Details of the Target

General Information of Target

Target ID LDTP07218
Target Name E3 ubiquitin-protein ligase BRE1A (RNF20)
Gene Name RNF20
Gene ID 56254
Synonyms
BRE1A; E3 ubiquitin-protein ligase BRE1A; BRE1-A; hBRE1; EC 2.3.2.27; RING finger protein 20; RING-type E3 ubiquitin transferase BRE1A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAE
MLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDL
LTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVES
SRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQ
EKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVN
SKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQN
EKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQV
ELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLI
SSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDS
EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKES
EKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDK
VQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAM
AKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEE
KEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEA
AQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPD
NVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKC
NAAFGANDFHRIYIG
Target Bioclass
Enzyme
Family
BRE1 family
Subcellular location
Nucleus
Function
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.; (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50.
Uniprot ID
Q5VTR2
Ensemble ID
ENST00000389120.8
HGNC ID
HGNC:10062

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C344(13.74)  LDD1699  [2]
ONAyne
 Probe Info  		K808(10.00)  LDD0275  [3]
Probe 1
 Probe Info  		Y713(20.66)  LDD3495  [4]
Johansson_61
 Probe Info  		_(6.33)  LDD1485  [5]
AHL-Pu-1
 Probe Info  		C905(10.36)  LDD0168  [6]
HHS-475
 Probe Info  		Y713(2.72)  LDD0264  [7]
DBIA
 Probe Info  		C925(0.89)  LDD0078  [8]
ATP probe
 Probe Info  		K491(0.00); K857(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C905(0.00); C960(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C905(0.00); C960(0.00); C922(0.00); C924(0.00)  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
IPM
 Probe Info  		C925(0.00); C905(0.00)  LDD0005  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
STPyne
 Probe Info  		K857(0.00); K778(0.00)  LDD0009  [13]
YN-1
 Probe Info  		N.A.  LDD0447  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
HHS-465
 Probe Info  		K716(0.00); Y713(0.00)  LDD2240  [20]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C141
 Probe Info  		9.32  LDD1823  [21]
C238
 Probe Info  		15.56  LDD1911  [21]
C240
 Probe Info  		13.83  LDD1913  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe3
 Probe Info  		7.71  LDD0465  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C344(0.89)  LDD2103  [2]
 LDCM0025  4SU-RNA HEK-293T C905(10.36)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C905(13.23)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C383(1.10); C905(0.98); C924(0.64); C937(1.05)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C383(0.81); C905(1.19); C924(1.06)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C383(0.93); C905(0.94); C922(0.79); C924(0.66)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C383(1.22); C905(1.11); C922(0.78); C924(0.86)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C383(1.04); C905(0.92); C922(0.74); C924(0.80)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C383(1.08); C905(1.09); C922(0.74); C924(0.86)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C383(1.08); C905(0.93); C922(0.97); C924(0.88)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C383(0.78); C905(1.13); C922(0.72); C924(0.80)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C383(0.91); C905(1.09); C922(0.78); C924(0.76)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C383(0.98); C905(0.98); C922(0.84); C924(0.84)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C383(0.91); C905(0.90); C922(0.66); C924(0.61)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C383(0.82); C905(0.96); C922(0.95); C924(0.77)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C383(0.70); C905(1.08); C924(1.02)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C383(0.78); C905(0.90); C922(0.69); C924(0.78)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C383(1.21); C905(1.08); C922(0.75); C924(0.85)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C383(1.02); C905(0.98); C922(0.73); C924(0.87)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C383(0.78); C922(0.78); C924(0.82); C925(0.78)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C383(0.78); C922(0.93); C924(0.96); C925(0.95)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C383(0.99); C922(0.94); C924(1.03); C925(0.96)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C383(0.86); C922(0.89); C924(0.97); C925(1.19)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C383(0.71); C922(0.68); C924(0.86); C925(0.82)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C383(0.88); C922(0.72); C924(0.97); C925(0.79)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C383(0.70); C922(0.66); C924(0.85); C925(0.66)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C383(0.75); C905(0.93); C924(0.96)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C383(1.04); C922(0.72); C924(0.87); C925(0.82)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C383(0.64); C922(0.43); C924(0.84); C925(0.60)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