Details of the Target

General Information of Target

Target ID LDTP07903
Target Name La-related protein 4 (LARP4)
Gene Name LARP4
Gene ID 113251
Synonyms
La-related protein 4; La ribonucleoprotein domain family member 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAEL
SEDICKEYEVMYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLK
ECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPIWTVANMEEIKKLTTDPDLILEVLRSS
PMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKGLFKSENCPKVISCEFAHNSNWYI
TFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSIYSHPIQTQAQ
YASPVFMQPVYNPHQQYSVYSIVPQSWSPNPTPYFETPLAPFPNGSFVNGFNSPGSYKTN
AAAMNMGRPFQKNRVKPQFRSSGGSEHSTEGSVSLGDGQLNRYSSRNFPAERHNPTVTGH
QEQTYLQKETSTLQVEQNGDYGRGRRTLFRGRRRREDDRISRPHPSTAESKAPTPKFDLL
ASNFPPLPGSSSRMPGELVLENRMSDVVKGVYKEKDNEELTISCPVPADEQTECTSAQQL
NMSTSSPCAAELTALSTTQQEKDLIEDSSVQKDGLNQTTIPVSPPSTTKPSRASTASPCN
NNINAATAVALQEPRKLSYAEVCQKPPKEPSSVLVQPLRELRSNVVSPTKNEDNGAPENS
VEKPHEKPEARASKDYSGFRGNIIPRGAAGKIREQRRQFSHRAIPQGVTRRNGKEQYVPP
RSPK
Target Bioclass
Other
Subcellular location
Cytoplasm, Stress granule
Function
RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Uniprot ID
Q71RC2
Ensemble ID
ENST00000293618.12
HGNC ID
HGNC:24320

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE30 SNV: p.E67K DBIA    Probe Info 
OV56 SNV: p.D567Y DBIA    Probe Info 
REH SNV: p.R639Q .
SNU1 SNV: p.E59D DBIA    Probe Info 
UACC257 SNV: p.D105G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K165(10.00); K272(7.21); K376(3.48); K476(1.79)  LDD0277  [2]
Probe 1
 Probe Info  		Y441(9.97); Y676(11.42)  LDD3495  [3]
BTD
 Probe Info  		C623(0.96); C224(0.34)  LDD2089  [4]
Sulforaphane-probe2
 Probe Info  		2.02  LDD0042  [5]
DA-P3
 Probe Info  		5.19  LDD0181  [6]
AHL-Pu-1
 Probe Info  		C623(2.86); C599(6.96)  LDD0171  [7]
DBIA
 Probe Info  		C130(69.11); C224(490.60); C199(11.67)  LDD0209  [8]
5E-2FA
 Probe Info  		H464(0.00); H387(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
NAIA_5
 Probe Info  		C599(0.00); C623(0.00)  LDD2224  [13]
TFBX
 Probe Info  		C199(0.00); C599(0.00)  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
ENE
 Probe Info  		N.A.  LDD0006  [14]
IPM
 Probe Info  		C199(0.00); C623(0.00); C599(0.00)  LDD0005  [14]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		C623(0.00); C199(0.00); C599(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		C599(0.00); C65(0.00)  LDD0217  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		N360(0.00); N365(0.00)  LDD0236  [17]
AOyne
 Probe Info  		12.80  LDD0443  [18]
HHS-475
 Probe Info  		Y619(0.73)  LDD2238  [19]
HHS-482
 Probe Info  		Y425(0.87); Y619(0.93)  LDD2239  [19]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		9.93  LDD0472  [20]
FFF probe13
 Probe Info  		12.08  LDD0475  [20]
FFF probe2
 Probe Info  		11.72  LDD0463  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C224(0.80)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C224(1.08)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C224(1.18)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C224(1.21)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C599(2.02)  LDD0172  [7]
 LDCM0026  4SU-RNA+native RNA DM93 C623(2.86); C599(6.96)  LDD0171  [7]
 LDCM0214  AC1 HEK-293T C76(1.12); C623(1.06); C130(0.95); C230(0.85)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C76(1.03); C623(1.07); C130(1.05); C599(0.96)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C76(0.99); C623(1.00); C130(1.04); C599(0.96)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C76(0.99); C623(0.94); C130(0.97); C599(1.19)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C76(0.99); C623(1.05); C130(0.92); C599(0.89)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C76(0.95); C623(0.97); C130(1.03); C599(1.23)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C76(0.97); C623(1.03); C130(0.97); C230(0.90)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C76(1.13); C623(1.00); C130(1.04); C599(1.17)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C76(1.26); C623(1.47); C130(1.04); C599(1.74)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C76(1.06); C623(1.06); C130(1.10); C599(1.07)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C76(0.98); C623(1.06); C130(0.94); C599(0.98)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C76(1.05); C623(1.00); C130(1.07); C599(1.09)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C76(1.28); C623(1.12); C130(0.96); C599(0.93)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C76(1.09); C623(1.00); C130(1.07); C599(1.06)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C76(1.07); C623(0.96); C130(1.01); C599(0.97)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C76(0.90); C623(1.07); C130(0.98); C230(1.01)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C76(0.99); C623(1.03); C130(1.09); C599(0.98)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C76(0.97); C623(1.14); C130(1.05); C599(0.97)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C76(0.96); C623(1.03); C130(0.88); C599(0.92)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C76(1.00); C623(0.99); C130(1.14); C599(1.10)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C76(1.01); C623(1.11); C130(1.06); C599(0.82)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C76(1.03); C623(1.12); C130(1.00); C599(1.02)