Details of the Target

General Information of Target

Target ID LDTP09495
Target Name Probable glutathione peroxidase 8 (GPX8)
Gene Name GPX8
Gene ID 493869
Synonyms
Probable glutathione peroxidase 8; GPx-8; GSHPx-8; EC 1.11.1.9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTV
SLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSK
EVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKF
WKPEEPIEVIRPDIAALVRQVIIKKKEDL
Target Bioclass
Enzyme
Family
Glutathione peroxidase family
Subcellular location
Membrane
Uniprot ID
Q8TED1
Ensemble ID
ENST00000503787.6
HGNC ID
HGNC:33100

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.51  LDD0197  [1]
Jackson_1
 Probe Info  		20.00  LDD0122  [2]
CHEMBL5175495
 Probe Info  		7.08  LDD0196  [3]
FBP2
 Probe Info  		2.20  LDD0323  [4]
STPyne
 Probe Info  		K128(6.79); K139(10.00); K141(6.66)  LDD0277  [5]
Curcusone 37
 Probe Info  		2.13  LDD0188  [6]
IPM
 Probe Info  		C108(3.99)  LDD1701  [7]
DBIA
 Probe Info  		C79(0.89)  LDD0532  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
AOyne
 Probe Info  		10.10  LDD0443  [12]
MPP-AC
 Probe Info  		N.A.  LDD0428  [13]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		6.23  LDD1733  [14]
C091
 Probe Info  		10.06  LDD1782  [14]
C092
 Probe Info  		17.15  LDD1783  [14]
C094
 Probe Info  		28.05  LDD1785  [14]
C112
 Probe Info  		20.25  LDD1799  [14]
C158
 Probe Info  		10.93  LDD1838  [14]
C169
 Probe Info  		21.71  LDD1849  [14]
C228
 Probe Info  		15.45  LDD1901  [14]
C231
 Probe Info  		15.78  LDD1904  [14]
C234
 Probe Info  		5.54  LDD1907  [14]
C235
 Probe Info  		36.76  LDD1908  [14]
C238
 Probe Info  		11.39  LDD1911  [14]
C251
 Probe Info  		58.49  LDD1924  [14]
C275
 Probe Info  		5.86  LDD1945  [14]
C278
 Probe Info  		81.57  LDD1948  [14]
C285
 Probe Info  		28.05  LDD1955  [14]
C289
 Probe Info  		32.00  LDD1959  [14]
C299
 Probe Info  		6.02  LDD1968  [14]
C349
 Probe Info  		9.78  LDD2010  [14]
C350
 Probe Info  		22.63  LDD2011  [14]
C388
 Probe Info  		43.41  LDD2047  [14]
C390
 Probe Info  		20.82  LDD2049  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]
FFF probe14
 Probe Info  		20.00  LDD0477  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]
OEA-DA
 Probe Info  		3.49  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C79(1.10); C108(0.76)  LDD1507  [17]
 LDCM0215  AC10 HCT 116 C79(0.89)  LDD0532  [8]
 LDCM0226  AC11 HCT 116 C79(0.78)  LDD0543  [8]
 LDCM0237  AC12 HCT 116 C79(0.56)  LDD0554  [8]
 LDCM0259  AC14 HCT 116 C79(0.67)  LDD0576  [8]
 LDCM0263  AC143 HCT 116 C79(0.93)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C79(0.99)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C79(0.99)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C79(0.96)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C79(0.92)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C79(0.79)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C79(0.89)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C79(0.83)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C79(0.92)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C79(1.13)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C79(0.91)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C79(0.63)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C79(0.80)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C79(0.91)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C79(1.19)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C79(0.92)  LDD2161  [8]
 LDCM0276  AC17 HEK-293T C79(1.09); C108(0.82)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C79(1.23); C108(1.27)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C79(0.95); C108(0.70)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C79(0.95); C108(1.10)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C79(0.87); C108(0.81)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C79(0.93)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C79(0.97); C108(1.44)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C79(0.96)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C79(0.98); C108(0.85)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C79(0.97); C108(1.24)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C79(1.05); C108(1.06)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C79(0.95); C108(1.17)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C79(0.94); C108(0.87)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C79(0.88)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C79(0.99); C108(0.99)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C79(0.93); C108(1.34)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C79(1.16)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C79(0.95); C108(1.18)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C79(1.04); C108(1.11)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C79(0.95); C108(1.07)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C79(0.95); C108(1.32)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C79(1.01); C108(0.77)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C79(0.89)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C79(0.88); C108(1.43)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C79(1.06)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C79(0.92); C108(0.74)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C79(1.09); C108(1.19)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C79(1.17); C108(0.85)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C79(1.01); C108(1.45)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C79(1.01); C108(1.24)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C79(0.96); C108(1.00)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C79(0.96)  LDD1546  [17]
 LDCM0308  AC46 HCT 116 C79(1.00)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C79(1.24)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C79(1.05)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C79(1.07)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C79(1.00)  LDD1551  [17]
