Details of the Target

General Information of Target

Target ID LDTP14064
Target Name TNF receptor-associated factor 6 (TRAF6)
Gene Name TRAF6
Gene ID 7189
Synonyms
RNF85; TNF receptor-associated factor 6; EC 2.3.2.27; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLN
IQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGER
TYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDA
GVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQL
GLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAG
VACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLED
TECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEV
AESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
TNF receptor-associated factor family, A subfamily
Subcellular location
Cytoplasm
Function
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. Participates also in the TCR signaling by ubiquitinating LAT.
TTD ID
T15051
Uniprot ID
Q9Y4K3
DrugMap ID
TTCDR6M
Ensemble ID
ENST00000348124.5
HGNC ID
HGNC:12036
ChEMBL ID
CHEMBL3588728

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P12
 Probe Info  		13.19  LDD0202  [2]
DA-P3
 Probe Info  		4.57  LDD0180  [3]
IPM
 Probe Info  		C27(1.08)  LDD1701  [4]
DBIA
 Probe Info  		C134(0.85); C139(0.85)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C403(0.00); C105(0.00); C85(0.00); C70(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C403(0.00); C105(0.00); C366(0.00)  LDD0037  [6]
AOyne
 Probe Info  		13.20  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C134(0.85); C139(0.85)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C134(0.95); C139(0.95); C349(1.06)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C134(0.87); C139(0.87)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C134(0.89); C139(0.89)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C134(0.97); C139(0.97)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C134(0.95); C139(0.95)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C134(0.94); C139(0.94)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C134(0.99); C139(0.99)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C134(1.01); C139(1.01)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C134(0.91); C139(0.85)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C134(0.87); C139(0.93)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C134(0.87); C139(0.93)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C134(0.87); C139(0.87); C349(1.11)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C134(0.90); C139(0.89)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C134(0.92); C139(1.04)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C134(0.90); C139(0.89)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C134(1.03); C139(1.03); C349(1.08)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C134(1.15); C139(1.15); C349(1.13)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C134(1.16); C139(1.16); C349(1.15)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C134(1.34); C139(1.34); C349(1.30)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C134(1.08); C139(1.08); C349(1.16)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C134(1.25); C139(1.25); C349(1.04)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C134(1.12); C139(1.12); C349(1.10)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C134(0.98); C139(0.98); C349(1.09)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C134(1.31); C139(1.31); C349(1.24)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C134(1.14); C139(1.14); C349(1.03)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C134(1.18); C139(1.18); C349(1.03)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C134(1.15); C139(1.15); C349(1.13)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C134(1.19); C139(1.19); C349(1.03)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C134(1.12); C139(1.12); C349(1.09)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C134(1.22); C139(1.22); C349(1.25)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C134(1.34); C139(1.34); C349(1.18)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C134(1.45); C139(1.45)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C134(0.85); C139(0.85)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C134(1.10); C139(1.10)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C134(0.86); C139(0.86)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C134(0.83); C139(0.83)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C134(0.98); C139(0.98)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C134(1.13); C139(1.13)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C134(1.27); C139(1.27)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C134(1.08); C139(1.08)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C134(1.07); C139(1.07)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C134(1.08); C139(1.08)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C134(1.05); C139(1.05)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C134(0.83); C139(0.83); C349(1.16)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C134(1.21); C139(1.21)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C134(0.94); C139(0.94)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C134(0.90); C139(0.90)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C134(1.01); C139(1.01)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C134(1.10); C139(1.12)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C134(0.88); C139(0.93)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C134(0.96); C139(1.08)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C134(1.00); C139(1.07)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C134(1.00); C139(1.05)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C134(1.02); C139(1.10)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C134(0.95); C139(0.95); C349(1.14)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C134(0.99); C139(1.09)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C134(1.22); C139(1.32)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C134(1.02); C139(1.09)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C134(0.89); C139(0.95)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C134(1.00); C139(1.00)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C134(0.94); C139(1.10)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C134(0.86); C139(1.02)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C134(0.82); C139(0.82)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C134(1.05); C139(1.05)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C134(0.84); C139(0.84)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C134(0.87); C139(0.87)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