Details of the Target

General Information of Target

Target ID LDTP00958
Target Name TBC1 domain family member 4 (TBC1D4)
Gene Name TBC1D4
Gene ID 9882
Synonyms
AS160; KIAA0603; TBC1 domain family member 4; Akt substrate of 160 kDa; AS160
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA
EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE
HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA
AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ
GEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERI
LEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQ
VGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQC
ASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVI
QRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTIS
NSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLAS
EKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGR
AQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQN
SGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRV
ASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELR
SLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNC
RAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLT
AQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLL
HMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISP
SLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENI
VEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLE
KLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQK
TVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm
Function
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Uniprot ID
O60343
Ensemble ID
ENST00000377625.6
HGNC ID
HGNC:19165

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.A961V DBIA    Probe Info 
HCT15 SNV: p.A1015D DBIA    Probe Info 
HEC1 SNV: p.P807T DBIA    Probe Info 
HEC1B SNV: p.P807T .
HT3 SNV: p.K30N DBIA    Probe Info 
KP4 SNV: p.V82G DBIA    Probe Info 
LNCaP clone FGC SNV: p.Q449L; p.L452Q DBIA    Probe Info 
MCC26 SNV: p.T960A DBIA    Probe Info 
MDAMB468 SNV: p.V82G DBIA    Probe Info 
MEC1 SNV: p.P947L DBIA    Probe Info 
MELJUSO SNV: p.A155P DBIA    Probe Info 
NCIH1155 SNV: p.P408S DBIA    Probe Info 
P31FUJ Insertion: p.C1277LfsTer2 DBIA    Probe Info 
SKMM2 SNV: p.V82G DBIA    Probe Info 
SKNSH SNV: p.G72C .
TOV21G SNV: p.L46M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K1210(9.16); K1219(10.00); K215(9.09); K560(7.14)  LDD0277  [2]
ONAyne
 Probe Info  		K1291(5.26)  LDD0275  [2]
P12
 Probe Info  		5.99  LDD0202  [3]
BTD
 Probe Info  		C74(1.14)  LDD1700  [4]
Sulforaphane-probe2
 Probe Info  		1.84  LDD0160  [5]
DA-P3
 Probe Info  		8.73  LDD0179  [6]
AHL-Pu-1
 Probe Info  		C45(2.50)  LDD0169  [7]
DBIA
 Probe Info  		C1286(72.90)  LDD0209  [8]
ATP probe
 Probe Info  		K393(0.00); K374(0.00); K380(0.00); K332(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C316(0.00); C402(0.00); C45(0.00); C156(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C6(0.00); C1277(0.00); C156(0.00)  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C156(0.00); C906(0.00); C1286(0.00); C402(0.00)  LDD0037  [10]
TFBX
 Probe Info  		C753(0.00); C93(0.00); C316(0.00); C74(0.00)  LDD0027  [12]
WYneN
 Probe Info  		C1277(0.00); C1286(0.00)  LDD0021  [13]
Compound 10
 Probe Info  		C316(0.00); C74(0.00)  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
ENE
 Probe Info  		C1286(0.00); C74(0.00)  LDD0006  [13]
IPM
 Probe Info  		C45(0.00); C74(0.00); C1277(0.00); C316(0.00)  LDD0005  [13]
SF
 Probe Info  		N.A.  LDD0028  [15]
VSF
 Probe Info  		C74(0.00); C1286(0.00); C753(0.00); C388(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		C316(0.00); C74(0.00); C45(0.00)  LDD0018  [16]
1c-yne
 Probe Info  		K1260(0.00); K1226(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C753(0.00); H339(0.00); C45(0.00); C885(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		C753(0.00); C885(0.00); K68(0.00); C74(0.00)  LDD0218  [18]
W1
 Probe Info  		C1277(0.00); C74(0.00); C1286(0.00); C885(0.00)  LDD0236  [19]
AOyne
 Probe Info  		15.00  LDD0443  [20]
NAIA_5
 Probe Info  		C388(0.00); C45(0.00); C402(0.00); C74(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C265
 Probe Info  		18.51  LDD1936  [22]
C277
 Probe Info  		9.25  LDD1947  [22]
OEA-DA
