Details of the Target

General Information of Target

Target ID LDTP08639
Target Name Stromal membrane-associated protein 1 (SMAP1)
Gene Name SMAP1
Gene ID 60682
Synonyms
Stromal membrane-associated protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIH
RNLGVHISRVKSVNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIR
DKYEKKKYYDKNAIAITNISSSDAPLQPLVSSPSLQAAVDKNKLEKEKEKKKEEKKREKE
PEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLN
DDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQL
SKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVM
GQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWS
LSQMNQQMAGMSISSATPTAGFGQPSSTTAGWSGSSSGQTLSTQLWK
Target Bioclass
Other
Subcellular location
Cell membrane
Function GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis.
Uniprot ID
Q8IYB5
Ensemble ID
ENST00000316999.9
HGNC ID
HGNC:19651

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.K39N .
BT549 SNV: p.K23E .
JURKAT SNV: p.Q194K .
MCC13 SNV: p.E191K
Substitution: p.P187L		 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K23(10.00)  LDD0277  [2]
P12
 Probe Info  		7.79  LDD0202  [3]
DBIA
 Probe Info  		C33(4.01); C36(4.01)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
AOyne
 Probe Info  		5.00  LDD0443  [6]
NAIA_5
 Probe Info  		C56(0.00); C85(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C33(1.01); C36(1.01)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C33(0.98); C36(0.98)  LDD0813  [4]
 LDCM0226  AC11 HEK-293T C33(0.93); C36(0.93)  LDD0824  [4]
 LDCM0230  AC113 PaTu 8988t C33(1.02); C36(1.02)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C33(1.42); C36(1.42)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C33(1.53); C36(1.53)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C33(1.32); C36(1.32)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C33(1.34); C36(1.34)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C33(0.78); C36(0.78)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C33(1.50); C36(1.50)  LDD1115  [4]
 LDCM0237  AC12 HEK-293T C33(0.89); C36(0.89)  LDD0835  [4]
 LDCM0238  AC120 PaTu 8988t C33(0.82); C36(0.82)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C33(1.28); C36(1.28)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C33(1.19); C36(1.19)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C33(1.16); C36(1.16)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C33(1.33); C36(1.33)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C33(1.21); C36(1.21)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C33(1.13); C36(1.13)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C33(2.06); C36(2.06)  LDD1124  [4]
 LDCM0246  AC128 HEK-293T C33(0.83); C36(0.80)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C33(0.81); C36(0.74)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C33(0.81); C36(0.71)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C33(1.02); C36(1.13)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C33(0.85); C36(0.79)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C33(0.84); C36(0.78)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C33(0.94); C36(0.91)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C33(0.89); C36(0.82)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C33(1.02); C36(0.97)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C33(0.79); C36(0.73)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C33(0.80); C36(0.68)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C33(0.82); C36(0.76)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C33(0.94); C36(0.94)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C33(0.90); C36(0.86)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C33(0.95); C36(0.87)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C33(0.87); C36(0.78)  LDD0860  [4]
 LDCM0263  AC143 PaTu 8988t C36(0.55)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C36(0.77)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C36(0.88)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C36(0.44)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C36(0.41)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C36(0.57)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C36(0.71)  LDD1148  [4]
 LDCM0270  AC15 HEK-293T C33(0.93); C36(0.93)  LDD0868  [4]
 LDCM0271  AC150 PaTu 8988t C36(0.52)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C36(0.43)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C36(0.52)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C36(0.54)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C36(0.49)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C36(0.64)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C36(0.59)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C36(0.49)  LDD2169  [4]
 LDCM0276  AC17 HEK-293T C33(0.53); C36(0.53)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C33(0.52); C36(0.52)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C33(0.72); C36(0.72)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C33(0.81); C36(0.81)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C33(0.75); C36(0.75)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C33(0.70); C36(0.70)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C33(0.72); C36(0.72)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C33(0.71); C36(0.71)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C33(0.76); C36(0.76)  LDD0882  [4]
 LDCM0287  AC27 HEK-293T C85(1.05)  LDD1526  [8]
 LDCM0290  AC3 HEK-293T C33(0.86); C36(0.86)  LDD0888  [4]
 LDCM0293  AC32 HEK-293T C85(0.96); C33(0.92)  LDD1532  [8]
 LDCM0296  AC35 HEK-293T C85(1.03)  LDD1535  [8]
 LDCM0301  AC4 HEK-293T C33(0.97); C36(0.97)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C85(1.05); C33(1.04)  LDD1541  [8]
 LDCM0305  AC43 HEK-293T C85(1.09)  LDD1544  [8]
 LDCM0308  AC46 PaTu 8988t C33(1.05); C36(1.05)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C33(0.97); C36(0.97)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C33(0.95); C36(0.95)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C33(1.02); C36(1.02)  LDD1190  [4]
 LDCM0312  AC5 HEK-293T C33(0.94); C36(0.94)  LDD0910  [4]