C383(0.79); C922(0.75); C924(0.80); C925(0.72)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C383(0.80); C922(0.44); C924(0.70); C925(0.56)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C383(0.68); C922(0.52); C924(0.81); C925(0.56)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C383(0.85); C922(0.66); C924(0.84); C925(0.65)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C383(0.79); C922(0.61); C924(0.82); C925(0.83)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C383(0.75); C922(0.58); C924(0.79); C925(0.58)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C383(1.17); C905(1.15); C922(0.83); C924(0.90)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C383(0.87); C905(1.24); C922(0.69); C924(0.80)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C383(1.13); C905(1.28); C922(0.71); C924(0.87)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C383(0.97); C905(1.13); C922(0.81); C924(0.79)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C383(0.84); C905(1.14); C922(0.74); C924(0.95)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C383(0.92); C905(1.29); C922(0.78); C924(0.88)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C383(1.10); C905(1.23); C922(0.66); C924(0.94)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C383(1.14); C905(1.27); C922(0.73); C924(0.94)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C383(1.15); C905(1.13); C922(0.78); C924(0.93)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C383(0.93); C905(1.07); C922(0.72); C924(0.85)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C383(0.93); C905(1.17); C922(0.58); C924(0.90)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C383(1.08); C905(1.29); C922(0.72); C924(0.83)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C383(0.74); C905(1.07); C924(1.06)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C383(1.02); C905(1.31); C922(0.61); C924(0.87)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C383(1.02); C905(1.23); C922(0.59); C924(0.84)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C383(0.77); C905(1.20); C922(0.69); C924(1.00)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C942(0.56); C945(0.56); C960(0.81); C924(0.90)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C942(0.52); C945(0.52); C924(0.58); C960(0.74)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C942(0.60); C945(0.60); C924(0.65); C960(0.72)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C960(0.68); C942(0.71); C945(0.71); C924(0.78)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C942(0.66); C945(0.66); C924(0.69); C960(0.77)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C942(0.66); C945(0.66); C960(0.78); C905(1.12)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C942(0.65); C945(0.65); C960(0.96); C924(1.17)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C383(0.83); C924(1.03); C905(1.14)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C942(0.62); C945(0.62); C924(0.65); C960(0.72)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C924(0.62); C960(0.84); C942(0.85); C945(0.85)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C960(0.57); C942(0.67); C945(0.67); C924(0.77)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C942(0.57); C945(0.57); C960(0.74); C924(1.01)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C905(1.11); C924(0.74); C942(0.55); C945(0.55)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C905(1.10); C924(0.85); C942(0.56); C945(0.56)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C905(1.07); C924(0.70); C942(0.74); C945(0.74)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C905(1.05); C924(0.74); C942(0.97); C945(0.97)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C942(0.75); C924(0.81); C937(0.91); C905(0.97)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C942(0.70); C924(0.77); C937(0.83); C905(0.92)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C942(0.73); C924(0.77); C937(0.89); C905(1.03)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C924(0.96); C383(1.01); C905(1.17); C937(1.23)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C942(0.76); C924(0.80); C905(0.98); C937(1.00)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C942(0.74); C937(0.82); C945(0.90); C905(0.93)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C942(0.73); C937(0.79); C945(0.86); C905(0.88)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C942(0.67); C937(0.70); C945(0.73); C905(0.90)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C942(0.88); C905(0.97); C383(0.99); C924(1.01)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C383(0.95); C937(0.96); C945(0.96); C924(1.08)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C937(0.79); C945(0.79); C383(1.12); C924(1.42)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C924(0.88); C937(0.90); C945(0.90); C383(0.95)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C937(0.80); C945(0.80); C924(0.91); C383(1.01)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C937(0.92); C945(0.92); C924(1.02); C383(1.50)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C924(0.82); C383(1.03); C905(1.05); C937(1.45)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C937(0.87); C945(0.87); C924(1.21); C383(1.55)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C937(0.82); C945(0.82); C383(1.16); C924(1.30)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C937(0.85); C945(0.85); C