 Probe Info  		5.37  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C74(1.05)  LDD2142  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C74(0.55)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C74(0.94); C316(0.67)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C74(1.16)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C74(1.03)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C74(0.47)  LDD2132  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C45(2.50)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C1277(1.41); C1286(1.01); C156(0.69); C207(0.82)  LDD0531  [24]
 LDCM0215  AC10 HCT 116 C1277(1.64); C1286(1.42); C156(0.67); C207(0.94)  LDD0532  [24]
 LDCM0216  AC100 HCT 116 C1277(0.99); C1286(0.89); C156(0.84); C207(1.18)  LDD0533  [24]
 LDCM0217  AC101 HCT 116 C1277(1.01); C1286(1.09); C156(0.71); C207(1.03)  LDD0534  [24]
 LDCM0218  AC102 HCT 116 C1277(1.01); C1286(0.95); C156(0.76); C207(1.08)  LDD0535  [24]
 LDCM0219  AC103 HCT 116 C1277(1.43); C1286(1.11); C156(0.70); C207(1.14)  LDD0536  [24]
 LDCM0220  AC104 HCT 116 C1277(1.23); C1286(0.79); C156(0.84); C207(1.05)  LDD0537  [24]
 LDCM0221  AC105 HCT 116 C1277(1.15); C1286(1.06); C156(0.75); C207(1.05)  LDD0538  [24]
 LDCM0222  AC106 HCT 116 C1277(1.20); C1286(1.02); C156(0.76); C207(1.08)  LDD0539  [24]
 LDCM0223  AC107 HCT 116 C1277(1.37); C1286(0.92); C156(0.80); C207(1.12)  LDD0540  [24]
 LDCM0224  AC108 HCT 116 C1277(0.94); C1286(0.88); C156(0.80); C207(1.12)  LDD0541  [24]
 LDCM0225  AC109 HCT 116 C1277(0.95); C1286(0.91); C156(0.80); C207(1.10)  LDD0542  [24]
 LDCM0226  AC11 HCT 116 C1277(1.00); C1286(1.52); C156(0.70); C207(0.98)  LDD0543  [24]
 LDCM0227  AC110 HCT 116 C1277(1.02); C1286(0.93); C156(0.76); C207(1.14)  LDD0544  [24]
 LDCM0228  AC111 HCT 116 C1277(0.97); C1286(0.95); C156(0.69); C207(1.21)  LDD0545  [24]
 LDCM0229  AC112 HCT 116 C1277(1.09); C1286(1.23); C156(0.75); C207(1.16)  LDD0546  [24]
 LDCM0230  AC113 HCT 116 C1277(0.70); C1286(1.02); C156(1.00); C207(0.94)  LDD0547  [24]
 LDCM0231  AC114 HCT 116 C1277(1.27); C1286(1.14); C156(0.98); C207(0.92)  LDD0548  [24]
 LDCM0232  AC115 HCT 116 C1277(1.18); C1286(1.11); C156(0.96); C207(0.99)  LDD0549  [24]
 LDCM0233  AC116 HCT 116 C1277(1.60); C1286(1.45); C156(0.91); C207(0.82)  LDD0550  [24]
 LDCM0234  AC117 HCT 116 C1277(1.12); C1286(1.13); C156(1.05); C207(0.97)  LDD0551  [24]
 LDCM0235  AC118 HCT 116 C1277(0.90); C1286(1.18); C156(1.08); C207(0.91)  LDD0552  [24]
 LDCM0236  AC119 HCT 116 C1277(1.60); C1286(1.18); C156(0.97); C207(0.97)  LDD0553  [24]
 LDCM0237  AC12 HCT 116 C1277(1.03); C1286(1.22); C156(0.85); C207(0.94)  LDD0554  [24]
 LDCM0238  AC120 HCT 116 C1277(1.33); C1286(1.14); C156(0.95); C207(0.93)  LDD0555  [24]
 LDCM0239  AC121 HCT 116 C1277(0.70); C1286(1.04); C156(1.15); C207(1.28)  LDD0556  [24]
 LDCM0240  AC122 HCT 116 C1277(0.81); C1286(1.08); C156(1.07); C207(1.02)  LDD0557  [24]
 LDCM0241  AC123 HCT 116 C1277(1.00); C1286(1.24); C156(1.86); C207(1.47)  LDD0558  [24]
 LDCM0242  AC124 HCT 116 C1277(0.70); C1286(0.99); C156(0.93); C207(1.07)  LDD0559  [24]
 LDCM0243  AC125 HCT 116 C1277(0.83); C1286(1.09); C156(1.00); C207(0.98)  LDD0560  [24]
 LDCM0244  AC126 HCT 116 C1277(1.22); C1286(1.35); C156(1.04); C207(1.08)  LDD0561  [24]
 LDCM0245  AC127 HCT 116 C1277(1.08); C1286(1.20); C156(1.03); C207(1.04)  LDD0562  [24]
 LDCM0246  AC128 HCT 116 C156(1.12); C207(1.11); C225(1.11); C316(0.96)  LDD0563  [24]
 LDCM0247  AC129 HCT 116 C156(0.91); C207(0.99); C225(1.04); C316(0.97)  LDD0564  [24]
 LDCM0249  AC130 HCT 116 C156(0.83); C207(0.97); C225(1.00); C316(1.60)  LDD0566  [24]
 LDCM0250  AC131 HCT 116 C156(0.91); C207(1.06); C225(1.01); C316(1.05)  LDD0567  [24]
 LDCM0251  AC132 HCT 116 C156(0.82); C207(0.98); C225(0.99); C316(0.81)  LDD0568  [24]
 LDCM0252  AC133 HCT 116 C156(0.90); C207(0.93); C225(1.05); C316(0.95)  LDD0569  [24]
 LDCM0253  AC134 HCT 116 C156(1.10); C207(1.00); C225(1.15); C316(0.97)  LDD0570  [24]
 LDCM0254  AC135 HCT 116 C156(0.96); C207(1.03); C225(1.09); C316(0.67)  LDD0571  [24]
 LDCM0255  AC136 HCT 116 C156(0.82); C207(1.00); C225(1.00); C316(0.98)  LDD0572  [24]
 LDCM0256  AC137 HCT 116 C156(0.80); C207(0.93); C225(0.95); C316(0.75)  LDD0573  [24]
 LDCM0257  AC138 HCT 116 C156(0.99); C207(1.04); C225(1.01); C316(0.97)  LDD0574  [24]
 LDCM0258  AC139 HCT 116 C156(0.96); C207(1.05); C225(1.12); C316(0.84)  LDD0575  [24]
 LDCM0259  AC14 HCT 116 C1277(1.00); C1286(1.36); C156(0.64); C207(0.90)  LDD0576  [24]
 LDCM0260  AC140 HCT 116 C156(0.91); C207(1.11); C225(1.13); C316(0.99)  LDD0577  [24]
 LDCM0261  AC141 HCT 116 C156(0.85); C207(1.03); C225(1.05); C316(1.27)  LDD0578  [24]
