Details of the Target

General Information of Target

Target ID LDTP09742
Target Name Protein ELYS (AHCTF1)
Gene Name AHCTF1
Gene ID 25909
Synonyms
ELYS; TMBS62; Protein ELYS; Embryonic large molecule derived from yolk sac; Protein MEL-28; Putative AT-hook-containing transcription factor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRDLRAQVTSGLLPFPEVTLQALGEDEITLESVLRGKFAAGKNGLACLACGPQLEVVNSI
TGERLSAYRFSGVNEQPPVVLAVKEFSWQKRTGLLIGLEETEGSVLCLYDLGISKVVKAV
VLPGRVTAIEPIINHGGASASTQHLHPSLRWLFGVAAVVTDVGQILLVDLCLDDLSCNQN
EVEASDLEVLTGIPAEVPHIRESVMRQGRHLCFQLVSPTGTAVSTLSYISRTNQLAVGFS
DGYLALWNMKSMKREYYIQLESGQVPVYAVTFQEPENDPRNCCYLWAVQSTQDSEGDVLS
LHLLQLAFGNRKCLASGQILYEGLEYCEERYTLDLTGGMFPLRGQTSNTKLLGCQSIEKF
RSHGDREEGVNEALSPDTSVSVFTWQVNIYGQGKPSVYLGLFDINRWYHAQMPDSLRSGE
YLHNCSYFALWSLESVVSRTSPHGILDILVHERSLNRGVPPSYPPPEQFFNPSTYNFDAT
CLLNSGVVHLTCTGFQKETLTFLKKSGPSLNELIPDGYNRCLVAGLLSPRFVDVQPSSLS
QEEQLEAILSAAIQTSSLGLLTGYIRRWITEEQPNSATNLRFVLEWTWNKVVLTKEEFDR
LCVPLFDGSCHFMDPQTIQSIQQCYLLLSNLNIVLSCFASEAREITERGLIDLSNKFVVS
HLICQYAQVVLWFSHSGLLPEGIDDSVQLSRLCYNYPVIQNYYTSRRQKFERLSRGKWNP
DCLMIDGLVSQLGERIEKLWKRDEGGTGKYPPASLHAVLDMYLLDGVTEAAKHSITIYLL
LDIMYSFPNKTDTPIESFPTVFAISWGQVKLIQGFWLIDHNDYESGLDLLFHPATAKPLS
WQHSKIIQAFMSQGEHRQALRYIQTMKPTVSSGNDVILHLTVLLFNRCMVEAWNFLRQHC
NRLNIEELLKHMYEVCQEMGLMEDLLKLPFTDTEQECLVKFLQSSASVQNHEFLLVHHLQ
RANYVPALKLNQTLKINVMNDRDPRLRERSLARNSILDQYGKILPRVHRKLAIERAKPYH
LSTSSVFRLVSRPKPLSAVPKQVVTGTVLTRSVFINNVLSKIGEVWASKEPINSTTPFNS
SKIEEPSPIVYSLPAPELPEAFFGTPISKASQKISRLLDLVVQPVPRPSQCSEFIQQSSM
KSPLYLVSRSLPSSSQLKGSPQAISRASELHLLETPLVVKKAKSLAMSVTTSGFSEFTPQ
SILRSTLRSTPLASPSPSPGRSPQRLKETRISFVEEDVHPKWIPGAADDSKLEVFTTPKK
CAVPVETEWLKSKDRTTSFFLNSPEKEHQEMDEGSQSLEKLDVSKGNSSVSITSDETTLE
YQDAPSPEDLEETVFTASKPKSSSTALTTNVTEQTEKDGDKDVFASEVTPSDLQKQMGNL
EDAETKDLLVAAEAFSELNHLSPVQGTEASLCAPSVYEGKIFTQKSKVPVLDEGLTSVET
YTPAIRANDNKSMADVLGDGGNSSLTISEGPIVSERRLNQEVALNLKEDHEVEVGVLKES
VDLPEEKLPISDSPPDTQEIHVIEQEKLEAQDSGEEARNLSFNELYPSGTLKLQYNFDTI
DQQFCDLADNKDTAECDIAEVDGELFVAQSNFTLILEGEEGEVEPGDFASSDVLPKAANT
ATEEKLVCSGENDNHGQIANLPSAVTSDQKSQKVDTLPYVPEPIKVAIAENLLDVIKDTR
SKEITSDTMEQSIHETIPLVSQNIMCPTKLVKSAFKTAQETSTMTMNVSQVDDVVSSKTR
TRGQRIQNVNVKSAQQEASADVATPKMPGQSVRKKTRKAKEISEASENIYSDVRGLSQNQ
QIPQNSVTPRRGRRKKEVNQDILENTSSVEQELQITTGRESKRLKSSQLLEPAVEETTKK
EVKVSSVTKRTPRRIKRSVENQESVEIINDLKVSTVTSPSRMIRKLRSTNLDASENTGNK
QDDKSSDKQLRIKHVRRVRGREVSPSDVREDSNLESSQLTVQAEFDMSAIPRKRGRPRKI
NPSEDVGSKAVKEERSPKKKEAPSIRRRSTRNTPAKSENVDVGKPALGKSILVPNEELSM
VMSSKKKLTKKTESQSQKRSLHSVSEERTDEMTHKETNEQEERLLATASFTKSSRSSRTR
SSKAILLPDLSEPNNEPLFSPASEVPRKAKAKKIEVPAQLKELVSDLSSQFVISPPALRS
RQKNTSNKNKLEDELKDDAQSVETLGKPKAKRIRTSKTKQASKNTEKESAWSPPPIEIRL
ISPLASPADGVKSKPRKTTEVTGTGLGRNRKKLSSYPKQILRRKML
Target Bioclass
Transporter and channel
Family
ELYS family
Subcellular location
Cytoplasm
Function
Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.
Uniprot ID
Q8WYP5
Ensemble ID
ENST00000326225.3
HGNC ID
HGNC:24618

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.T1345N DBIA    Probe Info 
COLO320 SNV: p.D1455G DBIA    Probe Info 
COLO679 SNV: p.A40V; p.W816Ter DBIA    Probe Info 
DU145 Deletion: p.K1260NfsTer11 DBIA    Probe Info 
HT115 SNV: p.R209C DBIA    Probe Info 
KMRC1 SNV: p.C313F DBIA    Probe Info 
KMS27 SNV: p.Q273H DBIA    Probe Info 
LS123 SNV: p.D1455G DBIA    Probe Info 
LS180 Deletion: p.N2164TfsTer12 DBIA    Probe Info 
MEWO SNV: p.V523I DBIA    Probe Info 
MFE319 Deletion: p.I2134Ter DBIA    Probe Info 
RKO Deletion: p.K1260NfsTer11 DBIA    Probe Info 
SNGM SNV: p.D414G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.37  LDD0402  [1]
STPyne
 Probe Info  		K1002(9.93); K1113(2.98); K359(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y1790(5.63)  LDD3495  [3]
P12
 Probe Info  		20.00  LDD0202  [4]
BTD
 Probe Info  		C1261(0.75)  LDD2092  [5]
AHL-Pu-1
 Probe Info  		C1628(2.46)  LDD0168  [6]
DBIA
 Probe Info  		C354(56.76)  LDD0209  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C693(0.00); C354(0.00); C722(0.00); C425(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C354(0.00); C1628(0.00); C722(0.00); C425(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C722(0.00); C354(0.00); C1628(0.00); C425(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C722(0.00); C1131(0.00); C1261(0.00); C1628(0.00)  LDD2226  [9]
NAIA_5
 Probe Info  		C1261(0.00); C521(0.00); C693(0.00); C1628(0.00)  LDD2224  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