 LDCM0313  AC50 HCT 116 C79(1.07)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C79(0.97)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C79(1.16)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C79(1.08)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C79(1.11)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C79(1.41)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C79(1.03)  LDD0636  [8]
 LDCM0320  AC57 HEK-293T C79(0.91); C108(0.95)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C79(1.08); C108(1.36)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C79(1.13); C108(1.27)  LDD1561  [17]
 LDCM0323  AC6 HCT 116 C79(1.04)  LDD0640  [8]
 LDCM0324  AC60 HEK-293T C79(1.14); C108(0.87)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C79(0.97)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C79(0.98); C108(0.97)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C79(0.97)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C79(1.08); C108(0.90)  LDD1567  [17]
 LDCM0334  AC7 HCT 116 C79(0.83)  LDD0651  [8]
 LDCM0345  AC8 HCT 116 C79(0.81)  LDD0662  [8]
 LDCM0349  AC83 HCT 116 C79(0.91)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C79(0.97)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C79(1.04)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C79(1.08)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C79(1.12)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C79(1.01)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C79(0.90)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C79(1.29)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C79(0.97)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C79(0.97)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C79(1.26)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C79(1.04)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C79(1.27)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C79(1.12)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C79(1.20)  LDD0681  [8]
 LDCM0248  AKOS034007472 HCT 116 C79(1.15)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C79(0.77)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C79(0.85)  LDD0592  [8]
 LDCM0367  CL1 HEK-293T C79(1.01); C108(1.18)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C79(1.01); C108(1.34)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C79(1.06); C108(1.02)  LDD1573  [17]
 LDCM0370  CL101 HCT 116 C79(0.74)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C79(0.77)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C79(0.75)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C79(0.57)  LDD0690  [8]
 LDCM0374  CL105 HEK-293T C79(1.00); C108(1.02)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C79(1.06)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C79(0.80); C108(1.39)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C79(1.15); C108(1.34)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C79(0.87); C108(0.99)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C79(1.23)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C79(0.93)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C79(0.85); C108(0.99)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C79(1.07); C108(0.94)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C79(0.91); C108(1.67)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C79(1.08)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C79(0.91); C108(1.11)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C79(1.09); C108(1.18)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C79(0.86); C108(1.26)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C79(1.06)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C79(0.91); C108(1.33)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C79(1.03); C108(0.88)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C79(1.17); C108(1.03)  LDD1595  [17]
 LDCM0392  CL121 HCT 116 C79(1.22)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C79(0.94)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C79(1.12)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C79(1.08)  LDD0712  [8]
 LDCM0396  CL125 HEK-293T C79(1.03); C108(0.74)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C79(0.97)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C79(0.99); C108(0.84)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C79(1.15); C108(0.84)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C79(1.18); C108(1.04)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C79(1.07)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C79(0.99); C108(1.51)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C79(1.14); C108(1.09)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C79(1.08); C108(0.93)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C79(1.03); C108(1.41)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C79(1.05); C108(1.25)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C79(1.07)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C79(1.02); C108(1.17)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C79(1.06)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C79(1.13); C108(0.99)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C79(1.23)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C79(1.30); C108(1.00)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C79(0.94); C108(1.39)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C79(1.02)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C79(0.93); C108(0.54)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C79(1.02); C108(1.15)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C79(1.10); C108(0.74)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C79(1.06); C108(0.87)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C79(1.12); C108(1.13)  LDD1623  [17]