 LDCM0262  AC142 HCT 116 C156(0.79); C207(0.91); C225(1.00); C316(0.73)  LDD0579  [24]
 LDCM0263  AC143 HCT 116 C388(0.76); C402(0.90); C906(0.95); C207(0.95)  LDD0580  [24]
 LDCM0264  AC144 HCT 116 C402(0.87); C1286(0.94); C207(0.98); C388(0.98)  LDD0581  [24]
 LDCM0265  AC145 HCT 116 C402(0.90); C225(0.94); C1286(0.99); C45(1.00)  LDD0582  [24]
 LDCM0266  AC146 HCT 116 C402(0.85); C388(0.93); C225(0.93); C207(0.96)  LDD0583  [24]
 LDCM0267  AC147 HCT 116 C402(0.89); C388(0.95); C225(0.96); C906(0.98)  LDD0584  [24]
 LDCM0268  AC148 HCT 116 C402(1.12); C207(1.19); C225(1.21); C156(1.22)  LDD0585  [24]
 LDCM0269  AC149 HCT 116 C402(0.94); C207(1.00); C156(1.07); C1286(1.07)  LDD0586  [24]
 LDCM0270  AC15 HCT 116 C156(0.75); C316(0.80); C225(0.83); C453(0.84)  LDD0587  [24]
 LDCM0271  AC150 HCT 116 C388(0.79); C156(0.91); C207(0.94); C225(0.98)  LDD0588  [24]
 LDCM0272  AC151 HCT 116 C402(0.83); C207(0.93); C388(0.98); C156(0.99)  LDD0589  [24]
 LDCM0273  AC152 HCT 116 C388(0.89); C402(0.92); C225(0.94); C207(1.05)  LDD0590  [24]
 LDCM0274  AC153 HCT 116 C388(1.01); C402(1.06); C225(1.12); C906(1.19)  LDD0591  [24]
 LDCM0621  AC154 HCT 116 C1286(1.18); C156(1.17); C207(0.98); C225(0.97)  LDD2158  [24]
 LDCM0622  AC155 HCT 116 C1286(1.26); C156(1.31); C207(0.99); C225(0.95)  LDD2159  [24]
 LDCM0623  AC156 HCT 116 C1286(1.29); C156(1.14); C207(0.99); C225(0.98)  LDD2160  [24]
 LDCM0624  AC157 HCT 116 C1286(1.42); C156(1.35); C207(0.99); C225(1.11)  LDD2161  [24]
 LDCM0276  AC17 HCT 116 C316(0.77); C402(0.94); C156(1.02); C207(1.03)  LDD0593  [24]
 LDCM0277  AC18 HCT 116 C316(0.54); C156(0.94); C388(1.08); C207(1.12)  LDD0594  [24]
 LDCM0278  AC19 HCT 116 C402(0.92); C156(0.97); C74(0.99); C207(1.02)  LDD0595  [24]
 LDCM0279  AC2 HCT 116 C156(0.75); C207(0.84); C402(0.90); C388(1.00)  LDD0596  [24]
 LDCM0280  AC20 HCT 116 C316(0.57); C906(0.95); C1286(0.99); C402(1.06)  LDD0597  [24]
 LDCM0281  AC21 HCT 116 C906(0.95); C74(0.99); C402(1.04); C388(1.04)  LDD0598  [24]
 LDCM0282  AC22 HCT 116 C74(0.93); C906(0.96); C402(1.01); C156(1.02)  LDD0599  [24]
 LDCM0283  AC23 HCT 116 C316(0.69); C906(0.97); C402(1.00); C207(1.03)  LDD0600  [24]
 LDCM0284  AC24 HCT 116 C316(0.93); C74(0.94); C906(0.98); C1286(1.00)  LDD0601  [24]
 LDCM0285  AC25 HCT 116 C453(0.65); C456(0.65); C156(0.86); C45(0.90)  LDD0602  [24]
 LDCM0286  AC26 HCT 116 C453(0.59); C456(0.59); C156(0.86); C45(0.97)  LDD0603  [24]
 LDCM0287  AC27 HCT 116 C156(0.82); C453(0.97); C456(0.97); C388(0.97)  LDD0604  [24]
 LDCM0288  AC28 HCT 116 C156(0.76); C453(0.81); C456(0.81); C402(0.98)  LDD0605  [24]
 LDCM0289  AC29 HCT 116 C156(0.78); C453(0.94); C456(0.94); C402(0.98)  LDD0606  [24]
 LDCM0290  AC3 HCT 116 C156(0.73); C207(0.80); C388(0.89); C402(0.90)  LDD0607  [24]
 LDCM0291  AC30 HCT 116 C156(0.78); C453(0.87); C456(0.87); C402(0.96)  LDD0608  [24]
 LDCM0292  AC31 HCT 116 C156(0.75); C453(0.80); C456(0.80); C402(0.99)  LDD0609  [24]
 LDCM0293  AC32 HCT 116 C453(0.75); C456(0.75); C156(0.78); C402(1.05)  LDD0610  [24]
 LDCM0294  AC33 HCT 116 C156(0.79); C453(0.92); C456(0.92); C402(0.97)  LDD0611  [24]
 LDCM0295  AC34 HCT 116 C156(0.81); C225(0.81); C885(0.93); C402(1.02)  LDD0612  [24]
 LDCM0296  AC35 HCT 116 C1286(0.86); C74(0.87); C207(0.94); C906(0.95)  LDD0613  [24]
 LDCM0297  AC36 HCT 116 C207(0.91); C402(0.92); C906(0.94); C388(0.95)  LDD0614  [24]
 LDCM0298  AC37 HCT 116 C402(0.81); C1286(0.86); C207(0.88); C388(0.91)  LDD0615  [24]
 LDCM0299  AC38 HCT 116 C156(0.89); C402(0.90); C906(0.91); C207(0.95)  LDD0616  [24]
 LDCM0300  AC39 HCT 116 C402(0.92); C156(0.97); C207(0.98); C74(0.99)  LDD0617  [24]
 LDCM0301  AC4 HCT 116 C156(0.69); C207(0.83); C402(0.93); C388(0.96)  LDD0618  [24]
 LDCM0302  AC40 HCT 116 C156(0.90); C207(0.98); C402(0.99); C906(1.01)  LDD0619  [24]
 LDCM0303  AC41 HCT 116 C156(0.83); C402(0.91); C885(0.93); C207(0.94)  LDD0620  [24]
 LDCM0304  AC42 HCT 116 C156(0.92); C207(0.96); C402(0.98); C885(1.00)  LDD0621  [24]
 LDCM0305  AC43 HCT 116 C156(0.85); C402(0.90); C207(0.93); C885(0.94)  LDD0622  [24]
 LDCM0306  AC44 HCT 116 C156(0.91); C74(0.94); C207(0.96); C402(0.96)  LDD0623  [24]
 LDCM0307  AC45 HCT 116 C156(0.93); C207(1.00); C402(1.01); C74(1.03)  LDD0624  [24]
 LDCM0308  AC46 HCT 116 C453(0.69); C456(0.69); C156(0.89); C402(0.95)  LDD0625  [24]
 LDCM0309  AC47 HCT 116 C453(0.78); C456(0.78); C156(0.81); C225(0.99)  LDD0626  [24]