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C76(1.04); C623(0.99); C130(1.05); C599(1.30)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C76(0.87); C623(0.99); C130(1.10); C599(1.12)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C76(1.01); C623(1.06); C130(1.01); C230(1.02)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C76(0.96); C623(1.10); C130(1.02); C599(1.39)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C76(1.05); C623(1.00); C130(1.09); C599(1.06)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C76(1.12); C623(1.00); C130(1.04); C599(1.06)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C76(0.92); C623(0.92); C130(1.14); C599(0.94)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C76(0.83); C623(1.09); C130(1.01); C599(1.06)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C76(0.97); C623(0.96); C130(1.02); C599(1.19)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C76(0.94); C623(0.99); C130(0.97); C599(1.12)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C76(1.13); C623(1.07); C130(1.08); C599(1.16)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C76(1.04); C623(1.02); C130(0.90); C230(1.07)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C76(0.93); C623(1.07); C130(1.00); C599(1.28)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C76(1.03); C623(0.98); C130(1.18); C599(1.06)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C76(1.05); C623(0.95); C130(1.01); C599(0.98)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C76(0.98); C623(0.98); C130(1.10); C599(1.16)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C76(0.97); C623(1.02); C130(0.97); C599(1.09)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C76(0.99); C623(0.99); C130(1.08); C599(1.39)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C76(1.07); C623(1.08); C130(1.02); C599(1.02)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C76(0.90); C623(1.06); C130(0.97); C230(1.02)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C76(0.99); C623(0.91); C130(1.12); C599(1.64)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C76(1.01); C623(1.02); C130(1.02); C599(1.23)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C76(1.01); C623(0.99); C130(1.09); C599(1.08)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C76(0.90); C623(0.99); C130(0.92); C599(0.99)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C76(0.89); C623(0.88); C130(1.05); C599(1.24)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C76(0.93); C623(1.09); C130(1.06); C599(1.02)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C76(0.97); C623(1.01); C130(1.03); C599(1.20)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C76(1.06); C623(1.10); C130(1.03); C599(1.06)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C76(0.94); C623(1.10); C130(1.01); C230(0.87)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C76(0.85); C623(1.07); C130(1.05); C599(1.11)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C76(0.90); C623(1.05); C130(1.10); C599(0.91)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C76(0.97); C623(1.06); C130(0.98); C599(0.94)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C76(1.05); C623(1.02); C130(0.99); C599(1.01)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C76(0.89); C623(0.91); C130(1.13); C599(0.97)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C76(1.08); C623(1.10); C130(0.94); C599(1.06)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C76(1.08); C623(1.03); C130(1.07); C599(1.40)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C76(1.29); C623(1.05); C130(1.03); C599(1.07)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C76(0.93); C623(0.97); C130(1.04); C599(1.27)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C76(1.18); C623(1.09); C130(1.08); C599(1.05)  LDD1569  [21]
 LDCM0545  Acetamide MDA-MB-231 C224(0.31)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C224(0.97)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C76(0.98); C623(1.00); C130(1.02); C599(0.87)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C76(0.92); C623(1.04); C130(1.01); C230(1.06)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C76(0.88); C623(1.03); C130(1.01); C599(1.20)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 12.04  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C224(0.72)  LDD2091  [4]
 LDCM0087  Capsaicin HEK-293T 7.06  LDD0185  [6]
 LDCM0630  CCW28-3 231MFP C599(1.32)  LDD2214  [22]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C76(0.91); C623(0.86); C130(1.08); C230(1.15)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C76(1.16); C623(0.75); C130(0.57); C599(0.69)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C76(0.91); C623(1.11); C130(0.96); C599(0.96)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C76(1.02); C623(0.97); C130(1.11); C230(0.99)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C76(0.96); C623(0.84); C130(0.95); C230(0.84)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C76(0.97); C623(1.21); C130(1.05); C230(0.95)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C76(0.98); C623(1.02); C130(0.93); C599(1.02)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C76(0.95); C623(1.01); C130(1.04); C230(1.12)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C76(1.03); C623(0.96); C130(0.98); C230(0.95)