Details of the Target

General Information of Target

Target ID LDTP10753
Target Name Sperm-associated antigen 5 (SPAG5)
Gene Name SPAG5
Gene ID 10615
Synonyms
Sperm-associated antigen 5; Astrin; Deepest; Mitotic spindle-associated protein p126; MAP126
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE
GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF
QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG
TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE
EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG
PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE
LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ
QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR
GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ
SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG
KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS
PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ
RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ
TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ
DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS
HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ
GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP
EAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK
EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFK
APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL
EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVR
AGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDS
GACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSP
ERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRR
ERSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRRRPYKECSTDLSI
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU.
Uniprot ID
Q96R06
Ensemble ID
ENST00000321765.10
HGNC ID
HGNC:13452

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TG42
 Probe Info  		5.34  LDD0326  [2]
STPyne
 Probe Info  		K556(0.96)  LDD0277  [3]
BTD
 Probe Info  		C1035(1.21)  LDD2099  [4]
NAIA_5
 Probe Info  		C382(20.00)  LDD2227  [5]
DA-P3
 Probe Info  		12.74  LDD0179  [6]
AHL-Pu-1
 Probe Info  		C758(4.59); C420(2.47); C1035(2.09)  LDD0168  [7]
DBIA
 Probe Info  		C1003(1.15); C544(1.06); C545(1.06); C1035(0.96)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C1003(0.00); C1035(0.00); C382(0.00); C838(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		C177(0.00); C420(0.00); C589(0.00)  LDD2226  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
IPM
 Probe Info  		C177(0.00); C1003(0.00); C822(0.00); C420(0.00)  LDD0147  [11]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
TFBX
 Probe Info  		C1003(0.00); C420(0.00); C838(0.00); C1035(0.00)  LDD0148  [11]
VSF
 Probe Info  		C1003(0.00); C177(0.00)  LDD0007  [13]
YN-1
 Probe Info  		N.A.  LDD0446  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C838(1.09)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1035(1.44)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C758(4.59); C420(2.47); C1035(2.09)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C907(2.94); C758(6.94); C420(3.09); C1035(2.45)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C1003(0.95); C1035(1.17); C177(1.19); C382(1.03)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C1003(1.53); C1035(0.78); C177(1.58); C382(2.09)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1035(1.53); C177(0.92); C46(0.91); C54(0.91)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1035(1.72); C177(0.85); C46(0.88); C54(0.88)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1035(1.37); C177(0.92); C46(0.88); C54(0.88)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1035(1.75); C177(1.18); C46(1.07); C54(1.07)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1035(1.87); C177(1.02); C46(0.95); C54(0.95)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1035(1.94); C177(1.26); C46(1.02); C54(1.02)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1035(1.80); C177(1.16); C46(1.05); C54(1.05)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1035(0.79); C177(0.77); C46(1.05); C54(1.05)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1035(2.06); C177(0.80); C46(0.94); C54(0.94)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1035(2.11); C177(1.40); C46(0.90); C54(0.90)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C1003(1.64); C1035(1.03); C177(1.32); C382(1.77)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1035(1.68); C177(1.06); C46(0.94); C54(0.94)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1035(2.39); C177(1.12); C46(0.96); C54(0.96)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1035(1.73); C177(0.92); C46(1.08); C54(1.08)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1003(1.07); C1035(1.04); C177(0.89); C46(0.98)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1003(0.93); C1035(1.12); C177(0.84); C46(1.09)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1003(0.97); C1035(1.54); C177(0.77); C46(1.22)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1003(1.18); C1035(1.39); C177(1.05); C46(1.33)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