 LDCM0310  AC48 HCT 116 C156(0.76); C885(0.92); C402(0.95); C1286(0.96)  LDD0627  [24]
 LDCM0311  AC49 HCT 116 C453(0.72); C456(0.72); C156(0.89); C885(1.00)  LDD0628  [24]
 LDCM0312  AC5 HCT 116 C156(0.64); C388(0.85); C207(0.86); C906(0.91)  LDD0629  [24]
 LDCM0313  AC50 HCT 116 C453(0.71); C456(0.71); C156(0.88); C885(0.98)  LDD0630  [24]
 LDCM0314  AC51 HCT 116 C453(0.74); C456(0.74); C1286(0.84); C388(0.93)  LDD0631  [24]
 LDCM0315  AC52 HCT 116 C453(0.76); C456(0.76); C1286(0.93); C156(0.93)  LDD0632  [24]
 LDCM0316  AC53 HCT 116 C453(0.74); C456(0.74); C225(0.94); C156(0.95)  LDD0633  [24]
 LDCM0317  AC54 HCT 116 C453(0.81); C456(0.81); C388(0.90); C225(0.93)  LDD0634  [24]
 LDCM0318  AC55 HCT 116 C453(0.68); C456(0.68); C45(0.87); C156(0.96)  LDD0635  [24]
 LDCM0319  AC56 HCT 116 C453(0.69); C456(0.69); C156(0.95); C885(1.01)  LDD0636  [24]
 LDCM0320  AC57 HCT 116 C388(0.86); C402(0.88); C453(0.89); C456(0.89)  LDD0637  [24]
 LDCM0321  AC58 HCT 116 C388(0.74); C402(0.94); C207(1.04); C1286(1.05)  LDD0638  [24]
 LDCM0322  AC59 HCT 116 C388(0.86); C207(0.90); C453(0.92); C456(0.92)  LDD0639  [24]
 LDCM0323  AC6 HCT 116 C156(0.72); C316(0.79); C402(0.89); C388(0.92)  LDD0640  [24]
 LDCM0324  AC60 HCT 116 C402(0.84); C388(0.86); C453(0.89); C456(0.89)  LDD0641  [24]
 LDCM0325  AC61 HCT 116 C388(0.76); C402(0.84); C453(0.87); C456(0.87)  LDD0642  [24]
 LDCM0326  AC62 HCT 116 C453(0.80); C456(0.80); C388(0.91); C402(0.93)  LDD0643  [24]
 LDCM0327  AC63 HCT 116 C388(0.83); C402(0.90); C453(0.97); C456(0.97)  LDD0644  [24]
 LDCM0328  AC64 HCT 116 C453(0.83); C456(0.83); C388(0.86); C402(0.94)  LDD0645  [24]
 LDCM0329  AC65 HCT 116 C453(0.80); C456(0.80); C156(0.95); C388(0.99)  LDD0646  [24]
 LDCM0330  AC66 HCT 116 C207(0.91); C453(0.95); C456(0.95); C402(0.98)  LDD0647  [24]
 LDCM0331  AC67 HCT 116 C453(0.94); C456(0.94); C207(0.94); C388(0.98)  LDD0648  [24]
 LDCM0332  AC68 HCT 116 C156(0.87); C45(0.93); C388(0.93); C1286(0.95)  LDD0649  [24]
 LDCM0333  AC69 HCT 116 C45(0.77); C1286(0.89); C225(0.97); C156(1.02)  LDD0650  [24]
 LDCM0334  AC7 HCT 116 C156(0.70); C1277(0.82); C45(0.90); C402(0.91)  LDD0651  [24]
 LDCM0335  AC70 HCT 116 C45(0.71); C156(0.82); C225(0.90); C906(0.95)  LDD0652  [24]
 LDCM0336  AC71 HCT 116 C45(0.80); C1286(0.88); C207(0.97); C156(0.99)  LDD0653  [24]
 LDCM0337  AC72 HCT 116 C156(0.86); C45(0.89); C207(0.99); C402(1.01)  LDD0654  [24]
 LDCM0338  AC73 HCT 116 C45(0.94); C156(1.02); C207(1.05); C1286(1.12)  LDD0655  [24]
 LDCM0339  AC74 HCT 116 C1286(0.93); C207(0.97); C156(1.01); C402(1.10)  LDD0656  [24]
 LDCM0340  AC75 HCT 116 C45(0.84); C156(0.96); C1286(0.97); C207(1.02)  LDD0657  [24]
 LDCM0341  AC76 HCT 116 C45(0.77); C1286(0.85); C207(1.02); C225(1.04)  LDD0658  [24]
 LDCM0342  AC77 HCT 116 C156(0.95); C45(0.98); C402(1.00); C1286(1.07)  LDD0659  [24]
 LDCM0343  AC78 HCT 116 C45(0.88); C906(0.94); C402(0.94); C156(0.99)  LDD0660  [24]
 LDCM0344  AC79 HCT 116 C45(0.80); C156(0.95); C906(1.06); C225(1.06)  LDD0661  [24]
 LDCM0345  AC8 HCT 116 C156(0.73); C225(0.88); C1277(0.92); C316(0.94)  LDD0662  [24]
 LDCM0346  AC80 HCT 116 C1286(0.84); C45(0.94); C207(1.00); C402(1.01)  LDD0663  [24]
 LDCM0347  AC81 HCT 116 C45(0.75); C402(1.01); C225(1.01); C1286(1.09)  LDD0664  [24]
 LDCM0348  AC82 HCT 116 C45(0.78); C1286(0.87); C156(0.92); C207(1.01)  LDD0665  [24]
 LDCM0349  AC83 HCT 116 C453(0.69); C456(0.69); C156(0.85); C316(0.95)  LDD0666  [24]
 LDCM0350  AC84 HCT 116 C453(0.82); C456(0.82); C156(0.85); C225(0.95)  LDD0667  [24]
 LDCM0351  AC85 HCT 116 C316(0.66); C453(0.80); C456(0.80); C156(0.85)  LDD0668  [24]
 LDCM0352  AC86 HCT 116 C453(0.79); C456(0.79); C207(0.86); C156(0.90)  LDD0669  [24]
 LDCM0353  AC87 HCT 116 C207(0.84); C316(0.93); C453(0.96); C456(0.96)  LDD0670  [24]
 LDCM0354  AC88 HCT 116 C453(0.91); C456(0.91); C207(0.92); C316(0.97)  LDD0671  [24]
 LDCM0355  AC89 HCT 116 C453(0.79); C456(0.79); C156(0.88); C207(0.89)  LDD0672  [24]
 LDCM0357  AC90 HCT 116 C316(0.71); C453(0.84); C456(0.84); C207(0.92)  LDD0674  [24]
 LDCM0358  AC91 HCT 116 C453(0.69); C456(0.69); C156(0.87); C207(1.01)  LDD0675  [24]
 LDCM0359  AC92 HCT 116 C453(0.75); C456(0.75); C156(0.90); C207(0.97)  LDD0676  [24]
 LDCM0360  AC93 HCT 116 C316(0.76); C453(0.79); C456(0.79); C207(0.85)  LDD0677  [24]
 LDCM0361  AC94 HCT 116 C316(0.53); C453(0.76); C456(0.76); C207(0.84)  LDD0678  [24]
 LDCM0362  AC95 HCT 116 C207(0.78); C402(0.82); C225(0.83); C388(0.83)  LDD0679  [24]