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C76(1.02); C623(1.17); C130(1.08); C230(1.05)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C76(0.91); C623(1.08); C130(1.02); C599(0.96)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C76(0.93); C623(0.94); C130(1.00); C230(1.00)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C76(1.09); C623(0.98); C130(0.75); C599(1.22)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C76(0.93); C623(0.85); C130(0.96); C230(0.92)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C76(1.08); C623(1.17); C130(1.07); C230(1.08)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C76(1.06); C623(1.10); C130(1.03); C599(0.95)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C76(0.90); C623(0.90); C130(1.06); C230(1.01)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C76(1.04); C623(0.88); C130(0.89); C230(0.93)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C76(1.00); C623(1.23); C130(1.08); C230(0.93)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C76(0.89); C623(1.11); C130(1.11); C599(1.08)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C76(1.04); C623(0.90); C130(1.15); C230(1.13)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C76(0.98); C623(1.01); C130(1.04); C230(0.90)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C76(0.89); C623(1.13); C130(1.13); C230(1.03)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C76(1.33); C623(0.92); C130(0.90); C599(1.15)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C76(0.91); C623(1.07); C130(1.10); C599(0.94)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C76(1.01); C623(0.93); C130(1.03); C230(0.96)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C76(0.83); C623(0.90); C130(1.05); C230(1.04)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C76(0.91); C623(1.05); C130(1.05); C230(0.93)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C76(0.99); C623(1.05); C130(0.98); C599(0.94)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C76(1.06); C623(0.97); C130(1.08); C230(0.92)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C76(0.89); C623(0.89); C130(1.05); C230(0.77)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C76(0.92); C623(1.42); C130(1.18); C230(0.86)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C76(1.01); C623(1.13); C130(1.11); C599(0.95)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C76(1.18); C623(1.06); C130(1.04); C230(1.11)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C76(0.85); C623(0.88); C130(1.18); C230(1.02)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C76(1.15); C623(1.13); C130(0.96); C230(1.04)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C76(0.91); C623(1.05); C130(1.07); C599(0.96)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C76(1.03); C623(1.05); C130(0.93); C230(0.91)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C76(1.19); C623(0.97); C130(0.97); C599(1.26)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C76(1.00); C623(0.82); C130(1.06); C599(1.16)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C76(0.98); C623(0.93); C130(1.22); C230(1.00)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C76(0.94); C623(0.93); C130(0.85); C599(1.15)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C76(0.97); C623(0.96); C130(0.81); C599(1.09)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C76(0.99); C623(0.81); C130(0.87); C599(1.00)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C76(1.09); C623(1.11); C130(0.80); C599(1.18)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C76(1.33); C623(0.87); C130(0.87); C599(0.94)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C76(1.03); C623(0.83); C130(0.98); C230(1.09)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C76(0.83); C623(0.91); C130(1.03); C230(1.06)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C76(0.95); C623(1.03); C130(1.11); C230(1.08)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C76(0.99); C623(0.96); C130(1.07); C599(1.00)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C76(1.02); C623(1.01); C130(0.95); C230(0.96)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C76(0.98); C623(1.08); C130(1.09); C230(1.16)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C76(1.07); C623(0.95); C130(1.06); C599(1.15)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C76(1.09); C623(0.79); C130(0.98); C599(1.09)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C76(0.98); C623(0.97); C130(0.94); C599(0.93)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C76(0.90); C623(1.06); C130(0.70); C599(0.86)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C76(0.99); C623(0.80); C130(0.84); C599(0.84)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C76(0.95); C623(1.10); C130(0.88); C599(1.23)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C76(1.12); C623(0.77); C130(0.85); C599(0.94)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C76(1.01); C623(0.89); C130(1.23); C230(1.09)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C76(0.86); C623(1.00); C130(1.01); C230(1.13)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C76(0.86); C623(1.07); C130(0.99); C599(1.03)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C76(0.96); C623(1.02); C130(1.08); C599(0.85)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C76(0.