DA-P3
 Probe Info  		C1628(0.00); C1412(0.00)  LDD0178  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
Compound 10
 Probe Info  		C1628(0.00); C521(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		C1628(0.00); C521(0.00)  LDD2213  [13]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		C521(0.00); C937(0.00); C1628(0.00)  LDD0005  [10]
TFBX
 Probe Info  		C354(0.00); C693(0.00); C521(0.00); C47(0.00)  LDD0148  [14]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		C1628(0.00); C1706(0.00); C1131(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		C1628(0.00); C1131(0.00); C354(0.00)  LDD0217  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
AOyne
 Probe Info  		8.20  LDD0443  [17]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Photonaproxen
 Probe Info  		S1956(0.00); E1950(0.00)  LDD0157  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1261(1.33)  LDD2112  [5]
 LDCM0025  4SU-RNA HEK-293T C1628(2.46)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1706(2.37); C1628(10.42); C1131(2.44)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C1131(1.14); C1628(1.09); C354(0.90); C693(1.25)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C1131(1.06); C1628(1.04); C354(0.94); C693(1.12)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C1131(1.04); C1628(1.01); C354(0.90); C693(0.95)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C1131(1.05); C1628(0.95); C354(0.86); C693(1.08)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C1131(1.04); C1628(1.08); C354(0.90); C693(0.91)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C1131(0.96); C1628(0.97); C354(0.98); C693(1.04)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C1131(1.03); C1628(1.03); C354(1.00); C693(1.16)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C1131(1.05); C1628(0.98); C354(1.01); C693(1.16)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C1131(1.42); C1628(1.13); C354(1.03); C693(1.09)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C1131(1.08); C1628(1.01); C354(0.92); C693(1.10)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C1131(0.97); C1628(0.97); C354(0.89); C693(0.94)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C1131(1.09); C1628(1.07); C354(1.00); C693(0.95)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C1131(1.02); C1628(1.06); C354(1.01); C693(0.86)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C1131(1.02); C1628(1.03); C354(0.96); C693(1.02)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C1131(0.92); C1628(1.01); C354(0.91); C693(1.03)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C1131(1.04); C1628(0.99); C354(1.00); C693(1.01)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C1131(1.04); C1628(0.94); C354(0.99); C693(1.01)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C1131(1.13); C1628(1.02); C354(1.02); C693(1.03)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C1131(0.96); C1628(1.04); C354(0.94); C693(1.00)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C1131(1.02); C1628(1.09); C354(1.01); C693(1.04)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C1131(1.06); C1628(1.06); C354(0.92); C693(1.05)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C1131(0.98); C1628(1.00); C354(0.98); C693(1.01)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C1131(1.00); C1628(1.00); C354(0.94); C693(1.04)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C1131(0.87); C1628(0.99); C354(0.96); C693(1.04)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C1131(1.08); C1628(1.12); C354(0.90); C693(1.10)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C1131(1.14); C1628(1.11); C354(0.96); C693(1.06)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C1131(1.01); C1628(1.07); C354(0.91); C693(0.91)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C1131(1.08); C1628(1.00); C354(0.85); C693(0.99)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C1131(0.91); C1628(1.09); C354(0.94); C693(0.95)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C1131(0.97); C1628(1.08); C354(0.88); C693(0.95)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C1131(0.94); C1628(1.03); C354(0.88); C693(1.05)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C1131(0.97); C1628(1.00); C354(0.82); C693(0.95)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C1131(0.84); C1628(1.05); C354(0.89); C693(0.