 LDCM0363  AC96 HCT 116 C453(0.66); C456(0.66); C207(0.86); C156(0.87)  LDD0680  [24]
 LDCM0364  AC97 HCT 116 C453(0.74); C456(0.74); C156(0.88); C207(0.94)  LDD0681  [24]
 LDCM0365  AC98 HCT 116 C156(0.58); C402(0.75); C225(0.87); C1286(0.90)  LDD0682  [24]
 LDCM0366  AC99 HCT 116 C225(0.63); C402(0.81); C156(0.85); C388(0.95)  LDD0683  [24]
 LDCM0545  Acetamide MDA-MB-231 C74(0.33); C316(0.38)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C74(0.81)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C1277(1.38); C1286(1.11); C156(0.78); C207(0.99)  LDD0565  [24]
 LDCM0356  AKOS034007680 HCT 116 C45(0.71); C156(0.73); C402(0.86); C207(0.89)  LDD0673  [24]
 LDCM0275  AKOS034007705 HCT 116 C156(0.67); C453(0.81); C456(0.81); C225(0.94)  LDD0592  [24]
 LDCM0156  Aniline NCI-H1299 11.65  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C74(0.99); C45(0.99); C1286(1.00)  LDD2171  [24]
 LDCM0498  BS-3668 MDA-MB-231 C74(0.40)  LDD2091  [4]
 LDCM0088  C45 HEK-293T 5.99  LDD0202  [3]
 LDCM0108  Chloroacetamide HeLa C753(0.00); C885(0.00); C45(0.00); H339(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C74(1.96); C45(1.54); C45(0.76)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C1286(0.82); C45(0.88); C388(0.89); C906(0.90)  LDD0684  [24]
 LDCM0368  CL10 HCT 116 C225(0.71); C156(0.83); C316(0.87); C402(0.88)  LDD0685  [24]
 LDCM0369  CL100 HCT 116 C156(0.71); C207(0.87); C402(0.90); C1286(0.96)  LDD0686  [24]
 LDCM0370  CL101 HCT 116 C156(0.74); C45(0.85); C402(0.92); C207(0.92)  LDD0687  [24]
 LDCM0371  CL102 HCT 116 C156(0.77); C45(0.78); C207(0.86); C402(0.89)  LDD0688  [24]
 LDCM0372  CL103 HCT 116 C45(0.73); C156(0.84); C207(0.85); C402(0.89)  LDD0689  [24]
 LDCM0373  CL104 HCT 116 C156(0.74); C45(0.79); C207(0.85); C388(0.87)  LDD0690  [24]
 LDCM0374  CL105 HCT 116 C316(0.60); C156(0.89); C402(0.93); C225(1.00)  LDD0691  [24]
 LDCM0375  CL106 HCT 116 C316(0.69); C156(0.99); C402(1.07); C388(1.10)  LDD0692  [24]
 LDCM0376  CL107 HCT 116 C316(0.92); C156(0.97); C225(1.06); C402(1.07)  LDD0693  [24]
 LDCM0377  CL108 HCT 116 C316(0.73); C156(0.95); C402(1.03); C225(1.07)  LDD0694  [24]
 LDCM0378  CL109 HCT 116 C156(0.88); C402(0.89); C388(0.99); C207(1.00)  LDD0695  [24]
 LDCM0379  CL11 HCT 116 C316(0.55); C156(0.82); C225(0.89); C207(0.97)  LDD0696  [24]
 LDCM0380  CL110 HCT 116 C156(0.88); C225(0.96); C402(0.96); C207(1.04)  LDD0697  [24]
 LDCM0381  CL111 HCT 116 C316(0.61); C156(0.91); C225(0.95); C402(0.96)  LDD0698  [24]
 LDCM0382  CL112 HCT 116 C885(0.90); C453(0.91); C456(0.91); C156(0.94)  LDD0699  [24]
 LDCM0383  CL113 HCT 116 C156(0.76); C453(0.78); C456(0.78); C225(0.93)  LDD0700  [24]
 LDCM0384  CL114 HCT 116 C156(0.73); C885(0.82); C225(0.88); C402(1.02)  LDD0701  [24]
 LDCM0385  CL115 HCT 116 C156(0.79); C885(0.96); C388(1.02); C906(1.05)  LDD0702  [24]
 LDCM0386  CL116 HCT 116 C156(0.81); C402(1.00); C225(1.03); C45(1.05)  LDD0703  [24]
 LDCM0387  CL117 HCT 116 C156(0.87); C402(0.97); C388(1.21); C906(1.22)  LDD0704  [24]
 LDCM0388  CL118 HCT 116 C156(0.87); C207(0.90); C388(0.95); C402(0.97)  LDD0705  [24]
 LDCM0389  CL119 HCT 116 C402(0.89); C156(0.90); C207(0.98); C388(1.00)  LDD0706  [24]
 LDCM0390  CL12 HCT 116 C225(0.78); C156(0.91); C207(0.94); C388(0.96)  LDD0707  [24]
 LDCM0391  CL120 HCT 116 C207(0.87); C45(0.89); C156(0.91); C402(0.93)  LDD0708  [24]
 LDCM0392  CL121 HCT 116 C74(0.86); C388(0.90); C453(0.90); C456(0.90)  LDD0709  [24]
 LDCM0393  CL122 HCT 116 C453(0.80); C456(0.80); C885(0.82); C156(0.83)  LDD0710  [24]
 LDCM0394  CL123 HCT 116 C885(0.73); C453(0.81); C456(0.81); C156(0.85)  LDD0711  [24]
 LDCM0395  CL124 HCT 116 C156(0.90); C453(0.93); C456(0.93); C885(0.98)  LDD0712  [24]
 LDCM0396  CL125 HCT 116 C453(0.80); C456(0.80); C1286(0.82); C388(0.85)  LDD0713  [24]
 LDCM0397  CL126 HCT 116 C388(0.79); C207(0.84); C402(0.92); C156(0.97)  LDD0714  [24]
 LDCM0398  CL127 HCT 116 C453(0.86); C456(0.86); C207(0.88); C388(0.88)  LDD0715  [24]
 LDCM0399  CL128 HCT 116 C453(0.92); C456(0.92); C402(0.94); C388(0.95)  LDD0716  [24]
 LDCM0400  CL13 HCT 116 C402(0.81); C156(0.81); C1277(0.87); C225(0.90)  LDD0717  [24]
 LDCM0401  CL14 HCT 116 C225(0.72); C402(0.81); C1286(0.87); C156(0.91)  LDD0718  [24]
 LDCM0402  CL15 HCT 116 C156(0.79); C1277(0.82); C402(0.82); C207(0.88)  LDD0719  [24]
 LDCM0403  CL16 HCT 116 C388(0.87); C45(0.92); C74(0.92); C156(0.92)  LDD0720  [24]
 LDCM0404  CL17 HCT 116 C45(0.67); C156(0.74); C316(0.75); C388(0.86)  LDD0721  [24]
