Details of the Target

General Information of Target

Target ID LDTP15947
Target Name Mitochondrial fission regulator 1-like (MTFR1L)
Gene Name MTFR1L
Gene ID 56181
Synonyms
FAM54B; Mitochondrial fission regulator 1-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGEATETVPATEQELPQSQAETGSGTASDSGESVPGIEEQDSTQTTTQKAWLVAAAEID
EEPVGKAKQSRSEKRARKAMSKLGLLQVTGVTRVTIWKSKNILFVITKLDVYKSPASDAY
IVFGEAKIQDLSQQAQLAAAEKFRVQGEAVGNIQENTQTPTVQEESEEEEVDETGVEVKD
VKLVMSQANVSRAKAVRALKNNSNDIVNAIMELTV
Target Bioclass
Other
Family
MTFR1 family
Uniprot ID
Q9H019
Ensemble ID
ENST00000374300.7
HGNC ID
HGNC:28836

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.A38T DBIA    Probe Info 
IGROV1 Deletion: p.L86Ter .
PANC0403 SNV: p.E72K .
SUDHL6 SNV: p.E194G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.68  LDD0402  [1]
STPyne
 Probe Info  		K253(4.68); K279(6.35)  LDD0277  [2]
BTD
 Probe Info  		C37(1.02)  LDD2090  [3]
DA-P3
 Probe Info  		37.46  LDD0181  [4]
AHL-Pu-1
 Probe Info  		C52(2.23)  LDD0169  [5]
EA-probe
 Probe Info  		C52(1.08)  LDD2210  [6]
IA-alkyne
 Probe Info  		C52(7.36); C37(11.31)  LDD1704  [7]
DBIA
 Probe Info  		C222(0.96); C230(0.96)  LDD0078  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
NAIA_5
 Probe Info  		C52(0.00); C37(0.00)  LDD2225  [10]
TFBX
 Probe Info  		C52(0.00); C230(0.00); C222(0.00)  LDD0027  [9]
Compound 10
 Probe Info  		C37(0.00); C52(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		C37(0.00); C52(0.00)  LDD2213  [11]
IPM
 Probe Info  		N.A.  LDD0005  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Methacrolein
 Probe Info  		C230(0.00); C222(0.00)  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		14.30  LDD0443  [16]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		10.59  LDD0476  [17]
FFF probe3
 Probe Info  		15.55  LDD0465  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C222(2.63)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C52(2.23)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C222(1.07); C230(1.07)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C222(0.92); C230(0.92)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C222(0.89); C230(0.89)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C222(0.94); C230(0.94)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C222(0.96); C230(0.96)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C222(1.11); C230(1.11)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C222(0.98); C230(0.98)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C222(1.03); C230(1.03)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C222(1.19); C230(1.19)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C222(0.96); C230(0.96)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C222(0.98); C230(0.98)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C222(0.92); C230(0.92)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C222(1.13); C230(1.13)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C222(0.98); C230(0.98)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C222(1.00); C230(1.00)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C222(1.16); C230(1.16)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C222(1.09); C230(1.09)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C222(1.26); C230(1.26)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C222(1.39); C230(1.39)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C222(1.31); C230(1.31)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C222(1.18); C230(1.18)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C222(1.13); C230(1.13)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C222(1.24); C230(1.24)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C222(0.98); C230(0.98)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C222(1.28); C230(1.28)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C222(1.15); C230(1.15)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C222(1.31); C230(1.31)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C222(1.10); C230(1.10)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C222(1.17); C230(1.17)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C222(1.14); C230(1.14)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C222(1.37); C230(1.37)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C222(1.31); C230(1.31)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C222(0.89); C230(0.89)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C222(0.77); C230(0.77)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C222(0.92); C230(0.92)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C222(0.90); C230(0.90)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C222(0.80); C230(0.80)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C222(0.79); C230(0.79)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C222(0.87); C230(0.87)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C222(0.73); C230(0.73)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C222(0.83); C230(0.83)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C222(0.84); C230(0.84)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C222(0.86); C230(0.86)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C222(0.84); C230(0.84)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C222(1.00); C230(1.00)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C222(0.84); C230(0.84)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C222(0.84); C230(0.84)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C222(0.75); C230(0.75)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C222(1.27); C230(1.27)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C230(1.36); C222(1.37)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C222(1.12); C230(1.23)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C222(1.21); C230(1.22)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C222(1.14); C230(1.28)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C222(1.33); C230(1.38)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C230(1.32); C222(1.40)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C222(1.02); C230(1.02)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C230(1.07); C222(1.12)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C222(1.20); C230(1.22)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C230(1.19); C222(1.32)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C222(1.79); C230(1.93)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C222(1.30); C230(1.41)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C222(1.52); C230(1.49)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C222(1.22); C230(1.25)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C222(1.37); C230(1.51)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C222(0.92); C230(0.92)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C222(1.10); C230(1.10)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C222(0.96); C230(0.96)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C222(1.00); C230(1.00)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C222(1.23); C230(1.23)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C222(1.01); C230(1.01)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C222(1.05); C230(1.05)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C222(0.92); C230(0.92)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C222(0.86); C230(0.86)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C222(1.04); C230(1.04)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C222(1.09); C230(1.09)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C222(1.20); C230(1.20)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C222(1.24); C230(1.24)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C222(1.21); C230(1.21)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C222(0.93); C230(0.93)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C222(1.24); C230(1.24)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C222(1.09); C230(1.09)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C222(1.22); C230(1.22)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C222(1.23); C230(1.23)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C222(1.26); C230(1.26)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C222(1.04); C230(1.04)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C222(1.04); C230(1.04)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C222(1.06); C230(1.06)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C222(1.01); C230(1.01)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C222(1.05); C230(1.05)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C222(0.96); C230(0.96)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