95); C623(1.02); C130(0.91); C230(1.06)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C76(1.04); C623(0.89); C130(1.12); C599(1.13)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C76(0.97); C623(0.77); C130(1.09); C599(0.97)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C76(0.94); C623(0.95); C130(0.86); C599(0.99)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C76(0.97); C623(1.20); C130(0.83); C599(1.00)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C76(1.00); C623(0.79); C130(0.79); C599(1.01)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C76(0.95); C623(1.05); C130(0.87); C599(1.05)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C76(1.15); C623(0.82); C130(0.94); C599(1.01)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C76(0.92); C623(0.80); C130(1.00); C230(1.19)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C76(1.05); C623(1.05); C130(1.09); C230(0.85)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C76(0.91); C623(0.92); C130(1.01); C230(0.83)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C76(0.97); C623(1.00); C130(1.07); C599(0.89)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C76(0.88); C623(0.99); C130(0.96); C230(1.00)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C76(0.90); C623(0.91); C130(0.96); C599(1.14)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C76(1.07); C623(0.72); C130(1.03); C599(0.95)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C76(1.04); C623(0.91); C130(0.92); C599(1.17)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C76(1.16); C623(1.14); C130(0.85); C599(0.98)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C76(0.98); C623(0.73); C130(0.80); C599(0.99)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C76(1.01); C623(1.10); C130(0.83); C599(1.27)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C76(1.05); C623(0.95); C130(0.90); C599(1.16)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C76(1.25); C623(0.83); C130(0.94); C599(0.98)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C76(1.08); C623(0.87); C130(1.08); C230(0.92)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C76(0.81); C623(0.87); C130(1.14); C230(1.05)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C76(0.93); C623(1.18); C130(1.14); C230(1.10)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C76(0.92); C623(1.01); C130(0.97); C599(0.97)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C76(0.99); C623(1.01); C130(1.03); C230(1.12)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C76(0.94); C623(0.91); C130(1.05); C599(1.05)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C76(0.99); C623(0.83); C130(1.05); C599(0.89)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C76(0.92); C623(0.84); C130(0.94); C599(1.07)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C76(0.96); C623(1.00); C130(0.92); C599(0.98)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C76(1.00); C623(0.87); C130(1.02); C599(1.14)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C76(1.12); C623(0.81); C130(0.82); C599(0.96)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C76(1.05); C623(1.09); C130(0.85); C599(1.43)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C76(1.34); C623(0.85); C130(0.95); C599(0.99)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C76(1.03); C623(0.91); C130(1.04); C230(1.01)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C76(0.94); C623(0.89); C130(1.06); C230(1.17)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C76(0.82); C623(1.02); C130(1.07); C599(1.08)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C76(1.00); C623(0.97); C130(0.87); C230(0.82)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C76(1.05); C623(0.97); C130(1.08); C599(0.95)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C76(1.13); C623(0.84); C130(1.03); C599(1.02)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C76(0.96); C623(0.85); C130(0.70); C599(0.99)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C76(1.03); C623(0.92); C130(0.92); C599(1.10)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C76(1.06); C623(1.05); C130(1.00); C599(0.98)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C76(1.04); C623(0.79); C130(0.92); C599(0.79)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C76(0.97); C623(1.04); C130(0.84); C599(1.21)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C76(1.19); C623(0.84); C130(0.86); C599(1.03)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C76(1.14); C623(0.93); C130(1.05); C230(0.90)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C76(0.92); C623(0.85); C130(1.19); C230(0.80)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C76(0.92); C623(1.41); C130(1.20); C230(1.05)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C76(0.84); C623(1.13); C130(1.11); C599(1.04)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C76(0.99); C623(1.04); C130(0.97); C230(0.70)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C76(1.06); C623(1.04); C130(0.95); C599(0.88)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C76(1.01); C623(0.98); C130(0.75); C599(0.97)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C76(1.00); C623(0.88); C130(1.23); C599(1.26)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C76(1.02); C623(0.93); C130(0.87); C599(0.93)