Details of the Target

General Information of Target

Target ID LDTP13088
Target Name Protein IMPACT (IMPACT)
Gene Name IMPACT
Gene ID 55364
Synonyms
Protein IMPACT; Imprinted and ancient gene protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKLAQWLWGLAILGSTWVALTTGALGLELPLSCQEVLWPLPAYLLVSAGCYALGTVGYR
VATFHDCEDAARELQSQIQEARADLARRGLRF
Target Bioclass
Other
Family
IMPACT family
Subcellular location
Cytoplasm
Function
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Uniprot ID
Q9P2X3
Ensemble ID
ENST00000284202.9
HGNC ID
HGNC:20387

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO679 SNV: p.E3G DBIA    Probe Info 
HS936T SNV: p.H175Y DBIA    Probe Info 
HT115 SNV: p.K35N .
KARPAS299 SNV: p.L104R .
LS180 SNV: p.A215T .
NCIH2172 SNV: p.I92R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.27  LDD0402  [1]
P12
 Probe Info  		9.39  LDD0202  [2]
AHL-Pu-1
 Probe Info  		C284(2.26)  LDD0169  [3]
DBIA
 Probe Info  		C284(0.84)  LDD0531  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
STPyne
 Probe Info  		N.A.  LDD0009  [8]
Phosphinate-6
 Probe Info  		C226(0.00); C195(0.00)  LDD0018  [9]
W1
 Probe Info  		N.A.  LDD0236  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C53(2.31)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C284(2.26)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C284(0.84)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C195(0.95); C284(0.72)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C195(0.94); C284(0.60)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C195(0.99); C284(0.63)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C195(0.99); C284(0.65)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C195(0.97); C284(0.51)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C195(1.17); C284(0.56)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C195(0.92); C284(0.55)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C195(1.14); C284(0.55)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C195(0.90); C284(0.55)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C195(0.91); C284(0.65)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C195(1.22); C284(0.64)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C195(0.51); C284(0.63)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C195(0.88); C284(0.55)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C195(1.17); C284(0.59)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C195(1.22); C284(0.50)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C195(0.99); C284(1.25)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C195(0.95); C284(0.89)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C195(0.98); C284(0.74)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C195(1.27); C284(0.78)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C195(0.92); C284(0.97)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C195(0.92); C284(0.97)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C195(1.10); C284(0.99)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C195(0.68); C284(0.78)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C195(1.08); C284(0.95)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C195(0.86); C284(1.32)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C195(0.88); C284(0.76)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C195(0.89); C284(1.04)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C195(0.88); C284(1.25)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C195(1.00); C284(0.84)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C195(1.03); C284(0.91)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C195(0.89); C284(0.89)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C284(1.11)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C284(1.20)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C284(0.89)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C284(1.19)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C284(1.01)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C284(0.98)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C284(0.98)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C284(0.89)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C284(1.04)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C284(1.34)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C284(0.87)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C284(1.03)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C195(0.77); C284(0.65)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C284(1.01)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C284(1.05)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C284(1.09)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C284(0.63)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C284(0.39)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C284(0.62)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C284(0.36)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C284(0.43)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C284(0.33)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C284(0.41)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C284(0.72); C195(0.87)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C284(0.77)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C284(0.59)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C284(0.42)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C284(0.32)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C284(0.42)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C284(0.49)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C284(0.66)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C284(0.47)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C195(0.84); C284(1.01)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C195(0.59); C284(0.74)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C195(0.60); C284(0.91)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C284(0.86)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C195(0.76); C284(1.04)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C195(0.67); C284(0.81)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C195(0.76); C284(0.98)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C195(0.83); C284(0.85)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C195(0.77); C284(1.16)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C284(0.93)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C284(0.91)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C284(0.72)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C284(0.76)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C284(0.72)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C284(0.96)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C284(0.73)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C284(0.67)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C284(0.62)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C284(0.73)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C284(0.59)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C284(1.29)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C284(0.89)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C284(0.89)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C284(0.97)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C284(1.03)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C284(1.04)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C284(0.96)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C284(0.74)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C284(0.79)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C284(0.74)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C284(0.79)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C284(0.89)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C284(0.88)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C284(0.97)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C284(1.12)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C284(0.82)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C284(0.99)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C284(0.91)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C284(1.03)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C284(0.89)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C284(1.00)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C284(1.17)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C284(1.15)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C284(0.97)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C284(0.71)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C284(0.63)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C284(0.62)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C284(0.69); C195(1.26)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C284(0.51)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C284(0.53)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C284(0.53)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C284(0.53)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C284(0.51)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C284(0.61)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C284(0.62)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C284(0.45)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C284(0.90); C195(1.14)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C195(1.00); C284(1.01)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C284(0.73); C195(1.46)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C195(0.77); C284(0.92)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C195(0.97); C284(1.29)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C195(0.98); C284(0.98)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C284(0.77); C195(1.06)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C284(1.02); C195(1.07)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C284(0.94); C195(1.08)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C284(0.98); C195(1.04)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C284(0.92); C195(1.19)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C284(0.96); C195(1.02)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C195(0.89); C284(1.16)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C284(0.70); C195(1.28)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C284(1.05); C195(1.19)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C195(0.88); C284(1.09)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C284(1.01); C195(1.17)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C284(0.59)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C284(0.63)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C284(0.73)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C284(0.90)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C284(0.83)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C284(0.86)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C284(0.63)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C284(1.04)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C284(0.62)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C284(0.69)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C284(0.71)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C284(0.70)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C284(0.56)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C284(0.66)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C284(0.64)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C284(0.46); C195(0.93)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C284(0.66); C195(0.87)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C195(0.62); C284(0.79)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C284(0.74); C195(0.84)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C284(0.61); C195(0.93)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 12.38  LDD0403  [1]