C222(1.13); C230(1.13)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C222(1.07); C230(1.07)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C222(1.06); C230(1.06)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C222(1.29); C230(1.29)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C222(1.04); C230(1.04)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C222(1.29); C230(1.29)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C222(1.05); C230(1.05)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C222(0.96); C230(0.96)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C222(0.95); C230(0.95)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C222(1.29); C230(1.29)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C222(0.83); C230(0.83)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C222(1.25); C230(1.25)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C222(1.03); C230(1.03)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C222(0.99); C230(0.99)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C222(1.26); C230(1.26)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C222(1.07); C230(1.07)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C222(1.37); C230(1.37)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C222(1.57); C230(1.57)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C222(1.04); C230(1.04)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C222(1.19); C230(1.19)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C222(1.22); C230(1.22)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C222(1.02); C230(1.02)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C222(1.10); C230(1.10)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C222(1.04); C230(1.04)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C222(1.11); C230(1.11)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C222(1.16); C230(1.16)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C222(1.08); C230(1.08)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C222(0.87); C230(0.87)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C222(0.83); C230(0.83)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C222(0.97); C230(0.97)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C222(1.04); C230(1.04)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C222(0.93); C230(0.93)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C222(0.83); C230(0.83)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C222(1.05); C230(1.05)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C222(0.74); C230(0.74)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C222(0.90); C230(0.90)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C222(1.13); C230(1.13)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C222(0.84); C230(0.84)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C222(1.32); C230(1.32)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C222(0.97); C230(0.97)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C222(1.14); C230(1.14)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C222(1.05); C230(1.05)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C222(1.00); C230(1.00)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C222(0.98); C230(0.98)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C222(0.97); C230(0.97)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C222(1.01); C230(1.01)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C222(1.13); C230(1.13)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C222(1.46); C230(1.46)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C222(1.40); C230(1.40)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C222(1.27); C230(1.27)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C222(1.29); C230(1.29)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C222(1.14); C230(1.14)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C222(1.39); C230(1.39)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C222(1.52); C230(1.52)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C222(1.11); C230(1.11)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C222(1.69); C230(1.69)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C222(1.67); C230(1.67)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C222(1.38); C230(1.38)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C222(1.46); C230(1.46)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C222(1.26); C230(1.26)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C222(1.59); C230(1.59)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C222(1.65); C230(1.65)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C222(1.19); C230(1.19)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C222(0.87); C230(0.87)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C222(0.83); C230(0.83)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C222(0.90); C230(0.90)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C222(1.44); C230(1.44)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C222(0.96); C230(0.96)  LDD0078  [8]
 LDCM0087  Capsaicin HEK-293T 12.20  LDD0185  [4]
 LDCM0632  CL-Sc Hep-G2 C37(20.00); C52(1.05); C37(0.91)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C222(0.87); C230(0.87)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C222(0.96); C230(0.96)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C222(1.06); C230(1.06)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C222(1.07); C230(1.07)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C222(0.84); C230(0.84)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C222(0.97); C230(0.97)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C222(0.91); C230(0.91)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C222(0.70); C230(0.70)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C222(0.63); C230(0.63)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C222(0.83); C230(0.83)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C222(0.61); C230(0.61)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C222(1.01); C230(1.01)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C222(1.18); C230(1.18)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C222(0.63); C230(0.63)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C222(0.80); C230(0.80)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C222(1.02); C230(1.02)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C222(1.19); C230(1.19)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C222(0.99); C230(0.99)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C222(1.10); C230(1.10)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C222(0.97); C230(0.97)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C222(1.22); C230(1.22)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C222(0.97); C230(0.97)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C222(1.19); C230(1.19)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C222(1.26); C230(1.26)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C222(1.07); C230(1.07)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C222(3.13); C230(3.13)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C222(0.87); C230(0.87)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C222(1.09); C230(1.09)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C222(1.14); C230(1.14)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C222(0.94); C230(0.94)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C222(0.81); C230(0.81)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C222(0.92); C230(0.92)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C222(1.18); C230(1.18)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C222(0.84); C230(0.84)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C222(0.84); C230(0.84)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C222(0.98); C230(0.98)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C222(1.22); C230(1.22)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C222(1.01); C230(1.01)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C222(1.16); C230(1.16)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C222(1.25); C230(1.25)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C222(0.91); C230(0.91)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C222(1.39); C230(1.39)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C222(1.43); C230(1.43)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C222(1.94); C230(1.94)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C222(1.38); C230(1.38)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C222(1.52); C230(1.52)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C222(1.26); C230(1.26)