1003(1.30); C1035(1.31); C177(1.06); C46(0.98)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1003(1.26); C1035(1.21); C177(1.06); C46(0.95)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1003(1.21); C1035(1.14); C177(1.06); C46(1.01)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C1003(1.45); C1035(1.06); C177(1.15); C382(0.68)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1003(0.90); C1035(1.57); C177(1.19); C46(1.21)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1003(0.90); C1035(1.09); C177(0.87); C46(0.95)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1003(1.08); C1035(1.07); C177(1.13); C46(1.06)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1003(0.86); C1035(1.08); C177(0.94); C46(1.04)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1003(0.98); C1035(0.99); C177(1.05); C46(1.00)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1003(1.10); C1035(1.08); C177(1.16); C46(0.95)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1003(0.92); C1035(1.30); C177(1.01); C46(1.17)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1003(0.97); C1035(1.27); C177(1.18); C46(1.34)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C1035(1.07); C46(0.77); C54(0.77); C838(1.46)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C1035(0.88); C46(0.67); C54(0.67); C838(1.23)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C1035(0.80); C46(0.74); C54(0.74); C838(0.98)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C1035(1.38); C46(0.90); C54(0.90); C838(1.43)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C1035(0.87); C46(0.62); C54(0.62); C838(1.14)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C1035(0.90); C46(0.59); C54(0.59); C838(1.30)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C1035(1.47); C46(0.67); C54(0.67); C838(1.26)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C1035(0.90); C46(0.61); C54(0.61); C838(1.04)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C1035(1.12); C46(0.68); C54(0.68); C838(0.95)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C1035(1.18); C46(0.66); C54(0.66); C838(0.84)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C1035(2.28); C46(0.60); C54(0.60); C838(1.28)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C1035(1.15); C46(0.64); C54(0.64); C838(1.24)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C1003(1.66); C1035(0.81); C177(1.37); C382(1.35)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C1035(1.55); C46(0.57); C54(0.57); C838(1.34)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C1035(1.60); C46(0.63); C54(0.63); C838(1.03)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C1035(1.12); C46(0.56); C54(0.56); C838(1.58)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C1003(1.04); C46(1.15); C54(1.15); C1035(1.18)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1003(0.70); C1035(0.84); C54(1.15); C46(1.15)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C1003(0.60); C54(0.93); C46(0.97); C1035(1.11)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C1003(0.93); C1035(1.09); C54(1.16); C46(1.25)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C1003(0.59); C1035(1.11); C54(1.13); C46(1.20)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1003(0.82); C1035(1.03); C46(1.67); C54(1.71)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C1003(0.69); C1035(0.79); C54(1.41); C46(1.46)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C838(0.71); C46(0.90); C54(0.90); C1035(0.91)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C1003(0.95); C46(0.99); C54(1.01); C1035(1.14)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C46(1.01); C54(1.03); C1003(1.23); C1035(1.28)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1035(1.17); C46(1.24); C54(1.24); C1003(1.52)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C1003(0.52); C1035(1.43); C54(1.79); C46(1.93)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1003(0.92); C1035(1.12); C46(1.14); C54(1.10)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1003(0.91); C1035(1.38); C46(1.28); C54(1.26)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1003(0.85); C1035(1.24); C46(1.20); C54(1.16)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1003(1.15); C1035(1.27); C46(1.36); C54(1.31)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C838(0.67); C177(0.88); C1035(1.05); C545(1.05)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C838(0.71); C46(0.93); C54(0.93); C177(0.99)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C838(0.83); C177(0.84); C544(1.11); C1035(1.11)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C46(0.68); C54(0.68); C1003(0.85); C546(0.92)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C838(0.93); C177(0.97); C544(1.05); C1035(1.08)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C838(0.82); C544(1.02); C177(1.03); C545(1.07)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C1035(0.85); C838(0.89); C177(0.91); C545(0.97)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C177(0.81); C838(0.81); C545