924(1.28); C383(1.35)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C937(0.78); C945(0.78); C924(1.10); C383(1.12)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C937(0.72); C945(0.72); C383(1.11); C924(1.21)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C905(0.74); C924(0.86); C937(0.94); C945(0.94)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C937(0.80); C945(0.80); C905(0.84); C924(0.96)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C924(0.77); C905(1.02); C937(1.10); C945(1.10)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C905(0.95); C937(0.97); C945(0.97); C924(1.10)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C937(0.87); C945(0.87); C905(0.98); C924(0.99)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C924(0.73); C905(1.11); C383(1.22); C937(1.41)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C924(0.95); C937(0.98); C945(0.98); C383(1.00)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C905(0.98); C924(1.02); C937(1.06); C945(1.06)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C937(0.91); C945(0.91); C924(0.91); C905(1.05)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C383(0.93); C905(1.09); C937(1.10); C945(1.10)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C924(0.89); C937(0.96); C945(0.96); C905(1.08)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C924(0.86); C937(0.90); C945(0.90); C383(1.05)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C924(1.00); C937(1.04); C945(1.04); C905(1.08)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C937(0.74); C945(0.74); C924(0.99); C905(0.99)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C924(0.81); C937(0.89); C945(0.89); C905(1.12)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C937(0.90); C945(0.90); C924(1.23); C905(1.26)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C924(0.79); C383(1.11); C905(1.20); C937(1.28)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C937(0.89); C945(0.89); C905(1.24); C924(1.25)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C905(0.96); C937(0.98); C945(0.98); C924(1.03)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C924(0.95); C905(0.97); C937(1.18); C945(1.18)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C937(0.89); C945(0.89); C383(1.01); C905(1.12)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C905(1.06); C937(1.08); C945(1.08); C383(1.16)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C937(1.08); C945(1.08); C383(1.22); C905(1.33)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C937(1.08); C945(1.08); C383(1.30); C905(1.47)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C937(0.49); C945(0.49); C924(0.61); C383(0.95)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C924(0.61); C937(0.66); C945(0.66); C905(0.87)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C937(0.41); C945(0.41); C924(0.69); C905(1.02)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C383(0.97); C924(1.14); C905(1.20)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C937(0.44); C945(0.44); C924(0.58); C383(0.96)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C937(0.49); C945(0.49); C924(0.62); C905(0.99)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C924(0.57); C937(0.66); C945(0.66); C383(0.92)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C937(0.50); C945(0.50); C924(0.62); C383(0.90)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C937(0.47); C945(0.47); C924(0.65); C383(0.93)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C937(0.42); C945(0.42); C924(0.55); C905(0.98)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C937(0.37); C945(0.37); C924(0.55); C905(0.97)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C937(0.27); C945(0.27); C924(0.58); C905(1.06)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C942(0.72); C937(0.78); C945(0.78); C905(0.88)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C960(0.77); C905(0.90); C383(0.91); C937(1.07)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C383(0.78); C905(0.99); C924(1.00)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C960(0.52); C937(0.74); C945(0.74); C905(0.95)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C937(0.84); C945(0.84); C942(0.87); C905(0.93)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C960(0.81); C937(0.88); C945(0.88); C942(1.00)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C937(0.90); C945(0.90); C960(0.92); C905(1.05)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C937(0.81); C945(0.81); C942(0.86); C960(0.89)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C937(0.88); C945(0.88); C942(0.99); C383(1.01)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C960(0.68); C937(0.97); C945(0.97); C942(1.03)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C942(0.74); C937(0.80); C945(0.80); C905(0.92)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C937(0.83); C945(0.83); C942(0.90); C905(0.92)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C960(0.75); C937(0.77); C945(0.77); C942(0.81)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C383(0.94); C905(0.99); C924(1.03)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C960(0.79); C383(1.00); C905(1.07); C937(1.08)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C960(0.62); C905(0.97); C383(1.02); C937(1.03)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C960(0.68); C937(0.75); C945(0.75); C942(0.92)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