Details of the Target

General Information of Target

Target ID LDTP01233
Target Name PC4 and SFRS1-interacting protein (PSIP1)
Gene Name PSIP1
Gene ID 11168
Synonyms
DFS70; LEDGF; PSIP2; PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP
YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE
DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR
GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE
EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR
NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK
NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY
NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG
GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
Target Type
Patented-recorded
Target Bioclass
Other
Family
HDGF family
Subcellular location
Nucleus
Function
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
TTD ID
T83196
Uniprot ID
O75475
DrugMap ID
TTH9LDP
Ensemble ID
ENST00000380715.5
HGNC ID
HGNC:9527
ChEMBL ID
CHEMBL3988590

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 Insertion: p.E252RfsTer7
SNV: p.S482Y		 DBIA    Probe Info 
NCIH23 SNV: p.Q485Ter DBIA    Probe Info 
PC9 SNV: p.F43L .
RKO SNV: p.G487D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.49  LDD0402  [1]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
BTD
 Probe Info  		C204(0.41)  LDD2118  [3]
DA-P3
 Probe Info  		6.37  LDD0180  [4]
AHL-Pu-1
 Probe Info  		C204(2.16)  LDD0169  [5]
HHS-475
 Probe Info  		Y18(0.42)  LDD0264  [6]
HHS-465
 Probe Info  		Y18(5.01)  LDD2237  [7]
DBIA
 Probe Info  		C204(0.99)  LDD0078  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C373(0.00); C204(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C373(0.00); C204(0.00)  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C204(0.00); C373(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		C373(0.00); C204(0.00)  LDD0026  [13]
NAIA_5
 Probe Info  		N.A.  LDD2224  [14]
TFBX
 Probe Info  		C204(0.00); C373(0.00)  LDD0027  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
1d-yne
 Probe Info  		N.A.  LDD0356  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		K364(0.00); K470(0.00); K360(0.00); K143(0.00)  LDD0010  [15]
PPMS
 Probe Info  		N.A.  LDD0008  [15]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Ox-W18
 Probe Info  		N.A.  LDD2175  [19]
1c-yne
 Probe Info  		K201(0.00); K39(0.00); K424(0.00); K442(0.00)  LDD0228  [16]
Acrolein
 Probe Info  		H393(0.00); H48(0.00); C204(0.00); H124(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		H393(0.00); C204(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C320
 Probe Info  		8.63  LDD1986  [21]
FFF probe13
 Probe Info  		16.25  LDD0475  [22]
FFF probe2
 Probe Info  		8.11  LDD0463  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C204(2.16)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C204(1.00)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C204(1.30)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C204(1.13)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C204(1.04)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C204(0.97)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C204(1.29)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C204(1.05)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C204(1.29)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C204(1.38)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C204(1.44)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C204(1.10)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C204(0.89)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C204(1.11)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C204(1.05)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C204(1.12)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C204(1.15)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C204(0.90)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C204(1.08)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C204(1.35)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C204(1.41)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C204(1.22)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C204(1.11)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C204(1.19)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C204(0.94)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C204(0.84)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C204(1.19)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C204(1.19)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C204(1.06)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C204(1.04)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C204(1.17)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C204(1.55)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C204(1.37)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C204(1.37)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C204(1.11)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C204(1.37)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C204(1.02)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C204(1.11)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C204(1.28)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C204(1.47)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C204(1.40)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C204(1.11)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C204(1.00)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C204(1.30)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C204(1.27)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C204(1.15)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C204(1.40)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C204(1.34)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C204(1.05)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C204(1.23)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C204(1.52)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C204(1.47)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C204(1.31)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C204(1.58)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C204(2.04)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C204(1.68)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C204(1.35)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C204(1.03)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C204(1.12)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C204(1.31)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C204(2.30)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C204(1.61)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C204(1.38)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C204(1.10)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C204(1.20)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C204(1.25)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C204(0.97)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C204(1.56)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C204(1.09)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C204(1.21)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C204(1.52)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C204(1.35)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C204(1.22)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C204(1.17)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C204(1.30)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C204(1.46)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C204(1.51)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C204(1.47)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C204(1.47)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C204(1.05)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C204(1.21)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C204(1.37)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C204(1.76)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C204(1.69)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C204(1.68)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C204(0.60)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C204(0.61)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C204(0.70)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C204(0.78)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C204(0.77)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C204(0.98)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C204(1.06)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C204(0.73)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C204(0.84)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C204(0.89)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C204(0.91)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C204(1.01)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C204(0.94)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C204(1.08)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C204(1.02)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C204(1.35)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C204(0.95)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C204(1.73)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C204(0.92)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C204(1.00)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C204(1.41)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C204(1.14)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C204(1.61)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C204(2.85)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C204(1.69)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C204(2.10)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C204(1.68)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C204(1.20)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C204(1.55)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C204(1.40)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C204(2.03)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C204(1.50)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C204(1.49)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C204(0.89)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C204(0.75)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C204(1.04)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C204(1.30)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C204(1.33)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C204(0.88)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C204(1.42)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C204(1.07)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C204(1.28)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C204(2.19)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C204(1.93)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C204(2.36)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C204(1.67)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C204(1.69)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C204(1.32)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C204(1.12)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C204(0.94)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C204(1.30)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C204(0.93)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C204(2.55)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C204(1.71)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C204(1.36)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C204(0.98)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C204(1.18)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C204(0.96)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C204(1.09)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C204(1.52)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C204(0.86)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C204(1.84)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C204(1.80)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C204(0.95)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C204(0.91)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C204(0.98)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C204(1.39)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C204(1.26)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C204(2.02)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C204(0.99)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C204(1.00)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C204(1.25)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C204(2.08)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C204(0.99)  LDD0078  [8]