 LDCM0405  CL18 HCT 116 C156(0.67); C45(0.70); C402(0.81); C388(0.85)  LDD0722  [24]
 LDCM0406  CL19 HCT 116 C156(0.70); C388(0.87); C402(0.92); C45(0.92)  LDD0723  [24]
 LDCM0407  CL2 HCT 116 C1277(0.79); C225(0.85); C316(0.89); C388(0.92)  LDD0724  [24]
 LDCM0408  CL20 HCT 116 C156(0.79); C388(0.84); C453(0.85); C456(0.85)  LDD0725  [24]
 LDCM0409  CL21 HCT 116 C156(0.65); C388(0.86); C453(0.95); C456(0.95)  LDD0726  [24]
 LDCM0410  CL22 HCT 116 C156(0.75); C906(0.91); C388(1.01); C453(1.05)  LDD0727  [24]
 LDCM0411  CL23 HCT 116 C388(0.86); C885(0.89); C156(0.90); C45(0.92)  LDD0728  [24]
 LDCM0412  CL24 HCT 116 C1277(1.46); C1286(1.20); C156(0.77); C207(1.07)  LDD0729  [24]
 LDCM0413  CL25 HCT 116 C1277(1.30); C1286(1.37); C156(0.78); C207(0.93)  LDD0730  [24]
 LDCM0414  CL26 HCT 116 C1277(1.05); C1286(1.17); C156(0.79); C207(0.92)  LDD0731  [24]
 LDCM0415  CL27 HCT 116 C1277(1.01); C1286(1.01); C156(0.76); C207(0.96)  LDD0732  [24]
 LDCM0416  CL28 HCT 116 C1277(1.22); C1286(1.19); C156(0.75); C207(0.91)  LDD0733  [24]
 LDCM0417  CL29 HCT 116 C1277(1.22); C1286(1.03); C156(0.68); C207(1.00)  LDD0734  [24]
 LDCM0418  CL3 HCT 116 C1277(0.84); C1286(0.97); C156(1.02); C207(1.01)  LDD0735  [24]
 LDCM0419  CL30 HCT 116 C1277(1.01); C1286(1.11); C156(0.89); C207(0.97)  LDD0736  [24]
 LDCM0420  CL31 HCT 116 C1286(1.15); C156(0.88); C207(1.01); C225(0.86)  LDD0737  [24]
 LDCM0421  CL32 HCT 116 C1286(1.26); C156(0.78); C207(1.01); C225(1.05)  LDD0738  [24]
 LDCM0422  CL33 HCT 116 C1286(1.02); C156(0.71); C207(1.00); C225(0.99)  LDD0739  [24]
 LDCM0423  CL34 HCT 116 C1286(1.35); C156(0.87); C207(1.00); C225(1.03)  LDD0740  [24]
 LDCM0424  CL35 HCT 116 C1286(1.18); C156(0.87); C207(0.96); C225(0.92)  LDD0741  [24]
 LDCM0425  CL36 HCT 116 C1286(1.11); C156(0.83); C207(1.16); C225(0.92)  LDD0742  [24]
 LDCM0426  CL37 HCT 116 C1286(1.47); C156(0.90); C207(1.03); C225(0.94)  LDD0743  [24]
 LDCM0428  CL39 HCT 116 C1286(1.19); C156(0.93); C207(1.14); C225(1.09)  LDD0745  [24]
 LDCM0429  CL4 HCT 116 C1277(0.90); C1286(0.93); C156(0.87); C207(0.95)  LDD0746  [24]
 LDCM0430  CL40 HCT 116 C1286(1.11); C156(0.80); C207(1.05); C225(0.96)  LDD0747  [24]
 LDCM0431  CL41 HCT 116 C1286(1.34); C156(0.91); C207(1.14); C225(1.04)  LDD0748  [24]
 LDCM0432  CL42 HCT 116 C1286(1.93); C156(0.94); C207(1.26); C225(0.96)  LDD0749  [24]
 LDCM0433  CL43 HCT 116 C1286(1.08); C156(0.93); C207(1.07); C225(1.16)  LDD0750  [24]
 LDCM0434  CL44 HCT 116 C1286(1.21); C156(0.78); C207(0.98); C225(0.96)  LDD0751  [24]
 LDCM0435  CL45 HCT 116 C1286(1.49); C156(0.84); C207(0.97); C225(0.93)  LDD0752  [24]
 LDCM0436  CL46 HCT 116 C1277(0.79); C1286(0.78); C156(1.17); C207(0.91)  LDD0753  [24]
 LDCM0437  CL47 HCT 116 C1277(0.89); C1286(0.88); C156(1.18); C207(0.92)  LDD0754  [24]
 LDCM0438  CL48 HCT 116 C1277(0.74); C1286(0.87); C156(1.20); C207(0.97)  LDD0755  [24]
 LDCM0439  CL49 HCT 116 C1277(0.97); C1286(0.99); C156(1.33); C207(1.02)  LDD0756  [24]
 LDCM0440  CL5 HCT 116 C1277(0.79); C1286(1.34); C156(0.91); C207(0.95)  LDD0757  [24]
 LDCM0441  CL50 HCT 116 C1277(0.92); C1286(0.98); C156(1.19); C207(0.91)  LDD0758  [24]
 LDCM0442  CL51 HCT 116 C1277(0.85); C1286(0.82); C156(1.05); C207(0.96)  LDD0759  [24]
 LDCM0443  CL52 HCT 116 C1277(0.79); C1286(0.87); C156(1.06); C207(0.92)  LDD0760  [24]
 LDCM0444  CL53 HCT 116 C1277(0.80); C1286(0.84); C156(1.22); C207(0.96)  LDD0761  [24]
 LDCM0445  CL54 HCT 116 C1277(0.85); C1286(0.87); C156(1.14); C207(0.90)  LDD0762  [24]
 LDCM0446  CL55 HCT 116 C1277(0.83); C1286(1.12); C156(1.37); C207(0.97)  LDD0763  [24]
 LDCM0447  CL56 HCT 116 C1277(0.98); C1286(1.10); C156(1.06); C207(0.95)  LDD0764  [24]
 LDCM0448  CL57 HCT 116 C1277(0.81); C1286(0.99); C156(1.20); C207(0.86)  LDD0765  [24]
 LDCM0449  CL58 HCT 116 C1277(0.92); C1286(0.90); C156(1.32); C207(0.93)  LDD0766  [24]
 LDCM0450  CL59 HCT 116 C1277(1.08); C1286(1.20); C156(1.18); C207(0.96)  LDD0767  [24]
 LDCM0451  CL6 HCT 116 C1277(0.99); C1286(1.05); C156(0.79); C207(0.86)  LDD0768  [24]
 LDCM0452  CL60 HCT 116 C1277(1.07); C1286(0.97); C156(1.13); C207(0.97)  LDD0769  [24]
 LDCM0453  CL61 HCT 116 C1286(0.99); C156(0.92); C207(0.99); C225(1.29)  LDD0770  [24]
 LDCM0454  CL62 HCT 116 C1286(0.95); C156(0.78); C207(0.89); C225(1.48)  LDD0771  [24]
 LDCM0455  CL63 HCT 116 C1286(1.17); C156(0.69); C207(0.88); C225(0.94)  LDD0772  [24]
 LDCM0456  CL64 HCT 116 C1286(1.09); C156(0.74); C207(0.97); C225(1.20)  LDD0773  [24]