 LDCM0420  CL31 HCT 116 C79(1.27)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C79(0.98)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C79(1.01)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C79(0.99)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C79(1.02)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C79(0.97)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C79(1.14)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C79(0.87)  LDD0745  [8]
 LDCM0429  CL4 HEK-293T C79(1.14); C108(1.21)  LDD1633  [17]
 LDCM0430  CL40 HCT 116 C79(1.02)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C79(1.04)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C79(1.15)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C79(1.17)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C79(1.00)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C79(1.01)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C79(1.04)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C79(1.00)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C79(1.13)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C79(1.01)  LDD0756  [8]
 LDCM0440  CL5 HEK-293T C79(1.03); C108(1.10)  LDD1644  [17]
 LDCM0441  CL50 HCT 116 C79(0.95)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C79(0.97)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C79(0.99)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C79(0.93)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C79(1.07)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C79(0.90)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C79(1.09)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C79(1.07)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C79(0.98)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C79(1.05)  LDD0767  [8]
 LDCM0451  CL6 HEK-293T C79(0.98); C108(1.34)  LDD1654  [17]
 LDCM0452  CL60 HCT 116 C79(0.96)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C79(1.21)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C79(0.78)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C79(1.21)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C79(0.96)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C79(0.77)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C79(1.03)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C79(0.96)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C79(0.95)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C79(1.60)  LDD0778  [8]
 LDCM0462  CL7 HEK-293T C79(1.13); C108(1.44)  LDD1665  [17]
 LDCM0463  CL70 HCT 116 C79(1.47)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C79(1.18)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C79(1.78)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C79(1.22)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C79(1.77)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C79(1.01)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C79(0.96)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C79(0.94)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C79(0.86)  LDD0789  [8]
 LDCM0473  CL8 HEK-293T C79(1.07); C108(0.85)  LDD1676  [17]
 LDCM0474  CL80 HCT 116 C79(0.99)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C79(1.11)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C79(1.01)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C79(1.03)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C79(0.94)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C79(0.94)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C79(0.87)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C79(0.97)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C79(0.97)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C79(0.96)  LDD0800  [8]
 LDCM0484  CL9 HEK-293T C79(1.00)  LDD1687  [17]
 LDCM0485  CL90 HCT 116 C79(1.05)  LDD0802  [8]
 LDCM0486  CL91 HEK-293T C79(1.32); C108(0.79)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C79(0.97); C108(0.74)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C79(0.90)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C79(0.95); C108(1.23)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C79(1.16)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C79(1.05); C108(0.80)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C79(0.87); C108(1.26)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C79(1.01)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C79(1.03); C108(1.05)  LDD1697  [17]
 LDCM0191  Compound 21 HEK-293T 5.60  LDD0508  [15]
 LDCM0190  Compound 34 HEK-293T 12.66  LDD0510  [15]
 LDCM0192  Compound 35 HEK-293T 9.13  LDD0509  [15]
 LDCM0193  Compound 36 HEK-293T 5.85  LDD0511  [15]
 LDCM0033  Curcusone1d MCF-7 2.13  LDD0188  [6]
 LDCM0495  E2913 HEK-293T C79(1.18); C108(0.86)  LDD1698  [17]
 LDCM0468  Fragment33 HCT 116 C79(1.09)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C79(1.17)  LDD0744  [8]
 LDCM0022  KB02 HEK-293T C108(1.20)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C108(0.90)  LDD1497  [17]
 LDCM0024  KB05 HMCB C79(2.91)  LDD3312  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) Lipase family P54315
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG8) ALG6/ALG8 glucosyltransferase family Q9BVK2
ATPase GET3 (GET3) ArsA ATPase family O43681
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
Palmitoyltransferase ZDHHC22 (ZDHHC22) DHHC palmitoyltransferase family Q8N966
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Sialidase-1 (NEU1) Glycosyl hydrolase 33 family Q99519
Epididymis-specific alpha-mannosidase (MAN2B2) Glycosyl hydrolase 38 family Q9Y2E5
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Microsomal glutathione S-transferase 2 (MGST2) MAPEG family Q99735
Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL) Membrane-bound acyltransferase family Q9HCP6
Phospholipid phosphatase 4 (PLPP4) PA-phosphatase related phosphoesterase family Q5VZY2
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) PA-phosphatase related phosphoesterase family Q8IY26
Atrial natriuretic peptide-converting enzyme (CORIN) Peptidase S1 family Q9Y5Q5
Transmembrane protease serine 4 (TMPRSS4) Peptidase S1 family Q9NRS4
Dolichol kinase (DOLK) Polyprenol kinase family Q9UPQ8
Rho-related GTP-binding protein Rho6 (RND1) Rho family Q92730