C134(0.76); C139(0.76)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C134(0.81); C139(0.81)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C134(0.75); C139(0.75)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C134(0.70); C139(0.70)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C134(0.60); C139(0.60)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C134(0.67); C139(0.67)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C349(0.93)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C349(0.98)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C349(0.86)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C349(1.02)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C349(1.06)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C134(0.71); C139(0.71)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C349(1.06)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C349(0.89)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C349(1.10)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C349(0.94)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C349(1.03)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C349(0.90); C134(1.07); C139(1.07)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C349(0.86); C134(1.23); C139(1.23)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C349(1.04); C134(1.21); C139(1.21)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C349(0.89); C134(1.35); C139(1.35)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C349(1.13); C134(1.36); C139(1.36)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C134(0.78); C139(0.78)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C349(0.99); C134(1.39); C139(1.39)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C134(0.70); C139(0.70); C349(0.97)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C134(0.89); C139(0.89); C349(1.02)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C134(0.92); C139(0.92); C349(1.08)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C134(0.92); C139(0.92); C349(1.12)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C134(1.03); C139(1.03); C349(1.18)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C349(0.90); C134(0.97); C139(0.97)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C134(1.02); C139(1.02); C349(1.07)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C134(0.95); C139(0.95); C349(0.96)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C134(0.92); C139(0.92); C349(1.31)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C134(0.78); C139(0.78)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C134(0.93); C139(0.93); C349(1.08)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C349(0.72); C134(1.12); C139(1.12)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C349(0.89); C134(1.08); C139(1.08)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C134(1.05); C139(1.05); C349(1.14)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C349(1.00); C134(1.04); C139(1.04)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C134(1.01); C139(1.01); C349(1.25)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C134(1.04); C139(1.04); C349(1.45)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C134(0.91); C139(0.91)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C134(0.90); C139(0.90)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C134(0.91); C139(0.91)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C134(1.05); C139(1.05); C349(1.15)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C134(1.00); C139(1.00)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C134(0.98); C139(0.98)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C134(0.91); C139(0.91)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C134(0.95); C139(0.95)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C134(0.80); C139(0.80)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C134(0.92); C139(0.92)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C134(0.80); C139(0.80)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C134(0.88); C139(0.88)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C134(1.07); C139(1.07)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C134(1.26); C139(1.26)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C349(1.01); C134(1.10); C139(1.10)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C134(0.99); C139(0.99)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C134(1.05); C139(1.05)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C134(1.07); C139(1.07)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C134(1.00); C139(1.00)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C134(0.86); C139(0.86)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C134(0.98); C139(0.98)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C134(1.10); C139(1.10)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C134(1.15); C139(1.15)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C134(0.91); C139(0.91)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C134(0.95); C139(0.95)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C134(1.08); C139(1.08); C349(1.18)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C134(1.13); C139(1.13)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C134(1.05); C139(1.05)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C134(0.80); C139(0.80)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C134(1.08); C139(1.15)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C139(0.94); C134(1.05)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C134(1.09); C139(1.15)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C134(1.01); C139(1.11)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C134(0.98); C139(1.01)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C139(1.01); C134(1.09)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C134(1.04); C139(1.07)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C134(0.98); C139(1.04)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C134(1.24); C139(1.33)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C134(1.26); C139(1.38)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C139(1.10); C134(1.23)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C139(0.93); C134(1.07)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C139(0.91); C134(0.98)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C139(0.92); C134(1.01)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C134(1.24); C139(1.26)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C134(0.75); C139(0.75)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C134(0.72); C139(0.72)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C134(1.02); C139(1.02); C349(1.12)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C134(1.08); C139(1.08); C349(1.13)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C134(1.15); C139(1.15); C349(1.34)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 9.23  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C134(0.85); C139(0.85)  LDD0078  [5]
