Details of the Target

General Information of Target

Target ID LDTP00737
Target Name Centriolar coiled-coil protein of 110 kDa (CCP110)
Gene Name CCP110
Gene ID 9738
Synonyms
CEP110; CP110; KIAA0419; Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; CP110; Cep110
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEYEKFCEKSLARIQEASLSTESFLPAQSESISLIRFHGVAILSPLLNIEKRKEMQQEK
QKALDVEARKQVNRKKALLTRVQEILDNVQVRKAPNASDFDQWEMETVYSNSEVRNLNVP
ATFPNSFPSHTEHSTAAKLDKIAGILPLDNEDQCKTDGIDLARDSEGFNSPKQCDSSNIS
HVENEAFPKTSSATPQETLISDGPFSVNEQQDLPLLAEVIPDPYVMSLQNLMKKSKEYIE
REQSRRSLRGSINRIVNESHLDKEHDAVEVADCVKEKGQLTGKHCVSVIPDKPSLNKSNV
LLQGASTQASSMSMPVLASFSKVDIPIRTGHPTVLESNSDFKVIPTFVTENNVIKSLTGS
YAKLPSPEPSMSPKMHRRRSRTSSACHILINNPINACELSPKGKEQAMDLIIQDTDENTN
VPEIMPKLPTDLAGVCSSKVYVGKNTSEVKEDVVLGKSNQVCQSSGNHLENKVTHGLVTV
EGQLTSDERGAHIMNSTCAAMPKLHEPYASSQCIASPNFGTVSGLKPASMLEKNCSLQTE
LNKSYDVKNPSPLLMQNQNTRQQMDTPMVSCGNEQFLDNSFEKVKRRLDLDIDGLQKENC
PYVITSGITEQERQHLPEKRYPKGSGFVNKNKMLGTSSKESEELLKSKMLAFEEMRKRLE
EQHAQQLSLLIAEQEREQERLQKEIEEQEKMLKEKKAMTAEASELDINNAVELEWRKISD
SSLLETMLSQADSLHTSNSNSSGFTNSAMQYSFVSANEAPFYLWGSSTSGLTKLSVTRPF
GRAKTRWSQVFSLEIQAKFNKITAVAKGFLTRRLMQTDKLKQLRQTVKDTMEFIRSFQSE
APLKRGIVSAQDASLQERVLAQLRAALYGIHDIFFVMDAAERMSILHHDREVRKEKMLRQ
MDKMKSPRVALSAATQKSLDRKKYMKAAEMGMPNKKFLVKQNPSETRVLQPNQGQNAPVH
RLLSRQGTPKTSVKGVVQNRQKPSQSRVPNRVPVSGVYAGKIQRKRPNVATI
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
Uniprot ID
O43303
Ensemble ID
ENST00000381396.9
HGNC ID
HGNC:24342

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C436(1.89)  LDD3325  [1]
Johansson_61
 Probe Info  		_(11.29)  LDD1485  [2]
DA-P3
 Probe Info  		6.09  LDD0179  [3]
CY-1
 Probe Info  		N.A.  LDD0246  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C535(0.00); C600(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		C535(0.00); C462(0.00)  LDD2224  [7]
Compound 10
 Probe Info  		C436(0.00); C462(0.00); C535(0.00); C600(0.00)  LDD2216  [8]
Compound 11
 Probe Info  		C436(0.00); C462(0.00); C535(0.00); C600(0.00)  LDD2213  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
AOyne
 Probe Info  		13.80  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C174(1.01); C535(1.01); C600(1.17); C436(1.10)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C174(1.01); C535(0.93); C600(1.00); C436(1.06)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C174(1.01); C535(1.08); C600(0.78); C436(1.11)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C174(1.01); C535(1.06); C600(1.15); C436(0.94)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C174(1.02); C535(1.08); C600(1.05); C436(1.08)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C174(1.20); C535(1.18); C600(1.03); C436(1.21)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C174(0.97); C535(1.07); C600(0.92); C436(1.11)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C174(0.99); C535(0.89); C600(1.24); C436(1.09)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C174(1.95); C535(1.93); C600(0.99); C436(1.32)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C174(0.95); C535(0.86); C600(1.10); C436(1.01)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C174(0.93); C535(1.07); C600(1.11); C436(0.98)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C174(1.02); C535(1.08); C600(1.04); C436(0.84)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C174(1.08); C535(1.02); C600(0.97); C436(1.08)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C174(1.00); C535(1.05); C600(1.08); C436(0.88)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C174(0.99); C535(0.97); C600(1.06); C436(1.02)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C174(0.93); C535(1.10); C600(1.22); C436(1.08)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C174(0.97); C535(0.82); C600(1.04); C436(1.03)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C174(0.97); C535(1.02); C600(0.83); C436(1.09)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C174(0.98); C535(0.93); C600(1.05); C436(0.97)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C174(1.02); C535(1.09); C600(0.99); C436(0.93)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C174(1.14); C535(1.08); C600(1.04); C436(1.10)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C174(0.91); C535(1.06); C600(1.05); C436(1.02)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C174(1.07); C535(1.00); C600(0.95); C436(1.04)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C174(1.02); C535(1.03); C600(0.96); C436(1.01)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C174(1.13); C535(1.08); C600(1.13); C436(1.19)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C174(0.99); C535(0.86); C600(1.09); C436(0.93)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C174(1.05); C535(1.03); C600(1.19); C436(1.11)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C174(1.08); C535(1.02); C600(1.09); C436(0.96)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C174(1.08); C535(1.02); C600(1.04); C436(0.86)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C174(1.11); C535(1.09); C600(1.05); C436(0.96)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C174(1.05); C535(1.08); C600(1.08); C436(0.98)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C174(1.05); C535(1.01); C600(1.12); C436(0.98)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C174(0.95); C535(1.17); C600(1.08); C436(1.02)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C174(0.99); C535(1.04); C600(0.92); C436(1.14)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C174(1.09); C535(1.19); C600(1.19); C436(1.07)