112
 Probe Info  		19.16  LDD1799  [5]
C134
 Probe Info  		21.26  LDD1816  [5]
C201
 Probe Info  		28.44  LDD1877  [5]
C210
 Probe Info  		53.08  LDD1884  [5]
C225
 Probe Info  		4.92  LDD1898  [5]
C228
 Probe Info  		25.11  LDD1901  [5]
C235
 Probe Info  		19.16  LDD1908  [5]
C238
 Probe Info  		11.16  LDD1911  [5]
C278
 Probe Info  		49.87  LDD1948  [5]
C289
 Probe Info  		30.06  LDD1959  [5]
C362
 Probe Info  		49.18  LDD2023  [5]
C366
 Probe Info  		6.11  LDD2027  [5]
C388
 Probe Info  		55.33  LDD2047  [5]
FFF probe11
 Probe Info  		12.14  LDD0471  [6]
FFF probe14
 Probe Info  		20.00  LDD0477  [6]
OEA-DA
 Probe Info  		3.38  LDD0046  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]
 LDCM0014  Panhematin K562 3.77  LDD0063  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 7 (ELOVL7) ELO family A1L3X0
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
E3 ubiquitin-protein ligase MARCHF8 (MARCHF8) . Q5T0T0
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Claudin-5 (CLDN5) Claudin family O00501
Gap junction beta-1 protein (GJB1) Connexin family P08034
Novel acetylcholine receptor chaperone (TMEM35A) DoxX family Q53FP2
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Synaptotagmin-1 (SYT1) Synaptotagmin family P21579
Syntaxin-1A (STX1A) Syntaxin family Q16623
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Protrudin (ZFYVE27) . Q5T4F4
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 79 (TMEM79) . Q9BSE2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1) . Q68D85
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR) . Q9H7M9
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) COQ9 family O75208
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Perilipin-3 (PLIN3) Perilipin family O60664
Bcl-2-interacting killer (BIK) . Q13323
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Protein KASH5 (KASH5) . Q8N6L0
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570