98)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C1131(1.01); C1628(1.06); C354(0.92); C693(1.08)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C1131(1.04); C1628(1.09); C354(0.96); C693(1.20)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C1131(1.10); C1628(1.05); C354(0.93); C693(0.99)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C1131(1.03); C1628(1.08); C354(0.86); C693(1.00)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C1131(0.96); C1628(1.11); C354(0.90); C693(1.01)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C1131(1.03); C1628(1.03); C354(0.95); C693(0.91)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C1131(1.00); C1628(0.98); C354(0.89); C693(0.98)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C1131(0.92); C1628(1.07); C354(0.84); C693(1.16)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C1131(1.05); C1628(1.13); C354(0.89); C693(1.12)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C1131(0.94); C1628(1.03); C354(0.94); C693(1.04)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C1131(1.03); C1628(1.03); C354(0.97); C693(0.99)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C1131(1.10); C1628(1.07); C354(0.92); C693(0.99)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C1131(1.04); C1628(1.02); C354(0.88); C693(1.10)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C1131(1.01); C1628(1.06); C354(0.97); C693(1.03)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C1131(1.04); C1628(1.05); C354(0.94); C693(0.96)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C1131(1.03); C1628(1.00); C354(0.92); C693(1.02)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C1131(0.86); C1628(1.03); C354(0.91); C693(1.16)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C1131(1.11); C1628(1.14); C354(0.97); C693(1.04)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C1131(1.04); C1628(0.98); C354(0.94); C693(1.09)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C1131(1.00); C1628(1.06); C354(0.94); C693(1.01)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C1131(0.97); C1628(1.06); C354(0.90); C693(0.93)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C1131(1.07); C1628(1.02); C354(0.86); C693(1.07)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C1131(0.92); C1628(1.05); C354(0.95); C693(1.01)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C1131(1.05); C1628(1.08); C354(0.95); C693(1.09)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C1131(1.03); C1628(0.97); C354(0.96); C693(1.13)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C1131(0.87); C1628(1.00); C354(0.90); C693(1.03)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C1131(1.01); C1628(1.01); C354(0.98); C693(1.04)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C1131(0.93); C1628(1.04); C354(0.88); C693(1.06)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C1131(0.93); C1628(1.10); C354(0.95); C693(0.95)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C1131(1.09); C1628(1.09); C354(0.96); C693(1.13)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C1131(1.02); C1628(1.03); C354(0.88); C693(1.03)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 11.62  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0202  [4]
 LDCM0087  Capsaicin HEK-293T 4.72  LDD0185  [11]
 LDCM0108  Chloroacetamide HeLa C1628(0.00); C354(0.00); C1131(0.00); H443(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C1261(20.00)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C1131(1.00); C1628(0.97); C354(0.91); C693(0.97)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C1131(1.31); C1628(0.91); C354(1.06); C693(1.23)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C1131(0.96); C1628(0.96); C354(0.93); C693(1.02)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C1131(0.95); C1628(1.03); C354(0.93); C693(1.09)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C1131(1.06); C1628(0.97); C354(0.99); C693(1.02)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C1131(0.91); C1628(1.05); C354(0.88); C693(1.03)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C1131(0.98); C1628(0.88); C354(0.95); C693(0.91)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C1131(1.08); C1628(0.96); C354(0.93); C693(0.98)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C1131(1.02); C1628(1.05); C354(0.99); C693(0.86)