 LDCM0088  C45 HEK-293T 13.19  LDD0202  [2]
 LDCM0367  CL1 HCT 116 C349(0.86); C134(1.00); C139(1.00)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C349(0.93); C134(1.13); C139(1.13)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C134(0.76); C139(0.76)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C134(1.23); C139(1.23); C349(1.39)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C134(0.94); C139(0.94); C349(1.08)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C134(1.00); C139(1.00); C349(1.10)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C134(0.80); C139(0.80); C349(1.09)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C134(0.90); C139(0.90)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C134(0.83); C139(0.83)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C134(1.02); C139(1.02)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C134(0.98); C139(0.98)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C134(0.73); C139(0.73)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C349(1.01); C134(1.21); C139(1.21)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C134(0.56); C139(0.56)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C134(0.61); C139(0.61)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C349(0.89)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C349(1.19)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C349(1.12)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C349(1.07)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C349(1.02)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C349(1.26); C134(1.31); C139(1.31)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C134(0.85); C139(0.85); C349(1.04)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C134(0.81); C139(0.81); C349(1.03)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C349(1.23); C134(1.26); C139(1.26)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C134(0.83); C139(0.83); C349(0.98)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C349(0.79); C134(1.01); C139(1.01)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C134(1.04); C139(1.04); C349(1.18)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C134(0.72); C139(0.72); C349(1.12)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C134(0.97); C139(0.97); C349(1.38)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C134(0.93); C139(0.93)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C134(0.91); C139(0.91)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C134(0.88); C139(0.88)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C134(1.03); C139(1.03)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C349(1.04); C134(1.05); C139(1.05)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C349(1.02); C134(1.07); C139(1.07)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C349(0.99); C134(1.11); C139(1.11)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C134(1.34); C139(1.35)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C139(1.10); C134(1.10)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C134(1.17); C139(1.17)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C139(1.11); C134(1.12)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C349(0.95); C134(1.13); C139(1.13)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C139(1.40); C134(1.40)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C134(1.17); C139(1.17)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C134(1.36); C139(1.38)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C134(1.41); C139(1.42)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C134(1.48); C139(1.48)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C134(1.38); C139(1.37)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C134(1.18); C139(1.19)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C134(1.33); C139(1.33)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C134(1.26); C139(1.28)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C134(1.24); C139(1.24)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C134(1.08); C139(1.08); C349(0.88)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C134(1.26); C139(1.27)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C134(0.93); C139(0.93); C349(0.94)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C134(0.85); C139(0.85); C349(0.94)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C134(0.74); C139(0.74); C349(0.90)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C134(0.88); C139(0.88); C349(1.16)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C134(0.89); C139(0.89); C349(1.00)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C134(0.96); C139(0.96); C349(0.93)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C134(0.88); C139(0.88); C349(0.99)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C134(0.89); C139(0.89); C349(0.95)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C134(1.03); C139(1.03); C349(0.85)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C134(0.85); C139(0.85); C349(0.85)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C134(0.89); C139(0.89); C349(1.05)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C134(0.75); C139(0.75); C349(0.92)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C134(0.86); C139(0.86); C349(0.98)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C134(0.77); C139(0.77); C349(0.93)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C134(0.88); C139(0.88); C349(1.05)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C134(0.88); C139(0.88)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C134(0.82); C139(0.82)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C134(0.86); C139(0.86)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C134(0.87); C139(0.87)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C134(1.15); C139(1.15); C349(0.87)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C134(0.89); C139(0.89)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C134(0.98); C139(0.98)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C134(0.84); C139(0.84)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C134(0.86); C139(0.86)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C134(0.94); C139(0.94)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C134(0.98); C139(0.98)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C134(1.09); C139(1.09)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