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C174(1.02); C535(0.93); C600(1.07); C436(1.11)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C174(0.98); C535(1.08); C600(1.15); C436(1.07)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C174(1.07); C535(1.07); C600(1.12); C436(0.92)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C174(0.93); C535(1.17); C600(1.02); C436(1.07)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C174(1.13); C535(1.15); C600(1.15); C436(1.03)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C174(0.88); C535(1.02); C600(1.07); C436(0.96)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C174(1.05); C535(1.16); C600(0.92); C436(1.02)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C174(1.12); C535(1.00); C600(1.05); C436(0.90)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C174(1.04); C535(0.85); C600(1.19); C436(0.98)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C174(1.07); C535(0.85); C600(0.76); C436(1.10)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C174(1.11); C535(1.09); C600(1.04); C436(0.96)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C174(1.00); C535(1.01); C600(1.04); C436(0.98)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C174(0.96); C535(1.15); C600(1.10); C436(1.11)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C174(1.03); C535(1.21); C600(1.07); C436(1.11)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C174(0.95); C535(1.06); C600(1.10); C436(0.97)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C174(1.07); C535(1.09); C600(0.99); C436(1.07)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C174(1.10); C535(0.93); C600(1.07); C436(1.14)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C174(1.09); C535(0.98); C600(0.93); C436(1.04)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C174(0.97); C535(1.06); C600(1.11); C436(1.11)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C174(1.11); C535(1.09); C600(0.99); C436(0.97)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C174(1.08); C535(1.05); C600(1.08); C436(0.97)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C174(1.23); C535(1.02); C600(1.25); C436(1.08)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C174(1.03); C535(1.06); C600(1.07); C436(1.29)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C174(1.01); C535(0.97); C600(1.10); C436(0.97)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C174(1.03); C535(1.04); C600(1.01); C436(1.04)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C174(0.93); C535(0.96); C600(1.16); C436(1.05)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C174(1.08); C535(1.09); C600(1.08); C436(0.96)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C174(1.06); C535(1.12); C600(1.19); C436(1.10)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C174(0.89); C535(1.02); C600(0.98); C436(0.92)  LDD1514  [11]
 LDCM0087  Capsaicin HEK-293T 13.16  LDD0185  [3]
 LDCM0632  CL-Sc Hep-G2 C498(0.58)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C174(0.98); C535(0.89); C600(1.18); C436(0.98)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C174(0.96); C535(1.09); C600(1.42); C436(1.05)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C174(1.11); C535(1.04); C600(0.82); C436(0.92)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C174(0.97); C535(1.03); C600(1.07); C436(1.02)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C174(0.97); C535(1.07); C600(1.21); C436(0.96)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C174(0.98); C535(1.19); C600(1.15); C436(1.05)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C174(0.94); C535(0.95); C600(0.83); C436(0.88)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C174(0.92); C535(1.01); C600(1.06); C436(1.02)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C174(1.00); C535(1.11); C600(1.20); C436(0.94)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C174(1.03); C535(0.95); C600(0.82); C436(0.96)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C174(1.08); C535(1.05); C600(1.01); C436(0.92)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C174(0.94); C535(1.04); C600(1.07); C436(1.03)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C174(0.97); C535(1.03); C600(1.04); C436(1.27)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C174(1.02); C535(1.14); C600(1.17); C436(1.01)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C174(1.07); C535(1.03); C600(1.18); C436(1.07)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C174(1.06); C535(1.17); C600(0.84); C436(0.95)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C174(0.98); C535(1.07); C600(1.10); C436(0.95)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C174(0.89); C535(1.14); C600(1.18); C436(1.06)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C174(1.02); C535(1.13); C600(1.25); C436(1.02)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C174(0.92); C535(1.10); C600(1.24); C436(0.98)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C174(1.04); C535(1.08); C600(1.06); C436(1.01)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C174(1.19); C535(1.31); C600(1.15); C436(1.07)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C174(1.06); C535(1.02); C600(1.10); C436(0.94)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C174(0.97); C535(1.14); C600(1.08); C436(0.98)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C174(0.95); C535(1.06); C600(1.05); C436(1.04)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C174(1.05); C535(1.07); C600(0.97); C436(1.01)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