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C76(0.96); C623(0.97); C130(0.86); C599(0.86)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C76(0.95); C623(0.85); C130(0.84); C599(0.82)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C76(1.09); C623(1.04); C130(0.68); C599(1.29)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C76(0.99); C623(1.06); C130(0.84); C599(0.99)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C76(0.88); C623(0.92); C130(1.00); C230(1.07)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C76(0.93); C623(0.92); C130(1.04); C230(0.88)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C76(0.93); C623(1.25); C130(1.00); C230(0.93)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C76(0.97); C623(1.13); C130(1.18); C230(1.17)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C130(2.43); C623(1.49)  LDD1702  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.48  LDD0183  [6]
 LDCM0625  F8 Ramos C599(1.27)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C599(0.83)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C599(20.00)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C599(0.74)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C599(1.02)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C599(1.00)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C599(0.51)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C599(1.12)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C599(1.98)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C599(1.18)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C599(0.82)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C599(1.00)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C599(1.21)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C599(1.34)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C76(0.98); C623(1.17); C130(1.06); C230(1.09)  LDD1671  [21]
 LDCM0596  Fragment38 Ramos C599(0.83)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C599(2.08)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C76(1.17); C623(0.97); C130(1.02); C230(0.98)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C599(1.01)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C599(1.28)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C599(1.24)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C599(0.73)  LDD2188  [23]
 LDCM0022  KB02 HEK-293T C76(0.90); C623(1.00); C599(0.96); C130(0.98)  LDD1492  [21]
 LDCM0023  KB03 Jurkat C130(69.11); C224(490.60); C199(11.67)  LDD0209  [8]
 LDCM0024  KB05 G361 C605(1.34); C136(1.97)  LDD3311  [24]
 LDCM0030  Luteolin HEK-293T 5.47  LDD0182  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C623(0.88)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C623(0.92); C224(0.45)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0224  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C623(0.96); C224(0.34)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C623(1.11); C224(0.89)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C224(0.53)  LDD2092  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C224(1.08)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C224(0.48)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C623(0.64); C224(0.81)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C224(0.90)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C224(0.97)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C224(0.99)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C623(0.89); C224(1.01)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C224(0.97)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C224(1.12)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C623(0.79); C224(0.90)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C224(0.84)  LDD2114  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C623(1.00)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C224(0.81)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C224(0.95)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C224(0.52)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C224(0.61)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C224(0.75)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C224(0.97)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C224(0.97)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C623(2.27); C224(0.88)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C623(0.80); C224(0.77)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C224(0.67)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C224(1.03)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C224(1.14)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C224(0.66)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C224(1.04)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C224(3.28)  LDD2144  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C623(0.55)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C224(1.02)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C224(0.44)  LDD2150  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C224(0.91)  LDD2153  [4]
 LDCM0029  Quercetin HEK-293T 5.19  LDD0181  [6]
 LDCM0003  Sulforaphane MCF-7 2.02  LDD0042  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleophosmin (NPM1) Nucleoplasmin family P06748

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840