 LDCM0457  CL65 HCT 116 C1286(0.92); C156(0.87); C207(0.96); C225(0.83)  LDD0774  [24]
 LDCM0458  CL66 HCT 116 C1286(1.19); C156(0.74); C207(1.00); C225(1.23)  LDD0775  [24]
 LDCM0459  CL67 HCT 116 C1286(1.07); C156(0.78); C207(1.02); C225(0.74)  LDD0776  [24]
 LDCM0460  CL68 HCT 116 C1286(1.09); C156(0.75); C207(0.97); C225(0.58)  LDD0777  [24]
 LDCM0461  CL69 HCT 116 C1286(1.04); C156(0.72); C207(0.83); C225(0.99)  LDD0778  [24]
 LDCM0462  CL7 HCT 116 C1277(0.78); C1286(1.28); C156(0.91); C207(0.83)  LDD0779  [24]
 LDCM0463  CL70 HCT 116 C1286(1.05); C156(0.70); C207(0.94); C225(0.94)  LDD0780  [24]
 LDCM0464  CL71 HCT 116 C1286(1.39); C156(0.79); C207(1.00); C225(1.04)  LDD0781  [24]
 LDCM0465  CL72 HCT 116 C1286(1.22); C156(0.80); C207(1.03); C225(0.88)  LDD0782  [24]
 LDCM0466  CL73 HCT 116 C1286(1.06); C156(0.79); C207(1.13); C225(1.09)  LDD0783  [24]
 LDCM0467  CL74 HCT 116 C1286(1.11); C156(0.73); C207(1.06); C225(0.86)  LDD0784  [24]
 LDCM0469  CL76 HCT 116 C1286(1.40); C156(0.92); C207(1.08); C316(1.08)  LDD0786  [24]
 LDCM0470  CL77 HCT 116 C1286(1.04); C156(0.97); C207(1.08); C316(1.21)  LDD0787  [24]
 LDCM0471  CL78 HCT 116 C1286(2.67); C156(1.02); C207(1.04); C316(1.12)  LDD0788  [24]
 LDCM0472  CL79 HCT 116 C1286(1.31); C156(1.04); C207(1.10); C316(1.17)  LDD0789  [24]
 LDCM0473  CL8 HCT 116 C1277(0.91); C1286(1.53); C156(0.91); C207(0.90)  LDD0790  [24]
 LDCM0474  CL80 HCT 116 C1286(1.01); C156(0.99); C207(1.03); C316(1.45)  LDD0791  [24]
 LDCM0475  CL81 HCT 116 C1286(1.35); C156(1.03); C207(1.09); C316(1.53)  LDD0792  [24]
 LDCM0476  CL82 HCT 116 C1286(1.57); C156(0.97); C207(1.05); C316(1.14)  LDD0793  [24]
 LDCM0477  CL83 HCT 116 C1286(1.38); C156(0.96); C207(1.01); C316(1.16)  LDD0794  [24]
 LDCM0478  CL84 HCT 116 C1286(1.62); C156(0.95); C207(1.00); C316(1.21)  LDD0795  [24]
 LDCM0479  CL85 HCT 116 C1286(1.31); C156(1.01); C207(1.11); C316(1.56)  LDD0796  [24]
 LDCM0480  CL86 HCT 116 C1286(1.03); C156(0.99); C207(0.95); C316(1.30)  LDD0797  [24]
 LDCM0481  CL87 HCT 116 C1286(1.15); C156(0.98); C207(0.99); C316(1.03)  LDD0798  [24]
 LDCM0482  CL88 HCT 116 C1286(1.41); C156(1.20); C207(1.07); C316(1.30)  LDD0799  [24]
 LDCM0483  CL89 HCT 116 C1286(1.69); C156(1.16); C207(1.09); C316(1.57)  LDD0800  [24]
 LDCM0484  CL9 HCT 116 C1277(0.89); C1286(1.09); C156(0.86); C207(0.87)  LDD0801  [24]
 LDCM0485  CL90 HCT 116 C1286(0.96); C156(1.01); C207(1.01); C316(1.07)  LDD0802  [24]
 LDCM0486  CL91 HCT 116 C1277(1.31); C1286(1.00); C156(0.74); C207(0.86)  LDD0803  [24]
 LDCM0487  CL92 HCT 116 C1277(1.33); C1286(1.52); C156(0.74); C207(0.91)  LDD0804  [24]
 LDCM0488  CL93 HCT 116 C1277(1.39); C1286(1.05); C156(0.80); C207(0.88)  LDD0805  [24]
 LDCM0489  CL94 HCT 116 C1277(1.46); C1286(1.34); C156(0.63); C207(0.85)  LDD0806  [24]
 LDCM0490  CL95 HCT 116 C1277(1.54); C1286(1.17); C156(0.67); C207(0.83)  LDD0807  [24]
 LDCM0491  CL96 HCT 116 C1277(1.43); C1286(1.15); C156(0.68); C207(0.79)  LDD0808  [24]
 LDCM0492  CL97 HCT 116 C1277(1.41); C1286(1.15); C156(0.73); C207(0.87)  LDD0809  [24]
 LDCM0493  CL98 HCT 116 C1277(1.52); C1286(1.05); C156(0.68); C207(0.82)  LDD0810  [24]
 LDCM0494  CL99 HCT 116 C1277(1.51); C1286(1.05); C156(0.70); C207(0.79)  LDD0811  [24]
 LDCM0027  Dopamine HEK-293T 8.73  LDD0179  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C74(2.49); C316(1.29); C906(1.24); C295(0.75)  LDD1702  [4]
 LDCM0625  F8 Ramos C1286(0.97); C316(1.19); C388(1.83); C1277(0.73)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C1286(1.02); C316(2.47); C388(0.81); C1277(2.17)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C1286(3.92); C316(0.25); C388(20.00); C1277(0.25)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C1286(0.58); C316(1.26); C388(0.80); C1277(1.17)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C1286(0.60); C316(1.15); C388(1.01); C1277(0.96)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C1286(1.17); C316(0.73); C388(0.96); C1277(1.59)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C1286(0.63); C316(1.17); C388(0.74); C1277(1.41)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C1286(0.54); C316(1.13); C388(1.05); C1277(0.92)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C1286(0.72); C316(1.46); C388(0.31); C1277(2.06)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C1286(0.52); C316(1.22); C388(0.98); C1277(1.17)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C1286(0.27); C316(0.92); C388(0.72); C1277(0.80)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C1286(0.75); C316(2.13); C388(1.17); C1277(1.07)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C1286(0.69); C316(1.27); C388(1.02); C1277(1.37)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C1286(0.80); C316(2.01); C388(0.80); C1277(1.89)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C1286(1.22); C156(0.77); C207(0.88); C225(1.08)  LDD0785  [24]