C134(0.86); C139(0.86)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C134(0.79); C139(0.79)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C134(0.91); C139(0.91)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C134(0.99); C139(0.99); C349(1.00)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C134(0.94); C139(0.94)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C134(1.19); C139(1.19)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C134(1.29); C139(1.29)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C134(1.01); C139(1.01)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C134(1.19); C139(1.19)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C134(1.04); C139(1.04)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C134(1.18); C139(1.18)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C134(1.44); C139(1.44)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C134(0.97); C139(0.97)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C134(0.91); C139(0.91)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C134(1.10); C139(1.10); C349(1.10)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C134(0.89); C139(0.89)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C134(0.98); C139(0.98)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C134(0.99); C139(0.99)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C134(0.89); C139(0.89)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C134(0.96); C139(0.96)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C134(0.85); C139(0.85)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C134(0.85); C139(0.85)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C134(1.06); C139(1.06)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C134(0.95); C139(0.95)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C134(0.99); C139(0.99); C349(1.16)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C134(0.90); C139(0.90)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C134(0.91); C139(0.91)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C134(0.95); C139(0.95)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C134(0.84); C139(0.84)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C134(0.75); C139(0.75)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C134(0.78); C139(0.78)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C134(0.75); C139(0.75)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C134(0.70); C139(0.70)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C134(0.73); C139(0.73)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C134(0.64); C139(0.64)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C134(1.22); C139(1.22); C349(1.02)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C134(0.58); C139(0.58)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C134(0.94); C139(0.94)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C134(0.91); C139(0.91)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C134(0.93); C139(0.93)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C134(0.88); C139(0.88)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C134(0.86); C139(0.86)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C134(0.98); C139(0.98)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C134(0.78); C139(0.78)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C134(0.82); C139(0.82)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C134(0.94); C139(0.94)  LDD0811  [5]
 LDCM0028  Dobutamine HEK-293T 4.57  LDD0180  [3]
 LDCM0495  E2913 HEK-293T C366(1.22); C105(1.16); C349(1.03); C139(1.04)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C134(1.03); C139(1.03)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C134(1.00); C139(1.00); C349(0.97)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C366(1.01); C85(1.12); C139(1.01); C134(0.92)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C366(1.04); C85(1.05); C139(1.04); C134(0.99)  LDD1497  [8]
 LDCM0024  KB05 MEL167 C85(1.09)  LDD3316  [9]
 LDCM0032  Oleacein HEK-293T 10.70  LDD0184  [3]
 LDCM0029  Quercetin HEK-293T 10.38  LDD0181  [3]
 LDCM0021  THZ1 HCT 116 C189(1.61); C192(1.61); C134(1.35); C139(1.35)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA polymerase iota (POLI) DNA polymerase type-Y family Q9UNA4
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) Peptidase C14B family Q9UDY8
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Ubiquitin thioesterase OTUB2 (OTUB2) Peptidase C65 family Q96DC9
Serine/threonine-protein kinase ULK1 (ULK1) Ser/Thr protein kinase family O75385
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) STE Ser/Thr protein kinase family O43318
TRAF2 and NCK-interacting protein kinase (TNIK) STE Ser/Thr protein kinase family Q9UKE5
Interleukin-1 receptor-associated kinase 1 (IRAK1) TKL Ser/Thr protein kinase family P51617
Interleukin-1 receptor-associated kinase 3 (IRAK3) TKL Ser/Thr protein kinase family Q9Y616
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) TKL Ser/Thr protein kinase family O43187
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Ubiquitin-conjugating enzyme family P61077
Ubiquitin-conjugating enzyme E2 N (UBE2N) Ubiquitin-conjugating enzyme family P61088
E3 ubiquitin ligase TRAF3IP2 (TRAF3IP2) . O43734
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Sphingosine kinase 1 (SPHK1) . Q9NYA1
Ubiquitin domain-containing protein 1 (UBTD1) . Q9HAC8
Ubiquitin thioesterase OTU1 (YOD1) . Q5VVQ6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein S100-B (S100B) S-100 family P04271
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Zinc finger and BTB domain-containing protein 25 (ZBTB25) . P24278
Zinc finger protein 675 (ZNF675) . Q8TD23
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-1 receptor type 1 (IL1R1) Interleukin-1 receptor family P14778
Tumor necrosis factor receptor superfamily member 27 (EDA2R) . Q9HAV5
Tumor necrosis factor receptor superfamily member 5 (CD40) . P25942
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maturin (MTURN) MTURN family Q8N3F0
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
TRAF-interacting protein with FHA domain-containing protein A (TIFA) TIFA family Q96CG3
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Ectodysplasin-A receptor-associated adapter protein (EDARADD) . Q8WWZ3
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Mitochondrial antiviral-signaling protein (MAVS) . Q7Z434
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Sequestosome-1 (SQSTM1) . Q13501
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) . Q9NYJ8
TNF receptor-associated factor 1 (TRAF1) . Q13077
UBX domain-containing protein 7 (UBXN7) . O94888

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840