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C1131(1.12); C1628(0.98); C354(1.00); C693(0.89)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C1131(0.96); C1628(1.03); C354(0.97); C693(0.98)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C1131(1.02); C1628(0.94); C354(0.93); C693(1.03)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C1131(1.35); C1628(0.98); C354(0.93); C693(1.09)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C1131(1.17); C1628(0.92); C354(1.09); C693(1.04)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C1131(1.00); C1628(1.00); C354(1.11); C693(1.19)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C1131(1.01); C1628(1.17); C354(0.96); C693(0.98)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C1131(0.99); C1628(1.00); C354(0.94); C693(1.01)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C1131(1.24); C1628(0.92); C354(1.04); C693(1.03)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C1131(0.90); C1628(1.05); C354(0.84); C693(0.98)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C1131(1.11); C1628(1.01); C354(0.95); C693(1.05)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C1131(0.98); C1628(0.98); C354(0.90); C693(0.99)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C1131(1.12); C1628(1.07); C354(0.98); C693(0.92)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C1131(0.83); C1628(1.05); C354(0.91); C693(0.98)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C1131(1.09); C1628(1.14); C354(0.93); C693(1.13)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C1131(1.05); C1628(0.99); C354(0.94); C693(1.11)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C1131(1.01); C1628(0.94); C354(0.94); C693(1.02)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C1131(1.08); C1628(0.96); C354(0.97); C693(1.12)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C1131(0.92); C1628(0.94); C354(1.10); C693(1.13)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C1131(1.06); C1628(0.93); C354(0.95); C693(0.98)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C1131(0.96); C1628(0.98); C354(0.94); C693(1.04)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C1131(1.05); C1628(0.97); C354(1.04); C693(1.05)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C1131(0.89); C1628(0.98); C354(0.91); C693(1.24)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C1131(1.00); C1628(0.97); C354(0.98); C693(1.07)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C1131(1.05); C1628(0.99); C354(0.91); C693(0.91)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C1131(1.20); C1628(0.98); C354(0.91); C693(0.90)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C1131(1.02); C1628(0.94); C354(1.05); C693(1.11)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C1131(1.11); C1628(1.00); C354(0.90); C693(1.05)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C1131(1.33); C1628(1.07); C354(0.95); C693(1.28)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C1131(1.40); C1628(1.02); C354(0.95); C693(1.17)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C1131(1.35); C1628(1.07); C354(0.97); C693(0.97)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C1131(1.20); C1628(1.08); C354(0.90); C693(0.86)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C1131(1.33); C1628(1.02); C354(0.92); C693(1.12)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C1131(1.14); C1628(1.17); C354(1.08); C693(1.16)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C1131(1.13); C1628(1.10); C354(0.97); C693(1.00)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C1131(1.33); C1628(1.01); C354(0.91); C693(1.05)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C1131(1.12); C1628(1.08); C354(0.92); C693(1.02)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C1131(0.95); C1628(0.89); C354(0.96); C693(1.11)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C1131(1.02); C1628(1.06); C354(0.91); C693(1.05)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C1131(0.98); C1628(0.96); C354(0.86); C693(1.00)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C1131(1.02); C1628(1.02); C354(0.93); C693(0.98)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C1131(1.02); C1628(0.83); C354(0.94); C693(1.20)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C1131(1.03); C1628(1.01); C354(0.86); C693(1.10)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