(1.04); C1035(1.08)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C177(0.99); C1035(1.05); C838(1.06); C46(1.11)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C838(0.79); C177(0.85); C1003(1.04); C1035(1.11)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C838(0.66); C177(1.08); C1035(1.26); C1003(1.28)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C838(0.88); C1003(1.00); C177(1.08); C1035(1.29)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C838(0.72); C1003(1.10); C177(1.22); C1035(1.29)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C838(0.78); C177(1.03); C1035(1.32); C1003(1.46)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C46(0.77); C54(0.77); C546(0.85); C1035(0.88)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C838(0.62); C177(1.13); C1003(1.21); C758(1.49)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C838(0.66); C1035(1.08); C1003(1.08); C177(1.13)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C838(0.82); C1003(1.26); C177(1.44); C46(1.53)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C838(0.70); C1003(1.08); C177(1.26); C758(1.60)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C838(0.82); C1003(0.98); C177(1.32); C758(1.69)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C838(0.86); C1003(0.93); C177(0.93); C1035(1.01)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C838(0.80); C1003(1.10); C177(1.12); C46(1.17)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C838(0.85); C177(0.90); C46(1.13); C54(1.13)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C1003(0.95); C177(1.11); C46(1.16); C54(1.16)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C838(1.00); C1003(1.00); C1035(1.06); C177(1.16)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C46(0.79); C54(0.79); C1003(0.91); C546(0.92)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C838(1.06); C177(1.11); C1035(1.22); C46(1.38)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C838(0.81); C1003(1.01); C177(1.14); C1035(1.24)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C838(0.79); C1003(1.05); C177(1.08); C1035(1.24)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C1003(0.97); C838(1.19); C177(1.25); C46(1.30)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C838(0.95); C177(0.99); C1003(1.16); C46(1.24)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C1003(1.09); C838(1.15); C177(1.26); C1035(1.38)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C177(0.90); C46(1.00); C54(1.00); C1035(1.17)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C46(0.89); C54(0.89); C1035(1.00); C1003(1.10)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C46(0.77); C54(0.77); C1035(0.93); C177(1.02)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C46(1.18); C54(1.18); C1003(1.29); C1035(1.55)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C46(0.62); C54(0.62); C382(0.79); C1003(0.84)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C177(1.43); C46(1.50); C54(1.50); C1003(1.53)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C1035(0.89); C177(0.89); C46(0.90); C54(0.90)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C177(0.91); C46(0.93); C54(0.93); C1035(1.16)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C1003(1.14); C46(1.24); C54(1.24); C177(1.39)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C177(1.05); C46(1.10); C54(1.10); C1035(1.13)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C1003(1.09); C46(1.27); C54(1.27); C177(1.52)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C1003(1.30); C46(1.85); C54(1.85); C177(1.95)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C46(0.81); C54(0.81); C1003(1.02); C546(1.38)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C46(0.79); C54(0.79); C546(1.21); C544(1.23)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C46(0.73); C54(0.73); C1003(1.26); C546(1.65)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C838(0.88); C46(0.95); C54(0.95); C1035(1.04)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C46(0.78); C54(0.78); C1003(0.89); C546(1.27)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C46(0.75); C54(0.75); C1003(1.14); C546(1.18)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C1003(0.91); C46(0.96); C54(0.96); C546(1.43)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C46(0.81); C54(0.81); C1003(1.01); C545(1.21)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C46(0.72); C54(0.72); C1003(1.11); C177(1.59)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C46(0.57); C54(0.57); C177(1.29); C1003(1.47)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C46(0.56); C54(0.56); C1003(1.27); C546(1.65)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C46(0.54); C54(0.54); C1003(0.99); C177(1.45)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C544(0.84); C545(1.06); C1003(1.11); C382(1.12)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C544(0.81); C177(0.97); C545(0.98); C1003(1.03)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C838(0.81); C1035(0.85); C46(0.85); C54(0.85)