 LDCM0088  C45 HEK-293T 9.39  LDD0202  [2]
 LDCM0632  CL-Sc Hep-G2 C195(0.69)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C284(1.00)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C284(0.73)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C284(0.90)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C284(0.64); C195(1.14)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C284(0.72); C195(2.16)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C195(0.70); C284(0.72)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C284(0.74); C195(1.01)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C195(0.75); C284(0.79)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C195(0.62); C284(0.98)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C195(0.64); C284(0.79)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C195(0.65); C284(0.76)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C284(0.62); C195(0.88)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C284(0.72)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C284(0.78); C195(1.13)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C284(0.71); C195(0.86)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C284(1.04)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C284(0.79)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C284(0.76)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C284(0.67)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C284(0.72)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C284(0.86)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C284(0.79)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C284(0.90)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C284(0.78)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C284(0.82)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C284(0.86)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C284(0.94)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C284(0.95)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C284(1.02)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C284(0.80)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C284(0.68)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C284(0.69)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C284(0.63)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C284(0.68)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C284(0.92)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C284(0.85)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C284(0.87)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C284(0.58); C195(1.86)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C284(0.39); C195(0.89)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C284(0.56); C195(1.05)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C284(0.83)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C284(0.66); C195(1.18)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C284(0.43); C195(2.59)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C284(0.46); C195(1.90)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C284(0.74); C195(1.23)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C284(0.57); C195(0.94)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C195(1.28); C284(0.52)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C195(1.07); C284(0.65)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C195(1.08); C284(0.69)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C195(1.31); C284(0.57)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C195(1.41); C284(0.63)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C284(0.93)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C195(0.89); C284(0.80)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C195(1.05); C284(0.77)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C284(0.64)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C284(0.57)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C284(0.68)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C284(0.69)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C284(0.70)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C284(0.72)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C284(0.78)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C284(0.68)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C284(0.76)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C284(0.79)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C284(0.72)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C284(0.65)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C284(0.71)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C284(0.64)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C284(0.77)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C284(0.88)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C284(0.93)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C284(0.99)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C284(0.84)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C284(0.93)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C284(0.98)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C284(0.76)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C284(0.75)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C284(0.77)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C284(1.08)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C284(1.00)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C284(0.94)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C284(0.68)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C284(0.90)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C284(0.62)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C284(0.86)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C284(1.19)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C284(0.90)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C284(0.80)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C284(0.66)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C284(0.87)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C284(0.71)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C284(0.73)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C284(0.67)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C284(0.56)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C284(0.76)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C284(0.66)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C284(0.72)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C284(0.97)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C284(0.79)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C284(0.78)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C195(1.48); C284(0.99)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C195(2.17); C284(1.03)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C195(1.08); C284(0.90)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C195(1.34); C284(0.82)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C284(0.69)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C195(1.12); C284(0.80)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C195(1.14); C284(1.04)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C195(1.05); C284(0.88)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C195(1.53); C284(0.83)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C195(1.22); C284(0.78)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C195(1.43); C284(1.00)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C195(1.30); C284(1.11)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C195(1.63); C284(1.14)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C195(1.49); C284(1.02)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C195(0.98); C284(0.82)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C284(0.72)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C195(2.61); C284(1.10)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C284(0.92)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C284(0.92)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C284(1.07)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C284(0.76)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C284(0.72)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C284(0.78)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C284(0.84)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C284(0.86)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C284(0.90)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C284(1.12); C195(1.69)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C195(2.19)  LDD1702  [13]
 LDCM0572  Fragment10 MDA-MB-231 C195(1.51)  LDD1389  [14]
 LDCM0573  Fragment11 MDA-MB-231 C195(20.00)  LDD1391  [14]
 LDCM0576  Fragment14 MDA-MB-231 C195(1.56)  LDD1471  [14]
 LDCM0584  Fragment25 MDA-MB-231 C195(0.87)  LDD1411  [14]
 LDCM0578  Fragment27 MDA-MB-231 C195(1.28)  LDD1401  [14]
 LDCM0586  Fragment28 MDA-MB-231 C195(1.09)  LDD1415  [14]
 LDCM0589  Fragment31 MDA-MB-231 C195(1.79)  LDD1421  [14]
 LDCM0590  Fragment32 MDA-MB-231 C195(20.00)  LDD1423  [14]
 LDCM0468  Fragment33 HCT 116 C284(0.79)  LDD0785  [4]
 LDCM0566  Fragment4 MDA-MB-231 C195(20.00)  LDD1461  [14]
 LDCM0603  Fragment45 MDA-MB-231 C195(20.00)  LDD1482  [14]
 LDCM0608  Fragment50 MDA-MB-231 C195(20.00)  LDD1449  [14]
 LDCM0427  Fragment51 HCT 116 C284(0.66)  LDD0744  [4]
 LDCM0614  Fragment56 MDA-MB-231 C195(1.68)  LDD1458  [14]
 LDCM0571  Fragment9 MDA-MB-231 C195(1.18)  LDD1387  [14]
 LDCM0022  KB02 MDA-MB-231 C195(20.00)  LDD1374  [14]
 LDCM0023  KB03 HEK-293T C284(0.95); C195(0.97)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C284(3.51)  LDD3310  [15]
 LDCM0627  NUDT7-COV-1 HEK-293T C195(1.18)  LDD2206  [16]
 LDCM0628  OTUB2-COV-1 HEK-293T C236(1.95)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pigment epithelium-derived factor (SERPINF1) Serpin family P36955

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.