C174(0.97); C535(1.06); C600(1.04); C436(1.00)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C174(0.98); C535(1.13); C600(1.03); C436(0.95)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C174(0.90); C535(1.16); C600(0.67); C436(0.94)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C174(0.97); C535(1.05); C600(1.12); C436(0.96)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C174(1.01); C535(1.03); C600(1.09); C436(0.99)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C174(1.03); C535(1.01); C600(1.17); C436(1.00)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C174(1.01); C535(0.99); C600(0.93); C436(0.97)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C174(1.30); C535(1.08); C600(1.31); C436(1.23)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C174(1.02); C535(1.08); C600(1.01); C436(0.98)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C174(1.11); C535(1.08); C600(1.38); C436(0.94)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C174(1.01); C535(0.98); C600(1.12); C436(0.84)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C174(0.97); C535(1.09); C600(1.93); C436(1.03)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C174(0.97); C535(1.03); C600(1.13); C436(1.05)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C174(1.03); C535(1.22); C600(0.99); C436(1.07)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C174(1.08); C535(1.09); C600(1.10); C436(1.02)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C174(0.92); C535(0.97); C600(1.09); C436(0.96)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C174(1.08); C535(1.11); C600(1.16); C436(0.89)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C174(0.93); C535(1.13); C600(1.10); C436(1.07)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C174(1.02); C535(1.01); C600(1.04); C436(1.22)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C174(0.95); C535(1.29); C600(1.13); C436(1.06)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C174(1.00); C535(1.00); C600(1.13); C436(0.97)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C174(0.98); C535(1.03); C600(1.12); C436(0.94)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C174(1.11); C535(1.05); C600(0.88); C436(0.97)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C174(0.95); C535(1.01); C600(0.96); C436(0.94)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C174(1.08); C535(1.10); C600(0.89); C436(1.02)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C174(1.14); C535(1.03); C600(1.01); C436(1.04)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C174(0.89); C535(1.05); C600(0.94); C436(0.97)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C174(0.97); C535(1.26); C600(0.90); C436(1.13)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C174(0.94); C535(1.04); C600(1.03); C436(0.92)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C174(0.92); C535(1.18); C600(1.15); C436(0.97)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C174(0.86); C535(1.06); C600(1.11); C436(1.01)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C174(0.96); C535(1.11); C600(1.00); C436(1.05)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C174(0.90); C535(1.03); C600(1.12); C436(0.99)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C174(1.06); C535(0.92); C600(1.23); C436(0.96)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C174(1.00); C535(1.06); C600(1.03); C436(1.04)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C174(1.20); C535(0.98); C600(1.02); C436(0.91)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C174(1.13); C535(0.99); C600(0.78); C436(0.94)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C174(0.94); C535(1.07); C600(0.95); C436(1.04)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C174(1.07); C535(0.93); C600(0.97); C436(1.07)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C174(0.92); C535(1.18); C600(0.87); C436(1.07)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C174(1.01); C535(1.02); C600(1.14); C436(1.01)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C174(0.95); C535(1.17); C600(1.08); C436(0.88)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C174(0.97); C535(0.93); C600(0.94); C436(1.05)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C174(0.89); C535(1.11); C600(1.03); C436(1.02)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C174(0.91); C535(0.97); C600(1.02); C436(0.96)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C174(0.96); C535(0.97); C600(0.79); C436(1.02)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C174(0.95); C535(1.04); C600(0.87); C436(0.99)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C174(1.07); C535(1.03); C600(1.15); C436(0.99)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C174(1.02); C535(0.99); C600(0.86); C436(0.83)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C174(0.94); C535(1.12); C600(1.35); C436(0.99)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C174(1.02); C535(1.10); C600(1.12); C436(0.96)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C174(0.95); C535(1.01); C600(1.11); C436(1.16)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C174(0.98); C535(1.07); C600(1.18); C436(0.97)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C174(1.19); C535(1.15); C600(1.13); C436(0.96)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C174(0.92); C535(1.25); C600(1.12); C436(1.06)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C174(0.92); C535(1.04); C600(1.06); C436(1.08)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C174(1.04); C535(0.86