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C544(1.13); C545(1.17); C177(1.19); C1003(1.36)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C544(0.85); C545(0.90); C382(1.12); C1003(1.13)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C177(0.98); C544(1.01); C545(1.09); C1003(1.12)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C1003(1.15); C545(0.97); C544(1.00); C382(1.39)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C1003(0.90); C544(0.92); C545(0.95); C382(1.10)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C544(1.06); C545(1.17); C1003(1.19); C382(1.21)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C544(0.76); C545(0.84); C382(1.05); C177(1.30)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C544(0.98); C177(1.07); C1003(1.12); C545(1.13)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C544(0.88); C545(1.02); C177(1.03); C382(1.05)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C544(0.98); C545(1.12); C1035(1.13); C1003(1.19)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C838(0.86); C46(0.91); C54(0.91); C382(0.93)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C544(0.83); C382(0.88); C545(0.94); C1003(1.03)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C544(0.91); C177(1.09); C545(1.12); C382(1.20)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C544(0.98); C1003(1.00); C545(1.13); C382(1.13)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C46(1.14); C54(1.14); C177(1.43); C1035(1.85)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C46(0.95); C54(0.95); C177(1.34); C1035(1.65)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C46(0.97); C54(0.97); C1035(1.19); C177(1.20)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C46(0.88); C54(0.88); C177(1.22); C1035(1.38)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C1035(1.00); C177(1.13); C46(1.19); C54(1.19)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C46(1.16); C54(1.16); C177(1.21); C1035(1.23)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C46(1.07); C54(1.07); C1035(1.16); C177(1.43)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C1035(0.98); C177(1.00); C46(1.30); C54(1.30)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C46(1.05); C54(1.05); C177(1.21); C1035(1.61)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C46(1.01); C54(1.01); C1035(1.41); C177(1.53)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C177(1.09); C46(1.12); C54(1.12); C1035(1.32)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C46(0.65); C54(0.65); C1035(1.17); C177(1.24)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C1035(0.99); C46(1.03); C54(1.03); C177(1.41)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C46(0.74); C54(0.74); C177(1.14); C1035(1.28)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C177(1.29); C46(1.33); C54(1.33); C1035(1.43)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C838(0.72); C758(1.13); C46(1.32); C54(1.32)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C838(0.64); C177(0.77); C46(0.87); C54(0.87)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C1003(1.23); C1035(0.90); C177(1.22); C382(0.76)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C838(0.78); C46(0.87); C54(0.87); C1035(0.89)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C46(0.93); C54(0.93); C1035(1.03); C838(1.16)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 14.94  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1003(1.15); C544(1.06); C545(1.06); C1035(0.96)  LDD0078  [8]
 LDCM0087  Capsaicin HEK-293T 28.04  LDD0185  [6]
 LDCM0630  CCW28-3 231MFP C420(2.03)  LDD2214  [17]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C382(20.00)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C758(0.84); C382(1.00); C544(1.03); C545(1.09)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C758(0.84); C382(0.93); C1003(1.15); C1035(1.19)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C46(0.85); C54(0.85); C546(0.93); C382(0.98)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C838(0.87); C1035(0.93); C46(1.06); C54(1.06)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C838(0.88); C1035(0.91); C382(0.92); C758(1.08)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C1035(0.83); C838(0.92); C758(0.97); C46(1.00)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C1035(0.88); C758(0.92); C838(0.96); C46(0.98)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C838(0.83); C177(0.93); C46(1.05); C54(1.05)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C838(0.98); C46(1.09); C54(1.09); C177(1.10)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C46(0.83); C54(0.83); C838(1.06); C177(1.08)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C46(0.97); C54(0.97); C177(0.99); C544(1.41)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C177(0.98); C838(1.11); C1035(1.20); C46(1.35)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C758(0.98); C382(1.14); C1003(1.14); C1035(1.15)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C177(0.95); C838(1.04); C1035(1.25); C544(1.40)