Details of the Target

General Information of Target

Target ID LDTP11250
Target Name MICOS complex subunit MIC26 (APOO)
Gene Name APOO
Gene ID 79135
Synonyms
FAM121B; MIC23; MIC26; MICOS complex subunit MIC26; Apolipoprotein O; MICOS complex subunit MIC23; Protein FAM121B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAG
SAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANG
PELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPD
GSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQP
DTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTV
RVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPL
ALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFD
LDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATAS
GQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGT
EGGVGELI
Target Bioclass
Transporter and channel
Family
Apolipoprotein O/MICOS complex subunit Mic27 family
Subcellular location
Mitochondrion inner membrane
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.
Uniprot ID
Q9BUR5
Ensemble ID
ENST00000379226.9
HGNC ID
HGNC:28727

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.W95G .
NCIH1155 SNV: p.Q160Ter .
SUPT1 SNV: p.Q49Ter .
WM2664 Insertion: p.N193KfsTer6 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.55  LDD0197  [1]
OPA-S-S-alkyne
 Probe Info  		K51(0.80)  LDD3494  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
HPAP
 Probe Info  		3.07  LDD0062  [4]
DBIA
 Probe Info  		C71(1.15); C78(1.15)  LDD0532  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
TFBX
 Probe Info  		C71(0.00); C78(0.00)  LDD0027  [7]
IPM
 Probe Info  		C78(0.00); C71(0.00)  LDD2156  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		C78(0.00); C71(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 61 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		9.51  LDD1728  [12]
C040
 Probe Info  		8.06  LDD1740  [12]
C055
 Probe Info  		14.93  LDD1752  [12]
C056
 Probe Info  		25.63  LDD1753  [12]
C063
 Probe Info  		11.16  LDD1760  [12]
C091
 Probe Info  		33.36  LDD1782  [12]
C092
 Probe Info  		60.97  LDD1783  [12]
C094
 Probe Info  		90.51  LDD1785  [12]
C106
 Probe Info  		22.94  LDD1793  [12]
C112
 Probe Info  		42.22  LDD1799  [12]
C134
 Probe Info  		40.79  LDD1816  [12]
C153
 Probe Info  		22.16  LDD1834  [12]
C161
 Probe Info  		12.38  LDD1841  [12]
C169
 Probe Info  		21.71  LDD1849  [12]
C186
 Probe Info  		8.17  LDD1864  [12]
C194
 Probe Info  		10.41  LDD1870  [12]
C196
 Probe Info  		16.80  LDD1872  [12]
C198
 Probe Info  		13.27  LDD1874  [12]
C201
 Probe Info  		49.18  LDD1877  [12]
C210
 Probe Info  		55.33  LDD1884  [12]
C218
 Probe Info  		13.83  LDD1892  [12]
C220
 Probe Info  		22.16  LDD1894  [12]
C225
 Probe Info  		5.35  LDD1898  [12]
C228
 Probe Info  		41.64  LDD1901  [12]
C231
 Probe Info  		31.12  LDD1904  [12]
C232
 Probe Info  		47.50  LDD1905  [12]
C233
 Probe Info  		11.08  LDD1906  [12]
C235
 Probe Info  		30.48  LDD1908  [12]
C238
 Probe Info  		12.04  LDD1911  [12]
C240
 Probe Info  		8.22  LDD1913  [12]
C243
 Probe Info  		10.78  LDD1916  [12]
C246
 Probe Info  		24.25  LDD1919  [12]
C264
 Probe Info  		22.01  LDD1935  [12]
C277
 Probe Info  		9.65  LDD1947  [12]
C278
 Probe Info  		73.01  LDD1948  [12]
C282
 Probe Info  		20.11  LDD1952  [12]
C285
 Probe Info  		38.05  LDD1955  [12]
C287
 Probe Info  		14.52  LDD1957  [12]
C288
 Probe Info  		7.41  LDD1958  [12]
C289
 Probe Info  		86.82  LDD1959  [12]
C293
 Probe Info  		46.85  LDD1963  [12]
C296
 Probe Info  		21.56  LDD1966  [12]
C310
 Probe Info  		10.63  LDD1977  [12]
C339
 Probe Info  		5.10  LDD2002  [12]
C343
 Probe Info  		22.32  LDD2005  [12]
C348
 Probe Info  		15.89  LDD2009  [12]
C349
 Probe Info  		27.47  LDD2010  [12]
C350
 Probe Info  		96.34  LDD2011  [12]
C353
 Probe Info  		6.54  LDD2014  [12]
C388
 Probe Info  		93.70  LDD2047  [12]
C390
 Probe Info  		38.32  LDD2049  [12]
C403
 Probe Info  		16.00  LDD2061  [12]
C407
 Probe Info  		18.51  LDD2064  [12]
FFF probe11
 Probe Info  		20.00  LDD0471  [13]
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]
FFF probe2
 Probe Info  		20.00  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0464  [13]
FFF probe4
 Probe Info  		19.49  LDD0466  [13]
JN0003
 Probe Info  		20.00  LDD0469  [13]
OEA-DA
 Probe Info  		20.00  LDD0046  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C71(0.90); C78(0.90)  LDD0812  [5]
 LDCM0215  AC10 HCT 116 C71(1.15); C78(1.15)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C71(0.97); C78(0.97)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C71(1.02); C78(1.02)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C71(0.80); C78(0.80)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C71(1.21); C78(1.21)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C71(1.27); C78(1.27)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C71(1.38); C78(1.38)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C71(1.05); C78(1.05)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C71(0.83); C78(0.83)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C71(0.85); C78(0.85)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C71(0.80); C78(0.80)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C71(1.27); C78(1.27)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C71(1.00); C78(1.00)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C71(0.88); C78(0.88)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C71(0.79); C78(0.79)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C71(1.06); C78(1.06)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C71(0.95); C78(0.95)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C71(0.99); C78(0.99)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C71(0.89); C78(0.89)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C71(0.87); C78(0.87)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C71(0.92); C78(0.92)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C71(0.92); C78(0.92)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C71(1.08); C78(1.08)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C71(0.93); C78(0.93)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C71(0.89); C78(0.89)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C71(0.90); C78(0.90)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C71(0.86); C78(0.86)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