); C600(1.15); C436(1.05)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C174(0.85); C535(1.17); C600(1.02); C436(0.96)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C174(1.03); C535(0.98); C600(1.05); C436(0.98)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C174(1.01); C535(1.09); C600(1.07); C436(1.05)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C174(1.04); C535(1.02); C600(1.16); C436(1.00)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C174(1.03); C535(0.92); C600(1.08); C436(1.10)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C174(0.99); C535(1.07); C600(0.93); C436(1.07)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C174(1.07); C535(1.04); C600(1.20); C436(1.06)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C174(1.02); C535(0.97); C600(0.81); C436(1.09)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C174(0.96); C535(1.00); C600(1.03); C436(0.94)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C174(0.96); C535(1.12); C600(1.03); C436(0.86)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C174(1.03); C535(1.02); C600(0.79); C436(1.13)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C174(0.97); C535(1.16); C600(1.08); C436(1.01)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C174(0.87); C535(1.14); C600(1.07); C436(1.04)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C174(0.88); C535(1.18); C600(1.09); C436(0.98)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C174(0.96); C535(0.93); C600(1.08); C436(0.99)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C174(1.06); C535(1.04); C600(1.19); C436(1.00)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C174(0.88); C535(1.05); C600(0.96); C436(0.93)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C174(1.05); C535(1.10); C600(1.16); C436(1.10)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C174(0.93); C535(0.96); C600(0.99); C436(0.91)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C174(1.07); C535(0.94); C600(0.58); C436(1.08)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C174(1.09); C535(0.87); C600(1.63); C436(0.96)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C174(0.93); C535(1.05); C600(1.04); C436(0.90)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C174(1.01); C535(1.07); C600(1.08); C436(0.91)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C174(0.99); C535(1.15); C600(0.94); C436(1.02)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C174(0.89); C535(1.06); C600(1.08); C436(1.06)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C174(0.93); C535(1.00); C600(1.06); C436(0.93)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C174(1.10); C535(0.94); C600(1.07); C436(0.97)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C174(1.04); C535(1.07); C600(1.07); C436(0.93)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C174(1.18); C535(1.07); C600(0.99); C436(0.91)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C174(0.87); C535(0.97); C600(0.83); C436(0.97)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C174(0.98); C535(1.05); C600(0.87); C436(1.08)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C174(1.03); C535(1.03); C600(1.03); C436(0.82)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C174(1.00); C535(0.83); C600(1.93); C436(1.08)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C174(1.04); C535(1.16); C600(0.85); C436(1.05)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C174(0.97); C535(1.05); C600(1.15); C436(0.92)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C174(1.09); C535(1.05); C600(1.01); C436(0.92)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C174(0.90); C535(1.20); C600(1.21); C436(1.12)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C174(1.08); C535(1.17); C600(1.33); C436(1.10)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C174(0.94); C535(1.00); C600(1.01); C436(0.96)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C174(1.03); C535(1.08); C600(1.20); C436(1.05)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C174(1.06); C535(1.05); C600(1.04); C436(0.96)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C174(1.01); C535(1.10); C600(1.58); C436(0.99)  LDD1697  [11]
 LDCM0028  Dobutamine HEK-293T 7.61  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 6.09  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C174(1.01); C535(1.17); C600(1.53); C436(0.95)  LDD1698  [11]
 LDCM0031  Epigallocatechin gallate HEK-293T 22.30  LDD0183  [3]
 LDCM0468  Fragment33 HEK-293T C174(0.96); C535(1.02); C600(0.88); C436(0.98)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C174(1.02); C535(1.00); C600(1.10); C436(0.97)  LDD1631  [11]
 LDCM0569  Fragment7 Jurkat _(11.29)  LDD1485  [2]
 LDCM0022  KB02 HEK-293T C462(1.04); C273(0.98); C174(1.07); C285(1.03)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C462(0.86); C273(1.17); C174(1.05); C285(0.94)  LDD1497  [11]
 LDCM0024  KB05 UACC257 C436(1.89)  LDD3325  [1]
 LDCM0030  Luteolin HEK-293T 18.72  LDD0182  [3]
 LDCM0032  Oleacein HEK-293T 8.53  LDD0184  [3]
 LDCM0029  Quercetin HEK-293T 14.54  LDD0181  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-like protein KIF24 (KIF24) Kinesin family Q5T7B8
Neuralized-like protein 4 (NEURL4) . Q96JN8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrin-2 (CETN2) Centrin family P41208
Cyclin-F (CCNF) Cyclin family P41002
Protein TALPID3 (KIAA0586) TALPID3 family Q9BVV6
Centrosomal protein of 290 kDa (CEP290) . O15078
Centrosomal protein of 97 kDa (CEP97) . Q8IW35

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402