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C222(1.20); C230(1.20)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C222(1.25); C230(1.25)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C222(1.33); C230(1.33)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C222(1.41); C230(1.41)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C222(1.01); C230(1.01)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C222(1.15); C230(1.15)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C222(0.90); C230(0.90)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C222(0.96); C230(0.96)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C222(0.83); C230(0.83)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C222(1.04); C230(1.04)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C222(1.23); C230(1.23)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C222(1.06); C230(1.06)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C222(1.17); C230(1.17)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C222(1.10); C230(1.10)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C222(1.02); C230(1.02)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C222(1.16); C230(1.16)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C222(1.04); C230(1.04)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C222(1.34); C230(1.34)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C222(1.04); C230(1.04)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C222(0.92); C230(0.92)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C222(1.21); C230(1.21)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C222(0.86); C230(0.86)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C222(0.78); C230(0.78)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C222(0.90); C230(0.90)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C222(0.99); C230(0.99)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C222(1.01); C230(1.01)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C222(0.81); C230(0.81)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C222(1.06); C230(1.06)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C222(1.17); C230(1.17)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C222(1.01); C230(1.01)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C222(1.06); C230(1.06)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C222(1.18); C230(1.18)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C222(0.99); C230(0.99)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C222(0.77); C230(0.77)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C222(0.94); C230(0.94)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C222(1.06); C230(1.06)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C222(1.09); C230(1.09)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C222(0.93); C230(0.93)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C222(1.03); C230(1.03)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C222(1.02); C230(1.02)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C222(1.11); C230(1.11)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C222(1.07); C230(1.07)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C222(0.92); C230(0.92)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C222(1.02); C230(1.02)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C222(1.11); C230(1.11)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C222(0.97); C230(0.97)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C222(0.97); C230(0.97)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C222(1.03); C230(1.03)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C222(1.00); C230(1.00)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C222(1.31); C230(1.31)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C222(1.02); C230(1.02)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C222(1.00); C230(1.00)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C222(1.14); C230(1.14)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C222(0.98); C230(0.98)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C222(0.72); C230(0.72)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C222(1.08); C230(1.08)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C222(1.04); C230(1.04)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C222(1.17); C230(1.17)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C222(0.83); C230(0.83)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C222(0.95); C230(0.95)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C222(1.09); C230(1.09)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C222(1.00); C230(1.00)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C222(1.17); C230(1.17)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C222(0.90); C230(0.90)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C222(0.72); C230(0.72)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C222(0.77); C230(0.77)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C222(1.13); C230(1.13)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C222(1.46); C230(1.46)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C222(1.02); C230(1.02)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C222(0.61); C230(0.61)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C222(0.97); C230(0.97)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C222(0.95); C230(0.95)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C222(0.81); C230(0.81)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C222(0.99); C230(0.99)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C222(0.99); C230(0.99)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C222(1.21); C230(1.21)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C222(0.97); C230(0.97)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C222(1.03); C230(1.03)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C222(0.93); C230(0.93)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C52(0.98)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C37(0.65)  LDD1702  [3]
 LDCM0175  Ethacrynic acid HeLa C52(1.08)  LDD2210  [6]
 LDCM0573  Fragment11 Ramos C37(0.96)  LDD2190  [19]
 LDCM0575  Fragment13 Ramos C37(0.67)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C37(1.38)  LDD2193  [19]
 LDCM0580  Fragment21 Ramos C37(1.14)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C37(0.33)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C37(0.61)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C37(0.62)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C37(1.51)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C37(0.82)  LDD2200  [19]
 LDCM0468  Fragment33 HCT 116 C222(1.03); C230(1.03)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C37(0.88)  LDD2203  [19]
 LDCM0427  Fragment51 HCT 116 C222(1.39); C230(1.39)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C37(0.90)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C37(1.52)  LDD2205  [19]
 LDCM0022  KB02 HCT 116 C222(4.01); C230(4.01)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C222(5.82); C230(5.82)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C222(6.82); C230(6.82)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0227  [14]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C37(1.02)  LDD2090  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C37(0.89)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C37(0.85)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C37(0.68)  LDD2107  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C37(1.74)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C37(1.00)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C37(0.64)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C37(1.06)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C37(0.63)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C37(0.98)  LDD2129  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C37(1.15)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C37(0.35)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C37(1.01)  LDD2143  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C37(0.66)  LDD2146  [3]
 LDCM0032  Oleacein HEK-293T 6.35  LDD0184  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C52(1.18)  LDD2207  [20]
 LDCM0029  Quercetin HEK-293T 37.46  LDD0181  [4]
 LDCM0021  THZ1 HCT 116 C52(1.15); C222(1.08); C230(1.08)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 2 (CNOT2) CNOT2/3/5 family Q9NZN8
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Armadillo repeat-containing protein 1 (ARMC1) . Q9NVT9
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
Melanoma-associated antigen 12 (MAGEA12) . P43365

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.