C71(0.80); C78(0.80)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C71(0.88); C78(0.88)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C71(0.84); C78(0.84)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C71(0.79); C78(0.79)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C71(0.91); C78(0.91)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C71(1.04); C78(1.04)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C71(1.00); C78(1.00)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C71(1.13); C78(1.13)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C71(1.08); C78(1.08)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C71(1.13); C78(1.13)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C71(1.37); C78(1.37)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C71(0.98); C78(0.98)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C71(1.16); C78(1.16)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C71(1.12); C78(1.12)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C71(1.52); C78(1.52)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C71(1.38); C78(1.38)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C71(1.56); C78(1.56)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C71(1.11); C78(1.11)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C71(1.09); C78(1.09)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C71(1.14); C78(1.14)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C71(1.16); C78(1.16)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C71(0.88); C78(0.88)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C71(0.74); C78(0.74)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C71(0.92); C78(0.92)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C71(0.91); C78(0.91)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C71(0.88); C78(0.88)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C71(0.76); C78(0.76)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C71(1.01); C78(1.01)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C71(1.11); C78(1.11)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C71(1.27); C78(1.27)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C71(0.94); C78(0.94)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C71(0.82); C78(0.82)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C71(0.99); C78(0.99)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C71(0.83); C78(0.83)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C71(0.99); C78(0.99)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C71(1.06); C78(1.06)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C71(0.95); C78(1.13)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C71(1.00); C78(1.04)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C71(0.98); C78(1.05)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C71(0.91); C78(0.91)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C71(0.95); C78(1.30)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C71(0.92); C78(1.48)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C71(0.86); C78(1.20)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C71(0.77); C78(1.41)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C71(0.77); C78(0.93)  LDD0882  [5]
 LDCM0285  AC25 PaTu 8988t C71(1.12); C78(1.12)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C71(0.88); C78(0.88)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C71(1.04); C78(1.04)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C71(1.00); C78(1.00)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C71(1.03); C78(1.03)  LDD1168  [5]
 LDCM0290  AC3 HEK-293T C71(1.02); C78(1.02)  LDD0888  [5]
 LDCM0291  AC30 PaTu 8988t C71(1.40); C78(1.40)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C71(1.35); C78(1.35)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C71(1.17); C78(1.17)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C71(0.80); C78(0.80)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C71(1.13); C78(1.13)  LDD1174  [5]
 LDCM0296  AC35 HEK-293T C71(0.96); C78(0.96)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C71(1.08); C78(1.08)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C71(1.11); C78(1.11)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C71(1.02); C78(1.02)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C71(0.92); C78(0.92)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C71(0.96); C78(0.96)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C71(0.95); C78(0.95)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C71(0.94); C78(0.94)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C71(1.06); C78(1.06)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C71(1.05); C78(1.05)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C71(0.93); C78(0.93)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C71(0.88); C78(0.88)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C71(1.13); C78(1.13)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C71(1.01); C78(1.01)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C71(0.92); C78(0.92)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C71(0.96); C78(0.96)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C71(0.81); C78(0.81)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C71(0.89); C78(0.89)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C71(1.00); C78(1.00)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C71(0.88); C78(0.88)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C71(1.13); C78(1.13)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C71(0.88); C78(0.88)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C71(0.96); C78(0.96)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C71(1.00); C78(1.00)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C71(0.66); C78(0.66)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C71(0.98); C78(0.98)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C71(1.14); C78(1.14)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C71(1.15); C78(1.15)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C71(0.89); C78(0.89)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C71(0.86); C78(0.86)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C71(0.79); C78(0.79)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C71(0.53); C78(0.53)