Phosphatidylcholine:ceramide cholinephosphotransferase 2 (SGMS2) Sphingomyelin synthase family Q8NHU3
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
Fatty acid 2-hydroxylase (FA2H) Sterol desaturase family Q7L5A8
Carbohydrate sulfotransferase 1 (CHST1) Sulfotransferase 1 family O43916
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) VKOR family Q8N0U8
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
E3 ubiquitin-protein ligase MARCHF2 (MARCHF2) . Q9P0N8
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) . Q9NX47
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3) . Q8NBI2
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transmembrane reductase CYB561D2 (CYB561D2) . O14569
Transporter and channel
Click To Hide/Show 44 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Monocyte to macrophage differentiation factor (MMD) ADIPOR family Q15546
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Protein lifeguard 1 (GRINA) BI1 family Q7Z429
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
Lysosome membrane protein 2 (SCARB2) CD36 family Q14108
Protein cornichon homolog 1 (CNIH1) Cornichon family O95406
Protein cornichon homolog 3 (CNIH3) Cornichon family Q8TBE1
Occludin (OCLN) ELL/occludin family Q16625
Glycophorin-A (GYPA) Glycophorin A family P02724
Insulin-induced gene 2 protein (INSIG2) INSIG family Q9Y5U4
Transmembrane 4 L6 family member 4 (TM4SF4) L6 tetraspanin family P48230
Lysosomal-associated transmembrane protein 4B (LAPTM4B) LAPTM4/LAPTM5 transporter family Q86VI4
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Major facilitator superfamily domain-containing protein 6 (MFSD6) MFSD6 family Q6ZSS7
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Aquaporin-2 (AQP2) MIP/aquaporin (TC 1.A.8) family P41181
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Ninjurin-1 (NINJ1) Ninjurin family Q92982
NIPA-like protein 3 (NIPAL3) NIPA family Q6P499
CMP-sialic acid transporter (SLC35A1) Nucleotide-sugar transporter family P78382
Nucleotide sugar transporter SLC35B4 (SLC35B4) Nucleotide-sugar transporter family Q969S0
Cardiac phospholamban (PLN) Phospholamban family P26678
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) PMP-22/EMP/MP20 family Q06432
Na(+)/dicarboxylate cotransporter 3 (SLC13A3) SLC13A/DASS transporter family Q8WWT9
Sodium-dependent phosphate transport protein 2C (SLC34A3) SLC34A transporter family Q8N130
Solute carrier family 41 member 2 (SLC41A2) SLC41A transporter family Q96JW4
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Syntaxin-3 (STX3) Syntaxin family Q13277
CD81 antigen (CD81) Tetraspanin (TM4SF) family P60033
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Tetraspanin-33 (TSPAN33) Tetraspanin (TM4SF) family Q86UF1
Uroplakin-1b (UPK1B) Tetraspanin (TM4SF) family O75841
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 218 (TMEM218) TMEM218 family A2RU14
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Translocating chain-associated membrane protein 1-like 1 (TRAM1L1) TRAM family Q8N609
Transmembrane protein 50B (TMEM50B) UPF0220 family P56557
Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B) VTI1 family Q9UEU0
Proteolipid protein 2 (PLP2) . Q04941
Transmembrane protein 60 (TMEM60) . Q9H2L4
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) . Q9BVC6
GPCR
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane progestin receptor delta (PAQR6) ADIPOR family Q6TCH4
Membrane progestin receptor gamma (PAQR5) ADIPOR family Q9NXK6
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Other
Click To Hide/Show 52 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-III (APOC3) Apolipoprotein C3 family P02656
BET1 homolog (BET1) BET1 family O15155
Apolipoprotein D (APOD) Lipocalin family P05090
Glycodelin (PAEP) Lipocalin family P09466
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Protein FAM3C (FAM3C) FAM3 family Q92520
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Myeloid-associated differentiation marker-like protein 2 (MYADML2) MAL family A6NDP7
Plasmolipin (PLLP) MAL family Q9Y342
Nurim (NRM) Nurim family Q8IXM6
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Protein NKG7 (NKG7) PMP-22/EMP/MP20 family Q16617
Stress-associated endoplasmic reticulum protein 1 (SERP1) RAMP4 family Q9Y6X1
Putative ribosome-binding factor A, mitochondrial (RBFA) RbfA family Q8N0V3
Selenoprotein K (SELENOK) Selenoprotein K family Q9Y6D0
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Serine incorporator 1 (SERINC1) TDE1 family Q9NRX5
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Transmembrane protein 19 (TMEM19) TMEM19 family Q96HH6
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Serotransferrin (TF) Transferrin family P02787
Protein unc-50 homolog (UNC50) Unc-50 family Q53HI1
Protein YIF1A (YIF1A) YIF1 family O95070
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Asialoglycoprotein receptor 1 (ASGR1) . P07306
Bcl-2-interacting killer (BIK) . Q13323
C-type lectin domain family 1 member A (CLEC1A) . Q8NC01
C-type lectin domain family 2 member A (CLEC2A) . Q6UVW9
CD302 antigen (CD302) . Q8IX05
Complement factor H-related protein 5 (CFHR5) . Q9BXR6
DnaJ homolog subfamily C member 30, mitochondrial (DNAJC30) . Q96LL9
Epididymal secretory protein E3-beta (EDDM3B) . P56851
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) . Q96E93
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Protein SNORC (SNORC) . Q6UX34
Pulmonary surfactant-associated protein C (SFTPC) . P11686
Scavenger receptor class F member 1 (SCARF1) . Q14162
Serine-rich and transmembrane domain-containing protein 1 (SERTM1) . A2A2V5
Thrombomodulin (THBD) . P07204
Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2) . Q71RG4
Transmembrane protein 107 (TMEM107) . Q6UX40
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 42 (TMEM42) . Q69YG0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutathione Small molecular drug DB00143
Glutathione Disulfide Small molecular drug DB03310
Benzoyl Peroxide . DB09096

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840