C922(0.79); C925(0.79); C905(1.00); C924(1.05)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C922(0.72); C925(0.72); C960(0.89); C905(0.98)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C924(0.82); C922(0.83); C925(0.83); C960(1.07)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C922(0.78); C925(0.78); C924(0.78); C905(1.09)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C922(0.92); C925(0.92); C905(1.05); C924(1.11)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C922(0.71); C925(0.71); C924(0.77); C905(0.99)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C922(0.67); C925(0.67); C924(0.82); C905(1.06)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C924(0.62); C922(0.72); C925(0.72); C905(1.21)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C922(0.84); C925(0.84); C924(0.89); C960(0.97)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C924(0.66); C922(0.85); C925(0.85); C905(1.04)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C924(0.68); C922(0.80); C925(0.80); C905(0.97)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C924(0.71); C905(1.15); C960(1.23); C922(1.26)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C922(0.77); C925(0.77); C924(0.92); C905(1.04)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C924(0.89); C905(1.13); C922(1.15); C925(1.15)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C922(0.81); C925(0.81); C924(0.92); C960(1.02)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C922(0.84); C925(0.84); C383(1.10); C905(1.14)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C924(0.71); C922(0.78); C925(0.78); C905(0.94)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C383(0.74); C905(1.03); C924(0.96)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C383(0.72); C924(1.04); C905(1.12)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C383(1.05); C924(1.11); C905(1.44)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.35  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C925(0.89)  LDD0078  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C905(0.78)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C383(0.91); C924(0.97); C905(1.00); C937(1.16)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C937(0.74); C942(0.74); C383(0.82); C924(0.88)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C924(0.71); C937(0.98); C942(0.98); C945(0.98)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C383(0.80); C924(0.97); C905(1.16)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C383(0.79); C924(0.99); C905(1.02)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C383(0.79); C905(0.99); C924(1.03)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C383(0.71); C924(1.01); C905(1.11)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C924(0.80); C942(0.83); C937(0.87); C945(0.91)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C942(0.81); C937(0.81); C945(0.82); C924(1.00)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C942(0.65); C937(0.73); C924(0.77); C945(0.82)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C942(0.72); C924(0.89); C937(0.89); C945(1.06)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C924(0.84); C945(0.85); C937(0.86); C942(0.87)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C924(0.76); C905(0.81); C383(0.88); C937(1.45)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C942(0.67); C937(0.72); C945(0.78); C924(0.87)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C942(0.67); C924(0.68); C937(0.81); C945(0.94)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C937(0.82); C945(0.82); C924(0.97); C383(1.10)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C937(0.71); C945(0.71); C924(1.23); C383(1.36)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C937(1.05); C945(1.05); C924(1.35); C383(1.55)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C937(0.82); C945(0.82); C924(1.11); C383(1.34)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C937(0.69); C945(0.69); C924(1.02); C383(1.18)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C937(0.83); C945(0.83); C383(0.87); C924(1.21)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C924(0.88); C905(0.96); C937(1.09); C945(1.09)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C937(0.89); C945(0.89); C905(0.95); C924(0.99)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C924(0.79); C383(0.88); C905(1.28); C937(1.83)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C937(0.84); C945(0.84); C383(1.00); C924(1.04)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C905(0.98); C924(1.06); C383(1.26); C937(2.13)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C937(0.90); C945(0.90); C383(1.09); C905(1.12)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C937(0.83); C945(0.83); C924(0.88); C905(1.13)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C937(0.93); C945(0.93); C383(1.11); C924(1.14)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C924(0.56); C937(0.83); C945(0.83); C905(0.99)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C937(0.60); C945(0.60); C924(0.64); C905(0.87)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C937(0.56); C945(0.56); C924(0.66); C905(0.97)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C937(0.55); C945(0.55); C924(0.60); C905(1.03)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C924(0.91); C383(0.99); C905(1.20); C937(1.21)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