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C71(0.61); C78(0.61)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C71(0.69); C78(0.69)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C71(1.09); C78(1.09)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C71(0.68); C78(0.68)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C71(1.19); C78(1.19)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C71(1.38); C78(1.38)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C71(1.04); C78(1.04)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C71(0.93); C78(0.93)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C71(1.24); C78(1.24)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C71(1.29); C78(1.29)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C71(1.00); C78(1.00)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C71(1.08); C78(1.08)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C71(1.19); C78(1.19)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C71(1.25); C78(1.25)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C71(1.26); C78(1.26)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C71(1.00); C78(1.00)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C71(1.60); C78(1.60)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C71(0.94); C78(0.94)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C71(1.27); C78(1.27)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C71(1.54); C78(1.54)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C71(1.06); C78(1.06)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C71(0.94); C78(0.94)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C71(0.92); C78(0.92)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C71(0.96); C78(0.96)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C71(1.13); C78(1.13)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C71(1.01); C78(1.01)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C71(1.14); C78(1.14)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C71(0.99); C78(0.99)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C71(0.73); C78(0.73)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C71(0.98); C78(0.98)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C71(0.72); C78(0.72)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C71(1.05); C78(1.05)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C71(0.93); C78(0.93)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C71(0.79); C78(0.79)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C71(1.07); C78(1.07)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C71(0.94); C78(0.94)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C71(0.98); C78(0.98)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C71(0.97); C78(0.97)  LDD0964  [5]
 LDCM0248  AKOS034007472 HCT 116 C71(1.14); C78(1.14)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C71(1.00); C78(1.00)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C71(1.05); C78(1.05)  LDD0592  [5]
 LDCM0367  CL1 HEK-293T C71(0.83)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C71(1.18); C78(0.34)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C71(1.08); C78(1.08)  LDD0967  [5]
 LDCM0370  CL101 HCT 116 C71(1.36); C78(1.36)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C71(1.22); C78(1.22)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C71(1.23); C78(1.23)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C71(1.19); C78(1.19)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C71(0.93); C78(1.06)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C71(0.78); C78(1.05)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C71(0.83); C78(1.03)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C71(1.06); C78(1.18)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C71(0.73); C78(0.97)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C71(1.55); C78(1.19)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C71(0.76); C78(1.08)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C71(0.85); C78(0.94)  LDD0979  [5]
 LDCM0382  CL112 PaTu 8988t C71(0.98); C78(0.98)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C71(1.19); C78(1.19)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C71(0.90); C78(0.90)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C71(1.08); C78(1.08)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C71(0.65); C78(0.65)  LDD1265  [5]
 LDCM0387  CL117 HEK-293T C71(0.96); C78(0.96)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C71(1.34); C78(1.34)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C71(1.21); C78(1.21)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C71(0.74)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C71(0.85); C78(0.85)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C71(0.88); C78(0.88)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C71(0.74); C78(0.74)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C71(0.85); C78(0.85)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C71(1.17); C78(1.17)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C71(0.86); C78(0.86)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C71(0.94); C78(0.94)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C71(0.79); C78(0.79)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C71(0.85); C78(0.85)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C71(0.80)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C71(1.05)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C71(1.21)  LDD1606  [15]
 LDCM0403  CL16 HCT 116 C71(0.77); C78(0.77)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C71(1.32); C78(1.32)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C71(0.86); C78(0.86)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C71(0.95); C78(0.95)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C71(0.96)  LDD1611  [15]
 LDCM0408  CL20 HCT 116 C71(0.85); C78(0.85)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C71(0.84); C78(0.84)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C71(0.89); C78(0.89)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C71(0.93); C78(0.93)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C71(0.80); C78(0.80)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C71(0.75); C78(0.75)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C71(0.76); C78(0.76)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C71(0.81); C78(0.81)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C71(0.70); C78(0.70)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C71(0.80); C78(0.80)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C71(0.90)  LDD1622  [15]
