Details of the Target

General Information of Target

Target ID LDTP17003
Target Name Matrix-remodeling-associated protein 7 (MXRA7)
Gene Name MXRA7
Gene ID 439921
Synonyms
Matrix-remodeling-associated protein 7
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MMGSKMASASRVVQVVKPHTPLIRFPDRRDNPKPNVSEALRSAGLPSHSSVISQHSKGSK
SPDLLMYQGPPDTAEIIKTLPQKYRRKLVSQEEMEFIQRGGPE
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
P84157
Ensemble ID
ENST00000355797.7
HGNC ID
HGNC:7541

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0448  [2]
FBPP2
 Probe Info  		8.66  LDD0318  [3]
STPyne
 Probe Info  		K170(9.04)  LDD0277  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
AOyne
 Probe Info  		7.60  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.73  LDD1725  [8]
C041
 Probe Info  		5.74  LDD1741  [8]
C055
 Probe Info  		17.03  LDD1752  [8]
C056
 Probe Info  		44.02  LDD1753  [8]
C091
 Probe Info  		19.43  LDD1782  [8]
C092
 Probe Info  		27.10  LDD1783  [8]
C094
 Probe Info  		39.12  LDD1785  [8]
C134
 Probe Info  		22.47  LDD1816  [8]
C135
 Probe Info  		9.92  LDD1817  [8]
C231
 Probe Info  		18.00  LDD1904  [8]
C234
 Probe Info  		5.86  LDD1907  [8]
C235
 Probe Info  		25.99  LDD1908  [8]
C238
 Probe Info  		15.14  LDD1911  [8]
C243
 Probe Info  		14.72  LDD1916  [8]
C244
 Probe Info  		14.72  LDD1917  [8]
C246
 Probe Info  		18.90  LDD1919  [8]
C278
 Probe Info  		61.39  LDD1948  [8]
C285
 Probe Info  		48.50  LDD1955  [8]
C287
 Probe Info  		17.03  LDD1957  [8]
C288
 Probe Info  		8.57  LDD1958  [8]
C289
 Probe Info  		76.64  LDD1959  [8]
C343
 Probe Info  		19.97  LDD2005  [8]
C349
 Probe Info  		17.15  LDD2010  [8]
C350
 Probe Info  		41.36  LDD2011  [8]
C362
 Probe Info  		36.76  LDD2023  [8]
C373
 Probe Info  		8.51  LDD2033  [8]
C388
 Probe Info  		99.73  LDD2047  [8]
C390
 Probe Info  		48.50  LDD2049  [8]
C403
 Probe Info  		19.56  LDD2061  [8]
C426
 Probe Info  		12.91  LDD2081  [8]
C431
 Probe Info  		15.67  LDD2086  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 14.57  LDD0403  [1]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587