C924(0.90); C383(0.97); C905(1.00); C937(1.14)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C924(0.81); C383(0.95); C905(1.05); C937(1.30)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C924(0.96); C960(0.98); C905(1.25); C383(1.31)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C924(0.75); C905(0.95); C383(1.04); C960(1.18)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C924(0.77); C383(1.08); C905(1.10); C937(1.71)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C905(0.96); C924(1.01); C960(1.18); C383(1.32)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C924(0.82); C383(0.83); C905(1.12); C937(1.16)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C924(0.95); C905(1.08); C937(1.19); C942(1.19)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C924(0.88); C905(1.01); C937(1.15); C942(1.15)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C905(0.90); C924(0.93); C937(1.34); C942(1.34)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C924(0.87); C905(1.01); C937(1.28); C942(1.28)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C383(1.74); C905(1.18); C924(0.78); C937(1.44)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C383(1.52); C905(1.01); C924(0.74); C937(1.11)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C383(1.30); C905(1.11); C924(1.06); C937(1.48)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C383(1.36); C905(1.16); C924(0.85); C937(1.26)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C383(1.51); C905(1.10); C924(1.07); C937(1.43)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C383(1.64); C905(1.13); C924(0.88); C937(1.52)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C383(0.89); C905(0.98); C924(0.80); C937(0.92)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C383(1.19); C905(1.05); C924(0.81); C937(1.31)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C383(1.56); C905(1.01); C924(0.95)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C383(1.34); C905(0.99); C924(0.70)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C383(1.51); C905(0.98); C924(0.77)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C383(1.89); C905(1.18); C924(1.55)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C383(2.10); C905(1.03); C924(1.14)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C383(1.80); C905(1.04); C924(0.72)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C383(2.29); C905(0.95); C924(0.99)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C383(1.96); C905(0.99); C924(0.84)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C383(0.88); C905(0.89); C924(0.75); C937(1.50)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C383(1.87); C905(0.83); C924(0.59)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C383(1.86); C905(0.94); C924(1.03)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C383(3.02); C905(0.99); C924(0.97)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C383(2.37); C905(0.99); C924(0.98)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C383(1.94); C905(0.95); C924(0.74)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C383(2.04); C905(1.02); C924(0.75)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C383(0.67); C905(1.26); C924(1.12); C925(0.96)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C383(0.61); C905(1.10); C924(0.83); C925(1.07)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C383(0.69); C905(0.99); C924(0.93); C925(1.24)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C383(0.87); C905(0.96); C924(0.69); C925(1.09)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C383(0.80); C905(0.95); C924(0.81); C937(0.97)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C383(0.76); C905(0.96); C924(0.76); C925(1.09)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C383(0.79); C905(1.19); C924(0.85); C925(0.92)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C383(0.69); C905(1.35); C924(0.92); C925(0.84)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C383(0.82); C905(0.95); C924(1.08); C925(1.07)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C383(0.59); C905(1.04); C924(0.77); C925(0.83)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C383(0.69); C905(1.05); C924(0.93); C925(0.83)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C383(0.93); C905(0.99); C924(0.99); C925(0.81)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C383(0.82); C905(0.91); C924(0.92); C925(0.85)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C383(0.70); C905(1.21); C924(1.11); C925(0.81)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C383(0.97); C905(1.01); C924(1.11); C925(0.82)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C383(0.85); C905(0.99); C924(0.90); C937(1.80)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C383(1.04); C905(1.19); C924(1.43); C925(0.82)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C383(1.30); C905(0.97); C922(1.24); C924(1.05)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C383(1.23); C905(1.18); C922(1.00); C924(1.01)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C383(1.37); C905(1.09); C922(1.01); C924(1.25)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C383(1.91); C905(1.01); C922(1.75); C924(1.31)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C383(1.41); C905(0.91); C922(1.37); C924(1.18)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C383(1.64); C905(1.19); C922(1.28); C924(1.04)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