Details of the Target

General Information of Target

Target ID LDTP15727
Target Name Protein LTV1 homolog (LTV1)
Gene Name LTV1
Gene ID 84946
Synonyms
C6orf93; Protein LTV1 homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGG
LDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDW
IRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRE
RCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAG
VFMGIALLQIFGICLAQNLVSDIKAVKANW
Target Bioclass
Other
Family
LTV1 family
Function Essential for ribosome biogenesis.
Uniprot ID
Q96GA3
Ensemble ID
ENST00000367576.6
HGNC ID
HGNC:21173

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		4.24  LDD0348  [2]
BTD
 Probe Info  		C309(0.68)  LDD1700  [3]
DA-P3
 Probe Info  		6.87  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C309(2.55)  LDD0168  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
DBIA
 Probe Info  		C350(1.15); C354(1.15)  LDD0078  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		K381(0.00); K461(0.00); K347(0.00); K305(0.00)  LDD0199  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0147  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
HHS-482
 Probe Info  		Y369(1.56)  LDD2239  [13]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		7.84  LDD0476  [14]
FFF probe3
 Probe Info  		12.79  LDD0465  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C309(2.55)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C354(2.21); C350(3.24); C309(3.05)  LDD0169  [4]
 LDCM0215  AC10 HCT 116 C350(1.05); C354(1.05)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C350(0.80); C354(0.80)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C350(0.85); C354(0.85)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C350(0.90); C354(0.90)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C350(1.12); C354(1.12)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C350(1.10); C354(1.10)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C350(0.85); C354(0.85)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C350(1.06); C354(1.06)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C350(1.11); C354(0.86)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C350(0.79); C354(1.02)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C350(1.00); C354(1.24)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C350(1.24); C354(1.24)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C350(0.88); C354(1.02)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C350(1.13); C354(1.25)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C350(1.12); C354(1.11)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C350(0.76); C354(0.76)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C350(0.51); C354(0.51)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C350(0.53); C354(0.53)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C350(0.56); C354(0.56)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C350(0.58); C354(0.58)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C350(0.56); C354(0.56)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C350(0.50); C354(0.50)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C350(1.05); C354(1.05)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C350(0.55); C354(0.55)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C350(0.51); C354(0.51)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C350(0.68); C354(0.68)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C350(0.66); C354(0.66)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C350(0.64); C354(0.64)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C350(0.76); C354(0.76)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C350(0.68); C354(0.68)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C350(0.71); C354(0.71)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C350(1.06); C354(1.06)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C350(0.94); C354(0.94)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C350(1.09); C354(1.09)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C350(1.14); C354(1.14)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C350(0.68); C354(0.68)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C350(0.78); C354(0.78)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C350(0.82); C354(0.82)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C350(0.91); C354(0.91)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C350(0.82); C354(0.82)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C350(0.68); C354(0.68)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C350(0.69); C354(0.69)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C350(0.75); C354(0.75)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C350(0.93); C354(0.93)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C350(0.74); C354(0.74)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C350(0.84); C354(0.84)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C350(0.63); C354(0.63)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C350(0.70); C354(0.70)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C350(1.35); C354(1.35)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C350(0.79); C354(0.79)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C350(0.96); C354(0.96)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C350(1.15); C354(1.15)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C350(1.38); C354(1.38)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C350(0.95); C354(0.95)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C350(1.20); C354(1.20)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C350(0.60); C354(0.60)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C350(0.88); C354(0.88)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C350(1.54); C354(1.54)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C350(1.77); C354(1.77)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C350(1.20); C354(1.20)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C350(1.39); C354(1.39)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C350(0.86); C354(0.86)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C350(1.17); C354(1.17)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C350(1.17); C354(1.17)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C350(1.42); C354(1.42)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C350(1.29); C354(1.29)  LDD0595  [6]
 LDCM0280  AC20 HCT 116 C350(1.14); C354(1.14)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C350(1.49); C354(1.49)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C350(1.08); C354(1.08)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C350(1.40); C354(1.40)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C350(1.24); C354(1.24)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C350(0.85); C354(0.85)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C350(0.88); C354(0.88)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C350(0.94); C354(0.94)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C350(1.20); C354(1.20)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C350(1.15); C354(1.15)  LDD0606  [6]