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C177(0.98); C838(1.02); C545(1.20); C46(1.21)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C177(0.87); C838(0.94); C1035(0.94); C1003(1.01)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C838(0.70); C1003(1.15); C177(1.19); C1035(1.54)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C838(0.70); C177(1.05); C758(1.15); C1003(1.27)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C838(0.89); C1003(1.15); C177(1.26); C1035(1.28)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C838(0.69); C1003(1.08); C177(1.22); C1035(1.27)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C1003(1.05); C838(1.09); C1035(1.57); C177(1.63)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C1003(0.89); C46(0.99); C54(0.99); C177(1.15)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C1003(1.03); C838(1.15); C46(1.25); C54(1.25)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C1003(1.03); C382(1.09); C758(1.10); C1035(1.13)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C1003(0.86); C177(0.96); C838(0.99); C46(1.10)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C1035(0.94); C177(0.98); C1003(1.22); C46(1.39)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C46(0.76); C54(0.76); C177(1.13); C1035(1.14)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C1035(1.05); C177(1.27); C46(1.32); C54(1.32)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C46(1.22); C54(1.22); C177(1.29); C1035(1.39)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C46(0.86); C54(0.86); C545(1.02); C544(1.11)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C46(0.78); C54(0.78); C177(0.93); C1035(1.08)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C46(0.69); C54(0.69); C177(0.98); C546(1.02)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C46(0.70); C54(0.70); C1003(0.96); C545(1.29)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C758(0.87); C382(1.06); C544(1.12); C545(1.16)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C544(1.03); C545(1.07); C1035(1.08); C382(1.10)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C1035(1.03); C1003(1.09); C382(1.18); C544(1.21)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C1003(0.94); C177(0.94); C1035(1.09); C46(1.22)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C177(0.83); C1035(1.02); C382(1.07); C46(1.12)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C382(0.93); C1035(0.94); C46(1.14); C54(1.14)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C1035(0.90); C46(1.11); C54(1.11); C177(1.14)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C545(0.87); C544(0.89); C1003(0.97); C382(1.02)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C177(0.79); C1035(0.91); C382(1.08); C46(1.32)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C1035(0.87); C177(1.00); C382(1.50); C46(1.82)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C177(0.90); C1035(1.15); C382(1.39); C545(1.98)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C177(0.70); C382(1.03); C1035(1.16); C545(1.23)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C1035(0.68); C177(0.69); C382(1.20); C46(1.80)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C1035(0.80); C177(0.80); C382(1.11); C46(1.98)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C1035(1.03); C177(0.83); C382(0.95); C46(1.39)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C1035(0.76); C177(0.76); C382(1.07); C46(1.46)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C1035(0.75); C177(0.78); C382(1.01); C46(1.66)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C1035(0.55); C177(0.71); C382(1.21); C46(1.33)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C1003(1.09); C1035(1.02); C382(0.96); C46(1.13)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C1035(0.68); C177(0.75); C382(0.86); C46(1.52)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C1035(0.85); C177(0.90); C382(1.28); C46(1.10)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C1003(1.14); C1035(1.13); C177(1.33); C382(1.12)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C1003(4.14); C1035(0.95); C177(1.11); C382(2.62)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C1003(0.65); C1035(0.92); C177(1.51); C382(2.04)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C1003(2.67); C1035(1.71); C177(1.54); C382(3.11)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C1003(0.47); C1035(0.83); C177(1.44); C382(1.76)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C1003(1.23); C1035(1.18); C177(1.70); C382(2.13)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C1003(1.37); C1035(1.05); C177(1.50); C382(2.02)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C1003(1.78); C1035(1.02); C382(0.98); C46(1.09)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C1003(3.70); C1035(1.09); C177(1.04); C382(1.77)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C1003(0.36); C1035(0.95); C177(1.01); C382(1.68)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C1003(0.32); C1035(1.06); C177(1.96); C382(3.83)