 LDCM0313  AC50 PaTu 8988t C33(0.89); C36(0.89)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C33(0.97); C36(0.97)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C33(0.81); C36(0.81)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C33(0.98); C36(0.98)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C33(0.97); C36(0.97)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C33(1.01); C36(1.01)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C33(0.62); C36(0.62)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C33(0.96); C36(0.96)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C33(0.78); C36(0.78)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C33(1.04); C36(1.04)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C33(0.89); C36(0.89)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C33(0.99); C36(0.99)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C33(1.03); C36(1.03)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C33(1.00); C36(1.00)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C33(0.81); C36(0.81)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C33(0.92); C36(0.92)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C33(0.94); C36(0.94)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C33(1.00); C36(1.00)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C33(0.99); C36(0.99)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C33(0.98); C36(0.98)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C33(1.05); C36(1.05)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C33(0.90); C36(0.90)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C33(1.43); C36(1.43)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C33(1.17); C36(1.17)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C33(0.84); C36(0.84)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C33(1.14); C36(1.14)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C33(1.59); C36(1.59)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C33(0.99); C36(0.99)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C33(1.12); C36(1.12)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C33(1.38); C36(1.38)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C33(1.14); C36(1.14)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C33(1.33); C36(1.33)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C33(0.90); C36(0.90)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C33(1.09); C36(1.09)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C33(1.17); C36(1.17)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C33(1.23); C36(1.23)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C33(0.92); C36(0.92)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C33(0.63); C36(0.63)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C33(0.83); C36(0.83)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C33(0.87); C36(0.87)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C33(0.96); C36(0.96)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C33(0.80); C36(0.80)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C33(0.75); C36(0.75)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C33(0.80); C36(0.80)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C33(1.10); C36(1.10)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C33(0.83); C36(0.83)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C33(1.10); C36(1.10)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C33(1.07); C36(1.07)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C33(1.14); C36(1.14)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C33(1.21); C36(1.21)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C33(1.09); C36(1.09)  LDD0962  [4]
 LDCM0248  AKOS034007472 HEK-293T C33(0.89); C36(0.89)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C33(0.92); C36(0.92)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C33(0.99); C36(0.99)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 12.38  LDD0403  [1]
 LDCM0088  C45 HEK-293T 7.79  LDD0202  [3]
 LDCM0367  CL1 HEK-293T C33(0.88); C36(0.88)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C33(0.84); C36(0.84)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C33(0.96); C36(0.96)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C33(0.78); C36(0.78)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C33(0.87); C36(0.87)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C33(0.87); C36(0.87)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C33(0.82); C36(0.82)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C33(0.85); C36(0.85)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C33(0.64); C36(0.64)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C33(0.70); C36(0.70)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C33(0.75); C36(0.75)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C33(0.63); C36(0.63)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C33(1.01); C36(1.01)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C33(0.58); C36(0.58)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C33(0.78); C36(0.78)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C85(0.94)  LDD1586  [8]
 LDCM0385  CL115 HEK-293T C85(1.07)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C85(1.00)  LDD1590  [8]
 LDCM0389  CL119 HEK-293T C85(0.96)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C33(1.06); C36(1.06)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C85(1.10)  LDD1595  [8]
 LDCM0392  CL121 PaTu 8988t C33(1.07); C36(1.07)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C33(1.00); C36(1.00)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C33(0.89); C36(0.89)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C33(0.85); C36(0.85)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C33(0.95); C36(0.95)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C33(0.88); C36(0.88)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C33(0.88); C36(0.88)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C33(0.80); C36(0.80)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C33(1.19); C36(1.19)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C33(1.03); C36(1.03)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C33(0.91); C36(0.91)  LDD1000  [4]
 LDCM0403  CL16 PaTu 8988t C33(0.83); C36(0.89)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C33(0.90); C36(0.93)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C33(0.91); C36(0.97)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C33(1.00); C36(0.85)  LDD1285  [4]
 LDCM0407  CL2 HEK-293T C33(0.96); C36(0.96)  LDD1005  [4]