 LDCM0291  AC30 HCT 116 C350(0.94); C354(0.94)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C350(0.89); C354(0.89)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C350(1.04); C354(1.04)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C350(1.22); C354(1.22)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C350(1.50); C354(1.50)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C350(0.79); C354(0.79)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C350(0.74); C354(0.74)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C350(0.69); C354(0.69)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C350(0.81); C354(0.81)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C350(0.86); C354(0.86)  LDD0617  [6]
 LDCM0302  AC40 HCT 116 C350(1.03); C354(1.03)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C350(0.68); C354(0.68)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C350(0.83); C354(0.83)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C350(0.81); C354(0.81)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C350(0.73); C354(0.73)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C350(0.87); C354(0.87)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C350(1.10); C354(1.10)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C350(1.07); C354(1.07)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C350(0.99); C354(0.99)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C350(1.02); C354(1.02)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C350(1.06)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C350(1.08); C354(1.08)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C350(1.09); C354(1.09)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C350(1.25); C354(1.25)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C350(1.52); C354(1.52)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C350(1.38); C354(1.38)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C350(1.19); C354(1.19)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C350(1.04); C354(1.04)  LDD0917  [6]
 LDCM0323  AC6 HCT 116 C350(1.00); C354(1.00)  LDD0640  [6]
 LDCM0325  AC61 HEK-293T C350(1.16)  LDD1564  [15]
 LDCM0332  AC68 HCT 116 C350(1.26); C354(1.26)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C350(1.21); C354(1.21)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C350(1.04); C354(1.04)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C350(0.70); C354(0.70)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C350(1.06); C354(1.06)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C350(1.05); C354(1.05)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C350(1.30); C354(1.30)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C350(1.40); C354(1.40)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C350(1.33); C354(1.33)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C350(1.05); C354(1.05)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C350(1.26); C354(1.26)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C350(1.24); C354(1.24)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C350(1.00); C354(1.00)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C350(1.14); C354(1.14)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C350(1.15); C354(1.15)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C350(0.82); C354(0.82)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C350(1.13); C354(1.13)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C350(1.32); C354(1.32)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C350(1.36); C354(1.36)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C350(1.68); C354(1.68)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C350(1.32); C354(1.32)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C350(0.91); C354(0.91)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C350(1.06); C354(1.06)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C350(1.32); C354(1.32)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C350(0.92); C354(0.92)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C350(1.30); C354(1.30)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C350(1.27); C354(1.27)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C350(1.15); C354(1.15)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C350(1.45); C354(1.45)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C350(1.11); C354(1.11)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C350(1.28); C354(1.28)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C350(1.56); C354(1.56)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C350(1.00); C354(1.00)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C350(0.82); C354(0.82)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C350(0.81); C354(0.81)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C350(1.12); C354(1.12)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C350(1.94); C354(1.94)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.27  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C350(1.15); C354(1.15)  LDD0078  [6]
 LDCM0087  Capsaicin HEK-293T 28.01  LDD0185  [2]
 LDCM0367  CL1 HEK-293T C350(1.19); C354(1.27)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C350(1.39); C354(1.66)  LDD0966  [6]
 LDCM0370  CL101 HCT 116 C350(1.00); C354(1.00)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C350(0.79); C354(0.79)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C350(1.12); C354(1.12)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C350(1.02); C354(1.02)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C350(1.17); C354(1.17)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C350(1.66); C354(1.66)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C350(1.27); C354(1.27)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C350(1.53); C354(1.53)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C350(1.39); C354(1.39)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C350(1.26); C354(1.36)  LDD0977  [6]
 LDCM0380  CL110 HCT 116 C350(1.49); C354(1.49)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C350(1.43); C354(1.43)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C350(0.72); C354(0.72)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C350(1.12); C354(1.12)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C350(0.98); C354(0.98)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C350(0.93); C354(0.93)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C350(0.82); C354(0.82)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C350(0.96); C354(0.96)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C350(0.74); C354(0.74)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C350(0.96); C354(0.96)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C350(1.20); C354(1.00)  LDD0988  [6]
 LDCM0391  CL120 HCT 116 C350(0.70); C354(0.70)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C350(1.21); C354(1.21)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C350(1.01); C354(1.01)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C350(1.71); C354(1.71)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C350(1.16); C354(1.16)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C350(0.99)  LDD1600  [15]
 LDCM0398  CL127 HEK-293T C354(0.95)  LDD1602  [15]