 LDCM0087  Capsaicin HEK-293T 6.75  LDD0185  [4]
 LDCM0108  Chloroacetamide HeLa C204(0.00); H393(0.00); H124(0.00); H48(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C204(20.00)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C204(1.09)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C204(1.46)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C204(1.25)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C204(1.43)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C204(1.04)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C204(0.97)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C204(0.99)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C204(1.25)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C204(1.38)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C204(1.34)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C204(1.43)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C204(1.38)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C204(1.45)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C204(1.64)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C204(1.22)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C204(0.98)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C204(1.56)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C204(1.20)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C204(1.33)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C204(1.16)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C204(1.56)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C204(0.70)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C204(1.10)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C204(2.05)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C204(0.76)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C204(0.92)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C204(1.06)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C204(1.37)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C204(1.42)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C204(0.97)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C204(1.02)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C204(1.05)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C204(1.87)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C204(1.25)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C204(1.37)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C204(1.41)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C204(1.21)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C204(0.97)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C204(1.11)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C204(1.19)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C204(0.92)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C204(1.38)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C204(1.38)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C204(1.97)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C204(1.21)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C204(1.71)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C204(1.68)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C204(1.33)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C204(1.35)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C204(1.60)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C204(1.62)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C204(1.11)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C204(1.43)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C204(0.94)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C204(0.94)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C204(1.07)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C204(1.18)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C204(1.16)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C204(1.17)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C204(1.07)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C204(1.01)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C204(1.09)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C204(0.95)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C204(1.19)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C204(0.99)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C204(1.11)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C204(1.01)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C204(0.91)  LDD0752  [8]
 LDCM0436  CL46 HEK-293T C204(0.89)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C204(1.07)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C204(0.96)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C204(0.99)  LDD1643  [23]
 LDCM0440  CL5 HCT 116 C204(1.12)  LDD0757  [8]
 LDCM0441  CL50 HEK-293T C204(0.96); C373(1.24)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C204(0.93)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C204(0.92)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C204(0.90)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C204(1.06)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C204(0.96)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C204(0.92)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C204(0.86)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C204(0.91)  LDD1653  [23]
 LDCM0451  CL6 HCT 116 C204(1.16)  LDD0768  [8]
 LDCM0452  CL60 HEK-293T C204(0.93)  LDD1655  [23]
 LDCM0453  CL61 HCT 116 C204(1.03)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C204(1.16)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C204(1.35)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C204(0.74)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C204(1.16)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C204(1.30)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C204(1.29)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C204(1.01)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C204(1.33)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C204(1.28)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C204(1.62)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C204(1.44)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C204(1.20)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C204(1.34)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C204(1.41)  LDD0784  [8]
 LDCM0469  CL76 HEK-293T C204(0.95)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C204(0.85)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C204(1.04)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C204(1.13)  LDD1675  [23]
 LDCM0473  CL8 HCT 116 C204(1.65)  LDD0790  [8]
 LDCM0474  CL80 HEK-293T C204(1.03)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C204(0.90)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C204(0.97)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C204(0.90)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C204(0.80)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C204(1.07)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C204(1.03); C373(1.15)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C204(1.01)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C204(0.94)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C204(0.97)  LDD1686  [23]
 LDCM0484  CL9 HCT 116 C204(1.33)  LDD0801  [8]
 LDCM0485  CL90 HEK-293T C204(0.83)  LDD1688  [23]
 LDCM0486  CL91 HCT 116 C204(0.90)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C204(0.88)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C204(0.95)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C204(1.13)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C204(0.84)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C204(0.98)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C204(1.02)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C204(1.14)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C204(1.10)  LDD0811  [8]
 LDCM0028  Dobutamine HEK-293T 6.37  LDD0180  [4]
 LDCM0495  E2913 HEK-293T C204(1.09)  LDD1698  [23]
 LDCM0468  Fragment33 HCT 116 C204(1.36)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C204(1.04)  LDD0744  [8]
 LDCM0116  HHS-0101 DM93 Y18(0.42)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y18(0.14)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y18(0.15)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y18(0.55)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y18(0.44)  LDD0268  [6]
 LDCM0107  IAA HeLa H48(0.00); H393(0.00); H124(0.00); H20(0.00)  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C204(1.58)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C204(1.24)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C204(1.31)  LDD0082  [8]
 LDCM0109  NEM HeLa H48(0.00); H393(0.00); H20(0.00)  LDD0223  [20]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C204(0.41)  LDD2118  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C204(0.44)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C204(0.41)  LDD2124  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C204(0.33)  LDD2126  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C204(0.70)  LDD2141  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C204(0.34)  LDD2149  [3]
 LDCM0131  RA190 MM1.R C204(1.14)  LDD0304  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA endonuclease RBBP8 (RBBP8) COM1/SAE2/CtIP family Q99708
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165

The Drug(s) Related To This Target

Patented
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us9132129, Cpd002 Small molecular drug D09SDN
Us9132129, Cpd023 Small molecular drug D08LBW
Us9132129, Cpd047 Small molecular drug D0RP0H

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.