C383(1.77); C905(1.02); C922(1.33); C924(1.10)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C383(1.33); C905(0.88); C922(1.44); C924(1.69)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C383(1.09); C905(0.98); C922(1.01); C924(1.06)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C383(0.85); C905(1.26); C924(0.93); C937(0.94)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C383(1.46); C905(1.04); C922(1.21); C924(1.18)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C383(1.39); C905(1.00); C922(1.24); C924(0.99)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C383(1.34); C905(0.98); C922(1.22); C924(1.21)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C383(1.82); C905(0.96); C922(1.24); C924(1.03)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C383(1.72); C905(0.92); C922(1.42); C924(1.28)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C905(0.87); C924(1.56)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C905(0.81); C924(1.55)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C905(0.86); C924(1.65)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C905(0.87); C924(1.71)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C383(1.07); C905(1.00); C924(1.03); C937(1.11)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C905(0.93); C924(1.10)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C905(0.98); C924(1.48)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C905(0.95); C924(1.97)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C905(1.00); C924(1.46)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C905(0.93); C924(1.50)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C905(1.07); C924(1.47)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C905(0.92); C924(1.53)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C905(0.87); C924(1.67)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C905(0.88); C924(1.42)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C905(0.87); C924(2.62)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C383(0.87); C905(1.10); C924(0.89); C937(1.13)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C905(0.77); C924(1.39)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C383(1.09); C905(1.17); C924(1.12); C937(0.94)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C383(1.01); C905(1.03); C924(0.93); C937(0.98)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C383(1.09); C905(1.00); C924(0.79); C937(1.12)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C383(1.09); C905(1.10); C924(0.85); C937(1.29)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C383(1.20); C905(1.19); C924(0.88); C937(1.01)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C383(1.03); C905(1.08); C924(1.01); C937(1.10)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C383(1.00); C905(1.03); C924(0.96); C937(1.31)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C383(1.17); C905(1.19); C924(0.77); C937(1.08)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C383(1.10); C905(1.10); C924(0.68); C937(1.09)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C905(0.96); C383(0.98); C924(0.91)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C905(1.82); C960(0.57)  LDD1702  [2]
 LDCM0576  Fragment14 Ramos C905(0.81)  LDD2193  [24]
 LDCM0468  Fragment33 HCT 116 C383(1.45); C905(1.05); C922(1.23); C924(1.08)  LDD0785  [8]
 LDCM0566  Fragment4 Ramos C905(1.16)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C383(3.10); C905(0.84); C924(0.63)  LDD0744  [8]
 LDCM0569  Fragment7 Jurkat _(6.33)  LDD1485  [5]
 LDCM0116  HHS-0101 DM93 Y713(2.72)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y713(3.01)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y713(2.30)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y713(2.92)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y713(2.63)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C905(1.32); C924(1.13)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C905(1.21); C924(1.45)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C905(1.47); C924(1.13)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C344(0.96)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C344(0.97)  LDD2119  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C344(0.68)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C344(0.66)  LDD2135  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C344(0.77)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C344(0.89)  LDD1700  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C344(1.86)  LDD2144  [2]
 LDCM0131  RA190 MM1.R C924(1.31)  LDD0304  [25]
 LDCM0021  THZ1 HCT 116 C924(0.88)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase BRE1A (RNF20) BRE1 family Q5VTR2
E3 ubiquitin-protein ligase BRE1B (RNF40) BRE1 family O75150
COP9 signalosome complex subunit 5 (COPS5) Peptidase M67A family Q92905
Serine/threonine-protein kinase Chk2 (CHEK2) CAMK Ser/Thr protein kinase family O96017
Ubiquitin-conjugating enzyme E2 E1 (UBE2E1) Ubiquitin-conjugating enzyme family P51965
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Nuclear cap-binding protein subunit 1 (NCBP1) NCBP1 family Q09161
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Parafibromin (CDC73) CDC73 family Q6P1J9
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Transforming acidic coiled-coil-containing protein 3 (TACC3) TACC family Q9Y6A5
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.