 LDCM0400  CL13 HEK-293T C350(1.12); C354(1.23)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C350(1.22); C354(1.19)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C350(1.46); C354(1.74)  LDD1000  [6]
 LDCM0407  CL2 HEK-293T C350(1.02); C354(1.00)  LDD1005  [6]
 LDCM0409  CL21 HEK-293T C350(0.95)  LDD1613  [15]
 LDCM0413  CL25 HEK-293T C350(0.85)  LDD1617  [15]
 LDCM0415  CL27 HEK-293T C354(1.17)  LDD1619  [15]
 LDCM0418  CL3 HEK-293T C350(1.01); C354(1.06)  LDD1016  [6]
 LDCM0420  CL31 PaTu 8988t C350(1.11); C354(1.11)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C350(1.43); C354(1.43)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C350(1.39); C354(1.39)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C350(1.39); C354(1.39)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C350(1.55); C354(1.55)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C350(1.67); C354(1.67)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C350(1.80); C354(1.80)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C350(1.13); C354(1.13)  LDD1307  [6]
 LDCM0429  CL4 HEK-293T C350(1.33); C354(1.31)  LDD1027  [6]
 LDCM0430  CL40 PaTu 8988t C350(0.99); C354(0.99)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C350(1.91); C354(1.91)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C350(2.08); C354(2.08)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C350(2.41); C354(2.41)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C350(1.60); C354(1.60)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C350(1.27); C354(1.27)  LDD1314  [6]
 LDCM0436  CL46 HCT 116 C350(0.86); C354(0.86)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C350(0.93); C354(0.93)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C350(1.17); C354(1.17)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C350(1.04); C354(1.04)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C350(1.29); C354(1.22)  LDD1038  [6]
 LDCM0441  CL50 HCT 116 C350(0.93); C354(0.93)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C350(0.83); C354(0.83)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C350(0.96); C354(0.96)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C350(1.33); C354(1.33)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C350(0.77); C354(0.77)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C350(1.09); C354(1.09)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C350(1.05); C354(1.05)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C350(0.97); C354(0.97)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C350(1.01); C354(1.01)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C350(0.93); C354(0.93)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C350(1.17); C354(1.06)  LDD1049  [6]
 LDCM0452  CL60 HCT 116 C350(0.91); C354(0.91)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C350(0.55); C354(0.55)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C350(0.40); C354(0.40)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C350(0.71); C354(0.71)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C350(0.50); C354(0.50)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C350(0.42); C354(0.42)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C350(0.45); C354(0.45)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C350(0.67); C354(0.67)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C350(1.07); C354(1.07)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C350(0.70); C354(0.70)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C350(1.23); C354(1.03)  LDD1060  [6]
 LDCM0463  CL70 HCT 116 C350(0.81); C354(0.81)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C350(0.50); C354(0.50)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C350(1.07); C354(1.07)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C350(0.66); C354(0.66)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C350(1.07); C354(1.07)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C350(1.16); C354(1.16)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C350(1.41); C354(1.41)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C350(1.06); C354(1.06)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C350(1.05); C354(1.05)  LDD0789  [6]
 LDCM0473  CL8 HEK-293T C354(1.00)  LDD1071  [6]
 LDCM0474  CL80 HCT 116 C350(0.95); C354(0.95)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C350(0.91); C354(0.91)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C350(0.93); C354(0.93)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C350(0.96); C354(0.96)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C350(0.97); C354(0.97)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C350(1.09); C354(1.09)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C350(1.09); C354(1.09)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C350(1.16); C354(1.16)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C350(1.54); C354(1.54)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C350(1.09); C354(1.09)  LDD0800  [6]
 LDCM0484  CL9 HEK-293T C354(1.17)  LDD1082  [6]
 LDCM0485  CL90 HCT 116 C350(1.22); C354(1.22)  LDD0802  [6]
 LDCM0488  CL93 HEK-293T C350(0.86)  LDD1691  [15]
 LDCM0492  CL97 HEK-293T C350(0.79)  LDD1695  [15]
 LDCM0494  CL99 HEK-293T C354(0.93)  LDD1697  [15]
 LDCM0027  Dopamine HEK-293T 6.87  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C354(1.10)  LDD1698  [15]
 LDCM0031  Epigallocatechin gallate HEK-293T 68.25  LDD0183  [2]
 LDCM0468  Fragment33 HCT 116 C350(0.66); C354(0.66)  LDD0785  [6]
 LDCM0427  Fragment51 PaTu 8988t C350(1.67); C354(1.67)  LDD1306  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HCT 116 C350(3.92); C354(3.92)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C350(2.26); C354(2.26)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C350(3.79); C354(3.79)  LDD0082  [6]
 LDCM0030  Luteolin HEK-293T 36.40  LDD0182  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C309(0.53)  LDD2092  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C309(0.61)  LDD2098  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C309(0.60)  LDD2101  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C309(0.44)  LDD2109  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C309(0.76)  LDD2115  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C309(0.61)  LDD2118  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C309(1.44)  LDD2122  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C309(0.73)  LDD2125  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C309(0.68)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C309(0.52)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C309(0.96)  LDD2135  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C309(0.68)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C309(0.58)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C309(1.01)  LDD2143  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C309(1.58)  LDD2147  [3]
 LDCM0032  Oleacein HEK-293T 11.14  LDD0184  [2]
 LDCM0029  Quercetin HEK-293T 18.31  LDD0181  [2]
 LDCM0021  THZ1 HCT 116 C350(1.10); C354(1.10)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein uS3 (RPS3) Universal ribosomal protein uS3 family P23396
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402