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C1003(0.78); C1035(1.10); C177(1.74); C382(2.11)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C1003(2.17); C1035(1.29); C177(1.40); C382(2.04)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C1003(1.84); C1035(1.42); C177(1.60); C382(1.72)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C1003(0.80); C1035(1.04); C177(0.63); C382(0.78)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C1003(0.84); C1035(0.97); C177(0.64); C382(0.89)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C1003(0.80); C1035(1.11); C177(0.65); C382(0.80)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C1003(0.97); C1035(1.07); C177(0.80); C382(1.02)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C1003(1.05); C1035(1.03); C382(1.05); C46(1.23)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C1003(0.99); C1035(1.00); C177(0.72); C382(1.03)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C1003(0.79); C1035(1.08); C177(0.73); C382(0.86)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C1003(0.90); C1035(1.17); C177(0.79); C382(0.84)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C1003(0.85); C1035(1.09); C177(0.66); C382(1.01)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C1003(0.98); C1035(1.02); C177(0.76); C382(0.89)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C1003(0.95); C1035(1.09); C177(0.57); C382(0.98)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C1003(0.88); C1035(0.95); C177(0.97); C382(1.00)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C1003(0.88); C1035(1.00); C177(0.71); C382(0.96)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C1003(0.74); C1035(1.06); C177(0.73); C382(0.93)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C1003(1.05); C1035(0.98); C177(0.78); C382(1.00)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C1003(1.13); C1035(1.05); C382(1.08); C46(1.57)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C1003(1.11); C1035(1.13); C177(0.84); C382(1.23)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C1003(0.99); C177(1.10); C46(1.16); C54(1.16)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C1003(1.20); C177(1.37); C46(0.97); C54(0.97)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C1003(1.25); C177(1.32); C46(1.10); C54(1.10)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C1003(0.93); C177(1.38); C46(1.34); C54(1.34)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C1003(1.06); C177(1.22); C46(0.88); C54(0.88)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C1003(1.21); C177(1.61); C46(1.12); C54(1.12)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C1003(0.83); C177(1.52); C46(1.66); C54(1.66)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C1003(1.02); C177(1.35); C46(1.14); C54(1.14)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C1003(1.43); C177(1.38); C46(1.26); C54(1.26)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C1003(1.14); C1035(1.45); C382(0.95); C46(1.30)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C1003(1.00); C177(1.23); C46(0.96); C54(0.96)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C1003(1.17); C177(1.21); C46(1.21); C54(1.21)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C1003(1.04); C177(1.15); C46(1.17); C54(1.17)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C1003(1.13); C177(1.22); C46(1.22); C54(1.22)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C1003(1.10); C177(1.42); C46(1.44); C54(1.44)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C1003(1.11); C1035(1.06); C46(0.67); C54(0.67)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C1003(1.21); C1035(1.05); C46(0.62); C54(0.62)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C1003(1.30); C1035(1.26); C46(0.89); C54(0.89)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C1003(1.06); C1035(1.07); C46(0.63); C54(0.63)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C1003(1.16); C1035(1.51); C382(2.03); C46(2.76)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C1003(0.90); C1035(1.24); C46(0.70); C54(0.70)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C1003(1.34); C1035(1.00); C46(0.57); C54(0.57)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C1003(1.04); C1035(0.97); C46(0.50); C54(0.50)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C1003(1.07); C1035(0.68); C46(0.73); C54(0.73)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C1003(1.25); C1035(1.33); C46(0.80); C54(0.80)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C1003(0.82); C1035(1.38); C46(0.81); C54(0.81)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C1003(0.95); C1035(1.10); C46(0.65); C54(0.65)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C1003(0.97); C1035(1.39); C46(0.57); C54(0.57)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C1003(0.97); C1035(0.89); C46(0.62); C54(0.62)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C1003(1.11); C1035(0.98); C46(0.60); C54(0.60)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C1003(1.28); C1035(1.15); C382(1.18); C46(1.72)