C1131(1.07); C1628(0.96); C354(0.98); C693(1.06)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C1131(1.12); C1628(1.00); C354(1.05); C693(0.87)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C1131(1.15); C1628(0.96); C354(0.90); C693(0.90)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C1131(1.36); C1628(0.96); C354(1.06); C693(1.40)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C1131(1.03); C1628(1.03); C354(1.01); C693(1.03)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C1131(1.23); C1628(0.96); C354(1.02); C693(1.01)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C1131(1.12); C1628(1.07); C354(1.02); C693(0.97)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C1131(0.95); C1628(1.01); C354(0.89); C693(0.97)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C1131(0.86); C1628(0.91); C354(0.90); C693(0.99)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C1131(1.12); C1628(0.91); C354(1.00); C693(1.07)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C1131(1.00); C1628(1.11); C354(0.92); C693(0.95)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C1131(1.24); C1628(0.98); C354(0.98); C693(1.12)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C1131(1.02); C1628(1.04); C354(1.04); C693(1.13)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C1131(1.05); C1628(0.99); C354(0.99); C693(0.85)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C1131(1.13); C1628(0.99); C354(0.89); C693(1.00)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C1131(1.42); C1628(1.14); C354(1.10); C693(1.30)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C1131(1.01); C1628(1.03); C354(1.00); C693(0.96)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C1131(1.13); C1628(0.98); C354(1.00); C693(0.95)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C1131(0.99); C1628(0.96); C354(0.98); C693(1.04)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C1131(1.02); C1628(0.93); C354(0.89); C693(1.05)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C1131(1.22); C1628(1.10); C354(0.84); C693(1.10)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C1131(1.12); C1628(0.87); C354(0.97); C693(0.85)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C1131(1.03); C1628(0.95); C354(0.91); C693(1.03)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C1131(1.12); C1628(0.79); C354(0.99); C693(1.04)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C1131(1.29); C1628(0.92); C354(0.94); C693(1.29)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C1131(1.12); C1628(0.98); C354(0.92); C693(0.89)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C1131(1.10); C1628(0.94); C354(0.82); C693(1.10)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C1131(1.20); C1628(1.12); C354(1.04); C693(0.96)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C1131(1.17); C1628(1.10); C354(0.91); C693(0.94)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C1131(1.12); C1628(0.94); C354(0.94); C693(0.95)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C1131(1.32); C1628(0.91); C354(1.03); C693(1.27)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C1131(1.15); C1628(0.98); C354(0.90); C693(1.02)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C1131(0.98); C1628(0.90); C354(0.85); C693(0.87)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C1131(1.12); C1628(0.93); C354(0.91); C693(0.90)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C1131(0.88); C1628(1.02); C354(1.02); C693(1.03)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C1131(1.07); C1628(0.96); C354(0.99); C693(1.09)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C1131(1.07); C1628(0.99); C354(0.94); C693(1.18)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C1131(1.04); C1628(0.93); C354(0.98); C693(1.06)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C1131(1.02); C1628(1.00); C354(0.96); C693(0.96)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C1131(1.05); C1628(0.90); C354(0.85); C693(1.04)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C1131(1.06); C1628(1.08); C354(1.00); C693(1.04)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C1131(1.23); C1628(1.04); C354(0.87); C693(0.91)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C1131(1.09); C1628(1.04); C354(0.99); C693(0.98)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C1131(1.12); C1