 LDCM0596  Fragment38 Ramos C1286(0.64); C316(1.26); C388(0.98); C1277(0.87)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C1286(1.01); C316(1.35); C388(0.82); C1277(1.32)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C1286(1.65); C156(0.80); C207(1.07); C225(0.81)  LDD0744  [24]
 LDCM0610  Fragment52 Ramos C1286(0.82); C316(1.62); C388(1.46); C1277(1.02)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C1286(0.89); C316(2.56); C388(1.38); C1277(0.98)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C1286(1.42); C316(0.96); C388(0.70); C1277(1.55)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C1286(1.06); C316(1.59); C388(0.81); C1277(1.57)  LDD2188  [25]
 LDCM0107  IAA HeLa H339(0.00); H483(0.00); C885(0.00)  LDD0221  [18]
 LDCM0022  KB02 Ramos C1286(2.41); C316(1.39); C388(0.87); C1277(2.50)  LDD2182  [25]
 LDCM0023  KB03 Jurkat C1286(72.90)  LDD0209  [8]
 LDCM0024  KB05 G361 C316(4.52); C207(2.46); C74(4.76); C295(4.22)  LDD3311  [26]
 LDCM0030  Luteolin HEK-293T 15.77  LDD0182  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C74(1.05)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C74(0.47)  LDD2121  [4]
 LDCM0109  NEM HeLa H339(0.00); H483(0.00)  LDD0223  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C74(0.49); C316(0.24)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C74(1.17)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C74(0.94)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C74(0.88)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C74(1.03)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C74(0.78)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C74(1.00)  LDD2098  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C74(0.94)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C74(0.73); C316(0.98)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C74(0.78); C316(0.66)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C74(0.84); C316(0.58)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C74(0.90)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C74(1.00)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C74(1.05)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C74(2.58)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C74(0.78)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C74(1.17)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C74(0.82); C316(0.46)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C74(0.98)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C74(0.55); C316(0.51)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C74(1.06)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C74(0.93)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C74(0.85)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C74(0.93); C316(0.58)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C74(0.90); C316(0.63)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C74(0.99); C316(1.08)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C74(0.77); C316(0.83)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C74(1.14)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C74(0.54); C316(0.44); C388(0.85)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C74(1.06)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C74(2.83)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C74(0.83)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C74(2.42)  LDD2147  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C74(1.11)  LDD2149  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C74(1.52)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C74(0.55); C74(0.41)  LDD2206  [27]
 LDCM0032  Oleacein HEK-293T 18.51  LDD0184  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C74(0.76); C74(0.39)  LDD2207  [27]
 LDCM0003  Sulforaphane MDA-MB-231 1.84  LDD0160  [5]
 LDCM0021  THZ1 HCT 116 C74(0.99); C45(0.99); C1286(1.00)  LDD2173  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.