 LDCM0419  CL30 HCT 116 C71(0.69); C78(0.69)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C71(0.96); C78(1.08)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C71(1.54); C78(1.32)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C71(0.96); C78(1.13)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C71(0.96); C78(1.08)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C71(1.09); C78(1.22)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C71(1.09); C78(1.08)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C71(1.47); C78(1.43)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C71(1.12); C78(1.74)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C71(0.95); C78(1.07)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C71(0.91); C78(1.13)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C71(0.74); C78(1.22)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C71(0.91); C78(1.23)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C71(0.78); C78(1.36)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C71(1.64); C78(1.38)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C71(0.58); C78(0.99)  LDD1033  [5]
 LDCM0436  CL46 HCT 116 C71(0.92); C78(0.92)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C71(1.06); C78(1.06)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C71(1.06); C78(1.06)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C71(1.19); C78(1.19)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C71(1.03); C78(0.91)  LDD1644  [15]
 LDCM0441  CL50 HCT 116 C71(1.02); C78(1.02)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C71(0.98); C78(0.98)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C71(1.00); C78(1.00)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C71(1.70); C78(1.70)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C71(1.04); C78(1.04)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C71(1.06); C78(1.06)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C71(1.19); C78(1.19)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C71(1.08); C78(1.08)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C71(1.02); C78(1.02)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C71(1.07); C78(1.07)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C71(0.96)  LDD1654  [15]
 LDCM0452  CL60 HCT 116 C71(1.05); C78(1.05)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C71(1.29); C78(1.29)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C71(1.09); C78(1.09)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C71(0.96); C78(0.96)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C71(1.19); C78(1.19)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C71(1.24); C78(1.24)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C71(1.03); C78(1.03)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C71(1.13); C78(1.13)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C71(1.17); C78(1.17)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C71(1.33); C78(1.33)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C71(1.05)  LDD1665  [15]
 LDCM0463  CL70 HCT 116 C71(1.55); C78(1.55)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C71(1.18); C78(1.18)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C71(1.01); C78(1.01)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C71(1.13); C78(1.13)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C71(1.02); C78(1.02)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C71(0.92); C78(0.92)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C71(0.90); C78(0.90)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C71(0.69); C78(0.69)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C71(0.83); C78(0.83)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C71(1.63)  LDD1676  [15]
 LDCM0474  CL80 HCT 116 C71(0.78); C78(0.78)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C71(0.74); C78(0.74)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C71(1.23); C78(1.23)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C71(1.18); C78(1.18)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C71(1.02); C78(1.02)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C71(1.12); C78(1.12)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C71(1.04); C78(1.04)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C71(1.01); C78(1.01)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C71(1.11); C78(1.11)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C71(0.95); C78(0.95)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C71(0.87); C78(1.28)  LDD1687  [15]
 LDCM0485  CL90 HCT 116 C71(0.88); C78(0.88)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C71(0.77); C78(0.77)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C71(0.87); C78(0.87)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C71(0.81); C78(0.81)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C71(0.89); C78(0.89)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C71(1.01); C78(1.01)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C71(0.95); C78(0.95)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C71(0.97); C78(0.97)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C71(0.96); C78(0.96)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C71(1.15); C78(1.15)  LDD1092  [5]
 LDCM0185  Compound 17 HEK-293T 7.17  LDD0512  [13]
 LDCM0191  Compound 21 HEK-293T 6.56  LDD0508  [13]
 LDCM0190  Compound 34 HEK-293T 18.35  LDD0510  [13]
 LDCM0192  Compound 35 HEK-293T 9.66  LDD0509  [13]
 LDCM0193  Compound 36 HEK-293T 10.10  LDD0511  [13]
 LDCM0495  E2913 HEK-293T C71(0.98)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C71(1.07); C78(1.07)  LDD0785  [5]
 LDCM0427  Fragment51 HEK-293T C71(1.61); C78(1.41)  LDD1025  [5]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 HEK-293T C71(0.90); C71(1.10); C78(1.10)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C71(0.84); C71(0.96); C78(0.96)  LDD1497  [15]
 LDCM0024  KB05 HEK-293T C71(0.87); C71(0.94); C78(0.94)  LDD1502  [15]
 LDCM0014  Panhematin HEK-293T 3.07  LDD0062  [4]

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402