628(0.95); C354(0.95); C693(1.04)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C1131(1.13); C1628(0.97); C354(0.92); C693(1.02)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C1131(1.07); C1628(0.95); C354(0.92); C693(1.02)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C1131(1.05); C1628(0.93); C354(0.93); C693(0.90)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C1131(1.01); C1628(0.94); C354(0.92); C693(1.02)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C1131(1.17); C1628(0.91); C354(1.02); C693(1.19)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C1131(1.11); C1628(1.03); C354(0.94); C693(1.10)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C1131(1.16); C1628(1.01); C354(0.87); C693(0.97)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C1131(1.44); C1628(0.79); C354(1.15); C693(1.04)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C1131(1.08); C1628(0.98); C354(0.89); C693(1.05)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C1131(1.01); C1628(1.04); C354(0.99); C693(1.01)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C1131(1.11); C1628(1.04); C354(0.98); C693(0.97)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C1131(1.14); C1628(0.89); C354(0.97); C693(1.16)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C1131(0.87); C1628(0.99); C354(0.96); C693(1.15)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C1131(0.98); C1628(1.03); C354(0.90); C693(1.06)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C1131(1.12); C1628(1.05); C354(0.99); C693(0.89)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C1131(0.90); C1628(0.93); C354(0.97); C693(1.14)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C1131(1.12); C1628(1.00); C354(0.91); C693(0.99)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C1131(1.08); C1628(1.02); C354(0.91); C693(1.31)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C1131(1.07); C1628(1.16); C354(0.99); C693(1.12)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C1131(1.69); C1628(0.84); C354(1.20); C693(1.13)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C1131(1.08); C1628(0.98); C354(0.95); C693(1.01)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C1131(1.20); C1628(0.98); C354(0.89); C693(1.08)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C1131(1.24); C1628(1.15); C354(1.03); C693(1.09)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C1131(1.24); C1628(1.00); C354(0.87); C693(0.94)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C1131(1.58); C1628(0.95); C354(1.17); C693(1.23)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C1131(1.14); C1628(0.97); C354(0.91); C693(1.08)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C1131(0.96); C1628(1.01); C354(0.98); C693(1.14)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C1131(1.04); C1628(1.00); C354(0.92); C693(0.88)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C1131(0.94); C1628(1.01); C354(0.93); C693(0.91)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C1131(1.04); C1628(0.88); C354(0.91); C693(0.98)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C521(7.61); C1628(0.96); C937(0.94); C354(0.87)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C1131(0.90); C1628(0.90); C354(0.94); C693(1.15)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C1131(1.15); C1628(0.99); C354(1.00); C693(0.85)  LDD1631  [19]
 LDCM0022  KB02 HEK-293T C1628(1.00); C354(0.87); C693(0.96); C1261(0.94)  LDD1492  [19]
 LDCM0023  KB03 Jurkat C354(56.76)  LDD0209  [7]
 LDCM0024  KB05 G361 C556(4.65)  LDD3311  [20]
 LDCM0109  NEM HeLa N.A.  LDD0225  [16]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1261(0.75)  LDD2092  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1261(0.55)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1261(0.68)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1261(2.01)  LDD2105  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1261(0.98)  LDD2108  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1261(0.74)  LDD2114  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1261(0.92)  LDD2122  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C354(0.87)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1261(1.17)  LDD2127  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C521(0.29)  LDD2207  [21]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.