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C1003(1.47); C1035(1.04); C46(0.91); C54(0.91)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C1003(0.88); C1035(0.97); C177(0.87); C382(1.07)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C1003(0.79); C1035(1.21); C177(0.81); C382(1.13)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C1003(0.87); C1035(1.04); C177(0.97); C382(0.78)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C1003(0.78); C1035(1.30); C177(1.49); C382(0.92)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C1003(0.80); C1035(1.03); C177(1.40); C382(1.42)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C1003(0.94); C1035(1.10); C177(1.20); C382(1.16)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C1003(0.93); C1035(1.01); C177(1.06); C382(1.13)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C1003(0.98); C1035(1.09); C177(1.05); C382(0.92)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C1003(0.82); C1035(1.08); C177(1.10); C382(0.87)  LDD0811  [8]
 LDCM0028  Dobutamine HEK-293T 4.45  LDD0180  [6]
 LDCM0027  Dopamine HEK-293T 12.74  LDD0179  [6]
 LDCM0495  E2913 HEK-293T C177(1.23); C1035(0.97); C822(1.09); C589(1.11)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1035(1.60); C838(0.81)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C1003(1.02); C177(1.17); C46(1.08); C54(1.08)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C1003(0.82); C1035(0.91); C177(2.15); C382(1.97)  LDD0744  [8]
 LDCM0022  KB02 HCT 116 C46(14.05); C54(14.05); C1035(2.48); C177(2.11)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C46(2.57); C54(2.57); C1035(1.30); C177(1.69)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C46(6.22); C54(6.22); C1035(3.15); C177(2.13)  LDD0082  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1035(1.21)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1035(0.51)  LDD2101  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1003(1.22)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1003(1.06); C838(0.81)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1035(1.07)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1003(0.97); C1035(1.31)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1035(0.39)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1003(1.43); C1035(0.95)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1035(0.91); C838(0.98)  LDD2123  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1035(0.49)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1035(0.93)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1035(1.21)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C838(1.36)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C838(0.97)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1003(0.66)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1003(1.21)  LDD2143  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1003(0.99)  LDD2146  [4]
 LDCM0032  Oleacein HEK-293T 6.63  LDD0184  [6]
 LDCM0029  Quercetin HEK-293T 7.02  LDD0181  [6]
 LDCM0021  THZ1 HCT 116 C46(1.09); C54(1.09); C544(1.01); C545(1.01)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) Archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family P62875
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Aurora kinase A (AURKA) Ser/Thr protein kinase family O14965
Serine/threonine-protein kinase PLK4 (PLK4) Ser/Thr protein kinase family O00444
GTP-binding protein GEM (GEM) RGK family P55040
Cell division cycle protein 20 homolog B (CDC20B) WD repeat CDC20/Fizzy family Q86Y33
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxysterol-binding protein-related protein 8 (OSBPL8) OSBP family Q9BZF1
Pericentriolar material 1 protein (PCM1) PCM1 family Q15154
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) . Q96FE5
Other
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
CLIP-associating protein 1 (CLASP1) CLASP family Q7Z460
Eukaryotic translation initiation factor 4E type 2 (EIF4E2) Eukaryotic initiation factor 4E family O60573
. GOLGA8 family Q08AF8
Putative golgin subfamily A member 8D (GOLGA8DP) GOLGA8 family Q0D2H9
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Keratin, type II cytoskeletal 3 (KRT3) Intermediate filament family P12035
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Origin recognition complex subunit 6 (ORC6) ORC6 family Q9Y5N6
Synaptosomal-associated protein 47 (SNAP47) SVAP1 family Q5SQN1
Regulatory-associated protein of mTOR (RPTOR) WD repeat RAPTOR family Q8N122
Zinc finger C2HC domain-containing protein 1C (ZC2HC1C) ZC2HC1 family Q53FD0
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) . Q96SN8
F-box only protein 28 (FBXO28) . Q9NVF7
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3
Nebulette (NEBL) . O76041
Neuronal migration protein doublecortin (DCX) . O43602
Placental protein 13-like (LGALS14) . Q8TCE9
Protein PIMREG (PIMREG) . Q9BSJ6
RNA-binding protein 41 (RBM41) . Q96IZ5
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Tetratricopeptide repeat protein 23 (TTC23) . Q5W5X9
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402