 LDCM0408  CL20 PaTu 8988t C33(0.82); C36(0.93)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C33(0.62); C36(0.81)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C33(0.80); C36(0.88)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C33(0.81); C36(0.65)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C33(0.84); C36(0.87)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C33(0.71); C36(0.72)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C33(0.72); C36(0.86)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C33(0.84); C36(0.71)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C33(0.93); C36(1.09)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C33(0.85); C36(1.09)  LDD1296  [4]
 LDCM0418  CL3 HEK-293T C33(0.86); C36(0.86)  LDD1016  [4]
 LDCM0419  CL30 PaTu 8988t C33(0.62); C36(0.76)  LDD1298  [4]
 LDCM0420  CL31 HEK-293T C33(0.86); C36(0.86)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C33(0.82); C36(0.82)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C33(0.62); C36(0.62)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C33(0.77); C36(0.77)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C33(0.94); C36(0.94)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C33(0.89); C36(0.89)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C33(0.83); C36(0.83)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C33(0.83); C36(0.83)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C33(0.92); C36(0.92)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C33(0.80); C36(0.80)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C33(1.01); C36(1.01)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C33(0.95); C36(0.95)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C33(0.99); C36(0.99)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C33(1.10); C36(1.10)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C33(0.90); C36(0.90)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C33(0.98); C36(1.35)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C33(0.84); C36(1.13)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C33(0.87); C36(1.18)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C33(1.05); C36(1.26)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C33(0.95); C36(0.95)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C33(0.80); C36(1.04)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C33(0.79); C36(0.95)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C33(0.83); C36(0.90)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C33(0.84); C36(0.96)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C33(0.83); C36(1.05)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C33(0.88); C36(1.05)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C33(0.91); C36(0.98)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C33(0.80); C36(0.99)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C33(0.91); C36(0.94)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C33(0.92); C36(1.35)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C33(0.85); C36(0.85)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C33(0.86); C36(1.18)  LDD1050  [4]
 LDCM0453  CL61 PaTu 8988t C33(0.85); C36(0.85)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C33(1.80); C36(1.80)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C33(1.23); C36(1.23)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C33(0.86); C36(0.86)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C33(1.14); C36(1.14)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C33(0.93); C36(0.93)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C33(0.97); C36(0.97)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C33(0.95); C36(0.95)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C33(0.94); C36(0.94)  LDD1340  [4]
 LDCM0462  CL7 HEK-293T C33(1.16); C36(1.16)  LDD1060  [4]
 LDCM0463  CL70 PaTu 8988t C33(0.97); C36(0.97)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C33(0.88); C36(0.88)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C33(1.37); C36(1.37)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C33(0.67); C36(0.67)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C33(0.98); C36(0.98)  LDD1346  [4]
 LDCM0469  CL76 HEK-293T C33(0.98); C36(1.08)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C33(0.79); C36(0.94)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C33(0.92); C36(1.84)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C33(1.09); C36(1.30)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C33(0.86); C36(1.56)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C33(0.90); C36(0.96)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C33(0.99); C36(1.16)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C33(1.09); C36(0.98)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C33(0.96); C36(0.93)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C33(0.87); C36(1.25)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C33(0.79); C36(1.43)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C33(0.72); C36(1.17)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C33(0.77); C36(1.04)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C33(0.85); C36(1.04)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C33(1.00); C36(1.21)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C33(0.86); C36(1.46)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C33(0.94); C36(1.11)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C33(0.74); C36(0.74)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C33(0.89); C36(0.89)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C33(0.85); C36(0.85)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C33(0.77); C36(0.77)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C33(0.69); C36(0.69)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C33(0.91); C36(0.91)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C33(0.65); C36(0.65)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C33(0.94); C36(0.94)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C33(1.02); C36(1.02)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C85(0.84)  LDD1698  [8]
 LDCM0468  Fragment33 PaTu 8988t C33(0.97); C36(0.97)  LDD1347  [4]
 LDCM0427  Fragment51 HEK-293T C33(1.08); C36(1.08)  LDD1025  [4]
 LDCM0022  KB02 HCT 116 C33(4.01); C36(4.01)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C33(3.86); C36(3.86)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C33(4.06); C36(4.06)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Aryl-hydrocarbon-interacting protein-like 1 (AIPL1) . Q9NZN9
Stromal membrane-associated protein 2 (SMAP2) . Q8WU79

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402